COVID-19: Our Response

The best and brightest scientists, researchers and clinicians are working together to study treatments and prevention strategies to overcome the novel coronavirus (SARS-CoV-2) causing COVID-19. Explore our latest research news and discoveries.

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Our Experts

Our investigators are experts in fields of microbiology, epidemiology, bioinformatics and more. Hear them share their insight into the COVID-19 pandemic.

Whether addressing the current world-wide COVID-19 pandemic or other major challenges like virus-related cancers, our history of innovation and a team-focused culture of physicians and scientists working together make us uniquely positioned to achieve research breakthroughs. Our rapid pivot in response to the COVID-19 pandemic demonstrates our agile, nimble, multidisciplinary team approach that is dedicated to saving lives through pioneering new treatment and prevention methods. Among others, some of the projects being conducted at Cleveland Clinic include:

The Center for Global and Emerging Pathogens

The goal of our Center for Global and Emerging Pathogens Research is to broaden understanding of emerging pathogens—ranging from Zika virus to SARS-CoV-2 (which causes COVID-19)—and to expedite critically needed treatments and vaccines. Planned for over 18 months, the new Center will co-locate in Cleveland Clinic’s Lerner Research Institute in Cleveland and the soon-to-open Cleveland Clinic Florida Research and Innovation Center. Learn more.

Biorepository and Predictive Analytics

Cleveland Clinic was one of the first organizations to develop a data registry and biobank specific to COVID-19. The biobank collects biological specimens from patients and links data to clinical outcomes using the electronic medical record (EMR). Researchers from across the Cleveland Clinic enterprise are using the dynamic registry data in more than 140 COVID-19 related research projects in areas such as cancer, pediatrics and intensive care.

Artificial Intelligence (AI) and Network Medicine

With no proven treatment, drug repurposing is one of the quickest ways to identify therapies to control the pandemic. Cleveland Clinic researchers published findings on a network-based prediction model using artificial intelligence to identify targets for drug repurposing in coronavirus and COVID-19. Their approach targets the interaction between human and virus proteins rather than the virus protein itself. Based on their findings, they prioritized 16 drugs and three drug combinations as potential treatments.

A preliminary analysis conducted by Cleveland Clinic researchers demonstrated that melatonin reduced the incidence of a positive SARS-CoV-2 test and is associated with lower hospital admission and lower intensive care unit (ICU) admission (unpublished data). Using Cleveland Clinic’s COVID-19 registry, we can use modeling to determine the right dose of drug combinations most effective for individual patients.

The Center for Therapeutics Discovery

Operating as a core service across the enterprise, a team of clinicians and scientists work closely with the Therapeutics Discovery team to identify biological targets on the virus or in host cells for drug development and intervention. This model integrates biomaterials, data, and information across different platforms to bridge the gap between translational research and clinical drug trials, which will accelerate discoveries and aid in identifying personalized treatments. The ultimate goal is to de-risk drug development efforts, making the programs viable investments for the government or an industry partner to bring to patients faster than ever before. Learn more about the Center for Therapeutics Discovery.

American Heart Association COVID-19 Heart and Brain Research Initiative

The American Heart Association has awarded $1.2 million in grants to teams at 12 institutions across the U.S. to begin fast-tracked studies of the effects of COVID-19 on the body’s cardiovascular and cerebrovascular systems. Cleveland Clinic will serve as the initiative’s COVID-19 Coordinating Center and will collect results from the research projects and coordinate the dissemination of all study findings. Learn more about this initiative.

COVID-19 Tracker

Stay current with our regularly updated case and mortality tracker.

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Clinical Trials

Cleveland Clinic is conducting COVID-19 clinical trials that are currently enrolling participants. Search our clinical trials database to learn more.

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Additional Information

Visit Cleveland Clinic’s website to learn more about COVID-19 and access information for patients and employees.

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