William A. Smith, D.Eng., P.E.

William A. Smith, D.Eng., P.E.
Associate Staff

Department of Biomedical Engineering (ND20)
Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Telephone: (216) 445-9334
Fax : (216) 444-9198
SMITH1@ccf.org

William A. Smith, D.Eng., P.E., Laboratory Director, Principal Investigator

CARL Research Team:

Stephan Weber, Dipl.-Ing, Assistant Director, Principal Research Engineer
David Dudzinski, B.S.M.E., Senior Research Engineer
Lei Gu, D.Eng., Research Engineer
Viviane Luangphakdy, M.S.B.M.E., Senior Research Engineer
Christine Flick, B.S.M.E., Research Engineer
Nicole Mielke, B.S.Che., Research Engineer

Collaborators:

Kiyotaka Fukamachi, M.D. Ph.D. (Biomedical Engineering, Lerner Research Institute)
George Mushler, M.D. (Biomedical Engineering, Lerner Research Institue)
Fernando Casas, Ph.D. (Biomedical Engineering, Lerner Research Institue)
Brian W. Duncan, M.D. (Children's Hospital, Cleveland Clinic)
Nina Desai, Ph.D. (Obstetrics& Gynecology, Cleveland Clinic)
Jaikrishnan R. Kadambi, Ph.D. (Department of Mechanical and Aerospace Engineering, Case Western University)
John M. Sankovic, Ph.D. (NASA Glenn Research Center)

Research Interest:

Cardiovascular device technology
Orthopedic device technology
Mechanical design of medical devices
Educational opportunities for engineers in biomedical engineering

Research Activities:

MagScrew Total Artificial Heart and Ventricular Assist Device
PediPump Ventricular Assist Device
Catheter Pump Technology
Inherently Controlled Bearing Technology for Ventricular Assist Devices
Bone Marrow Harvesting Device Development
Diagnostic Monitoring of Implantable Blood Pumps
Blood Cell Fragility
Fluid Flow and Fluid Dynamics
Computational Fluid Dynamics

Education:

Recent Publications:

MagScrew

Vitale N, Hirschman GB, Smith WA. Optimization of Drive Screw Pitch in a Pulsatile Ventricle Assist Device. Proceedings, IEEE 27th Annual Northeast Bioengineering Conference, March, 2001.

Doi K, Smith WA, Harasaki H, Takagaki M, Ochiai Y, Howard MW, Weber S, Byerman BP, Massiello AL, Vitale N, Donahue A, Hirschman G, Fukamachi K. In vivo studies of the MagScrew total artificial heart in calves. ASAIO Journal. 2002; 48(3): 222-5.

Weber S, Doi K, Massiello AL, Byerman BP, Takagaki M, Fukamachi K, Donahue A, Chapman P, Hirschman G, Vitale N, Smith WA. In vitro controllability of the MagScrew total artificial heart system. ASAIO Journal. 2002; 48(6): 606-11.

Schenk S. Weber S. Luangphakdy V. Flick CR. Chen JF. Inoue M. Kopcak MW Jr. Ootaki Y. Doi K. Dessoffy R. Hirschman GB. Vitale NG. Chapman PA Jr. Smith WA. Fukamachi K. In vivo performance and biocompatibility of the MagScrew ventricular assist device. ASAIO Journal. 49(5):594-8, 2003 Sep-Oct.

Schenk S, Weber S, Luangphakdy V, Klatte RS, Flick CR, Chen J-F, Kopcak MW, Jr., Ootaki Y, Kamohara K, Hirschman GB, Vitale NG, Chapman PA, Jr., Smith WA, Fukamachi K. MagScrew total artificial heart in vivo performance above 200 beats per minute. Ann Thorac Surg 2005;79:1378-1383.

Weber S, Kamohara K, Klatte RS, Luangphakdy V, Flick C, Chen JF, Casas F, Ootaki Y, Kopcak M, Akiyama M, Hirschman GB, Chapman PA, Donahue A, Wetterau W, Prisco C, Mast R, Sherman C, Fukamachi K, Smith WA. MagScrew TAH: an update. ASAIO J. 51(6):xxxvi-xlvi, 2005 Nov-Dec.

Schenk S, Weber S, Smith WA , Fukamachi K. MagScrew total artificial heart. [letter] Ann. Thorac. Surg. 81(6):2338-9, 2006 Jun.

Fluid Flow/Fluid Dynamics

Lorenz M, Smith WA. Rotodynamic pump scaling. ASAIO Journal. 2002; 48(4): 419-30.

Sankovic JM, Smith WA , Kadambi JR, Mehta M, Wernet MP. PIV investigations of the flow field in the volute of a rotary blood pump Proceedings of the ASME/JSME Joint Fluids Engineering Conference. v 2 A, 2003, p 807-815.

Smith WA . Allaire P. Antaki J. Butler KC. Kerkhoffs W. Kink T. Loree H. Reul H. Collected nondimensional performance of rotary dynamic blood pumps. ASAIO Journal. 50(1):25-32, 2004 Jan-Feb.

Cell Fragility

Carter J. Hristova K. Harasaki H. Smith WA. Short exposure time sensitivity of white cells to shear stress. ASAIO Journal. 49(6):687-91, 2003 Nov-Dec.

Gu L. Smith WA. Chatzimavroudis GP. Mechanical fragility calibration of red blood cells. ASAIO Journal. 51(3):194-201, 2005 May-Jun.

Gu L. Smith WA. Evaluation of computational models for hemolysis estimation. ASAIO Journal. 51(3):202-7, 2005 May-Jun.

PediPump

Duncan BW. Lorenz M. Kopcak MW. Fukamachi K. Ootaki Y. Chen HM. Chapman PA. Davis SJ. Smith WA . The PediPump: a new ventricular assist device for children. Artificial Organs. 29(7):527-30, 2005 Jul