Stanley L. Hazen
M.D., Ph.D.

Stanley L. Hazen, M.D., Ph.D.

The Jan Bleeksma Chair in Vascular Cell Biology and Atherosclerosis
The Leonard Krieger Chair in Preventive Cardiology

Department Chair

Director,Center for Cardiovascular Diagnostics & Prevention
Section Head, Preventive Cardiology & Rehabilitation

  • Department of Cellular and Molecular Medicine (NC10)
  • Cleveland Clinic Lerner Research Institute
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • (216) 445-9763
  • (216) 444-9404

Research interest

A long term goal of my laboratory is to understand mechanisms through which inflammation contributes to diseases like atherosclerosis and asthma. Several major research programs are currently under investigation. One research program focuses on the role of myeloperoxidase, a leukocyte heme protein, in promoting oxidant stress in vivo, and its participation in cardiovascular diseases. A second area focuses on HDL structure and function. The third area focuses on the role of peroxidases and tobacco exposure in airway remodeling in asthma. A final area of research interest focuses on the role of intestinal microbiota in cardiometabolic disease.

All research projects rely heavily on chemical and analytical methods to identify specific reactions/products, their mechanisms of formation, and their use as probes to elaborate pathways responsible for disease. Research efforts in each program span from bench-to-bedside, including basic/genetic, cellular, animal model, and human clinical investigations.

In other words ...

A long term goal of my laboratory is to understand the ways in which our immune system contributes to diseases like heart disease and asthma. I have several major areas of focus. One centers on the role of myeloperoxidase, a protein found in white blood cells that plays an important role in fighting infections, but which we have discovered also participates in development of heart diseases. A second area focuses on the role of microbes in our intestines (called gut flora) in heart disease. Another area focuses on the HDL particle (carrier of good cholesterol in the blood). The final area focuses on the role of white blood cells in the lungs in causing asthma.

Investigators

  • Kimberly Brinson
  • Research Technician
  • Location:NE1-224
  • brinsok@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Jennifer Ann Buffa M.S.
  • Senior Technologist
  • Location:NE6-216
  • leisinj@ccf.org
  • (216) 445-1900
  • (216) 636-0392
  • Yoon-Mi Chung
  • Senior Technologist
  • Location:NE1-224
  • chungy2@ccf.org
  • (216) 444-3136
  • (216) 636-0392
  • Brian DelFraino
  • Research Technologist
  • Location:NE1-124
  • delfrab@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Anthony DiDonato
  • Research Student
  • Location:NE1-224
  • didonaa@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Joseph A. DiDonato Ph.D.
  • Staff Scientist
  • Location:NE1-223
  • didonaj@ccf.org
  • (216) 445-2174
  • (216) 636-0396
  • Xiao Ming Fu M.S.
  • Lead Technologist
  • Location:NE1-224
  • fux@ccf.org
  • (216) 445-6466
  • (216) 445-6466
  • Valentin Gogonea PhD
  • Research Scholar
  • Location:NE1-27
  • gogonev@ccf.org
  • (216) 444-4220
  • (216) 636-0392
  • Jill Gregory
  • Graduate Student
  • Location:NE1-224
  • gregorj2@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Xiaodong Gu Ph.D
  • Predoctoral Fellow
  • Location:NE1-224
  • gux2@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Anu Guggilam PhD
  • Postdoctoral Fellow
  • Location:NE1-224
  • guggila@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Jane Lee Hoover-Plow Ph.D.
  • Staff Consultant
  • Location:NB5-85
  • hooverj@ccf.org
  • (216) 445-8207
  • (216) 444-8204
  • Ying Huang Ph.D.
  • Research Associate
  • Location:NE1-224
  • huangy2@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Bruce Levison Ph.D.
  • Project Scientist
  • Location:NE1-231
  • levisonb@ccf.org
  • (216) 445-9578
  • (216) 636-0393
  • Xin-Min Li Ph.D.
  • Research Associate
  • Location:NE-60
  • lix2@ccf.org
  • (216) 445-1900
  • (216) 636-0392
  • Lin Li Ph.D.
  • Lead Technologist
  • Location:NE6-216
  • lil@ccf.org
  • (216) 445-1900
  • (216) 636-0392
  • HongQiao Lin
  • Graduate Student
  • Location:NE1-224
  • linh@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Shirley Mann
  • Senior Technologist
  • Location:NE6-216
  • manns2@ccf.org
  • (216) 445-1900
  • (216) 636-0392
  • Daniel Schmitt
  • Student
  • Location:NE1-224
  • schmitd2@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • David Schmitt
  • Lead Technologist
  • Location:NE1-224
  • schmitd@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Celalettin Topbas
  • Visiting Grad Student
  • Location:NE1-224
  • topbasc@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Matthew Wagner
  • Sr. Technologist
  • Location:NE1-224
  • wagnerm4@ccf.org
  • (216) 445-6466
  • (216) 444-9404
  • Zeneng Wang Ph.D.
  • Project Scientist
  • Location:NE1-231
  • wangz2@ccf.org
  • (216) 444-3136
  • (216) 636-0392
  • Yuping Wu PhD
  • Research Scholar
  • Location:NE1-224
  • wuy2@ccf.org
  • (216) 445-6466
  • (216) 636-0392
  • Maryam Zamanian-Daryoush
  • Research Associate
  • Location:NE6-201
  • zamanim@ccf.org
  • (216) 444-0484
  • (216) 636-0392
  • Weifei Zhu PhD
  • Research Associate
  • Location:NE1-226
  • zhuw@ccf.org
  • (216) 444-5855
  • (216) 444-9404

