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Kiyotaka Fukamachi, M.D., Ph.D. Profile Slides Publications Program

Kiyotaka Fukamachi, M.D., Ph.D.

Staff

Section Head, Biomedical Devices

Department of Biomedical Engineering (ND20)
Lerner Research Institute
The Cleveland Clinic Foundation

Associate Professor
Department of Molecular Medicine
Cleveland Clinic Lerner College of Medicine of
Case Western Reserve University

9500 Euclid Avenue
Cleveland, Ohio 44195
Telephone: (216) 445-9344
Fax : (216) 444-9198
fukamak@ccf.org

Area of general research interest:

Dr. Fukamachi is interested in various surgical treatments for heart failure, including mechanical circulatory support devices, simple passive devices, and other novel surgical interventions.

Investigators:

  • Kiyotaka Fukamachi, M.D., Ph.D.
  • Yoko Arakawa, M.D.
  • Tohru Takaseya, M.D., Ph.D.
  • Akira Shiose, M.D., Ph.D.
  • Santosh Rao, M.D.
  • Kim Hyun-Il, M.D.
  • Alex Massiello, M.E. B.M.E.
  • Ray Dessoffy, A.A.
  • Nicole Mielke, B.S.
  • Amy E. Manzo

Collaborators:

  • Leonard A. R. Golding, M.D., Dept. of Biomedical Engineering, CCF
  • William A. Smith, D.Eng., Dept. of Biomedical Engineering, CCF
  • Nicholas G. Smedira, M.D., Dept. of Thoracic and Cardiovascular Surgery, CCF
  • Jose Navia, M.D., Dept. of Thoracic and Cardiovascular Surgery, CCF
  • Marc A. Gillinov, M.D., Dept. of Thoracic and Cardiovascular Surgery, CCF
  • Tomislav Mihaljevic, M.D., Dept. of Thoracic and Cardiovascular Surgery, CCF
  • Lars Svensson, M.D., Ph.D., Dept. of Thoracic and Cardiovascular Surgery, CCF
  • James B. Young, M.D., Division of Medicine, CCF
  • Randall C. Starling, M.D., Dept. of Cardiovascular Medicine, CCF
  • James D. Thomas, M.D., Dept. of Cardiovascular Medicine, CCF
  • Samir Kapadia, M.D., Dept. of Cardiovascular Medicine, CCF
  • Brian W. Duncan, M.D., Dept. of Pediatric & Congenital Heart Surgery, Children’s Hospital, CCF
  • Mark Luciano, M.D., Dept. of Neurosurgery, CCF
  • Patrick M. McCarthy, M.D., Northwestern Memorial Cardiovascular Institute
  • Michael Banbury, M.D., Christiana Care Health System
  • Roger E. Marchant, Ph.D., Dept. of Biomedical Engineering, CWRU

The Cardiovascular Dynamics Laboratory is operated under the Department of Biomedical Engineering by Kiyotaka Fukamachi, MD, PhD. The primary research interest of the Cardiovascular Dynamics Lab is cardiovascular physiology with major emphasis on cardiovascular dynamics relating to cardiac devices and surgical interventions to treat heart failure. Some of the research strengths within the Lab are: 1) extensive experience in animal experiments using cardiac devices including total artificial hearts and left ventricular assist devices, 2) established methodology to evaluate cardiac performance based on the ventricular time-varying elastance concept, 3) extensive experience in creating heart failure models, and 4) close collaboration with the Department of Thoracic and Cardiovascular Surgery and the Department of Cardiovascular Medicine. The Cardiovascular Dynamics Laboratory supports the research efforts of the Kaufman Center for Heart Failure, co-directed by James B. Young, MD (Division of Medicine), Nicholas G. Smedira, MD (Department of Thoracic and Cardiovascular Surgery), and Randall C. Starling, MD (Cardiovascular Medicine).

Our current programs include:

1) DexAide right ventricular assist system.

2) Mitral annular remodeling to treat mitral regurgitation

3) Coapsys™ – device to treat mitral regurgitation on a beating heart.

4) CorAide™ LVAS (Leonard A.R. Golding, M.D.)

5) MagScrew total artificial heart (William Smith, D.Eng., P.E.)

6) PediPump™ pediatric VAD (Brian Duncan, M.D.)

7) Left atrial appendage occlusion device (Marc Gillinov, M.D.)

8) Cardioscope (Tomislav Mihaljevic, M.D.)

9) Chest drainage system (Marc Gillinov, M.D.)

