Brian Gastman, M.D.

Staff

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NE6-303
gastmab@ccf.org
Phone: (216) 445-2103



Tumor Immunology- We are developing not only animal models to better understand this process, but also as a basis to investigate novel inhibitory strategies to enhance current immunotherapeutic approaches. Tumor secreted factors also appear to be an important part of this process, and thus identifying them and creating reagents for study and inhibition is also part of our investigations.

Cancer Therapy Resistance - We are moving toward a better understanding of these oncogenes from a molecular and biochemical standpoint as they inhibit chemotherapy induced senescence. Our goal is to identify new molecules involved in this process and new inhibitors of these oncogenes that will ultimately have clinical utility.


Abeba  Demelash Ph.D.
Abeba Demelash Ph.D.
Postdoctoral Research Fellow

Location:NE6-251
Phone:(216) 444-0202
demelaa@ccf.org
laboratory

Lukas W. Pfannenstiel Ph.D.
Lukas W. Pfannenstiel Ph.D.
Postdoctoral Research Fellow

Location:NE6-251
Phone:(216) 444-0202
pfannel@ccf.org
laboratory

Ye  Tian Ph.D.
Ye Tian Ph.D.
Postdoctoral Research Fellow

Location:NE6-251
Phone:(216) 444-0202
tiany2@ccf.org
laboratory


  1. Maniar A, Zhang X, Lin W, Gastman BR, Pauza CD, Strome SE, Chapoval AI. Human {gamma}{delta} T lymphocytes induce robust NK cell mediated antitumor cytotoxicity through CD137 engagement. Blood. Sep 9;116(10):1726-33. 2010
  2. Zhang X, Voskens CJ, Sallin M, Maniar A, Montes CL, Zhang Y, Lin W, Li G, Burch E, Tan M, Hertzano R, Chapoval AI, Tamada K, Gastman BR, et al. CD137 promotes proliferation and survival of human B cells. J Immunol. Jan 15;184(2):787-95, 2010.