The Clinical Ultrasound Laboratory (CUL) was established in April 2013 to improve and expand the use of ultrasound in medicine. The Principal Investigator is Greg Clement, PhD, who joined the Lerner Research Institute from Harvard University and the Brigham and Women’s Hospital in Boston, where he was an Associate Professor, Head of Imaging for the National Center for Image Guided Therapy, and the Technical Director of the Focused Ultrasound Laboratory.
Dr. Clement’s research has concentrated on methods to improve ultrasound resolution and ways to access areas in the body traditionally considered “off limits” to ultrasound due to the presence of bone. With specific concentration on the brain, he has developed several novel techniques for focusing ultrasound through the skull for improved ultrasound imaging and therapy.
Laboratory efforts at the Cleveland Clinic will center on developing disorder-specific noninvasive ultrasound tools and techniques. By using contrast agents, and with a better understanding of how these agents travel through the circulatory system, the laboratory will investigate methods for quantifying and mapping blood flow in the kidneys, the testicles, and in certain tumors. Imaging efforts in the brain will include the development of ultrasound brain tomography to detect hemorrhage and lesions, methods to detect brain shift during surgery, and monitors for hydrocephalus.
The laboratory is supported by grants from the National Institutes of Health and the US Army Medical Research and Materiel Command (Department of Defense).
Standard ultrasound machines can’t “see” through bone, making many organs – including the brain – unreachable. Dr. Clement is exploring ways to get ultrasound through bone to make images of the brain and other parts of the body. He has already developed several methods for focusing ultrasound energy through the skull and is now using these techniques to get better pictures that may show blood leakage or vessel blockage that, if untreated, could lead to stroke. His new ultrasound methods can detect how much the brain shifts during brain surgery and can help doctors monitor patients with "water on the brain."
Using ultrasound, the Clement team is also finding how to measure blood flow in the capillaries, the body’s tiniest vessels. The ability to detect unusual flows in these small vessels could help determine if organs, such as the kidney, are working properly. These same methods may also help doctors detect certain tumors that are currently invisible to other imaging methods. Dr. Clement’s new, nonsurgical techniques will help doctors in many specialties give patients better care.
For a comprehensive listing visit our PUBLICATIONS page.
G.T. Clement, H. Nomura, T. Kamakura, Ultrasound field measurement using a binary lens, IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control. 2015 to appear.
C. Arvanitis, G.T. Clement, N McDannold, Transcranial Assessment and Visualization of Acoustic Cavitation: Modeling and Experimental Validation In-Vivo, IEEE Transactions on Medical Imaging. 2015 to appear.
T. Kamakura, H. Nomura, GT Clement, Linear and nonlinear ultrasound fields formed by planar sources with random pressure distributions, Acoustical Science and Technology 2015 to appear.
Q. Wang, N. Reganti, Y. Yoshioka, M. Howell, G.T. Clement Comparison between diffuse infrared and acoustic transmission over the human skull ," Procedings of Meetings on Acoustics 2015 to appear.
S.C. Tang and G.T. Clement, A computerized tomography system for transcranial ultrasound imaging, Procedings of Meetings on Acoustics 2015 to appear.
G.T. Clement A projection-based approach to diffraction tomography on curved boundaries, Inverse problems, 2014 30(12):125010.
S.L. James, M. Howell, Q. Wang, G.T. Clement A transcranial device and method for detecting cerebellar brain motion, Proc 2014 International Ultrasonics Symposium.
Q. Wang, M. Howell,S. James, G.T. Clement, Head motion tracking using air ultrasound array , Proc 2014 International Ultrasonics Symposium, 2014; 738-741.
H. Noumura, H. Adachi, T. Kamakura, G.T. Clement " Feasibility of low-frequency directive sound source with high range resolution using pulse compression technique ," Japanese Journal of Applied Physics, 2014; 53(7S):07KC03.