George R. Stark, Ph.D., F.R.S. Staff, Distinguished Scientist of the Lerner Research Institute and Professor of Genetics, Case Western Reserve University Department of Molecular Genetics Lerner Research Institute / NE20 9500 Euclid Avenue Cleveland, Ohio 44195 Telephone: (216) 444-6062 Fax: (216) 444-0512 Email: starkg@ccf.org

Area of general research interest:

Signal transduction pathways involving interferons, STATs, NFKB, p53 and TGF ß ; Methods for forward genetics in mammalian cells

Current program:

• Use of insertional mutagenesis by retroviruses in mammalian cells
• Mechanisms of constitutive activation of NFKB in cancer
• Signaling pathways that respond to interferons
• Roles of STAT transcription factors in biology
• Activation and function of p53

Investigators:

• Cheon, HyeonJoo, Ph.D. (Postdoctoral Fellow)
• Dasgupta, Maupali (Postdoctoral Fellow)
• Lu, Tao, Ph.D. (Project Staff)
• Shultz, David (Medical Student)
• Van Boxel-Dezaire, Anette, Ph.D. (Research Associate)
• Wan, Youzhong (Graduate Student)
• Yang, Jinbo, Ph.D. (Project Staff)
• Yang, Maojing, B.S. (Technologist)
• Zula, Joana, B.S. (Technician)

Collaborators:

• Gudkov, Andrei, Ph.D., Roswell Park Cancer Institute
• Kerr, Ian, Ph.D., Cancer Research UK, London, U.K.
• Ransohoff, Richard, Ph.D., Cleveland Clinic
• Sizemore, Nywana, Ph.D., Cleveland Clinic