Saikh Jaharul Haque, Ph.D. | Research | Publications

Saikh Jaharul Haque, Ph.D. Assistant Staff Department of Cancer Biology Joint appointment with Pulmonary and Critical Care Medicine and Brain Tumor Institute Lerner Research Institute / NB40 9500 Euclid Avenue Cleveland, Ohio 44195 Telephone: (216) 445-6622 Fax: (216) 445-6269 haquej@ccf.org

Area of general research interest:

Cytokine-mediated cell signaling in health and disease, particularly in allergic inflammation and brain cancer.

Current programs:

• Cytokine signaling in glioblastoma cells
• Negative regulation of IL-4 signaling
• Signaling mast cell growth and survival

Investigators:

• Anupurna Kaul, Graduate Student
• Sreejith Panicker , Ph.D., Research Fellow
• Pankaj Sharma , Ph.D., Research Fellow
• Russell Tipps , Ph.D., Senior Research Technologist

Collaborators:

• Michael A. Vogelbaum, M.D., Ph.D., Dept. of Neurosurgery, CCF; Dept. of Cancer Biology, LRI, CCF
• Gene H. Barnett, M.D., Dept. of Neurosurgery, CCF
• Serpil C. Erzurum, M.D., Dept. of Pulmonary and Critical Care Medicine, CCF; Dept. of Cancer Biology, LRI, CCF
• George R. Stark, Ph.D., Dept. of Molecular Biology, LRI, CCF
• Taolin Yi, Ph.D., Dept. of Cancer Biology, LRI, CCF
• Fred Hsieh, M.D., Dept. of Pulmonary & Critical Care Medicine, CCF
• Mark Aronica, M.D., Dept. of Immunology, LRI, CCF

KEY PUBLICATIONS:

S. J. Haque, V. Flati, A. Deb and B. R. G. Williams (1995), Roles of protein-tyrosine phosphatase in Stat1-alpha-mediated cell signaling, J. Biol. Chem. 270: 25709-25714.

S. J. Haque, Q. Wu, W. Kammer, K. Friedrich, J. M. Smith, I. M. Kerr, G. R. Stark and B. R. G. Williams (1997), Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of Jak1, Proc. Natl. Acad. Sci. USA.  94: 8563-8568.

S. J. Haque, P. Harbor, M. Tabrizi, T. Yi and B. R. G. Williams (1998), Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. J. Biol. Chem. 273: 33893-33896.

S. J. Haque, P. C. Harbor and B. R. G. Williams (2000),  Identification of critical residues required for suppressor of cytokine signaling (SOCS)-specific regulation of IL-4 signaling.  J. Biol. Chem. 275: 26500-26506.

S. O. Rahaman, P. Sharma, P. C. Harbor, M.J. Aman, M. A. Vogelbaum, and S. J. Haque (2002),  IL-13R-alpha2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. Cancer Research 62:1103-1109.

S. O. Rahaman, O. Chernova, G. H. Barnett, M. A. Vogelbaum and S.J. Haque (2002), Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21:8404-8413.

S. Zheng, B. P. De, S. Choudhary, S. A. A.  Comhair, T. Goggans, R. Slee, B. R. G Williams, J. Pileswski, S. J. Haque and S. C. Erzurum (2003), Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis.  Immunity 18: 619-630.

S. O. Rahaman, M. A. Vogelbaum, and S. J. Haque (2005), Aberrant Stat3 signaling via IL-4R/IL-13R activation in malignant glioma cells: Involvement of IL-13R-alpha2. Cancer Research 65: 2956-2963.

M. K. Ghosh, P. Sharma, Phyllis C. Harbor, S. O. Rahaman, and S. J. Haque (2005), PI3K-AKT pathway negatively controls the EGFR-mediated activation of Stat3. Oncogene 24: 7290-7300.

F. H. Hsieh, P. Sharma, A. Gibbons, Goggans, S. C. Erzurum, S. J. Haque (2005), Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells.  Proc. Natl. Acad. Sci. USA. 102: 14380-14385.

S. J. Haque and P. Sharma (2006), Interleukins and Stat signaling (Review). In Vitamins and Hormones, Edited by G. Litwack, Vol. 74 [Chapter 7], pp165-206, Academic Press/Elsevier,