Postdoctoral Positions

The Lerner Research Institute is home to Cleveland Clinic's basic research departments and more than 2,000 scientists and support personnel. Research teams of more than 150 Faculty, 240 Postdoctoral Fellows and nearly 200 graduate students pursue a wide range of biomedical questions in our laboratories. The Institute's Postdoctoral Fellowship includes a competitive salary and benefits package and an opportunity to work and advance in a state-of-the-art facility with more than 700,000 square feet of space. Total annual research expenditures approached $250 million in 2011, including more than $110 million in federal funding.

The current postdoctoral opportunities are listed on the left. Please complete your application as directed and send to the investigator listed. We look forward to hearing from you!

Positions for Project Scientists, Research Associates and Postdoctoral Fellows posted by principal investigators.

Date Contact Description
04/18/2018 amit anand
ananda@ccf.org

We are looking for a PhD level post-doctoral fellow researcher in brain imaging analysis. The researcher will work with the Principal Investigator in conducting research in neurobiological basis of neuropsychiatric disorders, using brain imaging and bioinformatics techniques to combine behavioral data, imaging data and human genetic datasets.  High degree of mathematical and programming expertise required.  Use operating systems such as Linux, Unix and Matlab as well as Brain Imaging Analysis software. Be able to use statistical packages such as SPSS, SAS or R to conduct analysis.   Coordinate data collection, organization and analysis and preparation of publications and grant applications. Ensure accurate and satisfactory implementation of research protocols and comply with requirements of all regulatory bodies. they can contact me at ananda@ccf.org

  No time frame; the position is available now. 

04/17/2018 Laura Nagy
nagyl3@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic in the laboratory of Dr. Laura Nagy in the Department of Inflammation and Immunity to study the effects of ethanol on the innate immune system, including toll-like receptor signal transduction and complement activation.  The research will focus on the effects of chronic ethanol on key signal transduction pathways in hepatic innate immune cells (macrophages, infiltrating monocytes, neutrophils, etc) with a goal towards understanding the mechanism of development of chronic inflammatory responses in liverin order to develop rationale therapeutic interventions.  Our recent work using next generation sequencing of miRNA indicates that ethanol targets multiple levels in the regulation of cytokine expression leading to the development of alcoholic liver disease. We are also interested in identifying biomarkersand genetic risk factors for disease severity in a cohort of patients with alcoholic liver disease.

Experience in at least one of the following areas is desired:  cell biology, signal transduction, molecular biology, bioinformatics or macrophage biology. Experience in experimental design and data analysis in both cultured cells and animal models is preferred.  Strong written and oral communication skills are required.

Candidates should have a recent PhD in cell biology, immunology, biochemistry, or a related discipline and experience in signal transduction and cell biology. 

Interested applicants please submit a CV and names and contact information for three references to Dr. Laura Nagy, Department of Inflammation and Immunity (NE40) at Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland OH 44195 or via email to nagyL3@ccf.org

03/28/2018 Ela Plow PhD PT
plowe2@ccf.org

A postdoctoral fellow position is available at Cleveland Clinic’s Lerner Research Institute in the Department of Biomedical Engineering in the field of clinical neuroscience and neuro-rehabilitation. This is an exciting opportunity to join a laboratory that studies mechanisms of brain plasticity in neurologic recovery and targets these mechanisms with the use of behavioral and neuro-stimulation interventions to promote recovery. The successful candidate will have the opportunity to participate in clinical trials and neuroscientific studies, including an ongoing FDA-regulated clinical trial combining the use of non-invasive (transcranial) and invasive (deep) brain stimulation, and stroke recovery studies involving movement rehabilitation and neuroimaging.  

The position requires a highly creative, motivated and independent individual with a Ph.D. in kinesiology, rehabilitation science, exercise science/physiology, biomechanics and movement science, neuroscience, biomedical engineering or a related field. Candidates must demonstrate this experience through a record of relevant publications. Strong laboratory and clinical research skills, ability to lead and work well in a team, an understanding of human motor control in health and disease, and basic knowledge of neuroimaging and neurophysiology would be desirable. Past medical research is not required, but candidates must be willing to perform experiments in clinical settings. The successful candidate will be expected to interface with clinical staff, clinical coordinators, graduate students and fellows as well as participate in independent laboratory research. It would be desirable if candidates can begin in spring/summer 2018.

Please send your curriculum vitae and contact information for 3 references to Ela Plow PhD PT at plowe2@ccf.org

03/27/2018 Srinivasan Dasarathy MD
dasaras@ccf.org

We have an immediate opening for a Postdoctoral Fellow position in the Dr. Dasarathy Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interest in studying signal transduction during metabolic perturbations are encouraged to apply. The laboratory focus is on using integrated molecular metabolic approaches in a comprehensive array of cellular, mouse, and human models.

