Faculty 1

Date Contact Description
09/24/2020 Kelsey Duhaime
duhaimk@ccf.org

Department of Inflammation & Immunity

 

Faculty Recruitment

The Department of Inflammation & Immunity in the Cleveland Clinic Lerner Research Institute is conducting a search for new faculty members at the Assistant Professor academic level to develop research programs in innate and/or adaptive immune responses. Candidates must hold a Ph.D., M.D., or both.

We seek to recruit talented individuals with innovative ideas and models to explore new areas in immunology and inflammatory processes that have implications for human health. The applicant should have expertise in animal models and/or human experimental systems that address significant and fundamental questions using cellular, molecular or computational approaches. The successful candidate will establish and direct an independent research program in a collegial and collaborative environment. The Lerner Research Institute offers an outstanding mentorship for young faculty members, competitive start up and salary support, as well as world class facilities and core services.

We will focus on applicants with new approaches and skillsets to complement and synergize with the growing programs in basic and translational research within the Department that include: chronic inflammatory diseases, innate host defense, adaptive immunity, signaling networks, metabolism, and mucosal, cancer and transplant immunology.

We expect that the applicants will have rigorous training in immunobiology and/or synergistic areas as well as an outstanding track record of accomplishment during their graduate student and postdoctoral training. The Department is particularly interested in qualified candidates who can contribute to the diversity and excellence of the academic community. Applicants should send a cover letter, a short narrative of research accomplishments, interests and future plans, their curriculum vitae, and the names of three referees for letters of reference to Kelsey Duhaime, duhaimk@ccf.org.

Cleveland Clinic is pleased to be an equal employment/affirmative action employer: Women/ Minorities/Veterans/Individuals with Disabilities. Smoke/drug free environment.



Postdoctoral 14

Date Contact Description
01/06/2021 Dr. Feng Lin
linf2@ccf.org

An immediate opening is available for a Postdoctoral Fellow position (or higher) in the Lin laboratory, Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute.  We are seeking highly motivated candidates who are interested in translational medical research. The lab is well-funded with multiple grants from the NIH and other sources. Candidates with prior experience and knowledge of techniques in Molecular Immunology, and with expertise in cell and animal models of autoimmune diseases and tumors are encouraged to apply.

Must be familiar with cultivation of multiple cell lines and primary cells.  Flow cytometry, western blotting, ELISA, lenti- retro- and adenoviral systems of shRNA delivery, expression of exogenous proteins, and the Casp9/Crispr system. Experience in murine models of autoimmune diseases such as EAE and/or EAU as well as tumor models is an advantage. The successful candidate will be expected to design, implement and manage research projects addressing roles of complement and/or CD6 in human diseases.

A Ph.D. or M.D. degree with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Candidates at both junior and senior levels are welcome to apply. Interested candidates should send a single PDF file, including 1) Cover letter indicating current and future research interests; 2)Expected starting date; 3)Curriculum vitae, and 4) Brief summary of previous research experience (2-3 pages) by email to Feng Lin, Ph.D., Department of Inflammation & Immunity; Lerner Research Institute / NE4; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. linf2@ccf.org

12/29/2020 Dr. Rachel Scheraga
scherar@ccf.org

A post-doctoral fellow position is available to perform basic and translational research in the laboratory of Dr. Scheraga at the Cleveland Clinic, Lerner Research Institute Department of Inflammation and Immunity. Our NIH-funded work is focused on the role of a mechanosensitive, calcium ion channel and innate immune cell biology in the lung. We are seeking a hardworking and motivated individual who has experience in cell and molecular biology techniques and managing mouse colonies. The position has salary and fringe compensation as per the NIH guidelines with additional fringe benefits. Please apply to this position with your current CV and three letters of reference to Dr. Rachel Scheraga (scherar@ccf.org).

12/29/2020 Kurt Runge, PhD
rungek@ccf.org

Postdoctoral Research Fellow - Telomere Formation and DNA Damage Checkpoint Activation

An immediate opening for an NSF-funded Postdoctoral position to study telomere formation and DNA damage checkpoint suppression in fission yeast is available in the Runge lab at the Cleveland Clinic Lerner Research Institute.  Our lab uses a combination of molecular genetics, in vivo proximity labeling, proteomics and molecular biology to identify factors and pathways that distinguish telomeres from DNA double-strand breaks.  Individuals with experience in yeast and a strong background in molecular biology, genetics, and/or biochemistry are encouraged to apply.

