The Genomic Medicine Institute (GMI) serves as the expert base for the principles and practice of genomic medicine, including genetics and genomics research, clinical care, and outreach and education directed at genomics-based personalized healthcare. Research conducted at GMI focuses on both translational and clinical human genetics and genomic science, meaning discoveries made in the laboratory will advance the field of precision medicine and, ultimately, improve the quality of patient care.
GMI, founded over a decade ago by Charis Eng, MD, PhD, Chairperson, is specifically designed with open laboratory space in order to enhance genomics research. Researchers work together with clinicians in the clinical arm of the Institute — the Center for Personalized Genetic Healthcare — as well as the Genomic Medicine Biorepository, which processes and stores thousands of patient samples and biological molecules linked to a relational database, and the Genomics Core facility, which utilizes cutting-edge genomics technology for multiple researchers within the Cleveland Clinic and externally.
The Institute offers a unique training program to young investigators who wish to apply genomics to their research or medical practice. GMI also coordinates genomic research and practice across many disease areas to enhance interdisciplinary research and healthcare.
In an interview with Cleveland Clinic's Chief of Staff Dr. Brian Donley, Dr. Eng explains why the topic of genomics and precision medicine is so important right now and shares her own story as a patient.
CPGH genetic counselor Allison Schreiber, MS, LGC, discusses genetic testing for patients with autism with long-time GMI friend and Chief Science Officer of Autism Speaks Tom Frazier II, PhD, during his keynote address at MIS2017. (Allison joins Dr. Fraizer at 15:10.)
10/27/17 - Charis Eng, MD, PhD, founding Chair of Cleveland Clinic’s Genomic Medicine Institute and founding Director of the institute’s clinical component, the Center for Personalized Genetic Healthcare, was honored with a Professional Achievement Award from the University of Chicago Alumni Association. Click here for the full press release.
10/26/17 - More than 2,500 people gathered in downtown Cleveland on October 23-25 for the 15th annual Medical Innovation Summit hosted by Cleveland Clinic Innovations. This year’s theme was Genomics & Precision Medicine. GMI played a major role in planning the event, and GMI Chair Charis Eng, MD, PhD, spoke on multiple panels. Memorably, Dr. Eng shared her own cancer journey in a conversation with Cleveland Clinic’s Chief of Staff, Brian Donley, MD, to open the Summit.
Pictured above from left to right: Sirena Meade, Dr. Charis Eng, Lamis Yehia, Dr. Sara Akhavanfard
Dr. Eng participated in the following panel discussions:
Pictured above from left to right: Meg Tirrell, Cindy Collins, Christine Cournoyer, Dr. Charis Eng, Alexander Ford.
Wednesday’s keynote speaker was long-time GMI colleague Tom Frazier, PhD, Chief Scientific Officer of Autism Speaks. As part of his keynote address, Dr. Frazier interviewed GMI genetic counselor Allison Schreiber, MS, LGC, who played an important role in helping to identify a genetic component of his son’s autism diagnosis.
Pictured above: Dr. Tom Frazier and Allison Schreiber
Thanks to Cleveland Clinic Innovations and all who worked to make this summit a successful learning and networking opportunity!
10/6/17 - Charis Eng, MD, PhD, along with co-senior author Stephen Grobmyer, MD, uncovered differences in the bacterial composition of breast tissue in healthy women compared to that of women with breast cancer. The findings were recently published in the journal Oncotarget. According to Dr. Eng, this study of the breast tissue, oral and urinary microbiomes in breast cancer is the first to examine both breast tissue and distant sites for bacterial differences in breast cancer.
“Our hope,” said Dr. Eng, “is to find a biomarker that would help us diagnose breast cancer quickly and easily. In our wildest dreams, we hope we can use microbiomics right before breast cancer forms, and then prevent cancer with probiotics or antibiotics.”
Breast cancer is the second most common cancer in women (after skin cancer) in the United States, where 1 in 8 women will develop the disease in their lifetimes.
To read the full press release, click here.
9/29/17 - The Genomic Medicine Institute’s (GMI) 5th annual Genetics Education Symposium entitled, “Genetics & Genomics: A Focus on Women’s Health” was held on Thursday, September 9th at the InterContinental Hotel and Conference Center in Cleveland, Ohio. This day-long symposium was attended by more than 200 healthcare professionals and students from a variety of organizations.