A highly motivated candidate will join a productive research team to participate in NIH funded projects focusing on the molecular mechanisms of skeletal muscle loss and metabolic perturbations in disease. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise.

Must be familiar with mesenchymal cell culture (preferably skeletal muscle), Western blotting, and RNA based methods including quantitative PCR and reporter assays, subcloning between different vectors, lenti- retro- and adenoviral systems for cDNA and shRNA delivery. Preference will be given to candidates with previous experience in skeletal muscle biology, CRISPR/Cas9-dependent gene editing, confocal microscopy/cell imaging or mouse models of muscle loss. Excellent communication skills in English are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Dr. Srinivasan Dasarathy; Department of Pathobiology; Lerner Research Institute / NE4 208; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 636-0096; E-mail: dasaras@ccf.org.

03/20/2018 Bela Anand-Apte
anandab@ccf.org
Postdoctoral Researcher Applications are invited for a Postdoctoral Scientist to join the Laboratory of Dr. Bela Anand-Apte in the Department of Ophthalmic Research at the Cole Eye Institute at the Cleveland Clinic Foundation. The Anand-Apte Laboratory investigates mechanisms that contribute to retinal and choroidal neovascularization and breakdown of the blood retinal barrier with a particular focus in Sorsby’s Fundus Dystrophy, Age-related Macular Degeneration and Diabetic Retinopathy. Candidates are required to have a recent PhD (within 2-3 years of degree), with skills in vascular and/or epithelial cell biology, molecular biology as well as experience with confocal microscopy of cells and tissue. Expertise in mice and/or zebrafish models will be preferred. Applicants are expected to be self-motivated and team-oriented with good oral and written communication skills in English. The Lerner Research Institute and Cole Eye Institute Vision Science Training Program provides an excellent training environment with mentoring and career development opportunities. To apply for this position please email a cover letter (outlining research interests), curriculum vitae and 2-3 letters of reference to Dr. Bela Anand-Apte, anandab@ccf.org Bela Anand-Apte, i3-161 Department of Ophthalmic Research, Cole Eye Institute, 9500 Euclid Avenue, Cleveland OH 44195
02/28/2018 Kunio Nakamura, PhD
Nakamuk@ccf.org

A postdoctoral position is available in the laboratory of Dr. Kunio Nakamura in the Department of Biomedical Engineering at the Cleveland Clinic Lerner Research Institute. (http://www.lerner.ccf.org/bme/nakamura/)

The ideal candidate will have a strong research background, publication records, and a keen interest in neuroimaging research. Proficiency in programming, MRI analysis, neuroimaging tools, machine learning, and statistics is required.

The candidate must have (or be close to finishing) a PhD degree.

The successful postdoctoral fellow will receive a competitive salary and benefits package. Additional information about postdoctoral training at the Lerner Research Institute is available at www.lerner.ccf.org/education/postdoc/.

Highly motivated and qualified individuals should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Kunio Nakamura (nakamuk@ccf.org).

02/28/2018 Qing Wang
wangq2@ccf.org

A Postdoctoral Fellow or Research Associate is needed for a newly-created Director for the Animal Model Core at Department of Molecular Cardiology in Cleveland Clinic Lerner Research Institute.  Applicants should have experience in mouse surgical procedures such as MI, TAC, thrombosis, vascular injury, and/or other models for cardiovascular diseases.  A successful applicant should have a Ph.D., M.D., or Ph.D./M.D. and an interest in independent research opportunities or collaborative research opportunities with other faculty members.  

Applicants should send CV as well as names and contact information of 2-3 referees to:

Dr Qing Wang, Department of Molecular Cardiology, Lerner Research Institute/NB50, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195; Email: wangq2@ccf.org.   

 
02/27/2018 Dr. Sarah Schumacher-Bass
basss4@ccf.org

We are searching for highly motivated individuals to join the Schumacher-Bass lab within Molecular Cardiology. The lab has numerous ongoing projects regarding the molecular regulation of the transition from healthy adaptation to disease progression in the heart with a goal to find new targets for human therapy. These projects will utilize discovery-based approaches to identify novel protein interactions and signaling pathways in the development and progression of heart failure in response to different disease etiologies (https://www.lerner.ccf.org/moleccard/bass/). The lab utilizes numerous techniques from cloning and in vitro cell work, to the generation of novel murine models and use of surgical models of heart disease.

