The goal of our laboratory is to understand what roles telomeres play in chromosome stability and segregation and how this information is communicated to the cell cycle machinery. We approach these problems by studying the regulation of yeast telomere length and the proteins that are part of yeast telomeric chromatin using yeast genetics and molecular biological and biochemical approaches. These studies on telomere proteins have led us into a separate project investigating how these proteins regulate yeast life span.
No explanation available.
Chen, B.-R. and Runge, K.W. Unbiased Genetic Approaches to Yeast Aging: New Connections and New Opportunities. In: “Aging Research in Yeast”. Michal Jazwinski, Peter Laun and Michael Breitenbach, eds.; Published by Springer. (in press)
Abdallah, P., Luciano, P., Runge, K.W., Lisby, M., Géli, V., Gilson, E., and Teixeira, M.T. (2009) A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol. 11, 988-993. Erratum in: Nat Cell Biol. 2010 May;12(5):520.
Chen, B.R., and Runge, K.W. (2009) A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity. Exp Gerontol. 44, 493-502. PMCID: PMC2795633.
Hector, R.E., Shtofman, R.L., Ray, A., Chen, B.R., Nyun, T., Berkner, K.L. and Runge, K.W. (2007) Tel1p preferentially associates with short telomeres to stimulate their elongation. Mol Cell. 27, 851-858.