Cleveland Clinic Lerner Research Institute Logo
Cleveland Clinic Lerner Research Institute Logo
  • About
  • Science
    • Laboratories
    • Clinical & Translational Research
    • Departments
      Biomedical Engineering Cancer Biology Cardiovascular & Metabolic Sciences Florida Research & Innovation Center Genomic Medicine Immunotherapy & Precision Immuno-Oncology
      Infection Biology Inflammation & Immunity Neurosciences Ophthalmic Research Quantitative Health Sciences Translational Hematology & Oncology Research
    • Centers & Programs
      Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Computational Life Sciences Genitourinary Malignancies Research Microbiome & Human Health
      Musculoskeletal Research Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Therapeutics Discovery
  • Core Services
    • Ohio
      3D Printing BioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Immunology Platform Computing Services Discovery Lab Electron Microscopy Electronics Engineering Flow Cytometry
      Genomic Medicine Institute Biorepository Genomics Glassware Histology Hybridoma Immunohistochemistry Immunomonitoring Lab Instrument Refurbishing & Repair Laboratory Diagnostic Lerner Research Institute BioRepository
      Light MicroscopyMechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Resources Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics & Metabolomics Therapeutics Discovery
    • Florida
      Bioinformatics
      Flow Cytometry
      Imaging
  • Education & Training
    • Graduate Programs Molecular Medicine PhD Program Postdoctoral Program
      Research Intensive Summer Experience (RISE) Undergraduate & High School Programs
  • News
  • Careers
    • Faculty Positions Research Associate & Project Staff Postdoctoral Positions
      Technical & Administrative
  • Donate
  • Contact
  • About
  • Science
    • Scientific Programs
    • Laboratories
    • Clinical & Translational Research
    • Departments
      Biomedical Engineering Cancer Biology Cardiovascular & Metabolic Sciences Florida Research & Innovation Center Genomic Medicine Immunotherapy & Precision Immuno-Oncology
      Infection Biology Inflammation & Immunity Neurosciences Ophthalmic Research Quantitative Health Sciences Translational Hematology & Oncology Research
    • Centers & Programs
      Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Computational Life Sciences Genitourinary Malignancies Research Microbiome & Human Health
      Musculoskeletal Research Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Therapeutics Discovery
  • Core Services
    • All Cores
    • Ohio
      3D Printing BioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Immunology Platform Computing Services Discovery Lab Electron Microscopy Electronics Engineering Flow Cytometry
      Genomic Medicine Institute BiorepositoryGenomics Glassware Histology Hybridoma Immunohistochemistry Immunomonitoring Lab Instrument Refurbishing & Repair Laboratory Diagnostic Lerner Research Institute BioRepository
      Light MicroscopyMechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Resources Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics & Metabolomics Therapeutics Discovery
    • Florida
      Bioinformatics
      Flow Cytometry
      Imaging
  • Education & Training
    • Research Education & Training Center
    • Graduate Programs Molecular Medicine PhD Program Postdoctoral Program
      Research Intensive Summer Experience (RISE) Undergraduate & High School Programs
  • News
  • Careers
    • Faculty Positions Research Associate & Project Staff Postdoctoral Positions
      Technical & Administrative
  • Donate
  • Contact
  • Search

Feng Lin Laboratory

❮Inflammation & Immunity Feng Lin Laboratory
  • Feng Lin Laboratory
  • Principal Investigator
  • Research
  • Our Team
  • Publications
  • Research News

Principal Investigator

Feng Lin Headshot

Feng Lin, PhD

Staff
Email: linf2@ccf.org
Location: Cleveland Clinic Main Campus

Research


Biography


Education & Professional Highlights

Research

Research

The complement system is an important part of the innate immunity. Complement activation products not only directly help to eliminate invading pathogens, but also participate in many immunological reactions, including clearance of immune complexes, antibody production, and T-cell regulation. Insufficient or excess complement activation has been shown to be important in a wide range of disease states, such as multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis, and age-related macular degeneration, as well as in allograft rejection.

My laboratory is interested in studying complement activation and regulation in these disease states, thus eventually developing novel therapies.

During the last decade, we have also developed a program focusing on CD6.  We found evidence suggesting that CD6 is a promising new therapeutic target for treating many pathological conditions, and we have been developing novel CD6-related reagents as potential drugs.

Watch a video on the lab's work in CD6, featured in the annual State of the Clinic in 2021: 

Research Supported by VeloSano

Dr. Lin's research is partially supported through a VeloSano pilot award. Learn more on the VeloSano website. 

Our Team

Our Team

Salma Ben-Salem, PhD

Postdoctoral Fellow
bensals@ccf.org

Jin Chen, PhD

Postdoctoral Fellow
chenj13@ccf.org

Ping Huang, PhD

Lead Research Technologist
huangp@ccf.org

Liping Luo

Lead Research Technologist
luol2@ccf.org

Maojing Yang

Research Technician
yangm2@ccf.org

Lingjun Zhang, PhD

Research Associate
zhangl3@ccf.org

Publications

Selected Publications

Yan Li, Wen Qiu, Lingjun Zhang, John Fung, and Lin F (2016)  Painting factor H onto mesenchymal stem cells protects the cells from complement- and neutrophil-mediated damage

Biomaterials     102: 209-219

Li Y, Singer NG, Whitebred J, Bowen MA, Fox DA and Lin F (2017) CD6 as a potential target for treating multiple sclerosis

Proc Natl Acad Sci U S A 114(10):2687-2692

Enyindah-Asonye G, Li Y, Ruth JH, Spassov DS, Hebron KE, Zijlstra A, Moasser MM, Wang B, Singer NG, Cui H, Ohara RA, Rasmussen SM, Fox DA, Lin F (2017) CD318 is a ligand for CD6.

Proc Natl Acad Sci U S A. 114(33):E6912-E6921

Xu J, Zhang L, Xie M, Li Y, Huang P, Saunders TL, Fox DA, Rosenquist R, Lin F.(2018)  Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy.

J Immunol. 15;200(12):4094-4101

Zhang L, Sorensen MD, Kristensen BW, Reifenberger G, McIntyre TM, Lin F (2018) D-2-Hydroxyglutarate Is an Intercellular Mediator in IDH-Mutant Gliomas Inhibiting Complement and T Cells.

Clin Cancer Res. 1;24(21):5381-5391.

Research News

Research News

...
NEI Awards $1.6M to Advance Research into Autoimmune Uveitis

Dr. Lin and team will study T cells in the retina to understand the mechanisms that govern the onset and progression of autoimmune uveitis in preclinical models.



About Lerner

About Us Careers Contact Us Donate People Directory

Science

Clinical & Translational Research Core Services Departments, Centers & Programs Laboratories Research News

Education & Training

Graduate Programs Molecular Medicine PhD Program Postdoctoral Program RISE Program Undergraduate & High School Programs

Site Information & Policies

Search Site Site Map Privacy Policy Social Media Policy

9500 Euclid Avenue, Cleveland, Ohio 44195 | © 2023 Lerner Research Institute