The postdoctoral fellow duties will include, but are not limited to: organizing and implementing complex research plans, the development of new methods, testing and data collection, analysis and interpretation of data, writing detailed scientific reports, and mentoring graduate and undergraduate students. The candidate will be expected to possess superior communication and organizational skills and present their research findings on a regular basis to both peers within the institute and at national and international meetings. No teaching will be required of this position.

Competitive salary and benefits such as health insurance and paid vacation are provided.

Requirements

The qualified candidate must possess a Ph.D. and/or M.D. with relevant research experience in biological sciences or biotechnology. Prior experience in one or more of the following areas is preferred: cardiovascular biology, receptor pharmacology, protein biochemistry, protein-protein interaction, mouse models of disease, metabolic signaling, cardiac and vascular physiology. Applicants are expected to have excellent oral and written communication skills in English, and must be a self-motivated, team-oriented individual.

To apply for this position please email a cover letter, curriculum vitae, and 2-3 letters of reference to:

Dr. Schumacher-Bass, basss4@ccf.org

...

Sarah M. Schumacher-Bass, PhD, Department of Molecular Cardiology, Lerner Research Institute, NB50, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195

Office: (216) 444-9367 / Fax: (216) 445-8204 / basss4@ccf.org

 
02/26/2018 Kathleen Babb
babbk@ccf.org

The Lal Research Group, in the Genomic Medicine Institute (GMI) of the Cleveland Clinic Lerner Research Institute, seeks a postdoctoral researcher interested in data driven approaches to improve our understanding of brain disorders. Key words like Genomics, Precision Medicine, MRI, EEG, Computational biology, Machine learning, Clinical oriented data science, Translational genetics, Working in the Cloud, Web development or software engineering sound interesting to you? Join us.

The Lal Research group at Cleveland Clinic studies large-scale genetic and clinical biomarkers from thousands of patients to improve our understanding of brain disorders and aims to subsequently translate the gained knowledge into clinical care. We seek new team members to lead projects in genetics, electronic health records, neurophysiology and brain imaging data science as well as software engineers and web developers for the development of computational infrastructure. The accepted applicants will work in the Genomic Medicine Institute and the Epilepsy Center of the Cleveland Clinic in close collaboration with other data scientists, neuroscientists and clinical researchers from related fields, to ultimately develop personalized medicine approaches. Besides local collaborations, the team will interact on a daily to weekly basis with collaboration partners and other members of the Lal Research Groups located at the Broad Institute of MIT and Harvard, Boston, US, and the Cologne Center for Genomics in Germany.

 For requirements and more details see here: https://sites.google.com/view/lalresearchgroup/jobs

02/22/2018 Zong-Ming Li, PhD
liz4@ccf.org

A postdoctoral fellow position is available in the Hand Research Laboratory, Department of Biomedical Engineering of the Lerner Research Institute at Cleveland Clinic. The projects will involve investigating the biomechanics of the hand/wrist. Applicants must have 1) a doctoral degree demonstrating creative and independent research; 2) background in biomechanics, biomedical engineering, kinesiology, orthopaedics, rehabilitation, or closely related field; and 3) excellent written and oral communication skills in English. It is expected that applicants are highly self-motivated, possess a good balance of technical expertise and analytical thinking, and can work well both independently and collaboratively on interdisciplinary projects. For more information about the Hand Research Laboratory, please visit www.handlab.org or www.lerner.ccf.org/bme/li/. Applications for this position should include a cover letter, CV, and contact information for three references. Please email your application to liz4@ccf.org.

02/21/2018 Florian Rieder, MD
riederf@ccf.org

We have an opening for a Postdoctoral Fellow position in the Dr. Florian Rieder Laboratory in the Department of Pathobiology at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interest in studying intestinal inflammation and fibrosis and cell to extracellular matrix interactions are encouraged to apply.

A highly motivated candidate will join a productive research team to participate in NIH and industry funded projects focusing on the roles of the extracellular matrix and cell to matrix interactions during tissue inflammation and fibrosis of the intestine. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise.

The candidate should furthermore be familiar with primary human cell culture, Western blotting, and RNA based methods including quantitative PCR and reporter assays, immunohistochemistry and mouse models of gut inflammation. Excellent communication skills in English are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Dr. Florian Rieder; Department of Pathobiology; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445 7156; E-mail: riederf@ccf.org.

02/16/2018 Takuya Sakaguchi, Ph.D.
sakagut2@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute.

A Postdoctoral Fellow position is available to study liver organogenesis, physiology and pathology in the Department of Stem Cell Biology and Regenerative Medicine at the Cleveland Clinic Lerner Research Institute.  We use zebrafish as a model and focus on human digestive disease modeling.  Research projects involve genetic, biochemical and bioinformatic approaches utilizing the zebrafish model and human biospecimens (http://www.lerner.ccf.org/stemcellbio/sakaguchi/).

