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Marc S. Penn, M.D., Ph.D.Assistant Staff, Primary appointment with Cardiology
Director, Experimental Animal Laboratory |
Area of general research interest:
Left ventricular remodeling after myocardial infarction: mechanisms and treatment
Current program:
- Role of oxidant activation of metalloproteases during ischemia
- Optimization of gene delivery to infarcted myocardium
- Efficacy of cell transplantation as a treatment strategy for congestive heart failure
Investigators:
- Bian, Jing, M.S., Graduate Student
- Kiedrowski, Matthew, B.S., Sr. Technologist
- Lee, Kwang-Deok, M.S., Graduate Student
- Mal, Niladri, M.D., Fellow
- Weber, Kristal, B.S., Technologist
- Zhou, Xiaorong, M.D., Lead Technologist
- Forudi, Farhad, B.S., Technologist
Collaborators:
- Guy M. Chisolm III, Ph.D., Department of Cell Biology, The Cleveland Clinic Foundation
Key References:
Penn MS, Rangaswamy S, Saidel GM, Chisolm GM. Macromolecular transport in the arterial intima: comparison of chronic and acute injuries. Am J Physiol 272:H1560-70, 1997
Penn MS, Patel CV, Cui MZ, DiCorleto PE, Chisolm GM. LDL increases inactive tissue factor on vascular smooth muscle cell surfaces: hydrogen peroxide activates latent cell surface tissue factor. Circulation 99:1753-9, 1999.
Penn MS, Cui M-Z, Winokur AL, Bethea J, Hamilton TA, DiCorleto PE, Chisolm GM. Smooth muscle cell surface tissue factor pathway activation by oxidized LDL requires cellular lipid peroxidation. Blood 96(9): In Press, 2000.