Lerner Research Institute News

Read about the latest advances from Lerner Research Institute scientists, including new findings, grant awards, innovations and collaborations.

 

CYCLE-AD Trial: Testing High-Intensity Exercise to Stave Off Alzheimer’s Disease
01/19/2021

With a new $6.7 million grant from NIH, Drs. Alberts and Rao will test if home-based, high-intensity cycling may help prevent sedentary adults who carry the highest risk Alzheimer’s-related gene variant from developing the disease.

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Researchers Identify Protector of Intestinal Barrier
01/18/2021

Dr. Ivanov and his team have clarified the essential protective role of Β-actin in regulating the epithelial barrier and intestinal inflammation.

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Researchers Engineer Novel Disease Model to Develop New Ulcerative Colitis Drugs
01/11/2021

Dr. Huang developed an innovative patient-derived model of the chronic inflammatory bowel disease that mirrors the disease’s complexity better than others currently available and identified the protein CXCL8 as an actionable drug target.

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Study Shows Machine Learning’s Potential to Predict Cancer Therapy-Related Cardiac Risk
01/06/2021

An interdisciplinary team led by Drs. Cheng and Collier developed machine learning models that predict with promising accuracy the risk of cardiac dysfunction in cancer survivors and may be generalizable to clinical practice.

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Potential New Target for Treating Chemotherapy-Associated Kidney Damage
12/31/2020

Dr. Zhao and his team found that inhibiting the APE2 protein in a preclinical model of cisplatin-induced acute kidney injury significantly helped attenuate disease pathology.

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Concurrent Chemotherapy and Antibiotic Use Associated with Epithelial Ovarian Cancer Outcomes
12/28/2020

Findings from a new retrospective study reveal that caution should be practiced when prescribing antibiotics to patients as antibiotic therapy is associated with decreased overall survival among women with the ovarian cancer.

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Latest COVID-19-Related Prediction Model from Cleveland Clinic Forecasts Risk for ICU Admission, Death
12/22/2020

This latest prediction model from Drs. Kattan and Jehi helps identify which COVID-19-positive patients are at greatest risk for severe COVID-19, which may help physicians prioritize who should receive COVID-19 vaccines first.

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Study Reveals How Improved Type of Light Therapy Kills Pre-Cancerous Cells
12/16/2020

Dr. Maytin and colleagues developed a less painful but equally effective form of photodynamic therapy to treat pre-cancerous actinic keratosis, demonstrating that it works through a completely different signaling pathway than the conventional therapy.

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Combining Genomics and Mathematics Helps Personalize Radiation Therapy for Lung Cancer
12/14/2020

Rather than a one-size-fits-all approach, new technology from Dr. Scott provide opportunity to choose personalized radiation dose to improve outcomes and reduce toxicity.

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Cancer Researchers Identify Potential New Class of Drugs to Treat Blood and Bone Marrow Cancers
12/11/2020

Drs. Maciejewski and Jha developed a small molecule that selectively targeted and effectively eliminated cancer cells with a certain genetic mutation in preclinical models of myeloid leukemia, while simultaneously granting survival advantage to healthy cells.

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New Method for Diagnosing Pain Combines EEG and Artificial Intelligence
12/10/2020

Dr. Saab and his team are exploring a new, more objective way to diagnose pain that is rapid, less expensive and provides more accurate results.

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COVID-19 May Also Invade the Central Nervous System, Cause Neurological Illnesses
12/08/2020

In a new review, Dr. Ghosh notes that recent case reports of COVID-19-associated neurological disorders, which may result from blood-brain barrier dysfunction, demonstrate the virus’ neuroinvasive potential.

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How 3D Printing Can Optimize Care for Patients with Primary Tricuspid Valve Disease
12/07/2020

Research engineer Ryan Klatte co-authored an illustrated case series that profiles how valuable 3D printing is for the rare and complex disease, namely as a surgical planning and patient communication tool.

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Researchers Embark on New Study to Identify Predictors of Chemotherapy-Associated Pain Condition
11/16/2020

Dr. Rotroff and clinical collaborator Dr. Foss will compare genetic, epigenetic and metabolomic data from breast cancer patients who experience the condition versus those who don’t in an effort to develop a predictive machine learning-based algorithm for personalized risk.

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COVID-19 Risk Model Developed by Cleveland Clinic Now Available to Health Systems Around the World Through Epic
11/09/2020

Healthcare organizations can present the clinically validated model—first published by Drs. Kattan and Jehi in a June edition of CHEST—to patients in MyChart to assess their risk of having COVID-19.

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Cleveland Clinic Researchers Use “Big Data” Approach to Identify Melatonin as Possible COVID-19 Treatment
11/09/2020

Dr. Cheng and colleagues developed a network medicine strategy to predict disease manifestations associated with COVID-19 and find existing drugs with the potential to be effective COVID-19 treatments.

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Potential Target Discovered for Reversing Drug Resistance in Epilepsy
11/04/2020

Dr. Ghosh’s team has learned about an important relationship between the glucocorticoid receptor and heat shock proteins, which may have clinical implications for treating patients who have drug-resistant epilepsy.

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Not All Mutations are Bad: Researchers Identify Differences between Benign and Pathogenic Variants
10/26/2020

Dr. Lal’s team conducted the first big data characterization of missense variants from 1,300 disease-associated genes to identify features associated with pathogenic and benign variants.

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Possible Target Identified to Prevent Recurrent Blood Vessel Blockages Following Vascular Procedures
10/21/2020

The TRPC6 gene plays a role in arterial healing after an injury, according to a new study led by Dr. Graham. This could lead to the development of therapies to reduce the occurrence of intimal hyperplasia and stenosis.

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Cleveland Clinic Joins New Consortium to Map Nuclear DNA in Four-Dimension
10/16/2020

Dr. Hu and a group of international collaborators will investigate how chromatin is spatially organized within the nucleus of various cell types and how this organization changes over time—the fourth dimension—in an effort to identify targets for treating a host of diseases.

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Advancing the Study of Rare Genetic Disorder Shwachman-Diamond Syndrome
10/16/2020

Dr. Corey and team have successfully genetically engineered a model of zebrafish that mimics Shwachman-Diamond Syndrome pathologies observed in patients, which will help advance research into developing new therapies to treat the disease.

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Cleveland Clinic Joins Multi-site Study and International Network to Study Parkinson’s Disease
10/14/2020

Dr. Chan will serve as the core investigator at Cleveland Clinic, one of four institutions working together as part of this collaborative study funded through Aligning Science Across Parkinson’s.

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A 3D Epigenomic Characterization of the Developing Human Cortex
10/14/2020

In collaboration with researchers across the country, Dr. Hu used a multi-omics approach to define the epigenetic characteristics of cell types critical for cerebral cortex formation, revealing potential targets for neuropsychiatric diseases related to faulty cortical development.

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LRI Names 2020 Awards for Excellence Winners
10/05/2020

In a virtual ceremony hosted by the Research Education and Training Center, 11 students, trainees and staff members were honored with Awards for Excellence for their 2020 accomplishments.

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