Charis Eng, M.D., Ph.D. Department Chair Sondra J. and Stephen R. Hardis Chair of Cancer Genomic Medicine Genomic Medicine Institute (NE50) Lerner Research Institute 9500 Euclid Avenue Cleveland, Ohio 44195 Telephone: (216) 444-3440 Fax: (216) 636-0009 engc@ccf.org

Secondary Appointments: Taussig Cancer Center

Academic Appointments: Professor and Vice Chairman, Department of Genetics, Case Western Reserve University School of Medicine

Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine

Honorary Appointments: Honorary Fellow, Cancer Research UK Human Cancer Genetics Research Group, University of Cambridge, Cambridge, UK

National Scholar, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus

Education and Training:

• BA, University of Chicago, IL
• PhD, University of Chicago, IL
• MD, University of Chicago, IL
• Internal Medicine Residency, Beth Israel Hospital, Boston
• Medical Oncology Fellowship, Dana-Farber Cancer Institute, Boston
• Clinical Cancer Genetics Fellowship, University of Cambridge Addenbrooke’s Hospital and Royal Marsden NHS Trust, London, UK
• Postdoctoral Fellowship, CRC Human Cancer Genetics Research Group, University of Cambridge, UK

Selected Major Honors and Awards:

• Elected Member, American Society for Clinical Investigation (ASCI)
• Doris Duke Distinguished Clinical Scientist Award
• Elected Fellow, American Association for the Advancement of Science (AAAS)
• Elected Member, Association of American Physicians (AAP)
• Local Legend from Ohio, bestowed by the American Medical Women’s Association in conjunction with the National Library of Medicine on women physicians who have demonstrated commitment, originality, innovation and/or creativity in their fields of medicine
• ATA Van Meter Award for Outstanding Research on the Thyroid Gland and Related Topics, 13th International Thyroid Congress, Buenos Aires, Argentina
• Ernst Oppenheimer Memorial Award for Outstanding Achievements in Endocrine Research, The Endocrine Society, Boston, MA
• The Endocrine Society / Pfizer, International Inc. Finalist Award for Excellence in Published Clinical Research in J Clin Endocrinol Metab in 2005, The Endocrine Society, Boston, MA
• American Cancer Society (Ohio Division) John Peter Minton, MD, PhD Hero of Hope Research Medal of Honor in recognition of significant contributions to the advancement of cancer research in Ohio

Narrative Biosketch:

Charis Eng, MD, PhD is the Chair and founding Director of the Genomic Medicine Institute of the Cleveland Clinic Foundation, founding Director and attending clinical cancer geneticist of the institute’s clinical component, the Center for Personalized Genetic Healthcare, and Professor and Vice Chairman of the Department of Genetics at Case Western Reserve University School of Medicine. She holds a joint appointment as Professor of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine and is a member of Cleveland Clinic’s Taussig Cancer Center as well as the CASE Comprehensive Cancer Center. She was recently honored by the designation National Scholar of the Davis Heart and Lung Research Institute of The Ohio State University, and continues to hold an honorary appointment at the University of Cambridge. Dr. Eng’s research interests may be broadly characterized as cancer genomic medicine translational research. Her work on RET testing in multiple endocrine neoplasia type 2 and the characterization of the widening clinical spectra of PTEN gene mutations have been acknowledged as the paradigm for the practice of clinical cancer genetics.

Dr. Eng grew up in Singapore and Bristol, UK and entered the University of Chicago at the age of 16. After completing an MD and PhD at its Pritzker School of Medicine, she specialized in internal medicine at Beth Israel Hospital, Boston and trained in medical oncology at Harvard’s Dana-Farber Cancer Institute. She was formally trained in clinical cancer genetics at the University of Cambridge and the Royal Marsden NHS Trust, UK, and in laboratory-based human cancer genetics by Bruce Ponder, MB, PhD at the University of Cambridge. At the end of 1995, Dr. Eng was recruited back to the Farber as Assistant Professor of Medicine, and in January, 1999 was recruited by The Ohio State University as Associate Professor of Medicine and Director of the Clinical Cancer Genetics Program. In 2001, she was honored with the conferment of the Davis Professorship and appointed Co-Director of the Division of Human Genetics in the Department of Internal Medicine. In 2002, she was promoted to Professor and Division Director, and was conferred the Klotz Endowed Chair. She moved to the Cleveland Clinic in Sept, 2005. Dr. Eng has published over 300 peer reviewed original papers in such journals as the New England Journal of Medicine, Lancet, JAMA, Nature Genetics, Nature and Molecular Cell. She was the North American Editor of the Journal of Medical Genetics from 1998 to 2005, is Senior Editor of Cancer Research and Associate Editor of the Journal of Clinical Endocrinology and Metabolism and of the American Journal of Human Genetics. Dr. Eng is completing a three-year term on the Board of Directors of the American Society of Human Genetics, has just been elected to a give-year term on the Board of Scientific Counselors of the National Human Genome Research Institute and is the current chair of the clinical science committee of the Personalized Medicine Coalition.

Recent Peer Reviewed Publications:

Weber F, Xu Y, Zhang L, Patocs A, Shen L, Platzer P, Eng C.
Microenvironmental genomic alterations and clinico-pathologic behavior in
head and neck squamous cell carcinomas. JAMA 2007; 297:187-95.

Patocs A, Zhang L, Xu Y, Weber F, Caldes T, Mutter GL, Platzer P, Eng C.
Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl
J Med 2007; 357:2543-51. [PMID 18094375] Read more at The Washington Post
HealthDay here.

Pezzolesi MG, Platzer P, Waite KA, Eng C. Differential expression of
PTEN-targeting micro-RNAs miR-19a and miR-21 in Cowden syndrome. Am J Hum
Genet 2008; 82:1141-9. [PMID 18460397]

Assié G, LaFramboise T, Platzer P, Eng C. High frequency of germline genomic
homozygosity associated with cancer cases. JAMA 2008; 299:1437-45. [PMID
18364486] Read more in this article in The Washington Post

Ni Y, Zbuk KM, Sadler T, Patocs A, Lobo G, Edelman E, Platzer P, Orloff MS,
Waite KA, Eng C. Germline mutations and variants in the succinate
dehydrogenase genes in Cowden and Cowden-like syndromes. Am J Hum Genet
2008; 83:261-8

(go to publications page)