A long term goal of my laboratory is to understand mechanisms through which inflammation contributes to diseases like atherosclerosis and asthma. Several major research programs are currently under investigation. One research program focuses on the role of myeloperoxidase, a leukocyte heme protein, in promoting oxidant stress in vivo, and its participation in cardiovascular diseases. A second area focuses on HDL structure and function. The third area focuses on the role of peroxidases and tobacco exposure in airway remodeling in asthma. A final area of research interest focuses on the role of intestinal microbiota in cardiometabolic disease.
All research projects rely heavily on chemical and analytical methods to identify specific reactions/products, their mechanisms of formation, and their use as probes to elaborate pathways responsible for disease. Research efforts in each program span from bench-to-bedside, including basic/genetic, cellular, animal model, and human clinical investigations.
A long term goal of my laboratory is to understand the ways in which our immune system contributes to diseases like heart disease and asthma. I have several major areas of focus. One centers on the role of myeloperoxidase, a protein found in white blood cells that plays an important role in fighting infections, but which we have discovered also participates in development of heart diseases. A second area focuses on the role of microbes in our intestines (called gut flora) in heart disease. Another area focuses on the HDL particle (carrier of good cholesterol in the blood). The final area focuses on the role of white blood cells in the lungs in causing asthma.
Wang Z, et al. Gut flora dependent metabolism of dietary phosphatidylcholine contributes to cardiovascular disease. Nature (2011) 472(7341):57-63. PMCID: PMC3086762
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Wang Z, et al Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nature Medicine (2007) 13:1176-84.
Wu Z, et al. The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat. Struct. Mol. Biol. (2007) 14: 861-8.
Brennan ML, et al. Prognostic value of myeloperoxidase in patients with chest pain. New Engl J Med. (2003) 349(17):1595-604.