We are seeking highly motivated recent graduates with a PhD and/or MD with relevant research experience.  Applicants should have research experience in cell biology, molecular biology, developmental biology or a closely related field.  The ideal candidate will have experience in developmental genetics.  Proficiency in spoken and written English is required.

The Lerner Research Institute provides an excellent environment for biomedical science.  Our postdoctoral training program (http://www.lerner.ccf.org/education/postdoc/) provides excellent support for career development in science.   

Please send your CV and contact information of three references to Takuya Sakaguchi (sakagut2@ccf.org).

02/15/2018 Philip Ahern
ahernp@ccf.org

The Ahern Group (http://www.lerner.ccf.org/cmm/ahern/), in the Department of Cellular and Molecular Medicine at the Cleveland Clinic Lerner Research Institute, seeks a postdoctoral researcher to study the interplay between the intestinal immune system and gut microbiota, and the contribution of these interactions to inflammatory bowel disease (IBD).

The gut microbiota has long been appreciated to be a major driver of the development and pathogenesis of IBD. Despite this, the specific members of the gut microbiota that are responsible have remained enigmatic, hampering our ability to target components of the microbiota for the treatment of IBD. We have developed a strategy to systematically identify effector microbes that reside within complex microbial communities that are capable of modulating phenotypes of interest. We will leverage this approach, allied to cutting-edge microbiological and immunological techniques in gnotobiotic mouse models of IBD, to identify and characterize the microbes that contribute to the development and pathogenesis of IBD, and the mechanisms underlying these interactions. This position is ideally suited to candidates who are interested in working at the interface of immunology and microbiology in the context of inflammatory disease.

The candidate will have completed, or be close to completing, a Ph.D. degree (or M.D. with at least 3 years research experience), and have experience in cellular immunology and rodent models of inflammation. Familiarity with microbiological techniques is desirable, but not essential.

The candidate will join a dynamic research department (http://www.lerner.ccf.org/), whose areas of interest encompass a breadth of topics related to the cellular and molecular pathways that mediate disease. The Department is also home to a number of groups whose work focuses on the contributions of the microbiota to host health and pathology, as well as numerous state-of-the-art core facilities that facilitate these studies. Our group, and the Department as a whole, seeks to provide a stimulating and collaborative research environment, committed to the training and development of its trainees and enabling their growth as independent researchers. A competitive benefits and salary package is available.

Interested candidates should submit a cover letter (2 pages maximum) outlining their research interests, as well as a CV and the contact information for 3 references to Dr. Philip Ahern at ahernp@ccf.org   

02/01/2018 Jasmine Thomas
thomasj15@ccf.org

Postdoctoral research fellowship openings are available (actual start dates are open) on an NIH-funded training program in kidney biology and disease research.  Successful applicants will have the opportunity to train with nationally recognized, NIH-funded faculty from the Departments of Medicine, Immunology, Pathology, Pediatrics, Physiology and Biophysics, Quantitative Health Sciences, Population Health and Epidemiology, whose research interests include renal cell biology, basic and clinical transplantation immunology, human and mouse genetics, developmental biology, polycystic kidney disease, and transport physiology.

Candidates must have a PhD or MD, or equivalent degree.  PhD applicants must be less than 3 years post award of their terminal degree.  M.D. candidates generally have completed internal medicine residency training and wish nephrology specialty training.  An additional year of clinical nephrology training is available for qualified M.D. trainees.  Applicants must be United States citizens or permanent residents.    

Please send a cover letter and CV with the names of 3 references to:

John Sedor, M.D.

Department of Nephrology and Hypertension

Glickman Institute, Cleveland Clinic

Professor of Molecular Medicine

Lerner College of Medicine, Case Western Reserve University

Email to: Jasmine Thomas at THOMASJ15@ccf.org

01/31/2018 Mohamed Abazeed, MD, PhD
abazeem@ccf.org

The Abazeed laboratory at Cleveland Clinic has an immediate opening for highly motivated individualswith expertise in genomic and machine learning informatics. Thisposition is supported by multi-sourced grants.

Fellow will lead the design and implementation of data analysis projects addressing fundamental biological questions about the causes and consequences of inter- and intra-tumoral genetic variation in cancer. These projects involve integrated analysis of high-volume genomic, epigenomic, and gene expression data (next-generation sequencing – WES/WGS, RNA-seq, Bisulfite-seq, etc.). Successful candidate will work independently and take a leading role in data analysis, interpretation, and visualization, and drafting of manuscripts for publication.

This position offer a competitive salary and stimulating work environment, with opportunities for advancement. The Cleveland Clinic offers highly competitive salaries, a robust benefits package and a collegial work environment.

