Bruce D Trapp, Ph.D.

Staff and Department Chair

The Morris R. and Ruth V. Graham Endowed Chair in Biomedical Research

Professor, Molecular Medicine, CCLCM-CWRU

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Location: NC3-136
Phone: (216) 444-7177
Fax: (216) 444-7927


Our research aims are to obtain a better understanding of cellular/molecular events involved in glial cell development and myelin formation in the central and peripheral nervous systems (CNS and PNS) and to understand how myelin, myelin-forming cells, and axons are destroyed in autoimmune and inherited diseases of myelin.

New data about the normal functioning of myelin-forming cells and myelin-axon interactions will help us understand the pathogenic mechanisms involved in permanent neurological disability in human diseases of myelin.

Cellular/Molecular Biology of Myelination: Our aim is to obtain a better understanding of cellular/molecular events that regulate production and differentiation of oligodendrocytes and CNS myelination. Using transgenic mice, we study the role of myelin and myelin proteins in maintaining axonal function and survival. We also investigate the role ofCNS progenitor cells as a source of new oligodendrocytes in the adult brain.

Pathogenesis of Neurological Disability in Multiple Sclerosis (MS): In these studies, we seek to determine the causes of MS, an inflammatory demyelinating disease of the CNS, and to therapeutically preventirreversible neurological disability in MS patients. Historically, it has been assumed that axons were spared most of the pathological consequences of inflammatory demyelination. We have described axonal degeneration during demyelination and as a result of chronic demyelination. We also focus on neuronal degeneration and axonal pathology in the cerebral cortex and hippocampus of MS patients. Recent studies also focus on the therapeutic potential of progenitor cells to repair demyelinated or dysmyelinated brain.

Jacqueline  Chen  PhD Jacqueline Chen, PhD
Project Staff

Assistant Professor, Molecular Medicine, CCLCM-CWRU

Phone:(216) 445-3206
Anthony  Chomyk  Anthony Chomyk
Lead Research Technologist
Phone:(216) 445-2671
Jessica  Dudman  Jessica Dudman
Research Technologist
Phone:(216) 445-2671
Jordon  Dunham  PhD Jordon Dunham, PhD
Research Fellow
Phone:(216) 445-2671
Claire  Jones  Claire Jones
Research Technician
Phone:(216) 445-2671
Grahame J Kidd  PhD Grahame J Kidd, PhD
Project Staff
Phone:(216) 445-0534
Mynor  Mendez  Mynor Mendez
Research Technician
Phone:(216) 445-2671

Selected Publications (2013-present):

Trapp BD, Vignos M, Dudman J, Chang A, Fisher E, Staugaitis SM, Battapady H, Mork S, Ontaneda D, Jones SE, Fox RJ, Chen J, Nakamura K, Rudick RA. (2018) Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study. Lancet Neurol. Aug 21. pii: S1474-4422(18)30245-X. PMID: 30143361

Dutta R, Trapp BD. (2018) Much, if not all, of the cortical damage in MS can be attributed to the microglial cell - No. Mult Scler. 24(7):897-899. PMID: 29754529; PMCID: PMC5995597

Koenig KA, Rao SM, Lowe MJ, Lin J, Sakaie KE, Stone L, Bermel RA, Trapp BD, Phillips MD. (2018) The role of the thalamus and hippocampus in episodic memory performance in patients with multiple sclerosis. Mult Scler. Mar 1:1352458518760716. PMID: 29512427

He X, Zhang L, Queme LF, Liu X, Lu A, Waclaw RR, Dong X, Zhou W, Kidd G, Yoon SO, Buonanno A, Rubin JB, Xin M, Nave KA, Trapp BD, Jankowski MP, Lu QR. (2018) A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nat Med. 24(3):338-351. PMID: 29431744; PMCID: PMC5908710

Chen J, Kostenko V, Pioro EP, Trapp BD. (2018) MR Imaging-based Estimation of Upper Motor Neuron Density in Patients with Amyotrophic Lateral Sclerosis: A Feasibility Study. Radiology 287(3):955-964. PMID: 29361242; PMCID: PMC5978454

Jawaid S, Kidd GJ, Wang J, Swetlik C, Dutta R, Trapp BD. (2018) Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome. Glia 66(4):789-800. PMID: 29274095; PMCID: PMC5812820

Nakamura K, Chen JT, Ontaneda D, Fox RJ, Trapp BD. (2017) T1-/T2-weighted ratio differs in demyelinated cortex in multiple sclerosis. Ann Neurol 82(4):635-639. PMID: 28833377

Chomyk AM, Volsko C, Tripathi A, Deckard SA, Trapp BD, Fox RJ, Dutta R. (2017) DNA methylation in demyelinated multiple sclerosis hippocampus. Sci Rep 7(1):8696. PMID: 28821749; PMCID: PMC5562763

Yin X, Kidd GJ, Ohno N, Perkins GA, Ellisman MH, Bastian C, Brunet S, Baltan S, Trapp BD. (2016) Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling. J Cell Biol 215(4):531-542. PMID: 27872255; PMCID: PMC5119941

