William M. Baldwin M.D., Ph.D.

Staff

  • Department of Immunology
  • Cleveland Clinic Lerner Research Institute
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • baldwiw@ccf.org
  • (216) 445-2384
  • (216) 444-8372

Advances in immunosuppression have decreased the incidence of acute rejection, but the survival of all organ transplants continues to be limited by chronic rejection. Until recently, experimental models of transplantation have focused primarily on the T cell arm of adaptive immunity as the entire cause of acute and chronic rejection. Based on our knowledge of T cells, increasingly sophisticated immunosuppressive regimens have been designed. Unfortunately, the current immunosuppressive protocols are not effective in preventing antibody-mediated rejection. Antibody responses to transplants continue to present practical clinical problems because many patients have been exposed to histocompatibility antigens by previous blood transfusions, transplants or pregnancy. Previous exposure to alloantigens is one of the major differences between clinical patients and most experimental models of transplantation. Although rejection can result from pure antibody-mediated rejection, more frequently rejection is part of a comprehensive immune response that includes some degree of cellular rejection. Cellular and humoral immunity are highly interactive responses. The mechanisms underlying these interactions are incompletely understood. The goal of our studies is to understand the mechanisms through which antibodies alter lymphocyte responses at the level of endothelial cells, platelets and leukocytes. These mechanisms have general relevance to vascular pathology.

In other words ...

  • Determine the effects of intermittent interactions of antibodies and complement on endothelial cells.
  • Determine the mechanisms by which T cells promote antibody and complement interactions with endothelial cells resulting in activatation and release of cytokines.
  • Determine the mechanisms by which complement interactions with endothelial cells stimulate memory B cells resulting in local antibody production.
  • Modulation of T cell and B cell interactions with vascular endothelial cells by antibodies, complement, and platelets
  • Nina Dvorina M.D., B. S.
  • Senior Research Technologist
  • Location:NB3-20
  • Phone:(216) 444-5439
  • dvorinn@ccf.org
  • Sreedevi Goparaju
  • Graduate Student
  • Location:NB3-20
  • Phone:(216) 444-5439
  • goparas@ccf.org
  • Anupurna Kaul
  • Graduate Student
  • Location:NB3-20
  • Phone:(216) 444-5439
  • kaula@ccf.org
  • Hsiao-Hsuan Kuo
  • Graduate Student
  • Location:NB3-20
  • Phone:(216) 444-5439
  • kuoh@ccf.org

  1. Soong TR, Pathak AP, Asano H, Fox-Talbot K, Baldwin WM, III. Lymphatic injury and regeneration in cardiac allografts. Transplantation 89:500-8, 2010.
  2. Wehner JR, Fox-Talbot K, Halushka MK, Ellis C, Zachary AA, Baldwin WM III. B Cells and Plasma Cells in Coronaries of Chronically Rejected Cardiac Transplants. Transplantation 89:1141-8. 2010
  3. Swaim AF, Field DJ, Fox-Talbot K, Baldwin WM III, Morrell CN. Platelets contribute to allograft rejection through glutamate receptor signaling. J Immunol. 185:6999-7006, 2010.
  4. Baldwin WM 3rd, Valujskikh A, Fairchild RL. Antibody-mediated rejection: emergence of animal models to answer clinical questions. Am J Transplant. 2010 May;10(5):1135-42. Epub 2010 Mar 19.
  5. Jindra PT, Hsueh A, Hong L, Gjertson D, Shen XD, Gao F, Dang J, Mischel PS, Baldwin WM III, Fishbein MC, Kupiec-Weglinski JW, Reed EF. Anti-MHC Class I Antibody Activation of Proliferation and Survival Signaling in Murine Cardiac Allografts. J Immunol.180:2214-24, 2008.
  6. Murata K, Iwata T, Nakashima S, Fox-Talbot K, Qian Z, Wilkes DS, Baldwin WM III. C4d deposition and cellular infiltrates as markers of acute rejection in rat models of orthotopic lung transplantation. Transplantation. 86:123-9, 2008.
  7. Girnita AL, Lee TM, McCurry KR, Baldwin WM III, Yousem SA, Detrick B, Pilewski J, Toyoda Y, Jelinek L, Lomago J, Zaldonis D, Spichty KJ, Zeevi A. Anti-human leukocyte antigen antibodies, vascular C4d deposition and increased soluble c4d in broncho-alveolar lavage of lung allografts. Transplantation. 86:342-7, 2008.
  8. Choy JC, Yi T, Rao DA, Tellides G, Fox-Talbot K, Baldwin WM III, Pober JS. CXCL12 induction of inducible nitric oxide synthase in human CD8 T cells. J Heart Lung Transplant. 27:1333-9, 2008.
  9. Morrell CN, Murata K, Swaim AM, Mason E, Martin TV, Ballard M, Fox-Talbot K, Waswoska B, Baldwin WM III . In vivo platelet-endothelial cell interactions in response to MHC alloantibody. Circ Res.102:777-85, 2008.
  10. Kirk AD, Morrell CN, Baldwin WM III . Platelets influence vascularized organ transplants from start to finish Am J Transplant. 2008.