Recent PhDs in computer science, bioinformatics, computational biology, and related fields will be considered. A strong background in statistics, and programming experience in a UNIX/Linux environment using programming languages such as Perl are required. Experience in high-throughput analysis of next-generation sequencing data and familiarity with widely-used genomic databases and software are advantageous.

Candidate must have excellent verbal and written communication skills and be capable of working within a team of biologists and programmers. No biological background is required, but the ideal candidate will have some familiarity with genetics and genomics. This opportunity could present an outstanding training experience for someone with a solid computer science background who wishes to break into bioinformatics.

To apply, submit your CV, statement of research interests, and names and contact information of three references to: Mohamed E. Abazeed, MD, PhD, Department of Translational Hematology Oncology Research, Cleveland Clinic Foundation, 9500 Euclid Avenue, M3-029, 44195; E-mail: abazeem@ccf.org.

Cleveland Clinic is an equal opportunity, equal access employer.

12/12/2017 Jan Claesen
claesej@ccf.org

We are looking for a Postdoctoral Fellow excited about advancing our mechanistic understanding of the Human Microbiome, to join the newly established Claesen group at the Cleveland Clinic Lerner Research Institute. http://www.lerner.ccf.org/cmm/claesen/

Our aim is to functionally characterize molecular mechanisms that control bacterial interspecies and microbe-host interactions in the human microbiome. Bacteria use small molecule chemicals to mediate these interactions and the genetic information required for their production is typically encoded in one physical location of the bacterial chromosome, in biosynthetic gene clusters (BGCs). Using in silico techniques, we identified several widespread families of BGCs that we are now characterizing experimentally, prioritizing on the BGCs predicted to be involved in modulation of community composition or interaction with the host immune system. Our research will contribute to a better mechanistic understanding of the microbes that live in our body, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

Your profile

Candidates will have (or are close to obtaining) a PhD degree in a relevant biological or chemical subject and a good publication record in peer-reviewed scientific journals. Hands-on experience with microbiological, molecular genetics and standard biochemical techniques is required. Prior experience in manipulation of anaerobic microbes, mouse infection models, analytical chemistry or bioinformatics are desirable (but not required).

About us

The areas of expertise in the Claesen group include microbiology, bacterial genetics and synthetic biology, small molecule biosynthesis and biochemistry. We provide a stimulating, multidisciplinary training environment that will assist you in your successful scientific development. You will receive a competitive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute (http://www.lerner.ccf.org/), as well as plenty of opportunities for clinical collaboration at the Cleveland Clinic.

How to apply

Interested applicants should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Jan Claesen (claesej@ccf.org) by Friday January 19, 2018. Thereafter, applications will be considered on a rolling basis.

12/11/2017 Feng Lin
linf2@ccf.org

A postdoctoral position is available in the laboratory of Dr. Feng Lin in the Department of Immunology at the Cleveland Clinic Lerner Research Institute.

The ideal candidate will have a strong basic research background as evidenced by recent publications, and a keen interest in inflammation research. Proficiency in common immunological and/or molecular biology techniques − ELISA,  flow cytometry, DNA and protein electrophoresis, western blotting, PCR, transfection and mouse models of human diseases is required. 

 The selected candidate will receive a competitive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute, with opportunities for career advancement and multiple avenues for collaboration with clinicians at the Cleveland Clinic. More information about Lin Lab’s research may be found at www.lerner.ccf.org/immuno/lin/. Additional information about postdoctoral training at the Lerner Research Institute is available at www.lerner.ccf.org/education/postdoc/.

 The candidate must have (or be close to finishing) a PhD or MD/PhD degree.

 Highly motivated and qualified individuals should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Feng Lin (linf2@ccf.org). 

12/05/2017 Neetu Gupta
guptan@ccf.org

A postdoctoral position is available in the laboratory of Dr. Neetu Gupta in the Department of Immunology at the Cleveland Clinic Lerner Research Institute.

The ideal candidate will have a strong background in lung biology as evidenced by recent publications, and a keen interest in investigating asthma pathology. Proficiency in common immunological and molecular biology techniques − ELISA, multi-color flow cytometry, DNA and protein electrophoresis, western blotting, PCR, transfection − and mouse models of asthma is required. Additional experience in fluorescence microscopy/histology is desirable (but not required). The successful candidate will join a dynamic team of basic and translational immunology researchers to investigate novel regulators of airway inflammation and hyperresponsiveness.

The selected candidate will receive an attractive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute, with opportunities for career advancement and multiple avenues for collaboration with clinicians at the Cleveland Clinic. More information about Gupta Lab’s research may be found at www.lerner.ccf.org/immuno/gupta/. Additional information about postdoctoral training at the Lerner Research Institute is available at www.lerner.ccf.org/education/postdoc/.