Bai CB, Sun S, Roholt A, Benson E, Edberg D, Medicetty S, Dutta R, Kidd G, Macklin WB, Trapp B. (2016) A mouse model for testing remyelinating therapies. Exp Neurol 283(Pt A):330-340. PMID: 27384502; PMCID: PMC5207347

Chen Z, Chen JT, Johnson M, Gossman ZC, Hendrickson M, Sakaie K, Martinez-Rubio C, Gale JT, Trapp BD. (2015) Cuprizone does not induce CNS demyelination in nonhuman primates. Ann Clin Transl Neurol 2:208-13. PMID: 25750925; PMCID: PMC4338961

Mahad DH, Trapp BD, Lassmann H. (2015) Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol 14:183-93. PMID: 25772897

Yin X, Kiryu-Seo S, Kidd GJ, Feltri ML, Wrabetz L, Trapp BD. (2015) Proteolipid protein cannot replace P0 protein as the major structural protein of peripheral nervous system myelin. Glia 63:66-77. PMID: 25066805; PMCID: PMC4237650

Chiang H, Ohno N, Hsieh YL, Mahad DJ, Kikuchi S, Komuro H, Hsieh ST, Trapp BD. (2015) Mitochondrial fission augments capsaicin-induced axonal degeneration. Acta Neuropathol 129:81-96. PMID: 25322817; PMCID: PMC4282704

Chen Z, Jalabi W, Hu W, Park HJ, Gale JT, Kidd GJ, Bernatowicz R, Gossman ZC, Chen JT, Dutta R, Trapp BD. (2014) Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nat Commun 22:4486-97. PMID: 25047355; PMCID: PMC4109015

Ohno N, Chiang H, Mahad DJ, Kidd GJ, Liu L, Ransohoff RM, Sheng ZH, Komuro H, Trapp BD. (2014) Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons. Proc Natl Acad Sci USA 111:9953-58. PMID: 24958879; PMCID: PMC4103317

Dutta R, Trapp BD. (2014) Relapsing and progressive forms of multiple sclerosis: insights from pathology. Curr Opin Neurol 27:271-78. PMID: 24722325; PMCID: PMC4132635

Huynh JL, Garg P, Thin TH, Yoo S, Dutta R, Trapp BD, Haroutunian V, Zhu J, Donovan MJ, Sharp AJ, Casaccia P. (2014) Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nat Neurosci 17:121-30. PMID: 24270187; PMCID: PMC3934491

Koenig KA, Sakaie KE, Lowe MJ, Lin J, Stone L, Bermel RA, Beall EB, Rao SM, Trapp BD, Phillips MD. (2013) High spatial and angular resolution diffusion-weighted imaging reveals forniceal damage related to memory impairment. Magn Reson Imaging 31:695-99. PMID: 23295147; PMCID: PMC3648592

Chen JT, Easley K, Schneider C, Nakamura K, Kidd GJ, Chang A, Staugaitis SM, Fox RJ, Fisher E, Arnold JL, Trapp BD. (2013) Clinically feasible MTR is sensitive to cortical demyelination in MS. Neurology 80:246-52. PMID: 23269598; PMCID: PMC3589181

Dutta R, Chomyk AM, Chang A, Ribaudo MV, Deckard SA, Doud MK, Edberg DD, Bai B, Li M, Baranzini SE, Fox RJ, Staugaitis SM, Macklin WB, Trapp BD. (2013) Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol 73:637-45. PMID: 23595422; PMCID: PMC3679350

Nikolakopoulou AM, Dutta R, Chen Z, Miller RH, Trapp BD. (2013) Activated microglia enhance neurogenesis via trypsinogen secretion. Proc Natl Acad Sci USA 110:8714-19. PMID: 23650361; PMCID: PMC3666689

Koenig KA, Lowe MJ, Lin J, Sakaie KE, Stone L, Bermel RA, Beall EB, Rao SM, Trapp BD, Phillips MD. (2013) Sex differences in resting-state functional connectivity in multiple sclerosis. AJNR Am J Neuroradiol 34:2304-11. PMID: 23811974

Kang Z, Wang C, Zepp J, Wu L, Sun K, Zhao J, Chandrasekharan U, DiCorelto PE, Trapp BD, Ransohoff RM, Li X. (2013) Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells. Nat Neurosci 16:1401-08. PMID: 23995070; PMCID: PMC410602

US Patent Patent Title Issue Date First-Named Inventor


Multipotent neural stem cells

September 28, 2010

Bruce Trapp


Multipotent neural stem cells

February 26, 2013

Bruce Trapp


08/22/2018 |  

Cleveland Clinic Researchers Discover Novel Subtype of Multiple Sclerosis

Cleveland Clinic researchers have discovered a new subtype of multiple sclerosis (MS), providing a better understanding of the individualized nature of the disease.

02/07/2018 |  

Faulty Nerve Connections Responsible for Leading Inherited Cause of Autism Spectrum Disorders

Cleveland Clinic researchers have discovered for the first time that faulty connections between nerve cells (neurons) causes Fragile X Syndrome (FXS), the leading inherited cause of intellectual disability and autism spectrum disorders. FXS is caused by mutations that silence the FMR1 gene (Fragile X Mental Retardation 1).