Jay Alberts, Ph.D.

Staff

The Edward F. and Barbara A. Bell Family Endowed Chair

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:C5-005
albertj@ccf.org
Phone: (216) 445-3222
Fax: (216) 444-9198



The aim of my research is to understand structure-function relationships within the central nervous system and the upper extremity. In particular, my research is focused on determining how grasping forces and torques are controlled and coordinated during functional dexterous manipulations. Investigation of movement patterns produced by different patient groups and healthy adults provides a window into the brain with respect to the control of voluntary movement. Our current studies work with Parkinson’s disease (PD) patients to determine the role of the basal ganglia in movement control. Recently, we have shown that unilateral deep brain stimulation provides long-term bilateral motor benefits. We are also evaluating the effects of assisted and voluntary exercise on PD motor function. These studies suggest that assisted exercise increases activation patterns within the brain. The objective and quantitative assessment of motor function will aid in disease diagnostic capability and specificity, disease progression and intervention efficacy for patients in which movement is compromised.

In other words ...

Our laboratory is focused on understanding how the brain controls skilled movements and how changes in brain function affect the movement performance. Our first step is to understand how diseases or conditions such as Parkinson's disease, stroke or concussion affect movement and thinking. Once we identify the specific problems associated with these conditions, we then develop and test interventions or ways of monitoring that are aimed at improving movement and cognitive performance.  Our interventions range from deep brain stimulation (inserting an electrode in the brain) to exercise.


Masayuki   Agawa
Masayuki Agawa
Mobile App Developer Research

Location:C5-500
Phone:
agawam@ccf.org
Fax:(216) 444-9198
laboratory

Elise  Baron B.S.
Elise Baron B.S.
Graduate Student

Location:C5-005
Phone:(216) 445-3866
barone@ccf.org
laboratory

Michael  Buss B.S.
Michael Buss B.S.
Senior Software Architect

Location:C5-500
Phone:(216) 445-3866
bussm@ccf.org
Fax:(216) 444-9198
laboratory

Taylor  Dolezal
Taylor Dolezal
Systems Analyst II

Location:C5-500
Phone:(216) 445-3866
dolezat@ccf.org
Fax:(216) 444-9198
laboratory

Gerald  Fragapane
Gerald Fragapane
Lead Web Developer

Location:C5-500
Phone:(216) 445-3866
fragapg@ccf.org
Fax:(216) 444-9198
laboratory

Zachary  Goldfarb
Zachary Goldfarb
Research Student

Location:C5-004
Phone:(216) 445-3866
goldfaz@ccf.org
laboratory

Daniel  Gray
Daniel Gray
Mobile App Developer Research

Location:C5-500
Phone:(216) 445-3866
grayd@ccf.org
Fax:(216) 444-9198
laboratory

Mark  Gustetic B.S.
Mark Gustetic B.S.
Systems Analyst

Location:C5-500
Phone:(216) 444-3866
gustetm@ccf.org
Fax:(216) 444-9198
laboratory

A. Elizabeth  Jansen B.A.
A. Elizabeth Jansen B.A.
Project Manager II

Location:C5-005
Phone:(216) 445-3866
jansena@ccf.org
Fax:(216) 636-2599
laboratory

Susan   Linder PT, DPT, MHS, NCS
Susan Linder PT, DPT, MHS, NCS
Project Staff

Location:C5-005
Phone:(216) 445-9815
linders@ccf.org
Fax:(216) 444-9198
laboratory

Sarah  Ozinga B.S.
Sarah Ozinga B.S.
Postdoctoral Fellow

Location:C5-005
Phone:(216) 636-2542
richars6@ccf.org
Fax:(216) 444-9198
laboratory

Amanda  Penko M.A.
Amanda Penko M.A.
Exercise Physiologist

Location:C5-005
Phone:(216) 636-9717
penkoa@ccf.org
Fax:(216) 444-9198
laboratory

Rami  Rizk M.S.
Rami Rizk M.S.
Research Engineer

Location:C5-005
Phone:(216) 445-3866
rizkr2@ccf.org
Fax:(216) 444-9198
laboratory

David  Schindler BS
David Schindler BS
Project Manager IV

Location:C55-
Phone:(216) 445-3866
schindd@ccf.org
Fax:(216) 444-9198
laboratory


Alberts, J.L., Voelcker-Rehage C., Hallahan, K., Vitek, M., Bamzai, R., and Vitek, J.L. (2008) Bilateral subthalamic stimulation impairs cognitive-motor performance in Parkinson’s disease patients. Brain, 131(12)3348-60.

Ridgel, A., Thota, A., Vitek, J.L. and Alberts, J.L. (2009)  Forced, not voluntary, exercise improves motor function in Parkinson’s disease patients. Journal of Neurorehabilitation and Neural Repair, PMID: 19131578.

Mera, T.O., Johnson, M.D., Rothe, D., Zhang, J., Xu, W., Ghosh, D., Vitek, J.L., and Alberts, J.L. (2009) Quantifying Rigidity in MPTP-treated Primates. Journal of Neuroscience Methods, 177(1):20-9.

Alberts, J.L., Hallahan, K., Thota, A., Noecker, A.M., Vitek, J.L. and McIntyre, C.M. Reducing cognitive-motor declines associated with bilateral subthalamic deep brain stimulation through computational modeling in a Parkinson’s patient. Journal of Neurology, Neurosurgery and Psychiatry.


US Patent Patent Title Issue Date First-Named Inventor
8,608,622 Systems and Methods for Improving Motor Function with Assisted Exercise 12/17/2013 Jay Alberts Ph.D.
8,562,488 Systems and Methods for Improving Motor Function with Assisted Exercise 10/22/2013 Jay Alberts Ph.D.