Saikh Jaharul Haque, Ph.D. | Research | Publications

Selected Publications

  1. S. J. Haque and B. R. G. Williams (1994), Identification and characterization of an ISRE-ISGF3 independent pathway for interferon-alpha, J. Biol. Chem. 269: 19523-19529.
  2. A. Kumar, S. J. Haque, J. Lacoste, J. Hicott and B. R. G. Williams (1994), The dsRNA-activated p68 protein kinase (PKR) regulates transcription factor NF-kB via phoshorylation of its inhibitor, IkB.  Proc. Natl. Acad. Sci. USA, 91: 6288-6292.
  3. S. J. Haque, V. Flati, A. Deb and B. R. G. Williams (1995), Roles of protein-tyrosine phosphatase in Stat1alpha-mediated cell signaling, J. Biol. Chem. 270: 25709-25714.
  4. S. J. Haque, H. van der Kuip, A. Kumar, W. E. Aulitzky, M. N. Rutherford, C. Huber, T. Fischer and B. R. G. Williams (1996), Overexpression of mouse p140 subunit of replication factor C accelerates cellular proliferation, Cell Growth & Differentiation 7: 319-326.
  5. V. Flati, S. J. Haque and B. R. G. Williams (1996), Interferon-alpha-induced phosphorylation and activation of cytosolic phospholipase-A2 is required for the formation of interferon-stimulated gene factor 3, EMBO.  J. 15: 1566-1571.
  6. M. N. Rutherford, A. Kumar, S. J. Haque, J. Gysdael and B. R. G. Williams (1996), Specific binding of an ETS-domain protein to interferon-stimulated response element.  J. Interferon & Cytokine Res.17: 1-10.
  7. A. Kumar, Y-L Yang, V. Flati, S. Der, S. Kadereit,  A. Deb,  S. J. Haque, L Reis, C. Weissmann and B. R. G. Williams (1997), Deficient cytokine signalling in mouse embryo  fibroblasts with a targeted deletion in the PKR gene: Role of IRF-1 and NF-kB. EMBO J.16: 406-416.
  8. S. J. Haque, Q. Wu, W. Kammer, K. Friedrich, J. M. Smith, I. M. Kerr, G. R. Stark and B. R. G. Williams (1997), Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of Jak1, Proc. Natl. Acad. Sci. USA.  94: 8563-8568.
  9. F. H. Gou, K. Uetani, S. J. Haque, B. R. G. Williams, R. A. Dweik, F. B. J. M. Thunnissen, W. Calhoun and S. C. Erzuram (1997), Interferon-g and Interleukin-4 stimulate prolonged expression of inducuible Nitric Oxide Synthase in human airway epithelium through synthesis of soluble mediators, J. Clin. Invest. 100: 829-838.
  10. B. R. G. Williams and S. J. Haque (1997), Interacting pathways of Interferon Signaling, (Review), Seminars in Oncology 24: S970-S977.
  11. S. J. Haque and B. R. G. Williams (1998), Signal transduction in interferon systems (Review), Seminars in Oncology 25: 14-22.
  12. S. J. Haque, P. Harbor, M. Tabrizi, T. Yi and B. R. G. Williams (1998),    Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. J. Biol. Chem. 273: 33893-33896.
  13. H. van der Kuip, B. Carius, S. J. Haque, B. R. G. Williams, C. Huber, T. Fischer (1999), The DNA-binding subunit of p140 of replication factor C is upregulated in cycling cells and associates with G1-phase cell cycle regulatory proteins. J. Mol. Med. 77: 386-392.
  14. K. C. Goh, S. J. Haque and B. R. G. Williams (1999), A role for p38 MAP kinase in Stat1 serine phosphorylation and transcriptional activation by interferons.  EMBO J. 18: 5601-5608.
  15. S. J. Haque, P. C. Harbor and B. R. G. Williams (2000).  Identification of critical residues required for suppressor of cytokine signaling (SOCS)-specific regulation of IL-4 signaling.  J. Biol. Chem. 275: 26500-26506.
  16. S. J. Haque and B. R. G. Williams (2000) Interferon alpha/beta Receptors. In Cytokine Reference. Ed, J. J. Oppenheim, Vol. II, pp1845-1854. Academic Press (Review).
  17. A. Deb, S. J. Haque, T. Mogensen, R. H. Silverman, and B. R. G. Williams (2001).  RNA-dependent protein kinase PKR is required for activation of NF-kB by IFN-g in a Stat1-independent pathway.  J. Immunol. 166:6170-6180.
  18. S. O. Rahaman, P. Sharma, P.C. Harbor, M. J. Aman, M. A. Vogelbaum, and S. J. Haque (2002),  IL-13R-alpha2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells.  Cancer Research 62:1103-1109.
  19. S. O. Rahaman, O. Chernova, G. H. Barnett, M. A. Vogelbaum and S. J. Haque (2002), Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21:8404-8413.
  20. S.W. Fox, S. J. Haque, A. C. Lovibond and T. J. Chambers (2003), The possible role of transforming growth facor-beta (TGF-beta)-induced SOCS expression in osteoclast/macrophage lineage commitment in-vitro. J. Immunol. 170: 3679-3687.
  21. S. Zheng, B. P. De, S. Choudhary, S. A. A.  Comhair, T. Goggans, R. Slee, B. R. G Williams, J. Pileswski, S.J. Haque and S.C. Erzurum (2003), Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis.  Immunity 18: 619-630.
  22. W. Xu, S. A. A. Comhair, S. Zheng, S. C. Chu, J. Marks-Konczalik, J. Moss, S. J. Haque and S. C. Erzurum (2003), Stat1 and c-Fos interaction in nitric oxide synthase 2 gene activation. Am. J. Physiol. Lung Cell Mol. Physiol. L137-148.
  23. A. C. Lovibond, S. J. Haque, T. J. Chambers and S. W. Fox (2003), TGF-beta-induced SOCS3 expression augments TNF-alpha-induced osteoclast formation. Biochem Biophys Res Commun. 309:762-767.
  24. H. T. Katz, S. J. Haque, F. H. Hsieh (2005), Pediatric hypereosinophilic syndrome (HES) differs from adult HES. J. Pediatrics 146: 134-136.
  25. S. O. Rahaman, M. A. Vogelbaum, and S. J. Haque (2005), Aberrant Stat3 signaling via IL-4R/IL-13R activation in malignant glioma cells: Involvement of IL-13R-alpha2. Cancer Research 65: 2956-2963.
  26. M. K. Ghosh, P. Sharma, Phyllis C. Harbor, S. O. Rahaman, and S. J. Haque (2005), PI3K-AKT pathway negatively controls the EGFR-mediated activation of Stat3. Oncogene, 24: 7290-7300.
  27. D. Zhuang, Y. Qiu, S. J. Haque and F. Dong (2005),  Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1. J Leukoc Biol.78: 1008-1015.
  28. N. R. Maiti, P. Sharma, P Harbor and S. J. Haque (2005), Serine phosphorylation of Stat6 negatively controls its DNA-binding activity. J. Interferon Cytokine Res. 25:553-563.
  29. F. H. Hsieh, P. Sharma, A. Gibbons, Goggans, S. C. Erzurum, S. J. Haque (2005), Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells.  Proc. Natl. Acad. Sci. USA. 102: 14380-14385.
  30. S. J. Haque and P. Sharma (2006), Interleukins and Stat signaling. (Review). In Vitamins and Hormones, Edited by G. Litwack, Vol. 74 [Chapter 7], pp165-206, Academic Press/Elsevier.