Charis  Eng,  MD, PhD

Charis Eng, MD, PhD

Department Chair

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Location: NE5-314
Email: engc@ccf.org
Phone: (216) 444-3440
Fax: (216) 636-0655

 


Using multidisciplinary approaches, the Eng lab identifies and characterizes genes that cause susceptibility to inherited cancer syndromes, determines their role in sporadic carcinogenesis and performs molecular epidemiologic analyses as they relate to clinical applications. Using this framework, the lab examines PTEN and SDH in Cowden syndrome, which has a high risk of breast, thyroid and endometrial cancers, and SDH-related heritable neuroendocrine neoplasias. The lab examines PTEN, encoding a dual specificity phosphatase on 10q23.3, in Cowden and other hamartoma syndromes, as well as in isolated cancers. The lab pursues diverse mechanisms of PTEN inactivation for various sporadic cancers, including those of the breast and thyroid. Eng lab researchers explore gene-gene interactions and gene-environment interactions as relevant to ultimate clinical outcome. As such, a major focus of the Eng lab is to utilize multi-disciplinary approaches -- genomic modifiers, immune, microbiome, interrogation of cell fate and cellular phenotype, mouse models, etc.-- to dissect the mechanism of PTEN alterations leading to cancer predisposition or to the seemingly disparate autism spectrum disorder. This aim of this fundamental research is to not only resolve the mechanism, but also to identify novel targets for therapy and prevention.

In other words ...

An average 10% of all cancers are due to strong alterations in genes that predispose individuals to multiple cancers, often at young ages, and that can be inherited and passed on to their children.  Everyone is born with genes, whether “good” ones or “bad” ones.  Scientists estimate that an individual is born with an average of 6 “bad” genes that predispose to serious illness, such as cancer.  The Eng lab carries out patient-relevant research to increase genetic and genomic information resulting in intimate knowledge of human genes, which allows the creation of a roadmap for prevention and can lead to graceful aging.  The Eng lab’s cancer genetics and genomics research fulfills the adage “Knowledge is Power,” empowering patients to promote health and well-being for themselves and their families.


Ata  Abbas  PhD Ata Abbas, PhD
Research Associate
Location:NE5-255
Phone:(216) 445-7885
abbasa3@ccf.org
Sara  Akhavanfard  MD Sara Akhavanfard, MD
Graduate Student
Location:NE5-255
Phone:(216) 445-7885
akhavas@ccf.org
Takae  Brewer  MD Takae Brewer, MD
Clinical Fellow
Phone:(216) 410-3294
brewert2@ccf.org
Nicole  Brey  Nicole Brey
Project Manager
Location:NE5-272
Phone:(216) 442-8181
breyn@ccf.org
Hannah  Chen  Hannah Chen
Lead Research Technologist
Location:NE5-255
Phone:(216) 445-7885
chenj4@ccf.org
Masahiro  Hitomi  MD, PhD Masahiro Hitomi, MD, PhD
Project Staff
Location:NE5-255
Phone:(216) 445-0618
hitomim@ccf.org
Ritika  Jaini  PhD Ritika Jaini, PhD
Project Staff
Location:R4-058C
Phone:(216) 445-7885
jainir@ccf.org
Shinchung  Kang  MS Shinchung Kang, MS
Lead Research Technologist
Location:NE5-255
Phone:(216) 445-7885
kangs3@ccf.org
Hyunpil   Lee  PhD Hyunpil Lee, PhD
Postdoctoral Fellow
Location:R4-035C
Phone:(216) 445-7885
leeh@ccf.org
Scott  Lundy  MD, PhD Scott Lundy, MD, PhD
Resident
Location:NE5-255
Phone:(216) 445-7885
lundys@ccf.org
Roshan  Padmanabhan  PhD Roshan Padmanabhan, PhD
Postdoctoral Fellow
Location:NE5-255
Phone:(216) 445-7885
padmanr@ccf.org
Todd  Romigh  MS Todd Romigh, MS
Lead Research Technologist
Location:NE5-255
Phone:(216) 445-7885
romight@ccf.org
Tammy  Sadler  MS Tammy Sadler, MS
Lead Research Technologist
Location:NE5-255
Phone:(216) 445-7885
sadlert@ccf.org
Madhav  Sankunny  PhD Madhav Sankunny, PhD
Postdoctoral Research Fellow
Location:NE5-255
Phone:(216) 445-7885
sankunm@ccf.org
Nick  Sarn  Nick Sarn
Graduate Student
Location:R4-035D
Phone:(216) 445-7885
sarnn@ccf.org
Marilyn  Seyfi  MS Marilyn Seyfi, MS
Bioinformatics Technologist
Location:NE5-255
Phone:(216) 445-7885
seyfim@ccf.org
Elizabeth  Shay  Elizabeth Shay
Medical Student
Location:NE5-255
Phone:(216) 445-7885
shaye@ccf.org
Iris  Smith  PhD Iris Smith, PhD
Postdoctoral Fellow
Location:NE5-255
Phone:(216) 445-7885
smithi4@ccf.org
Stetson  Thacker  Stetson Thacker
Graduate Student
Location:R4-035B
Phone:(216) 445-7885
thackes@ccf.org
Lamis  Yehia  PhD Lamis Yehia, PhD
Postdoctoral Fellow
Location:NE5-255
Phone:(216) 445-7885
yehial@ccf.org
Qi  Yu  MS Qi Yu, MS
Senior Research Technologist
Location:NE5-255
Phone:(216) 445-7885
yuq@ccf.org

