Department of Cellular and Molecular Medicine
The Ahern Group (http://www.lerner.ccf.org/cmm/ahern/), in the Department of Cellular and Molecular Medicine at the Cleveland Clinic Lerner Research Institute, seeks a postdoctoral researcher to study the interplay between the intestinal immune system and gut microbiota, and the contribution of these interactions to inflammatory bowel disease (IBD).
The gut microbiota has long been appreciated to be a major driver of the development and pathogenesis of IBD. Despite this, the specific members of the gut microbiota that are responsible have remained enigmatic, hampering our ability to target components of the microbiota for the treatment of IBD. We have developed a strategy to systematically identify effector microbes that reside within complex microbial communities that are capable of modulating phenotypes of interest. We will leverage this approach, allied to cutting-edge microbiological and immunological techniques in gnotobiotic mouse models of IBD, to identify and characterize the microbes that contribute to the development and pathogenesis of IBD, and the mechanisms underlying these interactions. This position is ideally suited to candidates who are interested in working at the interface of immunology and microbiology in the context of inflammatory disease.
The candidate will have completed, or be close to completing, a Ph.D. degree (or M.D. with at least 3 years research experience), and have experience in cellular immunology and rodent models of inflammation. Familiarity with microbiological techniques is desirable, but not essential.
The candidate will join a dynamic research department (http://www.lerner.ccf.org/), whose areas of interest encompass a breadth of topics related to the cellular and molecular pathways that mediate disease. The Department is also home to a number of groups whose work focuses on the contributions of the microbiota to host health and pathology, as well as numerous state-of-the-art core facilities that facilitate these studies. Our group, and the Department as a whole, seeks to provide a stimulating and collaborative research environment, committed to the training and development of its trainees and enabling their growth as independent researchers. A competitive benefits and salary package is available.
Interested candidates should submit a cover letter (2 pages maximum) outlining their research interests, as well as a CV and the contact information for 3 references to Dr. Philip Ahern at email@example.com
We are looking for a Postdoctoral Fellow excited about advancing our mechanistic understanding of the Human Microbiome, to join the newly established Claesen group at the Cleveland Clinic Lerner Research Institute. http://www.lerner.ccf.org/cmm/claesen/
Our aim is to functionally characterize molecular mechanisms that control bacterial interspecies and microbe-host interactions in the human microbiome. Bacteria use small molecule chemicals to mediate these interactions and the genetic information required for their production is typically encoded in one physical location of the bacterial chromosome, in biosynthetic gene clusters (BGCs). Using in silico techniques, we identified several widespread families of BGCs that we are now characterizing experimentally, prioritizing on the BGCs predicted to be involved in modulation of community composition or interaction with the host immune system. Our research will contribute to a better mechanistic understanding of the microbes that live in our body, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.
Candidates will have (or are close to obtaining) a PhD degree in a relevant biological or chemical subject and a good publication record in peer-reviewed scientific journals. Hands-on experience with microbiological, molecular genetics and standard biochemical techniques is required. Prior experience in manipulation of anaerobic microbes, mouse infection models, analytical chemistry or bioinformatics are desirable (but not required).
The areas of expertise in the Claesen group include microbiology, bacterial genetics and synthetic biology, small molecule biosynthesis and biochemistry. We provide a stimulating, multidisciplinary training environment that will assist you in your successful scientific development. You will receive a competitive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute (http://www.lerner.ccf.org/), as well as plenty of opportunities for clinical collaboration at the Cleveland Clinic.
How to apply
Interested applicants should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Jan Claesen (firstname.lastname@example.org) by Friday January 19, 2018. Thereafter, applications will be considered on a rolling basis.
|07/25/2017||J. Mark Brown
Postdoctoral Fellow Position-Available Immediately
Gut Microbe-Driven Mechanisms Promoting Liver Disease Progression
A postdoctoral fellowship position supported by the National Institutes of Health are available in the laboratory of Dr. J. Mark Brown at the Cleveland Clinic Lerner Research Institute in the Department of Cellular and Molecular Medicine. Our laboratory is focused on identifying molecular mechanisms by gut microbe-derived metabolites promote human liver disease including both non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). Specific areas include:
1) Identification of novel gut microbial metabolites associated with human NAFLD and ALD.
2) Understanding the roles of gut microbial metabolites in animal models of NAFLD and ALD progression.
3) Identifying targets for the development of new pharmacologic therapies including drugging microbial enzymes that generate disease-causing metabolites.
Gut microbes represent a filter of our greatest environmental exposure – the foods we consume. In fact, it is now clear that we each experience a given meal differently, based on our unique gut microbial communities. Biologically active gut microbe-derived metabolites, such as short chain fatty acids, secondary bile acids, polysaccharide A, 4-ethylphenylsulfate, indoxyl-sulfate, p-cresyl-sulfate, and trimethylamine-N-oxide, are now recognized as contributors to type 2 diabetes and related kidney disease and cardiovascular disease (CVD). However, mechanistic insights into how microbe-derived metabolites promote these chronic diseases are largely unknown. The focus of this position will be to examine mechanistic links between gut microbial metabolites and liver disease progression using a highly translational approach.
The position will provide a unique and multidisciplinary exposure to in vivo gut microbiome studies, lipid/lipoprotein metabolism, metabolomics, and drug development. Further details are available at the following link: http://www.lerner.ccf.org/cmm/brown/. A list of publications from the Brown laboratory can found here: https://www.ncbi.nlm.nih.gov/pubmed/?term=j+mark+brown
Candidates should hold a recent doctoral degree with a background in molecular biology, metabolism or microbiome areas. Candidates must have proficiency in verbal and written English. Candidates with an interest in the position should send their CV and contact information for 3 references to:
J. Mark Brown, Ph.D.
Cleveland Clinic Lerner Research Institute
Department of Cellular and Molecular Medicine
9500 Euclid Avenue
Cleveland, Ohio 44195
A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute Department of Cellular and Molecular Medicine.
We are seeking to hire a highly-motivated Postdoctoral Fellow with a strong interest in translational bladder cancer research and epigenetics.
My lab is focused on investigating the mechanisms by which chromatin modifier gene mutations contribute to the initiation and progression of urothelial carcinomas of the bladder and upper tract.
Candidates must have scientific and technical expertise in molecular biology, gene delivery by transfection and lentivirus, and mouse husbandry. Preference will be given to those with experience in analysis of next generation sequencing data. Additional requirements include a Ph.D. degree in biological sciences, a strong publication record, proficiency in spoken and written English, and the ability to work/troubleshoot independently as well as understanding and incorporating findings in the scientific literature into his/her research. The postdoctoral fellow will be expected to take a lead role in data analysis, interpretation, visualization, and manuscript preparation.
Please send your curriculum vitae and contact information for 3 references to Byron Lee via email at:email@example.com.