Our lab developed a novel, rapidly inducible telomere formation system in the Schizosaccharomyces pombe.  We have used it to monitor the kinetics of telomere formation and the accompanying chromatin modifications (e.g. PubMed ID: 29784772).  We are combining this approach with our successful adaptation of proximity labeling for fission yeast to monitor the protein environment at the forming the telomere. This project provide a launching point for multiple new research directions in a system with strong similarities to human cells.

This project utilizes the state-of-the-art core facilities at the Cleveland Clinic and nearby Case Western Reserve University, and the active research communities in the Cleveland area.  Additional information about postdoctoral training at the Lerner Research Institute is available through links at www.lerner.ccf.org/education/postdoc/.

Applicants must have a Ph.D. with relevant laboratory experience and proficiency in written and spoken English.  To apply, please email a cover letter, CV, and contact information for 3 references to: Kurt Runge, Ph.D.; rungek@ccf.org; Department of Inflammation & Immunity.

12/16/2020 Brian Gastman
gastmab@ccf.org

There are immediate openings for 2 positions as post-doctoral fellows or other clinical trainee levels (medical students, residents, fellows) in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute and Department of Plastic Surgery, Cleveland Clinic. Individuals with clinical experience and knowledge of cancer are encouraged to apply.  The ideal candidate would be a medical student, resident or fellow interested in translational research related to cancer and specifically skin malignancies like melanoma as well as surgery (including but not limited to surgical oncology and plastic surgery).  As these projects are highly translational there will be more emphasis on tissue handling, storing and shipping than basic science assays.  However, both projects will be involving proprietary devices and reagents as they relate to industry sponsored research.  There may be extensions of this research that will require collaboration with bioinformatics teams.  In addition as these projects mature there is likely need for studies requiring immunohistochemsty and flow based analyses.    Finally, there may also be extensions requiring in vivo modeling with cancer specimens and PDX models.  Applicants with a clinical background as mentioned and with appropriate basic science skills will be prioritized – however these positions to lend themselves to learning of these techniques.  Finally excellent communication skills is also a priority as there will be significant correspondences between our institution and the sponsors.    Given that this is for translational studies, there may be associated chart review and even review article type activities asked of those accepted to these positions.

Ph.D. or M.D./D.O. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE40; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. gastmab@ccf.org.

12/14/2020 Florian Rieder
riederf@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic [Institute/Department]

Immediate opening for a Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute Department of Inflammation and Immunity. Individuals with experience and knowledge of techniques in tissue culture, primary human cell isolation, molecular biology techniques (qPCR, immunoblot, ELISA), IHC, confocal microscopy, mouse handling are encouraged to apply. This project includes animal husbandry, breeding, genotyping, animal models of colitis.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required. Please send your curriculum vitae and contact information for 3 references to Dr. Florian Rieder (riederf@ccf.org).

Please send your curriculum vitae and contact information for 3 references to [Name of Contact Person]

12/07/2020 Dr. Dennis Stuehr
stuehrd@ccf.org

A NIH-funded postdoctoral fellow position is available in the laboratory of Dr. Dennis Stuehr in the Department of Inflammation and Immunity, Cleveland Clinic, USA. The scientific project aims to uncover the molecular mechanisms of heme trafficking in mammalian cells and the molecular mechanisms of heme insertion into biomedically-important heme proteins including soluble guanylyl cyclase, hemoglobin, myoglobin, cytochrome P450’s, and indoleamine and tryptophan dioxygenases. Our research approach combines biochemical, biophysical, and computational experiments on the purified proteins with confirmatory and exploratory experiments in cultured mammalian cells. Candidates with a recent or upcoming PhD with expertise in protein biochemistry, biophysics, or structural biology are invited to send their CV and names of three references to:

Dr. Dennis Stuehr stuehrd@ccf.org

For representative articles see:

Heat shock protein 90 associates with the Per-Arnt-Sim domain of heme-free soluble guanylyl cyclase: Implications for enzyme maturation. Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ. (2015) J Biol Chem. 290:21615-28. PMID: 26134567

Heat shock protein 90 regulates soluble guanylyl cyclase by a dual mechanism. Dai Y, Schlanger S, Haque MM, Misra S, Stuehr DJ. (2019) J Biol Chem. 294: 12880-91. PMID: 31311859

Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells. Sweeny EA, Singh AB, Chakravarti R, Martinez-Guzman O, Saini A, Haque MM, Garee G, Dans PD, Hannibal L, Reddi AR, Stuehr DJ. (2018) J Biol Chem. 293:14557-14568. PMID: 30012884.

