John O‘Toole, MD
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
John O'Toole is an adult nephrologist at the Cleveland Clinic and is focused on basic and translational research investigating the molecular genetic mechanisms of chronic kidney disease.
He is participating in several NIH-sponsored observational trials characterizing rare and common forms of kidney disease using high-throughput -omics approaches to redefine kidney disease on a molecular level. His laboratory uses molecular biologic approaches and model systems to study the biologic mechanisms underlying genetic variation that has been associated with increased risk for kidney disease.
The laboratory is actively investigatingthe pathobiology ofAPOL1 geneticvariants that are common in African ancestral populations and are associated with common kidney disease, such as kidney disease attributed to hypertension as well as less common forms of kidney disease, such as focal segmental glomerulosclerosis, HIV-associated nephropathy, and lupus nephritis.
Drs. Bruggeman, Sedor and O’Toole will investigate the pathogenic mechanisms of chronic kidney disease to develop greater understanding of genetic susceptibility and develop new treatment strategies.
Dr. Bruggeman shows in a new study that genetic variants to the APOL1 gene are associated with increased risk for pregnancy-induced hypertension in African American women.
By studying a model of HIV-associated nephropathy, a group of kidney disease researchers and clinicians discovered that in patients with the APOL1 risk gene, the presence of an environmental stressor, like a virus, can trigger cell changes that lead to chronic kidney diseases.