Feng Lin, PhD
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 445-6637
The complement system is an important part of the innate immunity. Complement activation products not only directly help to eliminate invading pathogens, but also participate in many immunological reactions, including clearance of immune complexes, antibody production, and T-cell regulation. Insufficient or excess complement activation has been shown to be important in a wide range of disease states, such as multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis, and age-related macular degeneration, as well as in allograft rejection.
My laboratory is interested in studying complement activation and regulation in these disease states, thus eventually developing novel therapies.
During the last decade, we have also developed a program focusing on CD6. We found evidence suggesting that CD6 is a promising new therapeutic target for treating many pathological conditions, and we have been developing novel CD6-related reagents as potential drugs.
Yan Li, Wen Qiu, Lingjun Zhang, John Fung, and Lin F (2016) Painting factor H onto mesenchymal stem cells protects the cells from complement- and neutrophil-mediated damage
Biomaterials 102: 209-219
Li Y, Singer NG, Whitebred J, Bowen MA, Fox DA and Lin F (2017) CD6 as a potential target for treating multiple sclerosis
Proc Natl Acad Sci U S A 114(10):2687-2692
Enyindah-Asonye G, Li Y, Ruth JH, Spassov DS, Hebron KE, Zijlstra A, Moasser MM, Wang B, Singer NG, Cui H, Ohara RA, Rasmussen SM, Fox DA, Lin F (2017) CD318 is a ligand for CD6.
Proc Natl Acad Sci U S A. 114(33):E6912-E6921
Xu J, Zhang L, Xie M, Li Y, Huang P, Saunders TL, Fox DA, Rosenquist R, Lin F.(2018) Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy.
J Immunol. 15;200(12):4094-4101
Zhang L, Sorensen MD, Kristensen BW, Reifenberger G, McIntyre TM, Lin F (2018) D-2-Hydroxyglutarate Is an Intercellular Mediator in IDH-Mutant Gliomas Inhibiting Complement and T Cells.
Clin Cancer Res. 1;24(21):5381-5391.
The National Eye Institute, part of the National Institutes of Health, has awarded Feng Lin, PhD, a four-year, $1.6 million grant to investigate the biological mechanisms underlying autoimmune uveitis (AU), a common cause of blindness. The long-term goal of the preclinical study is to gain insights into the causes of AU that may reveal novel targets and help researchers develop therapies to treat the disease in patients.