|
Damir Janigro, Ph.D.Staff
Dept. of Cell Biology |
Area of general research interest:
- Epilepsy
- Blood Brain Barrier
Current program:
- Blood Brain Barrier
- Multiple Drug Resistance
- Stroke and Cerebrovascular Damage
- Peripheral Markers of CNS damage
- Molecular and Proteomic Analysis of Neurological Disorders
Investigators:
- Giulia Betto, Student
- Erin Carlton, Research Technician
- Luca Cucullo, Ph.D., Project Scientist & Lab Manager
- Qingyuan Fan, M.D., Ph.D., Fellow
- Vincent Fazio, M.S., Lead Technologist
- Chaitali Ghosh-Sinha, Ph.D., Fellow
- Mohammed Hossain, M.S., Technologist
- Nicola Marchi Ph.D., Research Associate
- Nkwadi (Roger) Nvangmi, Research Scholar
- Carla Scollo, Student
Brief Description:
The Center for Cerebrovascular Research was created in 1998 as part of the bridge program between the Departments of Neurological Surgery and Neurology and the Lerner Research Institute. The Center provides state-of-the-art facilities to interactively perform a broad variety of experiments, ranging from laboratory models of acute neurological disorders to molecular and electrophysiological investigation of the mechanisms of human disease. The director of the Center, Damir Janigro is a Professor of Molecular Medicine at The Cleveland Clinic Foundation Lerner College of Medicine and Staff in Neurological Surgery and Cell Biology. The Center enjoys a vast array of local and extramural collaborations aimed at promoting awareness of the importance of cerebrovascular research to treat and prevent neurological diseases.
Key References:
Cucullo, L., Couraud, P. Weksler, B., Romero, IA, Hossain, M, Rapp, E. and JANIGRO D. Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. J Cereb Blood Flow Metab. 2007 in press
- Bassanini S, Santaguida S, Battaglia G, Hallene K, Barnes V, Finardi A, Cipolla M, JANIGRO D (2007) Early cerebrovascular and parenchymal events following prenatal exposure to the putative neurotoxin methylazoxymethanol. Neurobiology of Disease 26(2):481-95
- Cucullo L, Hossain M, Rapp E, Manders T, Marchi N, JANIGRO D (2007) Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. Epilepsia 48:505-16.
- Marchi N, Oby E, Fernandez N, Uva L, de Curtis M, Batra A, Santaguida S, Barnes V, van Boxel A, Najm I, JANIGRO D (2007) In vivo and in vitro effects of pilocarpine: relevance to epileptogenesis. Epilepsia Jul 20; [Epub ahead of print]
- Marchi N, Angelov L, Fazio V, Masaryk T, Granata T, Hernandez N, Oby E, Hallene K, Diglaw T, Franic L, Najm I, JANIGRO D (2007) Seizure-promoting effect of blood-brain barrier disruption. Epilepsia 48(4):732-42.
- Oby E, Caccia S, Vezzani A, Moeddel G, Hallene K, Guiso G, Said T, Bingaman W, Marchi N, Baumgartner C, Pirker S, Czech T, Lo RG, JANIGRO D (2006) In vitro responsiveness of human-drug-resistant tissue to AED: insights into the mechanisms of pharmacoresistance. Brain Res 1086: 201-213.
- Hallene KL, Oby E, Lee BJ, Santaguida S, Bassanini S, Cipolla M, Marchi N, Hossain M, Battaglia G, JANIGRO D (2006) Prenatal exposure to thalidomide, altered vasculogenesis, and CNS malformations. Neuroscience 142: 267-283.
- Santaguida S, JANIGRO D, Hossain M, Oby E, Rapp E, Cucullo L (2006) Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: A permeability study. Brain Res 1109: 1-13.
- Krizanac-Bengez L, Hossain M, Fazio V, Mayberg M, JANIGRO D (2006) Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood-brain barrier model: role of pro-inflammatory cytokines. Am J Physiol Cell Physiol 291: C740-C749.
- Janigro D, Perju C., Hallene K., Fazio V., Dini G, Agarwal M, and Cucullo L. (2006) AC electrical stimulation enhanced chemotherapy: a novel drug delivery strategy to bypass the intrinsic multidrug resistance of malignant tumoral cells. BMC Cancer 6: 72