10) Heart transplant rejection detection device

 

Key References (Publication List):

•  McCarthy PM, Takagaki M, Ochiai Y, Young JB, Tabata T, Shiota T, Qin JX, Thomas JD, Mortier TJ, Schroeder RF, Schweich CJ Jr., Fukamachi K . Device-based change in left ventricular shape: a new concept for the treatment of dilated cardiomyopathy. J Thorac Cardiovasc Surg 2001;122:482-490.

•  Takagaki M, McCarthy PM, Tabata T, Dessoffy R, Cardon LA, Connor J, Ochiai Y, Thomas JD, Fukamachi K . Induction and maintenance of an experimental model of severe cardiomyopathy with a novel protocol of rapid ventricular pacing. J Thorac Cardiovasc Surg 2002;123:544-549.

•  Takagaki M, McCarthy PM, Chung M, Connor J, Dessoffy R, Ochiai Y, Howard M, Doi K, Kopcak M, Mazgalev TN, Fukamachi K . Preload-adjusted maximal power: a novel index of left ventricular contractility in atrial fibrillation. Heart 2002;88:170-176.

•  Ochiai Y, McCarthy PM, Smedira NG, Banbury MK, Navia JL, Feng J, Hsu AP, Yeager ML, Buda T, Hoercher KJ, Howard MW, Takagaki M, Doi K, Fukamachi K . Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients. Circulation 2002;106[supple I]:I-198-I-202.

•  Fukamachi K , Inoue M, Popovic ZB, Doi K, Schenk S, Nemeh H, Ootaki Y, Kopcak MW, Jr., Dessoffy R, Thomas JD, Bianco RW, Berry JM, McCarthy PM. Off-pump mitral valve repair using the Coapsys device; a pilot study in a pacing-induced mitral regurgitation model. Ann Thorac Surg 2004;77:688-693.

•  Inoue M, McCarthy PM, Popovic ZB, Doi K, Schenk S, Nemeh H, Ootaki Y, Kopcak MW Jr., Dessoffy R, Thomas JD, Fukamachi K . The Coapsys device to treat functional mitral regurgitation: in vivo long-term canine study. J Thorac Cardiovasc Surg 2004;127:1068-1077.

•  Schenk S, McCarthy PM, Starling RC, Hoercher KJ, Hail MD, Ootaki Y, Francis GS, Doi K, Young JB, Fukamachi K . Neurohormonal response to left ventricular reconstruction surgery in ischemic cardiomyopathy. J Thorac Cardiovasc Surg 2004;128:38-43.

•  Fukamachi K . New technologies for mechanical circulatory support: Current status and future prospects of CorAide and MagScrew technologies. J Artif Organs 2004;7:45-57.

•  Schenk S, Popovic ZB, Ochiai Y, Casas F, McCarthy PM, Starling RC, Kopcak MW Jr., Dessoffy R, Navia JL, Greenberg NL, Thomas JD, Fukamachi K . Preload-adjusted right ventricular maximal power: concept and validation. Am J Physiol Heart Circ Physiol 2004;287:H1632-H1640.

•  Duncan BW, Dudzinski DT, Noecker AM, Kopcak MW, Fukamachi K , Ootaki Y, Chen HM, Chapman PA, Davis SJ, Smith WA. The PediPump: Development status of a new pediatric ventricular assist device. ASAIO J 2005;51:536–539.

•  Ootaki Y, Kamohara K, Akiyama M, Zahr F, Kopcak MW, Jr., Dessoffy R, Fukamachi K . Phasic coronary blood flow pattern during a continuous flow left ventricular assist support. Eur J Cardiothorac Surg 2005;28:711-716.

•  Kamohara K, Fukamachi K , Ootaki Y, Akiyama M, Zahr F, Kopcak MW, Jr., Dessoffy R, Popovic ZB, Daimon M, Cosgrove DM, Gillinov AM . A novel device for left atrial appendage exclusion. J Thorac Cardiovasc Surg 2005;130:1639-1644.

•  Fukamachi K , Horvath DJ, Massiello AL, Ootaki Y, Kamohara K, Akiyama M, Zahr F, Kopcak MW, Jr., Dessoffy R, Chen Ji-F, Benefit S, Golding LAR. Development of a small, implantable right ventricular assist device. ASAIO J 2005;51:730-735.

•  Schenk S, McCarthy PM, Blackstone EH, Feng J, Starling RC, Navia JL, Zhou L, Hoercher KJ, Smedira NG, Fukamachi K . Duration of inotropic support after left ventricular assist device implantation: Risk factors and impact on outcome. J Thorac Cardiovasc Surg 2006;131:447-454.