The candidate must have (or be close to finishing) a PhD or MD/PhD degree. Proficiency in spoken and written English is required.

Highly motivated and qualified individuals should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Neetu Gupta (guptan@ccf.org). 

12/04/2017 Neetu Gupta
guptan@ccf.org

A postdoctoral position is immediately available in the laboratory of Dr. Neetu Gupta in the Department of Immunology at the Cleveland Clinic Lerner Research Institute.

The ideal candidate will have a strong background in cellular immunology with deep interest in and understanding of B cell biology and signal transduction as evidenced by recent publications. Proficiency in common immunological and molecular biology techniques (including, but not limited to, ELISA, multi-color flow cytometry, DNA and protein electrophoresis, western blotting, PCR, transfection), and mouse models of disease is required. Additional experience with confocal and/or TIRF microscopy is highly desirable. The successful candidate will join a dynamic team of basic and translational immunology researchers to investigate molecular mechanisms regulating B lymphocyte effector functions in the context of inflammation and autoimmunity.

The selected candidate will receive an attractive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute, with opportunities for career advancement and multiple avenues for collaboration with clinicians at the Cleveland Clinic. More information about Gupta Lab’s research may be found at www.lerner.ccf.org/immuno/gupta/. Additional information about postdoctoral training at the Lerner Research Institute is available at www.lerner.ccf.org/education/postdoc/.

The candidate must have (or be close to finishing) a PhD or MD/PhD degree.  Proficiency in spoken and written English is required.

Highly motivated and qualified individuals should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Neetu Gupta (guptan@ccf.org). 

11/15/2017 Jianguo Cheng, MD, PhD
chengj@ccf.org

A Senior Postdoctoral Fellow/Research Associate position is available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work for Dr. Jianguo Cheng, Professor of Anesthesiology, Staff in the Department of Neurosciences, and Director of the Cleveland Clinic Multidisciplinary Pain Medicine Fellowship Program. Areas of interest include 1) investigating how a nerve injury causes persistent pain behavior and neuroinflammation in the CNS and PNS; 2) investigating how stem cells modulate neuroinflammation, reduce neuropathic pain, and prevent and/or reverse opioid tolerance; and 3) investigating the feasibility and optimizing the key parameters of applying stem cell therapy in patients with chronic pain. The successful candidate(s) will help lead a multidisciplinary approach that combines behavioral, electrophysiological, molecular, and immunohistochemistry techniques to address important research questions. A Ph.D. and/or M.D. in a relevant discipline and research experience in a pain, neuroinflammation, or stem cell-related field are required.

Interested applicants should submit a curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Jianguo Cheng, Department of Neurosciences, via email at: chengj@ccf.org.

11/01/2017 Anand Ramamurthi, PhD
ramamua@ccf.org

Postdoctoral Fellow in Aortic Aneurysm Research

Ramamurthi Lab at the Cleveland Clinic Lerner Research Institute, Cleveland, OH

Job Description

Dynamic and highly motivated candidates are sought to fill a postdoctoral research associate position in the Cardiovascular Matrix Engineering Laboratory directed by Dr. Anand Ramamurthi in the Department of Biomedical Engineering at the Cleveland Clinic (https://www.lerner.ccf.org/bme/ramamurthi/). The Ramamurthi lab investigates extracellular matrix (ECM) regenerative therapies for abdominal aortic aneurysms (AAAs). The candidate will investigate new therapeutic targets for multimodal downstream effects on vascular smooth muscle cell biology, proteolytic cascades, and regeneration and repair of the ECM, specifically the elastic matrix. The research project will involve vascular cell and ECM biology and cell-matrix interactions, proteases, small animal models for AAAs, and drug delivery. This position is funded by an award from the National Institutes of Health.

Candidate Experience

Candidates must have an MD, MD/PhD, or PhD in Biomedical Engineering, Cell or Molecular Biology, Pharmacology, or other related disciplines. Significant experience in molecular biology, and small animal cardiovascular disease models/treatment and rodent microsurgery is required. Familiarity with human tissue handling and processing, sterile cell culture, histology, confocal and electron microscopy and is a plus. The candidate is expected to be significantly independent, have strong communication skills, actively participate in exploring new research avenues and interdisciplinary collaborations, develop and write research grants, and participate in training and mentoring of junior lab personnel.

Application Process

Interested individuals should forward their electronic application dossier via email to Dr. Ramamurthi at ramamua@ccf.org. The dossier should include a cover letter summarizing research experience relevant to the position, curriculum vita, a one page statement of research interests and long-term career goals, and a list of 3 professional referees.  Review of applications will begin on November 15, 2017 and will continue until the position is filled.

