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Location:
Research
Dr. Caini Liu lab studies the role of cytokine signaling in airway diseases in search of new therapeutics for asthma.
Biography
Education & Professional Highlights
Research
Overall areas of interest
- IL17 family cytokine signaling, innate and adaptive immunity, asthma therapeutics
Tools and expertise of the lab
- Allergic asthma models (Sci Signal. 2011; Sci Signal. 2017; JCI Insight. 2020)
- IL-17 cytokine signaling (Nat Immunol. 2007; Nat immunol. 2011; Sci Signal. 2009, 2011; J Exp Med, 2015)
Examples of collaborators inside and outside of I&I
- Xiaoxia Li–Cytokine signaling and airway diseases
- Mark Aronica-Mouse asthma models
- Sepil Eruzum/Suzy Comhair- Human asthma studies
Lab discoveries
- Defined TRAF4 acts as an important regulator of IL-17A signaling -mediated inflammatory pathology (J Immunol. 2012; J Exp Med. 2015; J Exp Med. 2019)
- Development of different athma models for studying different human asthma endotypes (Sci Signal. 2017; JCI Insight 2020)
How could these discoveries help patients?
- New drug targets in IL-17 cytokine signaling
- Novel pathway-specific therapeutics for treating allergic asthma
- Better molecular biomarkers for human asthma endotyping