The Northern Ohio Alcohol Center is an NIAAA/NIH funded P50 Developmental/Exploratory Center that takes advantage of the many strengths of the world-class research community at the Cleveland Clinic and Case Western Reserve University to address the important public health issue of alcoholic liver disease (ALD). The CAC is an interdisciplinary team of investigators expert in measuring in vivo markers of biochemical and molecular stress, as well as assessing the cellular/organismal responses to that stress. Basic scientists and clinical investigators will interact not only to translate basic science advances to clinical investigations (bench to bedside), but also to translate the clinical experience into refining and advancing the approach of basic research studies (bedside to bench) on the mechanisms for ALD.
Our long-term goal is to promote interdisciplinary investigations into understanding the molecular targets of ethanol-induced damage, as well as the cellular and systemic responses to damage, in order to rationally design and test therapeutic interventions to either slow and/or reverse the progression of ALD.
Northern Ohio Alcohol Center News
Laura Nagy, PhD, a staff member in the Lerner Research Institute’s Department of Pathobiology, received a five-year, $11 million P50 “program project” grant from the National Institute on Alcohol Abuse and Alcoholism to create the Northern Ohio Alcohol Research Center. The regional collaboration consists of researchers across Cleveland Clinic, Case Western Reserve University, Northeast Ohio Medical University and Ohio State University.