Department of Molecular Cardiology
|07/31/2018||Olga Cherepanova, Ph.D.
A Postdoctoral Fellow position is available at Cleveland Clinic's Lerner Research Institute Department of Molecular Cardiology in the Cherepanova Lab to study the role of the pluripotency/iPS factor OCT4 and its downstream signaling in vascular smooth muscle cells and endothelial cells during atherosclerosis and after vascular injury.
Our lab is interested in molecular and cellular mechanisms responsible for smooth muscle cells and endothelial cells phenotypic transitions. We use a combination of animal and cell culture models to better understand these transitions, with the goal to develop novel therapeutic interventions for stabilizing atherosclerotic plaques in order to reduce the risk of plaque rupture with possible myocardial infarction or stroke.
Although outstanding candidates in all areas of biomedical science will be considered, special consideration will be given to individuals with strong experience/expertise in: 1) working with transgenic and knockout animals; 2) studies of atherosclerosis and/or mouse vascular injury models; 3) studies of molecular mechanisms responsible for smooth muscle cell phonotypic transitions and/or endothelial cell dysfunction.
Applicants must have (or have nearly completed) a PhD degree or MD degree with relevant laboratory experience, as well as proficient written and oral communication skills. The successful applicant is expected to apply for external fellowships, present results at scientific conferences, and prepare manuscripts for publication.
Review of applicants will begin immediately and continue until the position is filled. The contract will be renewed annually and extended for a period of 4 years or possibly longer, dependent upon satisfactory progress and the lab’s funding situation.
Applicants should send their CV, a statement of research interests and long term scientific goals, and the names and contact information for 3 references as a single PDF file to Dr. Olga A. Cherepanova at firstname.lastname@example.org.
For many years, Cleveland Clinic and Lerner Research Institute have been at the forefront of biomedical research. Applicants are invited to fill two unique positions as Cleveland Clinic’s Molecular Cardiology Scholars.
We seek researchers with experience in molecular and cell biology, integrin and growth factor signaling and/or vascular biology and animal models. Applicants must document their success during their PhD or initial postdoctoral studies by first-author publications in reputable journals. The chosen candidates will have an opportunity to work with several PIs on projects interlinking Vascular Biology and Inflammation. The projects integrate molecular and cellular biology approaches (adhesions dynamics, migration in 3D, mechanotransduction) and state-of-the-art in vivo models and multi-photon imaging to address important biomedical problems. We emphasize motivation and productive work in a collegial environment and an opportunity for translational and clinical collaborations. For further details see published works: West et al, Nature, 2010; Ding et al., Cell Metab. 2012; Kerr et al., Sci Signal., 2013. Applications from motivated and skilled individuals with MS or BS degrees are also invited for a position of research technologist on these projects.
The institution has a history of offering outstanding benefits to its employees.
Applicants should send curriculum vitae and names and addresses of three references to:
Dr. Tatiana Byzova
Department of Molecular Cardiology
Taussig Cancer Center
The Cleveland Clinic
9500 Euclid Avenue, Cleveland, OH 44195
Phone: (216) 444-1019; Fax: (216) 445-8204
A senior experienced Postdoctoral Fellow/Research Associate is needed for a newly-created Director for the Animal Model Core in the Department of Molecular Cardiology at Cleveland Clinic Lerner Research Institute. Applicants should have experience in mouse surgical procedures such as MI, TAC, thrombosis, vascular injury, and/or other models for cardiovascular diseases. A successful applicant should have a Ph.D., M.D., or Ph.D./M.D. with excellent communications skills and an interest in independent as well as collaborative research opportunities with other faculty members in the institute. Candidates with a DVM and relevant research or mouse surgery experience will also be considered.
Applicants should send a CV as well as names and contact information of 2-3 referees to:
Dr Qing Wang, Department of Molecular Cardiology, Lerner Research Institute/NB50, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195; Email: email@example.com.
A postdoctoral position is available in Ryota Matsuoka’s Laboratory in the Department of Molecular Cardiology at Cleveland Clinic Lerner Research Institute. This newly established group starting in April, 2018, aims to define the cellular and molecular basis of vascular and lymphatic assembly in the central nervous system (CNS) using zebrafish and mouse as model organisms. Dr. Matsuoka’s past work addressed how the vascularization of tissues surrounding the spinal cord is established in zebrafish (Matsuoka et al. eLife, 2016: PNAS, 2017) and how retinal neural circuits are organized in mouse (Matsuoka et al. Nature, 2011: Neuron, 2011). The future lab projects are directed towards understanding dynamic coordination of neuronal and vessel growth at the cellular and molecular level, which leads to the formation of the mature, functional CNS in vertebrates. The lab uses a combination of advanced 3D imaging, forward and reverse genetic approaches to uncover this coordinated process during development and regeneration, with the goal to reconstitute fully vascularized functional neuronal tissues following CNS disease/injury.
The successful applicant is expected to apply for external fellowships, present data at scientific conferences, and prepare manuscripts for publication. Candidates with a publication record in developmental biology, genetics, neuroscience, or cell biology are preferred. Former experiences working with zebrafish or other animal models are also preferred.
Review of applicants will start immediately and continue until the position is filled. The contract will be renewed annually and extended for a period of 4 years and possibly longer, dependent upon satisfactory progress and the lab’s funding situation. Interested individuals should submit a single PDF file containing the following materials to firstname.lastname@example.org:
1) CV, including publication list and contact information for 2â€3 references
2) Cover letter describing previous research, research interests, and career goals