Recent Key References

Tuohy VK, Jaini R, Johnson JM, Loya MG, Wilk D, Downs-Kelly E, Mazumder S. Targeted vaccination against human α-lactalbumin for immunotherapy and primary immunoprevention of triple negative breast cancer. Cancers (in press)

Tuohy VK. Primary immunoprevention: The great unmet need for controlling breast cancer. Oncology (Williston Park) 2016; 30(5):pii: 217055

Sakalar C, Mazumder S, Johnson JM, Altuntas CZ, Jaini R, Aguilar R, Naga Prasad SV, Connolly DC, Tuohy VK. Regulation of murine ovarian epithelial carcinoma by vaccination against the cytoplasmic domain of anti-Müllerian hormone receptor II. Journal of Immunology Research 2015; 2015:630287

Emens LA, Tuohy VK, Stanton SE, Clarke E. Immunotherapy for breast cancer: is it feasible? Immunotherapy 2015; 7:1135-1143

Jaini R, Altuntas CZ, Loya MG, Tuohy VK. Disruption of estrous cycle homeostasis in mice with experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 2015; 279:71-74

Tuohy VK. Bench-to-bedside challenges in developing immune protection against breast cancer. Cleveland Clinic Journal of Medicine 2014; 81:605-607

Bicer F, Altuntas CZ, Izgi K, Ozer A, Kavran M, Tuohy VK, Daneshgari F. Chronic pelvic allodynia is mediated by CCL2 through mast cells in an experimental autoimmune cystitis model. American Journal of Physiology: Renal Physiology 2015; 308:F103-113

Tuohy VK. Retired self-proteins as vaccine targets for primary immunoprevention of adult-onset cancers. Expert Review of Vaccines 2014; 13:1447-1462

Singh V, Jaini R, Torricelli AA, Tuohy VK, Wilson SE. A method to generate enhanced GFP+ chimeric mice to study the role of bone marrow-derived cells in the eye. Experimental Eye Research 2013; 116:366-370

Jaini R, Rayman P, Cohen PA, Finke JH, Tuohy VK. Combination of sunitinib with anti-tumor vaccination inhibits T cell priming and requires careful scheduling to achieve productive immunotherapy. International Journal of Cancer 2014; 134:1695-1705

Izgi K, Altuntas CZ, Bicer F, Ozer A, Sakalar C, Li X, Tuohy VK, Daneshgari F. Uroplakin peptide-specific autoimmunity initiates interstitial cystitis/painful bladder syndrome in mice. PLoS One 2013; 8:e72067

Jaini R, Popescu DC, Flask CA, Macklin WB, Tuohy VK. Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity. Journal of Neuroimmunology 2013; 259:37-46

Altuntas CZ, Daneshgari F, Veizi E, Izgi K, Bicer F, Ozer A, Grimberg KO, Bakhautdin B, Sakalar C, Tasdemir C, Tuohy VK. A novel murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) induced by immunization with a spermine binding protein (p25) peptide. American Journal of Physiology: Regulation, Integrative, and Comparative Physiology 2013; 304:R415-422

Altuntas CZ, Daneshgari F, Izgi K, Bicer F, Ozer A, Sakalar C, Grimberg KO, Sayin I, Tuohy VK. Connective tissue and its growth factor CTGF distinguish the morphometric and molecular remodeling of the bladder in a model of neurogenic bladder. American Journal of Physiology: Renal Physiology 2012; 303:F1363-1369

Kesaraju P, Jaini R, Johnson JM, Altuntas CZ, Gruden JJ, Sakalar C, Tuohy VK. Experimental autoimmune breast failure: a model for lactation insufficiency, postnatal nutritional deprivation, and prophylactic breast cancer vaccination. American Journal of Pathology 2012; 181:775-784

Altuntas CZ, Daneshgari F, Sakalar C, Goksoy E, Gulen MF, Kavran M, Qin J, Li X, Tuohy VK. Autoimmunity to uroplakin II causes cystitis in mice: a novel model of interstitial cystitis. European Urology 2012; 61:193-200

Altuntas CZ, Jaini R, Kesaraju P, Jane-wit D, Johnson JM, Covey K, Flask CA, Dutertre M, Picard JY, Tuohy VK. Autoimmune mediated regulation of ovarian tumor growth. Gynecologic Oncology 2012; 124:98-104

Altuntas CZ, Daneshgari F, Sakalar C, Goksoy E, Gulen MF, Kavran M, Qin J, Li X, Tuohy VK. Autoimmunity to uroplakin II causes cystitis in mice: a novel model of interstitial cystitis. European Urology 2012; 61:193-200

Tuohy VK, Jaini R. Prophylactic cancer vaccination by targeting functional non-self. Annals of Medicine 2011; 43:356-365

Tuohy VK. A prophylactic vaccine for breast cancer? Why not? Breast Cancer Research 2010; 12:405

Jaini R, Kesaraju P, Johnson JM, Altuntas CZ, Jane-Wit D, Tuohy VK. An autoimmune-mediated strategy for prophylactic breast cancer vaccination. Nature Medicine 2010; 16:799-803

• Commentary:  Alexandra Flemming. Cancer: steps towards a prophylactic breast cancer vaccine. Nature Reviews Drug Discovery 2010; 9:594-595
• Commentary:  Michael J. Haas. Breast cancer prophylaxis. Breast cancer prophylaxis. SciBX 2010; 3(24)
• Commentary:  Michael Eisenstein. Vaccines: know your enemy. Nature 2011; 471:S8-9
• Commentary:  Kelly Rae Chi. Cancer Research: Promise of protection. Nature 2011; 471:537-538

Kang Z, Altuntas CZ, Gulen MF, Liu C, Giltiay N, Qin H, Liu L, Qian W, Ransohoff RM, Bergmann C, Stohlman S, Tuohy VK, Li X. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 2010; 32:414-425

Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 2010; 32:54-66

Staschke KA, Dong S, Saha J, Zhao J, Brooks NA, Hepburn DL, Xia J, Gulen MF, Kang Z, Altuntas CZ, Tuohy VK, Gilmour R, Li X, Na S. IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease. Journal of Immunology 2009; 183:568-577

Tigno-Aranjuez JT, Jaini R, Tuohy VK, Lehmann PV, Tary-Lehmann M. Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells. Journal of Immunology 2009; 183:5654-5661

Buniel MC, Geelan-Hansen K, Weber PC, Tuohy VK. Immunosuppressive therapy for autoimmune inner ear disease. Immunotherapy 2009; 1:425-434