Research Slides

DBS model 1

The McIntyre Lab builds detailed computer models of Deep Brain Stimulation (DBS). Anatomical models enable analysis of the neuroanatomy and electrode location in the brain. Electrical models allow description of the electric field generated in the brain and the neural response to the stimulation.

DBS model 2

Patient-specific models of DBS are generated by warping a 3D brain atlas (thalamus - yellow volume; subthalamic nucleus - green volume) to the patient MRI.

DBS model 3

Single unit microelectrode recordings define the electrophysiology of the target brain region (yellow dots - thalamus; white dots - white matter; green dots - STN; red dots - substantia nigra)

DBS model 4

Detailed electrical models of the neural response to DBS predict the volume of tissue activated as a function of the stimulation parameters (contact 1; 1 kOhm; -2 V; 0.06 ms; 130 Hz)