The presentations focused on advances in the diagnosis, management, and treatment of genetic conditions in diseases affecting women. Presentations included: Genetics Primer & Clinical Updates by Linford Williams, MS, LGC; Genetics and Women’s Health: Seeing and Foreseeing the Ethical Challenges Ahead by Ruth Farrell, MD, MA; Preimplantation Genetic Screening and Diagnosis: What You Need to Know by Marissa Coleridge, MS, LGC; Evolution of Prenatal Genetic Screening and Testing: NIPT and Beyond by Jeff Chapa, MD, MBA; Promises and Pitfalls of Prenatal Whole Exome Sequencing by Amanda Kalan, MD; Fertility Preservation and Cancer: Survivors, Previvors, and the Newly Diagnosed by Rebecca Flyckt, MD; Improving Access to Cancer Genetics via Telegenetics by Ryan Noss, MS, LGC; Breast Cancer: Management of Moderate Penetrance Predisposition Genes by Holly Pederson, MD; Use of Hormonal and Non-hormonal Therapies in Breast Cancer Survivors and Women at High Risk for Breast/Gyn Cancers by Holly Thacker, MD; Addressing Commonly Asked Patient Questions about Genetics by Rebekah Moore, MS, LGC, Christina Rigelsky, MS, LGC and Allison Schreiber, MS, LGC; and a panel discussion on Genetic Testing Reimbursement featuring Bruce Rogen, MD, MPH and John Yao, MD, MBA, MPH, which was moderated by Daniel Sullivan, MD. Charis Eng, MD, PhD, course director, founding Chair of the GMI and Director of the Center for Personalized Genetic Healthcare, concluded the day with her presentation Your Genes, Your Wine, Your Health, followed by a wine reception.
Pictured above from left to right: Dr. Daniel Sullivan, Dr. Bruce Rogen, Dr. John Yao
Pictured above: Marissa Coleridge
This year’s symposium also showcased GMI trainees who gave “lightning talks,” or quick summaries, of GMI research and poster presentations displayed throughout the day.
Keep updated on all GMI events, seminars, and next year’s symposium by subscribing to our newsletter. To subscribe, email Jenn Lonzer, GMI’s Communication and Education Coordinator at firstname.lastname@example.org.
Pictured above from left to right: Dr. Holly Pederson, Dr. Holly Thacker, Dr. Charis Eng
4/21/17 - Charis Eng, MD, PhD and her research team including first author Ying Ni, PhD, postdoctoral fellow, at the Cleveland Clinic’s Genomic Medicine Institute have discovered that a faulty, rarely studied gene called USF3 may predispose individuals to thyroid cancer.This exciting research was recently published in Human Molecular Genetics.
The discovery of this cancer predisposition gene will facilitate predictive genetic testing, risk assessment, genetic counseling and clinical management of the disease.
Featured in over 13 media outlets, including:
American Association for the Advancement of Science - EurekAlert
Cleveland Clinic - ConsultQD
Full journal publication here:
Human Molecular Genetics
1/19/17 - Since her discovery of the PTEN gene in 1997, cancer geneticist and Cleveland Clinic Genomic Medicine Institute Chair, Charis Eng, MD, PhD has collaborated with physicians and scientists across the nation to determine the impact of a PTEN gene mutation. Their research determined that this gene, in some cases, can cause both cancer and autism. This subtype of autism has been named PTEN-ASD and is estimated to affect up to 2% of individuals with autism.
That was the story of a boy in Tulsa, Oklahoma, Charlie Ryan, one of Dr. Eng’s patients at Cleveland Clinic’s Center for Personalized Genetic Healthcare. After her son developed autism and a benign tumor - Charlie’s mother was determined to find out what could cause such seemingly polar diseases. Her research led Charlie to Cleveland Clinic to be treated by Dr. Eng and autism expert, Thomas Frazier, PhD. In a story by Spectrum, an autism news site, Charlie’s parents tell their story. The article also includes how PTEN was discovered, the impact of a PTEN gene mutation, and finally, the treatment options for Charlie and others like him. Read the whole story on Spectrum’s website here.