David Serre Ph.D.

Associate Staff

  • Genomic Medicine Institute
  • Lerner Research Institute
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • serred@ccf.org
  • Phone: (216) 444-0676
  • Fax: (216) 636-0009

Our lab is interested in better understanding the molecular mechanisms underlying different human diseases using genomic approaches. In particular, we are using next generation sequencing to address fundamental biological questions that were difficult to investigate with former technologies. Currently, we are focusing on two research themes: malaria genomics and epigenetic regulation of metabolic traits.

Molecular Basis and Consequences of Developmental Epigenetic Programming - While diet and lack of physical exercise are the main risk factors for obesity and diabetes, epidemiological and animal studies have shown that intrauterine conditions can also influence the regulation of body weight and glucose homeostasis in adulthood. We have developed a mouse model of diet-induced maternal obesity and we are using a combination of high-throughput genomic tools to better understand the influence of the maternal metabolic status during gestation on the regulation of metabolic traits in adult offspring.

Whole genome sequencing of Plasmodium vivax - Plasmodium vivax is the main cause of malaria outside Africa with up to 390 million clinical infections each year. In contrast to P. falciparum, P. vivax cannot be propagated in continuous in vitro cultures which greatly limits our understanding of the parasite’s biology. We are sequencing the entire genome of P. vivax isolates directly isolated from blood samples of infected patients. Our analyses provide rigorous characterization of the genetic diversity throughout the genome. We are applying this approach to better understand the molecular mechanisms underlying different parasite traits with a focus on red blood cell invasion and drug resistance

In other words ...

My laboratory uses recent developments in genomic technologies to investigate various biological questions.

We are studying the molecular consequences of maternal nutrition during pregnancy in adult offspring. In particular, we are interested in understanding why genetically identical offspring born from lean vs. obese female mice respond differently to high fat diet in adulthood (and develop diabetes and obesity). Our findings will provide a better understanding of the mechanisms responsible for the life-long metabolic consequences of maternal obesity, which currently affects 20-40% of pregnant women in the US.

A second area of research of my lab is malaria. Malaria is disease transmitted by bites of Anopheles mosquitoes infected by plasmodium parasites. We are sequencing the genomes of Plasmodium vivax strains directly isolated from infected patients, as well as of some of the Anopheles species transmitting these parasites, to better understand the biology of these organisms and, eventually, develop better control or elimination strategies

  • Matt Cannon Ph.D.
  • Postdoctoral Fellow
  • Location:NE5-315
  • Phone:(216) 444-0242
  • Fax:(216) 636-0009
  • cannonm3@ccf.org
  • Adam Kim Ph.D.
  • Postdoctoral Fellow
  • Location:NE5-315
  • Phone:(216) 444-0242
  • Fax:(216) 636-0009
  • kima7@ccf.org
  • Kyle Logue B.S.
  • Graduate Student
  • Location:NE5-315
  • Phone:(216) 444-0242
  • Fax:(216) 636-0009
  • loguek@ccf.org
  • Tenisha Phipps M.S.
  • Research Technician
  • Location:NE5-315
  • Phone:(216) 444-0242
  • phippst@ccf.org

Highlighted publications

  1. Chan ER et al. (2015) Comparative analysis of field-isolates and monkey-adapted Plasmodium vivax genomes. PLoS Negl Trop Dis. 9(3):e0003566.
  2. Logue K (2015) Whole-genome sequencing reveals absence of recent gene flow and separate demographic histories for Anopheles punctulatus mosquitoes in Papua New Guinea. Mol Ecol. 24(6):1263-1274.
  3. Cannon MV et al. (2014) Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring. PLoS One. 9(3):e90335.
  4. Hester J et al. (2013) De Novo Assembly of a field isolate Genome Reveals Novel Plasmodium vivax Erythrocyte Invasion Genes. PLoS Negl Trop Dis. 7:e2569.
  5. Menard D et al. (2013) Whole Genome Sequencing of Field Isolates Reveals a Common Duplication of the Duffy Binding Protein Gene in Malagasy Plasmodium vivax Strains. PLoS Negl Trop Dis. 7:e2489.
  6. Logue K et al. (2013) Mitochondrial genome sequences reveal deep divergences among Anopheles punctulatus sibling species in Papua New Guinea. Malaria J. 12:64.
  7. Chan ER et al. (2012) Whole genome sequencing of field isolates provides robust characterization of genetic diversity in Plasmodium vivax. PLoS Negl Trop Dis. 6(9): e1811
  8. Chan ER et al. (2011) A novel method for determining microflora composition using dynamic phylogenetic analysis of 16S ribosomal RNA deep sequencing data. Genomics 98(4):253-259.