GAPDH delivers heme to soluble guanylyl cyclase. Dai Y, Sweeny EA, Schlanger S, Ghosh A, Stuehr DJ. J Biol Chem. (2020) 295:8145-8154. PMID: 32358060

10/14/2020 Dr. Arnab Ghosh
ghosha3@ccf.org

A post-doctoral position is available immediately in the laboratory of Drs. Stuehr https:/ http://www.lerner.ccf.org/immuno/stuehr and Ghosh (https://www.lerner.ccf.org/immuno/ghosh) to work on an NIH funded project which relates to soluble guanalyl cyclase dysfunction in asthma. The desired candidate should have a PhD degree in Biochemistry/Life Sciences/ Immunology or in a related field with a good publication record in graduate study. Applicants should have excellent writing skills and should be well versed in current cell biology and molecular biology techniques, including proteomics and epigenetic modifications. Applicants will be preferred who have additional experience in working with and maintaining mouse colonies. Internationals applying would require a TOEFL score. The position has the pay and compensation as per NIH guidelines with additional fringe benefits. Please apply to this position with your current CV and three letters of reference to Drs. Dennis Stuehr (email: stuehrd@ccf.org) and Dr. Arnab Ghosh (e-mail: ghosha3@ccf.org).

09/29/2020 Dr. Michelle Longworth
longwom@ccf.org

Immediate opening for a postdoctoral fellow position in the Longworth laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Our lab investigates the role of DNA organizing complexes in innate immune responses to bacterial and viral infections, and to endogenous retrovirus and retrotransposon expression. We are seeking highly motivated individuals with experience and knowledge of techniques in molecular biology, genetics, and biochemistry. Candidate must be familiar with cultivation of cell lines. Familiarity with lenti- and retroviral based systems of nucleic acid delivery, with CRISPR/Cas9, and with chromatin based biochemical assays including ChIP-seq, ATAC-seq, and 4C-seq are advantages.

Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required. Email cover letter, CV, and contact information for 3 references to Michelle Longworth, Ph.D.; Department of Inflammation and Immunity; Lerner Research Institute, longwom@ccf.org.

09/26/2020 Dr. Andrei Ivanov, PhD
ivanova2@ccf.org

We have an immediate opening for a Postdoctoral Fellow position in the Dr. Andrei Ivanov Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interests in studying intercellular junctions, epithelial barriers, epithelial wound healing, actin cytoskeleton and epithelial responses during intestinal inflammation are encouraged to apply.

A highly motivated candidate will join a productive research team to participate in an NIH funded project focusing on the roles of the actin cytoskeleton and myosin motors in disassembly and reformation of tight and adherens junctions in the intestinal epithelium during mucosal inflammation and colonic tumorigenesis. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise, or experience with mouse models of inflammatory diseases.

Must be familiar with mammalian cell culture, Western blotting, and RNA based methods including quantitative RT-PCR and reporter assays, subcloning between different vectors, lenti- retro- and adenoviral systems for cDNA and shRNA delivery. Preference will be given to candidates with previous experience in epithelial cell biology, CRISPR/Cas9-dependent gene editing, confocal microscopy/cell imaging or mouse models of gut inflammation. Excellent communication skills and ability to work as a team are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grant applications.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  E-mail cover letter and CV and contact information for 3 references to: Dr. Andrei Ivanov; Department of Inflammation and Immunity; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 444-5620; E-mail: ivanova2@ccf.org.

 

09/21/2020 Dr. Fariba Rezaee
rezaeef@ccf.org

We have an immediate opening for a motivated, and qualified Postdoctoral Fellow position in the Dr. Rezaee Laboratory, Center for Pediatric Research in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in all of the above listed technical skills are encouraged to apply.

Must be familiar with cultivation of multiple cell lines, primary airway epithelial cells, Western blotting, RNA based methods including quantitative PCR and reporter assays, subcloning between different vectors, and the Crispr/ Casp9 system. Must be familiar with working with rodents, including intratracheal inoculation, isolation of airway cells and immunohistochemistry.  Excellent communication skills in English are essential. The successful candidate will be expected to design, implement and manage research projects addressing cellular response to viral infection and pollutions. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Please send cover letter, CV, and contact information for 3 references to: Dr. Fariba Rezaee; Pediatrics/Department of Inflammation and Immunity; Lerner Research Institute / NC 22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-0564; rezaeef@ccf.org

08/26/2020 Brian Gastman
gastmab@ccf.org

Immediate opening for a Postdoctoral Fellow position in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in immunology, molecular biology and biochemistry, and with expertise in cell, animal, or human models of cancer, and specifically cancer immunity are encouraged to apply. 