Collaborators

  • Erzurum, Serpil M.D., Department of Cancer Biology, Cleveland Clinic Foundation
  • Febbraio, Maria Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Feldstein, Ariel, Ph.D., Departments of Pediatric Gastroenterology and Cell Biology, Cleveland Clinic Foundation
  • Fisher , Edward, M.D., Ph.D., Department of Cardiovascular Medicine New York University School of Medicine
  • Fox, Paul, Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Gogonea, Valentin, Ph.D., Department of Chemistry, Cleveland State University
  • Gornik, Heather, M.D., Department of Cardiovascular Medicine, Cleveland Clinic Foundation
  • Ischiropoulos, Harry, Ph.D., Departments of Pediatrics, Biochemistry and Biophysics, University of Pennsylvania,
  • McIntyre, Thomas, Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Nicholls, Stephen, M.D., Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Nissen, Steve, M.D., Department of Cardiovascular Medicine, Cleveland Clinic Foundation
  • Salomon, Robert, Ph.D., Chemistry Department, Case Western Reserve University, Cleveland
  • Schauer, Phil, M.D., Department of Surgery, Cleveland Clinic Foundation
  • Sehayek, Ephraim, M.D., Genomic Medicine Institute, Cleveland Clinic Foundation
  • Silverstein, Roy M.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Smith, Jonathan, Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • Stuehr, Dennis, Ph.D., Department of Immunology, Cleveland Clinic Foundation
  • Tang, Wilson, Ph.D., Department of Cell Biology, Cleveland Clinic Foundation
  • van Lente, Fred, Ph.D., Department of Clinical Pathology, Cleveland Clinic Foundation
  • Jennifer Meyers B.S.
  • Department Coordinator
  • Location:NC1-128
  • meyersj@ccf.org
  • (216) 445-1937
  • (216) 444-9404
  • Judith Schiciano MBA., A.R.M.
  • Department Administrator
  • Location:NC1-129
  • schicij@ccf.org
  • (216) 444-8710
  • (216) 444-9404

Highlighted Publications

  1. Wang Z, et al. Gut flora dependent metabolism of dietary phosphatidylcholine contributes to cardiovascular disease. Nature (2011) 472(7341):57-63. PMCID: PMC3086762
  2. Bhattacharyya T, et al. Relationship of paraoxonase (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. J. Amer. Med. Assoc. (2008) 299(11): 1265-76.
  3. Podrez EA, et al. Platelet CD36 links hyperlipidemia, oxidant stress and a pro-thrombotic phenotype. Nature Medicine (2007) 13:1086-1095.
  4. Wang Z, et al Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nature Medicine (2007) 13:1176-84.
  5. Wu Z, et al. The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat. Struct. Mol. Biol.  (2007) 14: 861-8.
  6. Brennan ML, et al. Prognostic value of myeloperoxidase in patients with chest pain. New Engl J Med.  (2003) 349(17):1595-604.

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