Stanley L. Hazen
M.D., Ph.D.

Stanley L. Hazen, M.D., Ph.D.

The Jan Bleeksma Chair in Vascular Cell Biology and Atherosclerosis
The Leonard Krieger Chair in Preventive Cardiology

Department Chair

Director,Center for Cardiovascular Diagnostics & Prevention
Section Head, Preventive Cardiology & Rehabilitation

  • Department of Cellular and Molecular Medicine (NC10)
  • Cleveland Clinic Lerner Research Institute
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • (216) 445-9763
  • (216) 444-9404

Research interest

A long term goal of my laboratory is to understand mechanisms through which inflammation contributes to diseases like atherosclerosis and asthma. Several major research programs are currently under investigation. One research program focuses on the role of myeloperoxidase, a leukocyte heme protein, in promoting oxidant stress in vivo, and its participation in cardiovascular diseases. A second area focuses on HDL structure and function. A final area of research interest focuses on the role of intestinal microbiota in cardiometabolic disease.

All research projects rely heavily on chemical and analytical methods to identify specific reactions/products, their mechanisms of formation, and their use as probes to elaborate pathways responsible for disease. Research efforts in each program span from bench-to-bedside, including basic/genetic, cellular, animal model, and human clinical investigations.

In other words ...

A long term goal of my laboratory is to understand the ways in which our immune system contributes to diseases like heart disease and asthma. I have several major areas of focus. One centers on the role of myeloperoxidase, a protein found in white blood cells that plays an important role in fighting infections, but which we have discovered also participates in development of heart diseases. A second area focuses on the role of microbes in our intestines (called gut flora) in heart disease. Another area focuses on the HDL particle (carrier of good cholesterol in the blood). 

Investigators

  • Hassan Alamri
  • Graduate Student
  • Location:NE1-224
  • hassana@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Camelia Baleanu-Gogonea PhD
  • Visiting Scientist
  • Location:NE1-224
  • baleanc@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Shawna Battle
  • Graduate Student
  • Location:NE1-224
  • battles@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Nancy Bell
  • Technologist
  • Location:NE6-217
  • belln@ccf.org
  • (216) 444-5447
  • (216) 444-9404
  • Kimberly Brinson
  • Research Technician
  • Location:NE1-224
  • brinsok@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Jennifer Ann Buffa M.S.
  • Lead Research Technologist
  • Location:NE6-216
  • leisinj@ccf.org
  • (216) 445-1900
  • (216) 636-0392
  • Ibrahim Choucair
  • Graduate Student
  • Location:NE1-224
  • choucai@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Brian DelFraino
  • Lead Research Technologist
  • Location:NE1-124
  • delfrab@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Joseph A. DiDonato Ph.D.
  • Staff Scientist
  • Location:NE1-223
  • didonaj@ccf.org
  • (216) 445-2174
  • (216) 636-0396
  • Anthony DiDonato
  • Research Student
  • Location:NE1-224
  • didonaa@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Xiao Ming Fu M.S.
  • Lead Research Technologist
  • Location:NE1-224
  • fux@ccf.org
  • (216) 445-6466
  • (216) 445-6466
  • Valentin Gogonea PhD
  • Research Scholar
  • Location:NE1-27
  • gogonev@ccf.org
  • (216) 444-4220
  • (216) 636-0392
  • Xiaodong Gu Ph.D
  • Postdoctoral Fellow
  • Location:NE1-224
  • gux2@ccf.org
  • (216) 445-5903
  • (216) 636-0392
  • Anu Guggilam PhD
  • Postdoctoral Fellow
  • Location:NE1-224
  • guggila@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Nilaksh Gupta PhD
  • Fellow
  • Location:NE1-237
  • guptan2@ccf.org
  • (216) 444-1029
  • (216) 444-9404
  • Jane Lee Hoover-Plow Ph.D.
  • Staff Consultant
  • Location:NB5-85
  • hooverj@ccf.org
  • (216) 445-8207
  • (216) 444-8204
  • Ying Huang Ph.D.
  • Research Associate
  • Location:NE1-224
  • huangy2@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Alex Hurd
  • Research Student
  • Location:NE1-224
  • hurda2@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Xin-Min Li Ph.D.
  • Research Associate
  • Location:NE6-216
  • lix2@ccf.org
  • (216) 445-1900
  • (216) 636-0392
  • Lin Li Ph.D.
  • Lead Research Technologist
  • Location:NE6-216
  • lil@ccf.org
  • (216) 445-1900
  • (216) 636-0392
  • HongQiao Lin
  • Graduate Student
  • Location:NE1-224
  • linh@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Kara Rieth
  • Research Student
  • Location:NE1-224
  • riethk@ccf.org
  • (216) 444-6466
  • (216) 444-9404
  • Adam Roberts PhD
  • Fellow
  • Location:NE1-224
  • roberta3@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • David Schmitt
  • Lead Research Technologist
  • Location:NE1-224
  • schmitd@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Ting Shi PhD
  • Project Scientist
  • Location:NE1-233
  • shiti@ccf.org
  • (216) 445-9653
  • (216) 444-3164
  • Celalettin Topbas
  • Visiting Grad Student
  • Location:NE1-224
  • topbasc@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Matthew Wagner
  • Senior Technologist
  • Location:NE1-224
  • wagnerm4@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Zeneng Wang PhD
  • Project Scientist
  • Location:NE1-231
  • wangz2@ccf.org
  • (216) 445-2484
  • (216) 636-0392
  • Yuping Wu PhD
  • Research Scholar
  • Location:NE1-224
  • wuy2@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Maryam Zamanian-Daryoush
  • Research Associate
  • Location:NE6-201
  • zamanim@ccf.org
  • (216) 444-0484
  • (216) 636-0392
  • Weifei Zhu PhD
  • Research Associate
  • Location:NE1-226
  • zhuw@ccf.org
  • (216) 444-5855
  • (216) 444-9404

