Department of Cellular and Molecular Medicine
A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute Department of Cellular and Molecular Medicine. Several project are underway including defining the effects of plasma kininogen on tumor angiogenesis and cancer stem cells, the role of extracellular vesicles in vascular complications of cancer, the structural biology of beta2-glycoprotein 1 and its role as an autoantigen and mediator of endothelial cell activation in patients with the antiphospholipid antibody syndrome, and the responses of endothelial cells differentiated from iPSC to inflammatory stimuli.
Experience in cell culture, animal models, immunoprecipitation, analysis of signaling pathways, receptor identification, gene knockdown approaches required. Experience with bioinformatics would be a plus. A strong work ethic and ability to function in a team environment is essential.
Please send your curriculum vitae and contact information for 3 references to Keith McCrae, M.D., email@example.com
The Ahern Group (http://www.lerner.ccf.org/cmm/ahern/), in the Department of Cellular and Molecular Medicine at the Cleveland Clinic Lerner Research Institute, seeks a postdoctoral researcher to study the interplay between the intestinal immune system and gut microbiota in the development of inflammatory bowel disease (IBD).
The gut microbiota has long been appreciated to be a major driver of the development and pathogenesis of IBD. Despite this, the specific members of the gut microbiota that are responsible for disease initiation and progression, and the molecular details of immune-microbiota interactions that promote IBD, have remained enigmatic. We have developed a strategy to systematically identify effector microbes that reside within complex microbial communities that are capable of modulating phenotypes of interest. We will leverage this approach, allied to cutting-edge microbiological and immunological techniques in gnotobiotic mouse models of IBD, to identify and characterize the microbes that contribute to the development and pathogenesis of IBD, and the mechanisms underlying these interactions. This position is ideally suited to candidates who are interested in working at the interface of immunology and microbiology in the context of inflammatory disease.
The candidate will have completed, or be close to completing, a Ph.D. degree (or M.D. with at least 3 years research experience), and have experience in cellular immunology and rodent models of inflammation OR intestinal microbiology, including genetic modification of intestinal microbes.
The candidate will join a dynamic research department (http://www.lerner.ccf.org/), whose areas of interest encompass a breadth of topics related to the cellular and molecular pathways that mediate disease. The Department is also home to a number of groups whose work focuses on the contributions of the microbiota to host health and pathology, as well as numerous state-of-the-art core facilities that facilitate these studies. Our group, and the Department as a whole, seeks to provide a stimulating and collaborative research environment, committed to the training and development of its trainees and enabling their growth as independent researchers. A competitive benefits and salary package is available.
Interested candidates should submit a cover letter (2 pages maximum) outlining their research interests, as well as a CV and the contact information for 3 references to Dr. Philip Ahern at firstname.lastname@example.org
Postdoctoral Fellow – Functional Microbiome
We are looking for a Postdoctoral Fellow excited about advancing our mechanistic understanding of the Human Microbiome, to join the Claesen group at the Cleveland Clinic Lerner Research Institute. http://www.lerner.ccf.org/cmm/claesen/
Our aim is to functionally characterize molecular mechanisms that control bacterial interspecies and microbe-host interactions in the human microbiome. Bacteria use small molecule chemicals to mediate these interactions and the genetic information required for their production is typically encoded in one physical location of the bacterial chromosome, in biosynthetic gene clusters (BGCs). Using in silico techniques, we identified several widespread families of BGCs that we are now characterizing experimentally, prioritizing on the BGCs predicted to be involved in modulation of community composition or interaction with the host immune system. Our research will contribute to a better mechanistic understanding of the microbes that live in our body, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.
Candidates will have (or are close to obtaining) a PhD degree in a relevant biological or chemical subject and a good publication record in peer-reviewed scientific journals. Hands-on experience with microbiological, molecular genetics and standard biochemical techniques is required. Prior experience in mouse infection/colonization models is highly desirable.
The areas of expertise in the Claesen group include microbiology, bacterial genetics and synthetic biology, small molecule biosynthesis and biochemistry. We provide a stimulating, multidisciplinary training environment that will assist you in your successful scientific development. You will receive a competitive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute (http://www.lerner.ccf.org/), as well as plenty of opportunities for clinical collaboration at the Cleveland Clinic, the #2 Hospital in the Nation.
How to apply
Interested applicants should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Jan Claesen (email@example.com) by Saturday September 1, 2018. Thereafter, applications will be considered on a rolling basis.