About Us

The Cleveland Clinic (https://my.clevelandclinic.org/) is ranked the # 2 hospital in the United States by U.S. News & World Report and has held the top rank for treatment of cardiovascular disease for 22 years. The Lerner Research Institute (LRI; (https://www.lerner.ccf.org/) is home to all basic, translational and clinical research at Cleveland Clinic. With nearly 1,500 researchers and support personnel in 175 laboratories in 12 departments, the LRI is one of the largest research institutes in the nation, consistently ranking in the top 10 in National Institutes of Health funding, a benchmark of research success. The LRI maintains a strong academic program in collaboration with local universities, a medical school and has outstanding research core facilities. The Clinic is located in the famed University Circle area of Cleveland in close proximity to Case Western Reserve University and University Hospitals. Cleveland is an affordable, medium-sized city with a wealth of opportunities for cultural and outdoor activities.

11/01/2017 Anand Ramamurthi, PhD
ramamua@ccf.org

Postdoctoral Fellow in Aortic Aneurysm Research

Ramamurthi Lab at the Cleveland Clinic Lerner Research Institute, Cleveland, OH

Job Description

Dynamic and highly motivated candidates are sought to fill a postdoctoral research associate position in the Cardiovascular Matrix Engineering Laboratory directed by Dr. Anand Ramamurthi in the Department of Biomedical Engineering at the Cleveland Clinic (https://www.lerner.ccf.org/bme/ramamurthi/). The Ramamurthi lab investigates extracellular matrix (ECM) regenerative therapies for abdominal aortic aneurysms (AAAs). The candidate will investigate new therapeutic targets for multimodal downstream effects on vascular smooth muscle cell biology, proteolytic cascades, and regeneration and repair of the ECM, specifically the elastic matrix. The research project will involve vascular cell and ECM biology and cell-matrix interactions, proteases, small animal models for AAAs, and drug delivery. This position is funded by an award from the National Institutes of Health.

Candidate Experience

Candidates must have an MD, MD/PhD, or PhD in Biomedical Engineering, Cell or Molecular Biology, Pharmacology, or other related disciplines. Significant experience in molecular biology, and small animal cardiovascular disease models/treatment and rodent microsurgery is required. Familiarity with human tissue handling and processing, sterile cell culture, histology, confocal and electron microscopy and is a plus. The candidate is expected to be significantly independent, have strong communication skills, actively participate in exploring new research avenues and interdisciplinary collaborations, develop and write research grants, and participate in training and mentoring of junior lab personnel.

Application Process

Interested individuals should forward their electronic application dossier via email to Dr. Ramamurthi at ramamua@ccf.org. The dossier should include a cover letter summarizing research experience relevant to the position, curriculum vita, a one page statement of research interests and long-term career goals, and a list of 3 professional referees.  Review of applications will begin on November 15, 2017 and will continue until the position is filled.

About Us

The Cleveland Clinic (https://my.clevelandclinic.org/) is ranked the # 2 hospital in the United States by U.S. News & World Report and has held the top rank for treatment of cardiovascular disease for 22 years. The Lerner Research Institute (LRI; (https://www.lerner.ccf.org/) is home to all basic, translational and clinical research at Cleveland Clinic. With nearly 1,500 researchers and support personnel in 175 laboratories in 12 departments, the LRI is one of the largest research institutes in the nation, consistently ranking in the top 10 in National Institutes of Health funding, a benchmark of research success. The LRI maintains a strong academic program in collaboration with local universities, a medical school and has outstanding research core facilities. The Clinic is located in the famed University Circle area of Cleveland in close proximity to Case Western Reserve University and University Hospitals. Cleveland is an affordable, medium-sized city with a wealth of opportunities for cultural and outdoor activities.

11/01/2017 George Lawrence
lawreng@ccf.org

Postdoctoral Fellow Position-Available Immediately

Our research team focuses on understanding the mechanisms of thermo-modelling and thermo-modulation in the human brain, mainly related to the diagnosis and treatment of medically refractory epilepsy, and translating findings to clinical utility. We have built a research infrastructure that provides capabilities in experimentation, prototyping and computational modeling & simulation. Among other results, the research activities will generate safety data, prototype implementations and results, which will likely culminate in a pilot human trial. The lab is a collaborative translational effort between the Department of Biomedical Engineering and the Neurological Institute.

