Christine McDonald, Ph.D.
Associate Staff

Christine McDonald, Ph.D.

Associate Staff, Department of Pathobiology
Assistant Professor of Molecular Medicine

  • Department of Pathobiology
  • Lerner Research Institute (NC22)
  • Cleveland Clinic
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • Office: NB2-87
  • Lab: NB2-118
  • Office phone: (216) 445-7058
  • Lab phone: (216) 444-0624
  • Fax: (216)636-0104
  • Email:
  • Postdoctoral Fellowship in Innate Immunity Mediated by NOD-like receptors
  • Laboratory of Gabriel Nuñez, MD
  • University of Michigan Medical School, Department of Pathology
  • 2003-2006
  • Postdoctoral Fellowship in Microbial Pathogenesis
  • Laboratory of Jack E. Dixon, PhD
  • University of Michigan, Department of Biochemistry
  • 2001-2003
  • Graduate Education
  • PhD in Cellular & Molecular Pathology
  • Dissertation: Functional characterization of the interleukin-4 activated transcription factor, STAT6
  • Laboratory of Nancy C. Reich, PhD
  • State University of New York at Stony Brook
  • 2001
  • Undergraduate Education
  • BA in Biology
  • Macalester College
  • 1992
  • Crohn’s disease
  • Inflammatory bowel disease
  • Auto-inflammatory disease
  • Innate Immunity
  • Host defense mechanisms of the skin & intestine
  • Nod-like receptors (NLRs)
  • Autophagy

PubMed Publications

Marinis J.M., Homer C.R., McDonald C., & Abbott D.W. (2011) A novel motif in the Crohn’s disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses. J. Biol. Chem. 286:1938-50. Epub 2010 Nov 19, PMCID: PMC3023490 [Available on 2012/1/21].

Homer C.R., Richmond A.L., Rebert N.A., Achkar J.-P., & McDonald C. (2010) ATG16L1 and NOD2 interact in an autophagy-dependent, anti-bacterial pathway implicated in Crohn’s disease pathogenesis. Gastroenterology 139:1630-1641.

Marina-García N., Franchi L., Kim Y.-G., Miller D., McDonald C. , Boons G.-J., & Nuñez G. (2008) Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2. J. Immunol. 180: 4050-4057.

Lécine P., Esmiol S., Métais J.-Y., Nicoletti C., Nourry C., McDonald C. , Nuñez G., Hugot J.-P., Borg J.-P., & Ollendorff V. (2007) The Nod2-Rick Complex Signals from the Plasma Membrane. J. Biol. Chem. 282:15197-15207.

Park J.-H., Kim Y.-G., McDonald C. , Kanneganti T.-D., Body-Malapel M., Inohara N., & Nuñez G. (2007) RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but not TLRs. J. Immunol. 178:2380-2386.

Coussens N.P., Mowers J. C., McDonald C. , Nuñez G. & Ramaswamy S. (2007) Crystal Structure of the Nod1 Caspase Activation and Recruitment Domain. Biochem. Biophys. Res. Comm. 353:1-5.

Franchi L., McDonald C. , Kanneganti T.-D., Amer A., & Núñez G. (2006) NLRs:Intracellular Pattern Recognition Receptors for Pathogen Detection and Host Defense, J. Immunol. 177:3507-13.

McDonald C. , Chen F.F., Ollendorff V., Ogura Y., Marchetto S., Lécine P., Borg J.-P. & Nuñez G. (2005) A role for Erbin as a regulator of Nod2-dependent NF-kB signaling. J. Biol. Chem. 280:40301-40309.

McDonald C. , Inohara N. & Nuñez G. (2005) Peptidoglycan signaling in innate immunity and inflammatory disease. Review J. Biol. Chem. 280:20177-80.

Inohara N., Chamaillard M., McDonald C. & Nuñez G. (2005) NOD-LRR proteins: role in microbial-host interactions and inflammatory disease. Ann. Rev. Biochem. 74: 355-383.