Collaborators

  • Erzurum, Serpil M.D., Department of Cancer Biology, Cleveland Clinic Foundation
  • Febbraio, Maria Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Feldstein, Ariel, Ph.D., Departments of Pediatric Gastroenterology and Cell Biology, Cleveland Clinic Foundation
  • Fisher , Edward, M.D., Ph.D., Department of Cardiovascular Medicine New York University School of Medicine
  • Fox, Paul, Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Gogonea, Valentin, Ph.D., Department of Chemistry, Cleveland State University
  • Gornik, Heather, M.D., Department of Cardiovascular Medicine, Cleveland Clinic Foundation
  • Ischiropoulos, Harry, Ph.D., Departments of Pediatrics, Biochemistry and Biophysics, University of Pennsylvania,
  • McIntyre, Thomas, Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Nicholls, Stephen, M.D., Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Nissen, Steve, M.D., Department of Cardiovascular Medicine, Cleveland Clinic Foundation
  • Salomon, Robert, Ph.D., Chemistry Department, Case Western Reserve University, Cleveland
  • Schauer, Phil, M.D., Department of Surgery, Cleveland Clinic Foundation
  • Sehayek, Ephraim, M.D., Genomic Medicine Institute, Cleveland Clinic Foundation
  • Silverstein, Roy M.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Smith, Jonathan, Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Stuehr, Dennis, Ph.D., Department of Immunology, Cleveland Clinic Foundation
  • Tang, Wilson, Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • van Lente, Fred, Ph.D., Department of Clinical Pathology, Cleveland Clinic Foundation
  • Judith Schiciano MBA., A.R.M.
  • Department Administrator
  • Location:NC1-129
  • schicij@ccf.org
  • (216) 444-8710
  • (216) 444-9404

Highlighted Publications

  1. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature.(2011) 472(7341):57-63. PMCID: PMC3086762
  2. Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. New England Journal of  Medicine. (2013) 368(17):1575-84. PMCID: PMC3701945
  3. Koeth RA, Wang Z, Levison BS, Buffa J, Org E, Sheehy B, Li  H, Britt EB, Fu X, Wu Y, Smith JD, DiDonato JA, Chen J, Li H, Wu G, Lewis JD, Warrier M, Brown, JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, and Hazen SL. Intestinal microbiota metabolism of L-Carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine. (2013) 19(5): 576-85. PMCID: PMC36501111
  4. Huang Y, Didonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF, Fox PL, Gogonea V, Tang WH, Parks JS, Fisher EA, Smith JD, Hazen SL. An abundant dysfunctional apolipoprotein A1 form in human atheroma. Nature Medicine. (2014) 20(2):193-203. PMCID: PMC3923163
  5. Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, Wagner MA, Bennett BJ, Li L, DiDonato JA, Lusis AJ, Hazen SL. Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation. The Journal of Biological Chemistry. (2015) 290(9):5647-60 PMCID: PMC4342477
  6. Tang WHW, Wang Z, Kennedy DJ, Wu Y, Buffa J, Agatisa-Boyle B, Li XS, Levison BS, Hazen SL. The Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease. Circulation Research. (2015) 116(3):448-55 PMCID: PMC4312512

Search PubMed for articles by Dr. Hazen