Requirements

We are seeking a motivated, independent postdoctoral fellow or research associate who will help lead investigations into the functional mechanisms of thermo-coagulation in the human brain. Specifically, we are seeking an individual with a solid background in biomedical engineering and/or neuroscience, in particular the use of computational modelling for development of treatment strategies and devices for neurological disorders. Applicants must have a Ph.D. or M.D., excellent verbal and written communication skills in English, a strong publication record, the ability to work and troubleshoot independently, and to design, implement and analyze research projects. The selected candidate will have opportunities for collaboration and career development with clinicians in the Neurological Institute and scientists at the Department of Biomedical Engineering at Lerner Research Institute.

10/26/2017 Anand Ramamurthi, PhD
ramamua@ccf.org

Postdoctoral Fellow in Nanomedicine

Ramamurthi Lab at the Cleveland Clinic Lerner Research Institute, Cleveland, OH

Job Description

We are seeking dynamic and highly motivated candidates to fill a postdoctoral research associate position in the laboratory of Dr. Anand Ramamurthi at the Department of Biomedical Engineering at the Cleveland Clinic (https://www.lerner.ccf.org/bme/ramamurthi/). The position is funded by a grant from the NHLBI/National Center for Accelerated Innovations-Cleveland Clinic (NCAI-CC). The Ramamurthi lab seeks to develop technologies for biomimetic regeneration and repair of structural extracellular matrix in tissues compromised by proteolytic disorders. The candidate will lead efforts to design, synthesize, and characterize novel bioresponsive nanoparticles for gene silencing- and drug-induced matrix repair primarily in vascular disease. The project will involve testing nanoparticle efficacy in in vitro cell culture models and in vivo small animal models of disease.

Candidate Experience

Candidates must have a PhD in Biomedical Engineering, Chemical Engineering, Material Science, Chemistry or a related discipline. Significant experience in polymer chemistry and synthesis, characterization of drug delivery nanoparticles, and their testing in biological systems (cell culture, in vivo) is required. Familiarity with sterile cell culture, molecular biology techniques, histology, confocal and electron microscopy, and rodent microsurgery is highly desired. The candidate is expected to be significantly independent, have strong communication skills, actively participate in exploring new research avenues and interdisciplinary collaborations, develop and write research grants, and participate in training and mentoring of junior lab personnel.

Application Process

Interested individuals should forward their electronic application dossier via email to Dr. Ramamurthi at ramamua@ccf.org. The dossier should include a cover letter summarizing research experience relevant to the position, curriculum vita, a one page statement of research interests and long-term career goals, and a list of 3 professional referees.  Review of applications will begin on November 15, 2017 and will continue until the position is filled.

About Us

The Cleveland Clinic (https://my.clevelandclinic.org/) is ranked the # 2 hospital in the United States by U.S. News & World Report and has held the top rank for treatment of cardiovascular disease for 22 years. The Lerner Research Institute (LRI; (https://www.lerner.ccf.org/) is home to all basic, translational and clinical research at Cleveland Clinic. With nearly 1,500 researchers and support personnel in 175 laboratories in 12 departments, the LRI is one of the largest research institutes in the nation, consistently ranking in the top 10 in National Institutes of Health funding, a benchmark of research success. The LRI maintains a strong academic program in collaboration with local universities, a medical school and has outstanding research core facilities. The Clinic is located in the famed University Circle area of Cleveland in close proximity to Case Western Reserve University and University Hospitals. Cleveland is an affordable, medium-sized city with a wealth of opportunities for cultural and outdoor activities.

10/25/2017 Kali Casale
casalek@ccf.org

Drug Discovery for Advanced Prostate Cancer

A postdoctoral fellowship position for drug discovery is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic in the Department of Cancer Biology. 

Our laboratory and translational research program is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy. 

A postdoctoral fellowship is available for drug discovery against a newly credentialed molecular target against prostate cancer.  The candidate will take a leading role in the development of a compound screening assay for the identification and validation of a lead inhibitor compound against the molecular target, defining the mechanism of compound interaction with the target and optimizing the properties and potency of the lead compound.

The ideal candidate has a Ph.D. degree in biochemistry, chemistry or molecular biology and has the appropriate expertise that can be applied to drug development.  Outstanding verbal and communication skills are required.

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084), that we have shown drives poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44; Hearn, et al. JAMA Oncol. 2017 Oct 12), yet serves as a tumor vulnerability to alternative steroid ablation inhibitors (Almassi, et al. JAMA Oncol. 2017 Oct 12). 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), and that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20).   

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates with an interest in the position should send their CV and contact information for 3 references to: 

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

casalek@ccf.org


Submission of resumes will be considered an expression of interest in the available opportunity. Applicants who best meet the education and experience requirements of the position will be contacted by the interviewing department and invited to formally apply for consideration. Cleveland Clinic is proud to be an equal opportunity employer and a smoke-free/drug-free environment.