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Jan Jensen, Ph.D.Associate StaffEddie J. Brandon Endowed Chair in Diabetes ResearchDirector, Diabetes Research |
Area of general research interest:
Developmental biology of the pancreas with a focus on the molecular mechanisms controlling insulin-cell development.
Programs:
- Role of FGF10 in pancreatic development
- Evaluation of a novel cell surface marker, Betacam, of pancreatic beta-cells
- Conditional gene activation in developing pancreas
- Systems biology of the morphogen-signaling network in the pancreas
- Development of GeneSpeed, GeneSpeed Beta Cell and GeneSpeed Stem cell: online resources for the islet and stem cell research communities.
Investigators:
- Solomon Afelik, Ph.D., Postdoctoral Fellow
- Michael Bukys, Ph.D., Postdoctoral Fellow
- Xiaoling Qu, Ph.D., Postdoctoral Fellow
- Nayeem Quayum, Programmer
- Fan Xiao, Technologist
Collaborators:
- Jose Oberholzer, U. Illinois Chicago
- John Hutton, Barbara Davis Center for Childhood Diabetes, U. Colorado HSC
- Steven Leach, Johns Hopkins Medical Institute
- Anne Grapin-Botton, ISREC, Lausanne, CH.
Recent publications:
Embryonic stem cells as a potential cure for diabetes
Michael A. Bukys and Jan Jensen
In “Stem Cell Therapy for Diabetes”, chapter 10,, Springer verlag, editor S. Efrat. In press.
Isolation and Characterization of Centroacinar/Terminal Ductal Progenitor Cells in Adult Mouse Pancreas
Meritxell Rovira, Sherri-Gae Scott, Andrew S. Liss, Jan Jensen, Sarah P. Thayer, Steven D. Leach
Proc. Natl. Acad. Sci, 2009, Accepted for publication
Transcription factor Glis3: a novel critical player in the regulation of pancreatic β-cell development and insulin gene expression
Hong Soon Kang, Yong-Sik Kim, Gary ZeRuth, Ju Youn Beak1 Kevin Gerrish, Gamze Kilic, Beatriz Sosa-Pineda, Jan Jensen, Julie Foley, and Anton M. Jetten
Molecular and Cellular Biology, 2009, Accepted for publication
Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by FGF10
Sune Kobberup, Martin Schmerr,My-Linh Dang, Pia Nyeng, Raymond J. MacDonald, and Jan Jensen
Mechanisms of Development, 2009, Accepted for publication.
GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist
Nayeem Quayum, Alecksandr Kutchma, Suparna A. Sarkar, Kirstine Juhl, John C. Hutton and Jan Jensen
Experimental Diabetes Research, 2008;2008:312060
The mouse pancreatic endocrine cell transcriptome defined in the embryonic
Ngn3 null mouse
Kirstine Juhl, Suparna A. Sarkar, Randall Wong, Jan Jensen, John C. Hutton
Diabetes, 2008 Oct;57(10):2755-61
Loss of hedgehog signaling impairs epithelial regeneration in chemically-induced acute pancreatitis
Volker Fendrich, Farzad Esni, Jan Nygaard Jensen, M. Veronica Albertoni, Yuval Dor, Georg Feldman, Jan Jensen,
Steven Leach, Anirban Maitra.
Gastroenterology. 2008 Apr 16
Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration
Tessem JS, Jensen JN, Pelli H, Dai XM, Zong XH, Stanley ER, Jensen J, DeGregori J.
Diabetes. 2008 Jun;57(6):1605-17.
FGF10 overexpression leads to progenitor state arrest, distalization and goblet cell metaplasia during embryonic lung development
Pia Nyeng, Gitte Anker Norgaard and Jan Jensen
BMC Dev Biol. 2008 Jan 10;8:2
Global Gene Expression Profiling and Histochemical Analysis of the Developing Human Fetal Pancreas
Suparna A. Sarkar, Sune Kobberup, Nayeem Quayuum, Randall Wong, Ana D. Lopez2, Travis Still, Alecksander Kutchma, Roberto Gianani, Gillian M. Beattie2, Alberto Hayek2, Jan Jensen and John C. Hutton
Diabetologia. 2008 Feb;51(2):285-97
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
Janet M. Wenzlau, Kirstine Juhl*, Liping Yu, Ong Moua, Suparna A. Sarkar, Peter Gottlieb, Marian Rewers, George S. Eisenbarth, Jan Jensen, Howard W. Davidson, and John C. Hutton
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5
Ets-family genes in pancreatic development
Sune Kobberup, Pia Nyeng, Kirstine Juhl, John Hutton and Jan Jensen
Dev Dyn. 2007 Sep 28;236(11):3100-3110
Pathway decision-making strategies for generating pancreatic b-cells: systems biology or hit-and-miss?
Jan Jensen
Current Opinion in Endocrinology and Diabetes, 2007, vol 14, 277-282,
FGF10 signaling controls stomach morphogenesis
Pia Nyeng, Gitte Anker Norgaard, Sune Kobberup and Jan Jensen
Developmental Biology, 2007 Mar 1;303(1):295-310.
SOX9 Is Required for Maintenance of the Pancreatic Progenitor Cell Pool
Philip A. Seymour1, Kristine K. Freude1, Man N. Tran1, Erin E. Mayes1, Jan
Jensen2, Ralf Kist3, Gerd Scherer4 and Maike Sander1
Proc. Natl. Acad. Sci., February 6, 2007, vol. 104, no. 6, pp 1865-1870
Genespeed: Domain organization of the transcriptome
Kutchma, A.J., Quayum N., Jensen J.