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Saikh Jaharul Haque, Ph.D. |
Area of general research interest:
Cytokine-mediated cell signaling in health and disease, particularly in allergic inflammation and brain cancer.
Current programs:
- Cytokine signaling in glioblastoma cells
- Negative regulation of IL-4 signaling
- Signaling mast cell growth and survival
Investigators:
- Rikhia Chakraborty, Graduate Student
- Atreyi Dasgupta, Ph.D., Research Fellow
- Tapati Mazumdar, Graduate Student
- Olga Mikityuk, Research Technician
- Pankaj Sharma, Ph.D., Research Fellow
Collaborators:
- Michael A. Vogelbaum, M.D., Ph.D., Dept. of Neurosurgery, CCF; Dept. of Cancer Biology, LRI, CCF
- Gene H. Barnett, M.D., Dept. of Neurosurgery, CCF
- Serpil C. Erzurum, M.D., Dept. of Pulmonary and Critical Care Medicine, CCF; Dept. of Cancer Biology, LRI, CCF
- George R. Stark, Ph.D., Dept. of Molecular Biology, LRI, CCF
- Taolin Yi, Ph.D., Dept. of Cancer Biology, LRI, CCF
- Fred Hsieh, M.D., Dept. of Pulmonary & Critical Care Medicine, CCF
- Mark Aronica, M.D., Dept. of Immunology, LRI, CCF
KEY PUBLICATIONS:
S. J. Haque, V. Flati, A. Deb and B. R. G. Williams (1995), Roles of protein-tyrosine phosphatase in Stat1-alpha-mediated cell signaling, J. Biol. Chem. 270: 25709-25714.
S. J. Haque, Q. Wu, W. Kammer, K. Friedrich, J. M. Smith, I. M. Kerr, G. R. Stark and B. R. G. Williams (1997), Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of Jak1, Proc. Natl. Acad. Sci. USA. 94: 8563-8568.
S. J. Haque, P. Harbor, M. Tabrizi, T. Yi and B. R. G. Williams (1998), Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. J. Biol. Chem. 273: 33893-33896.
S. J. Haque, P. C. Harbor and B. R. G. Williams (2000), Identification of critical residues required for suppressor of cytokine signaling (SOCS)-specific regulation of IL-4 signaling. J. Biol. Chem. 275: 26500-26506.
S. O. Rahaman, P. Sharma, P. C. Harbor, M.J. Aman, M. A. Vogelbaum, and S. J. Haque (2002), IL-13R-alpha2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. Cancer Research 62:1103-1109.
S. O. Rahaman, O. Chernova, G. H. Barnett, M. A. Vogelbaum and S.J. Haque (2002), Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21:8404-8413.
S. Zheng, B. P. De, S. Choudhary, S. A. A. Comhair, T. Goggans, R. Slee, B. R. G Williams, J. Pileswski, S. J. Haque and S. C. Erzurum (2003), Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis. Immunity 18: 619-630.
S. O. Rahaman, M. A. Vogelbaum, and S. J. Haque (2005), Aberrant Stat3 signaling via IL-4R/IL-13R activation in malignant glioma cells: Involvement of IL-13R-alpha2. Cancer Research 65: 2956-2963.
M. K. Ghosh, P. Sharma, Phyllis C. Harbor, S. O. Rahaman, and S. J. Haque (2005), PI3K-AKT pathway negatively controls the EGFR-mediated activation of Stat3. Oncogene 24: 7290-7300.
F. H. Hsieh, P. Sharma, A. Gibbons, Goggans, S. C. Erzurum, S. J. Haque (2005), Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc. Natl. Acad. Sci. USA. 102: 14380-14385.
S. J. Haque and P. Sharma (2006), Interleukins and Stat signaling (Review). In Vitamins and Hormones, Edited by G. Litwack, Vol. 74 [Chapter 7], pp165-206, Academic Press/Elsevier,