The Genomic Medicine Institute (GMI) serves as the expert base for the principles and practice of genomic medicine as a single platform for scholarly activity (research), academic clinical care and outreach and education ultimately directed at genomics-based personalized healthcare. Thus, GMI research will focus on translational and clinical human genetics and genomics (also to include epigenomics and proteomics) which would be eminently applicable to the routine clinical arena. GMI is helping to coordinate genomics research across many disciplines such that inter-disciplinary research and healthcare are being enhanced.
GMI is a nascent institute directed by Charis Eng, MD, PhD, and is housed in the new Center for Genomics Research Building’s fifth floor, which has been specifically designed to enhance translational genomic medicine. Open design laboratory space is in proximity to the GMI’s clinical component, the Center for Personalized Genetic Healthcare, as well as to its Genomic Medicine Biorepository and the Genomics Core Facility. A unique training program that will prepare the next generation to be facile in the investigation related to and evidence-based practice of cancer genomic medicine has been initiated.
Angela Jolie made headlines on Tuesday, when she published an Op-Ed piece in the New York Times about her decision to have a double mastectomy to lower her risk of developing breast cancer. Dr. Charis Eng responded to questions about the prevalence of BRCA gene mutations, the associated risks of developing breast, ovarian and other, cancers, as well as the gene testing and treatment options available. Read more...
Pulmonary arterial hypertension (PAH) is high blood pressure in the arteries to the lungs. It is a serious, life-threatening disease, for which there are some treatments, but no known cures. Dr. Aldred’s team investigated ataluren as a possible therapeutic drug for PAH. Read more...
February Publications (2013)
Heald B, PLesec T, Liu X, Pai R, Moline J, Sharp RR, Burke CA, Kalady MF, Church J, Eng C. Implementation of Universal Microsatellite Instability and Immunohistochemistry Screening for Diagnosing Lynch Syndrome in a Large Academic Medical Center. J Clin Oncol 2013 Feb 11 [Epub ahead of print]
Ngeow J*, Heald B*, Rybicki LA, Orloff MS, Chen JL, Liu X, Yerian L, Willis J, Lehtonen H, Lehtonen R, Mester JL, Moline J, Burke CA, Church J, Aaltonen LA, Eng C. Prevalence of Germline PTEN, BMPR1A, SMAD4, STK11, and ENG Mutations in Patient with Moderate-Load Colorectal Polyps. Gastroenterology 2013 Feb 8 [Epub ahead of print]
Lee BH, Taylor MG, Robinet P, Smith JD, Schweitzer J, Sehayek E, Falzarano SM, Magi-Galluzzi C, Klein EA, Ting AH. Dysregulation of Cholesterol Homeostasis in Human Prostate Cancer through Loss of ABCA1. Cancer Res. 2013 Feb 1;73(3):1211-8. Epub 2012 Dec 11. This article was also recommended by the Faculty of 1000.
Logue K, Chan ER, Phipps T, Small ST, Reimer L, Henry-Halldin C, Sattabongkot J, Siba PM, Zimmerman PA and Serre D (2013) Mitochondrial genome sequences reveal deep divergences among Anopheles punctulatus sibling species in Papua New Guinea. Malaria J 12(1):64.
GMI's Postdoctoral Trainee Presents Research Findings at National Conference
Matthew Cannon, postdoctoral fellow (Serre Lab) gave an oral presentation at the Keystone meeting on Nutrition, Epigenetics and Human Disease, Feb 19 - Feb 24, 2013, in Santa Fe, New Mexico on "Genome-wide Gene Expression and Epigenetic Changes Induced by Maternal Obesity in Mice"