In my Urological Biomechanics Laboratory, we investigate female pelvic floor dysfunction (FPFD), including stress urinary incontinence (SUI), fecal incontinence (FI), and pelvic organ prolapse (POP). FPFD often result from the maternal injuries of childbirth. We investigate the nature of maternal birth injuries and the post-injury healing process with the goal of improving prevention and treatment of FPFD. We have developed animal models of FPFD that simulate the maternal injuries of childbirth. We use genetic mouse models to investigate how genetic factors play a role in FPFD development. In collaboration with Marc Penn we are investigating if homing of innate stem cells facilitates recovery from simulated childbirth injuries. This application of stem cell technology to facilitate injury recovery could help prevent and treat FPFD. In collaboration with Massarat Zutshi we have developed an animal model of FI and are using it to test methods of treatment and prevention. We are also developing devices for improved diagnosis and treatment of FPFD and have developed a simulation of the effects of cough on the bladder and pelvic floor. We are developing a functional virtual reality model of the human pelvic floor for use in research, teaching, and surgical simulation. We expect that this multifactorial approach will lead to improved methods of diagnosing and treating FPFD.
We investigate female pelvic floor dysfunction (FPFD), including stress urinary incontinence or leakage of urine, fecal incontinence or leakage of stool, and pelvic organ prolapse, in which the genitourinary organs fall out of their appropriate position in the pelvic region. These conditions are common among older women and, in part, are caused by delivery of children. Therefore we study how childbirth causes these conditions and have developed several therapeutic methods for treatment and prevention of these conditions. We use genetic mouse models to investigate how genetic factors play a role in FPFD development. We are also developing devices for improved diagnosis and treatment of FPFD.
Jiang HH, Salcedo LB, Damaser MS. Quantification of neurological and other contributors to continence in female rats. Brain Res 2011;25:198-205.
Cruz M, Dissaranan C, Cotleur A, Kiedrowski M, Penn M, Damaser M. Pelvic organ distribtuion of mesenchymal stem cells injuected intravenously after simulated childvirth injury in female rats. Obstet Gynecol Int 2012;2012:612946.
Dissaranan C, Cruz M, Couri B, Goldman HB, Damaser MS. Stem Cell Therapy for Incontinence and Bladder Dysfunction: Where Are We Now? What is the Realistic Potential? Curr Urol Rep 2011;12:336-44. Review.
Gustilo-Ashby AM, et al. The Impact of Cesarean Delivery on Female Pelvic Floor Dysfunction in Lysyl Oxidase Like-1 (LOXL1) Knockout Mice. Female Pelvic Med Reconstruct Surg 2010;16:21-30.
Salcedo L, Damaser MS, et al. Long-term effects of pressure and electromyography in a rat model of anal sphincter injury. Diseases of the Colon and Rectum 2010:53:1209-17.
Lerner Research Institute
Mail Code NB21
9500 Euclid Avenue
Cleveland, Ohio 44195