Must be familiar with immunologic assays (FACS, cytotoxicity, mouse tumor models, etc..), cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting,  expression of exogenous proteins, and the Casp9/Crispr system.    Experience with in vivo murine models is also important.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the role of suppressor cells in the tumor microenvironment.  The applicant will have significant exposure to human specimens from a multitude of research protocols and clinical trials.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Our laboratory is highly collaborative and works closely with industry.  The prospective applicant would be expected to not only be involved in high level research, but also to act as an ambassador between our lab and our industry partners.  Thus, proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE4-303; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-6950; gastmab@ccf.org

08/18/2020 Srinivasan Dasarathy
dasaras@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic [Institute/Department]

Please send your curriculum vitae and contact information for 3 references to

dasaras@ccf.org

We have an immediate opening for a Postdoctoral Fellow position in the Dr. Dasarathy Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interest in studying signal transduction during metabolic perturbations are encouraged to apply. The laboratory focus is on using integrated molecular metabolic approaches in a comprehensive array of cellular, mouse, and human models. 

A highly motivated candidate will join a productive research team to participate in NIH funded projects focusing on the molecular mechanisms of skeletal muscle loss and metabolic perturbations in disease. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise. 

Must be familiar with mesenchymal cell culture (preferably skeletal muscle), Western blotting, and RNA based methods including quantitative PCR and reporter assays, subcloning between different vectors, lenti- retro- and adenoviral systems for cDNA and shRNA delivery. Preference will be given to candidates with previous experience in skeletal muscle biology, CRISPR/Cas9-dependent gene editing, confocal microscopy/cell imaging or mouse models of muscle loss. Excellent communication skills in English are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Dr. Srinivasan Dasarathy; Department of Pathobiology; Lerner Research Institute / NE4 208; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 636-0096; E-mail: dasaras@ccf.org.

08/17/2020 Neetu Gupta, Ph.D
guptan@ccf.org

Immediate opening for a Postdoctoral Fellow position in the Gupta Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with demonstrable experience in mechanistic immunology research, B cell biology, mouse models of autoimmunity and/or inflammation and/or infection, and a strong record of publication are encouraged to apply. The successful candidate will design, implement and manage exciting research projects addressing the regulation of B cell antibody response during infection and inflammation.

Must be proficient in immunological techniques (multicolor flow cytometry, ELISA), cell culture, and molecular biology methods (western blotting, quantitative PCR, lentiviral gene expression, and CRISPR/Cas9 gene modification). Prior experience in murine lung and colon isolation and analysis is an advantage, as is cellular imaging. Excellent verbal and written communication skills are essential. The appointee will be expected to take advantage of this career opportunity to further develop skills in manuscript publication and grantsmanship.

Applicants must have a Ph.D. or an M.D.,Ph.D degree in immunology, with strong motivation, a passion for science, ability to work as a team and design experiments independently, and a strong work ethic. Proficiency in spoken and written English is required. Send a cover letter describing research accomplishments, future interests and career goals, CV and contact information for 3 references to Dr. Neetu Gupta (guptan@ccf.org).

08/12/2020 Dr. Michelle Longworth
longwom@ccf.org

Immediate opening for a Postdoctoral Fellow position in the Longworth Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in molecular biology, genetics, and biochemistry, and with expertise in mitochondrial biology and metabolism research are encouraged to apply.

Candidate must be familiar with cultivation of cell lines; previous experience with organoid-based systems is desired, but not required.  Candidate must also be familiar with Western blotting, qRT-PCR, immunofluorescence assays, and various cloning techniques. Familiarity with lenti- and retroviral based systems of nucleic acid delivery, and expression of exogenous proteins is required. Experience using CRISPR/Cas9 and/or chromatin based techniques such as ChIP-seq, ATAC-seq, and 3C/4C-seq are advantages. Candidate will be expected to design, implement and manage research projects focused on newly discovered mechanisms that lead to Reactive Oxygen Species accumulation in epithelial stem cells and their role in tumor development. 

Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Email cover letter, CV, and contact information for 3 references to: Michelle Longworth, Ph.D.; Department of Inflammation & Immunity; Lerner Research Institute, longwom@ccf.org.



Technical & Adminstrative

Applications for technical research positions and administrative positions at the Lerner Research Institute can be submitted on the Cleveland Clinic jobs web site.