Research Seminars & Events
The Lerner emphasizes translational research that has the potential to improve patient care. Our scientists work closely with Cleveland Clinic physicians to transform groundbreaking discoveries made in the laboratory to the bedside. Our collaborative Research Centers of Excellence bring together scientific and clinical experts to solve problems seen in patients and accelerate discoveries into new treatments and cures.
March 2019 16
Title: Targeting Metabolic Vulnerabilities in Cancer
Katherine Aird Pennsylvania State University College of Medicine
Title: "Mechanosensory function of Kindlin3 in microglia is crucial for retinal vascular patterning"
Tejasvi Dudiki, Ph.D., Laboratory of Dr. Tatiana Byzova
Our study demonstrates that microglia control vascular growth and patterning in retinas by altering its gene expression in response to its surrounding extra cellular matrix. Using microglia-specific genetic knockout and knock-in mouse models, we show that this process is orchestrated by Kindlin3, an intracellular integrin adaptor. Lack of Kindlin3 in microglia caused abnormal vascular patterning and excessive vascular growth, which is reminiscent of early stages of human retinal angiomatous proliferation.
Title: Cancelled-to be rescheduled
Jonathan Godbout, PhD, Professor, Department of Neuroscience, Institute for Behavioral Medicine Research, Center for Brain and Spinal Cord Repair, The Ohio State University
Hosted by: Jessica Williams
Title: Plugging leaks: Identifying targets to reverse molecular disruption of tight junctions by alcohol
Michael Koval, PhD Professor of Medicine, Emory University School of Medicine
Title: Immunity in response to colonization with the microbiota
Timothy Hand University of Pittsburgh-Children's Hospital of Pediatrics Assistant Professor
Title: "Gender Differences in Severe Asthma"
Joe Zein, MD, Faculty update
Title: Mechanisms of Blood Brain Barrier Disruption in Neuroinflammatory Disease
Nozha Borjini, Ph.D., Laboratory of Dr. Dimitrios Davalos
Title: "Degradation of the Deubiquitinase Otulin by RIPA pathway Inhibits Viral Replication"
Rameez Raja - Sen Lab
Title: "Lymphatics in the liver"
Yasuko Iwakiri, PhD. Associate Professor of Medicine, Yale University
Title: Design and execution of the first polygenic risk study in epilepsy
Costin Leu, PhD - Lal Lab - Genomic Medicine Institute
Title: "T cell Metabolism and Fueling Immunity"
Jeff Rathmell, PhD; Vanderbilt University
Hosted by Xiaoxia Li, PhD
Title: "Thalamic MRI, histopathologic, and clinical correlations in multiple sclerosis"
Kedar R. Mahajan, MD, PhD, Associate Staff, Neurological Institute, Cleveland Clinic
Hosted by: Bruce Trapp
Darshana Poddar - Sen Lab
Title: PTEN in cell fate decision; Case of neural stem cell
Masahiro Hitomi, M.D., PhD - Eng Lab - Genomic Medicine Institute
Title: "Repairing the Glomerulus through Regeneration"
Stuart Shankland, MD, MBA, FRCP; Professor, Division of Nephrology Head at University of Washington - Seattle
Hosted by Leslie Bruggeman, PhD
Mike Cheung - Gupta Lab