Joint injury – and anterior cruciate ligament (ACL) tear in particular – is a known risk factor for post-traumatic osteoarthritis (PTOA). This degenerative joint disease develops 10-15 years after injury in up to 80% of patients. What’s more, surgery to reconstruct the torn ligament does not change this risk. Because ACL injuries are most prevalent in physically active adolescents and young adults, ACL-injured individuals can develop symptomatic PTOA by the time they’re just 30 years old. This is of serious concern, given there are currently no disease-modifying drugs or treatments available for osteoarthritis. Afflicted individuals must manage their condition over the majority of their lifespans, creating an enormous health and economic burden in this at-risk population. Changes in both joint mechanics and biology are likely key factors that promote PTOA pathogenesis and progression after joint injury, but our understanding of the relative contributions and temporal importance of each factor remains elusive. Furthermore, the mechanical and biological response to injury is likely individualized, since not all people develop PTOA at the same rate or with the same degree of severity. Our research group’s interest is to understand how the mechanobiology of the joint and its component tissues is affected by ACL injury in order to inform novel solutions that reduce the risk and severity of PTOA. Our lab works with translational models of joint injury, as well as with patients. We use a combination of traditional marker-based motion capture, force data, and electromyography to quantify joint biomechanics and neuromuscular function. In addition, we employ biplane videoradiography, a sophisticated x-ray imaging technique that yields highly accurate (≤0.5˚/mm) 3D motion of the underlying bones during dynamic activities; we couple this with quantitative magnetic resonance imaging that collectively provides detailed insight into tissue function, structure and composition. At the same time, our translational studies allow us to perform biological analyses of the tissues and joint fluid. To meet our goals, we collaborate with orthopaedic surgeons, fellows, imaging scientists, and biologists. These collaborations and the translational and clinical arms of investigation support our effort to discover solutions for people who sustain joint injuries. https://www.youtube.com/watch?v=eYirRvLEBaU&feature=youtu.be
In other words ...
Our lab strives to understand the mechanisms that drive post-traumatic arthritis after intra-articular joint injuries, and anterior cruciate ligament injury in particular. We will use this information to test new therapies and approaches that improve long-term patient outcomes.
- Howard, RA, Rosvold, JM, Tapper, JE, Darcy, SP, Beveridge, JE, Corr, DT, Marchuk, LL, Ronsky, JL, Frank, CB, Shrive, NG. (2007). Reproduction of ovine gait using a parallel robot. Journal of Biomechanical Engineering, 129(5), p.743-749.
- Darcy, SP, Rosvold, JM, Beveridge, JE, Corr, DT, Sutherland, CA, Brown, JJY, Marchuk, LL, Frank, CB, and Shrive, NG. (2008). A Comparison of passive flexion-extension to normal gait in the ovine stifle joint. J Biomech, 41, p.854-860.
- Beveridge, JE, Shrive, NG, Frank, CB. (2011). Meniscectomy causes significant in vivo kinematic changes and mechanically induced focal chondral lesions in a sheep model. JOR, 29(9), p.1397-405.
- Frank, CB, Beveridge, JE, Huebner, KD, Heard, BJ, Tapper, JE, O’Brien, EJO, Shrive, NG. (2012). Complete ACL/MCL deficiency induces variable degrees of instability in sheep with kinematic abnormalities correlating with degrees of early osteoarthritis. JOR, 30(3), p.384-92.
- O'Brien, EJO, Beveridge, JE, Huebner, KD, Heard, BJ, Tapper, JE, Shrive, NG, CB Frank. (2013). Osteoarthritis develops in the operated joint of an ovine model following ACL reconstruction with immediate anatomic reattachment of the native ACL. JOR, 31(1), p. 35-43.
- Beveridge, JE, Shrive, NG, Frank, CB. Repeatability and precision of a weighted centroid method for estimating dynamic in vivo tibiofemoral surface interactions in sheep. (2013). CMBBE, 17(16), p.1853-1863.
- Beveridge, JE, Heard, BJ, Brown, JJY, Shrive, NG, Frank, CB. (2014). Tibiofemoral centroid velocity correlates more consistently with cartilage damage than does contact path length in two ovine models of stifle injury. JOR, 31(11), p.1745-1756.
- Beveridge, JE, Heard, BJ, Brown, JJY, Shrive, NG, Frank, CB. (2014). A new measure of tibiofemoral subchondral bone surface interactions that correlates with early cartilage damage in injured sheep. JOR, 32(10), p.1371-1380.
- Lichti, DD, Sharma, GB, Kuntze, G, Mund, B, Beveridge, JE, Ronsky, JL. (2015). Rigorous geometrical self-calibrating bundle adjustment for a dual fluoroscopic imaging system. IEEE Transactions on Medical Imaging, 32(2), p. 589-98.
- Beveridge, JE, Atarod, M, Heard, BJ, O’Brien, EJ, Frank, CB, Shrive NG. (2016). Relationship between increased in vivo meniscal loads and abnormal tibiofemoral surface alignment in ACL deficient sheep is varied. J Biomech, 49(16), p.3824-3832.
- Heard, BJ*, Beveridge, JE*, Atarod, M, O’Brien, EJ, Rolian, C, Frank, CB, Hart, DA, Shrive, NG. (2017). Analysis of change in gait in the ovine stifle: normal, injured, and anterior cruciate ligament reconstructed. BMC Musculoskeletal Disorders, 18(1), p. 212-222. *Co-first authors
- Beveridge, JE, Walsh, EG, Murray, MM, Fleming, BC. (2017). Sensitivity of ACL volume and T2* relaxation time to magnetic resonance imaging scan conditions. J Biomech, 56, p.117-121.
- Beveridge, JE, Machan, JT, Walsh, EG, Kiapour, AM, Karamchedu, NP, Chin, KE, Proffen, BL, Sieker, JT, Murray, MM, Fleming, BC. (2018). Magnetic resonance measurements of tissue quantity and quality using T2* relaxometry predict temporal changes in the biomechanical properties of the healing ACL. JOR, 36(6), p.1701-1709.
- Shekarfoursh, M, Beveridge, JE, Hart, DA, Frank, CB, Shrive NG. (2018). Correlation between translational and rotational kinematic abnormalities and osteoarthritis-like damage in two in vivo sheep injury models. J Biomech, 75, p.67-76.
- Shekarfoursh, M, Barton, KI, Beveridge, JE, Scott, M, Martin, CR, Muench, G, Heard, BJ, Sevick, JL, Hart, DA, Frank, CB, Shrive, NG. (2019). Alterations in joint angular velocity following traumatic knee injury in ovine models. Ann Biomed Eng, Epub ahead of print: doi: 10.1007/s10439-019-02203-6.
- Beveridge, JE, Proffen, BL, Karamchedu, NP, Chin, KE, Sieker, JT, Badger, GJ, Kiapour, AM, Murray, MM, Fleming, BC. Cartilage Damage is Related to ACL Stiffness in a Porcine Model of ACL Repair. JOR, Epub ahead of print: doi: 10.1002/jor.24381.
No news currently found.