Brian Gastman, M.D.

Staff

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Location: NE4-303
Email: gastmab@ccf.org
Phone: (216) 445-2103

 


Tumor Immunology- We are developing not only animal models to better understand this process, but also as a basis to investigate novel inhibitory strategies to enhance current immunotherapeutic approaches. Tumor secreted factors also appear to be an important part of this process, and thus identifying them and creating reagents for study and inhibition is also part of our investigations.

Cancer Therapy Resistance - We are moving toward a better understanding of these oncogenes from a molecular and biochemical standpoint as they inhibit chemotherapy induced senescence. Our goal is to identify new molecules involved in this process and new inhibitors of these oncogenes that will ultimately have clinical utility.


Dechen  Fu
Dechen Fu
Research Associate
Location:NE4-217
Phone:(216) 444-0202
fud@ccf.org
Yee Peng  Phoon  PhD
Yee Peng Phoon PhD
Postdoctoral Research Fellow
Location:NE4-217
Phone:(216) 444-0202
phoony@ccf.org
Ye  Tian  Ph.D.
Ye Tian Ph.D.
Postdoctoral Research Fellow
Location:NE4-217
Phone:(216) 444-0202
tiany2@ccf.org

  1. Maniar A, Zhang X, Lin W, Gastman BR, Pauza CD, Strome SE, Chapoval AI. Human {gamma}{delta} T lymphocytes induce robust NK cell mediated antitumor cytotoxicity through CD137 engagement. Blood. Sep 9;116(10):1726-33. 2010
  2. Zhang X, Voskens CJ, Sallin M, Maniar A, Montes CL, Zhang Y, Lin W, Li G, Burch E, Tan M, Hertzano R, Chapoval AI, Tamada K, Gastman BR, et al. CD137 promotes proliferation and survival of human B cells. J Immunol. Jan 15;184(2):787-95, 2010.


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