01/09/2019 |  

Five Researchers Win Annual Fund Grants

Cleveland Clinic recently announced the 29 projects selected for 2019 grant funding as part of the Annual Fund program, including five led by Lerner Research Institute researchers.




01/03/2019 |  

Personal Mutanomes Meet Precision Oncology

Thanks to remarkable scientific and technological advancements of late, researchers now have a deluge of sequencing data, which, with the right analysis, may help with the discovery and development of targeted cancer treatments. In a cover article published in Pharmacological Reviews, Cleveland Clinic’s Feixiong Cheng, PhD, Genomic Medicine, and collaborators review the current use of personal mutanomes in the discovery of modern oncology drugs, including therapies that are targeted to specific genomic or molecular profiles, as well as immunotherapies.




01/03/2019 |  

FDA Recognizes PTEN Variant Criteria

Recently, for the first time, the FDA formally recognized the process that led to curation of a public database containing information about genes, gene variants and their relationship to disease as a source of valid scientific evidence that can be used to support clinical validity in premarket submissions. Among the gene variants listed in this database are variants of PTEN, a highly penetrant cancer susceptibility gene.




10/18/2018 |  

Dr. Charis Eng Receives Medal of Honor from American Cancer Society

Charis Eng, MD, PhD, Chair of Cleveland Clinic’s Genomic Medicine Institute, has received the American Cancer Society’s Medal of Honor, the organization’s highest award. An internationally recognized physician-scientist in the cancer genetics field, Dr. Eng is among five honorees to receive the award at the ceremony in Washington, D.C. on October 18.




12/04/2017 |  

Dr. Eng Wins Professional Achievement Award from Alma Mater

Charis Eng, MD, PhD, founding chair, Genomic Medicine Institute, and founding director, Center for Personalized Genetic Healthcare, received the 2017 Professional Achievement Award from University of Chicago. This award honors distinguished alumni whose achievements have brought distinction to themselves, credit to the university and real benefit to their community. In the decades since she earned her bachelor's, medical and doctorate degrees from University of Chicago, Dr. Eng has certainly accomplished this, and has an impressive list of professional titles, awards and groundbreaking publications to prove it.




10/30/2017 |  

VIDEO: Dr. Charis Eng Explains CRISPR-Cas9

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a gene editing system commonly used in research labs. Like an edit/replace feature for correcting misspelled words in a document, CRISPR finds errors, or genetic mutations, in DNA. Then, using an enzyme called Cas9, CRISPR technology edits the error and pastes correct bits of DNA at the site.