•  Ootaki Y, Kamohara K, Schenk S, Kopcak MW, Jr., Dessoffy R, Schoenhagen P, Fukamachi K . Transmural distribution of myocardial blood perfusion and phasic coronary blood flow pattern in a canine model of acute ischemia. Int J Cadiol 2006;107:382-388.

•  Ootaki Y, Kamohara K, Schenk S, Kopcak M, Dessoffy R, Graham L, Fukamachi K . Experimental study of new diagnostic system for coronary artery disease using coronary transit index. Int J Cardiol 2006;106:55-60.

•  Popovic ZB, Richards KE, Greenberg NL, Rovner A, Drinko J, Cheng Y, Penn MC, Fukamachi K , Mal N, Levine BD, Garcia MJ, Thomas JD. Scaling of diastolic intraventricular pressure gradients is related to filling time duration. Am J Physiol Heart Circ Physiol 2006;291:H762-H769.

•  Kamohara K, Fukamachi K , Ootaki Y, Akiyama M, Cingoz F, Ootaki C, Vince DG, Popovic ZB, Kopcak MW, Jr., Dessoffy R, Liu J, Gillinov AM. Evaluation of a novel device for left atrial appendage exclusion: The second generation atrial exclusion device. J Thorac Cardiovasc Surg 2006;132:340-346.

•  Dombrowski SM, Schenk S, Leichliter A, Leibson Z, Fukamachi K , Luciano MG. Chronic hydrocephalus-induced changes in cerebral blood flow: mediation through cardiac effects. J Cereb Blood Flow Metab 2006;26:1298-1310.

•  Fukamachi K , Ootaki Y, Horvath DJ, Massiello AL, Kamohara K, Akiyama M, Cingoz F, Ootaki C, Kopcak MW, Dessoffy R, Liu J, Chen JF, Zhou Q, Benefit S, Golding LA, Alfini S, Rowe DT. Progress in the development of the DexAide right ventricular assist device. ASAIO J 2006;52:630-633.

•  Ootaki Y, Kamohara K, Akiyama M, Zahr F, Kopcak MW, Jr., Dessoffy R, Fukamachi K . Ventral cardiac denervation increased right coronary arterial blood flow. Int J Cardiol 2007;114:309-314.

•  Kamohara K, Popovic ZB, Daimon M, Martin M, Ootaki Y, Akiyama M, Zahr F, Cingoz F, Ootaki C, Kopcak MW, Jr., Dessoffy R, Liu J, Thomas JD, Gillinov AM, Fukamachi K . Impact of left atrial appendage exclusion on left atrial function. J Thorac Cardiovasc Surg 2007;133:174-181.

•  Navia JL, Doi K, Garcia MG, Atik FA, Fukamachi K , Kopcak MW, Jr., Dessoffy R, Ruda-Vega P, Garcia M, Houghtaling PL, Martin M, Blackstone EH, McCarthy PM, Lytle BW. Acute in vivo evaluation of a new stentless mitral valve. J Thorac Cardiovasc Surg 2007;133:986-994.

•  Fukamachi K , Ootaki Y, Ootaki C, Akiyama M, Kamohara K, Cingoz F, Horvath DJ, Chen JF, Massiello AL, Dessoffy R. Innovative, replaceable heart valve: Concept, in vitro study, and acute in vivo study. Artif Organs 2008;32:226-239.

•  Mihaljevic T, Ootaki Y, Robertson JO, Durrani AK, Kamohara K, Akiyama M, Cingoz F, Ootaki C, Dessoffy R, Kopcak M, Liu J, Fukamachi K . Beating heart cardioscopy: a platform for real-time, intracardiac imaging. Ann Thorac Surg 2008;85:1061-1066.

•  Fukamachi K . Percutaneous and off-pump treatments for functional mitral regurgitation. J Artif Organs 2008;11:12-18.

•  Akiyama M, Popovic ZB, Kamohara K, Cingoz F, Daimon M, Ootaki C, Ootaki Y, Martin M, Liu J, Kopcak MW, Jr., Dessoffy R, Fukamachi K . Acute reduction of functional mitral regurgitation in canine model using an epicardial device. Ann Thorac Surg (in press).

•  Ootaki C, Yamashita M, Ootaki Y, Kamohara K, Weber S, Klatte RS, Smith WA, Massiello AL, Emancipator SN, Golding LAR, Fukamachi K . Reduced pulsatility induces periarteritis in kidney and the role of the local renin-angiotensin system. J Thorac Cardiovasc Surg (in press).