Postdoctoral Positions

The Lerner Research Institute's Postdoctoral Fellowship includes a competitive salary and benefits package and an opportunity to work and advance in a state-of-the-art facility with more than 700,000 square feet of space.

The current postdoctoral opportunities are listed below.

Postdoctoral Fellow/Research Associate candidates will be expected to conduct research under the mentorship of a principal investigator in a predominantly independent manner. Fellows will be expected to pursue testing of hypotheses by developing experimental designs, managing and processing data and interpreting and preparing results for publication in peer-reviewed journals. Fellows will work closely with the principal investigator and will be expected to communicate effectively both in writing and in oral presentations. Qualified candidates will have successfully completed all requirements for the degree of doctorate in philosophy (Ph.D.) or doctor in medicine (M.D.) in relevant scientific programs.

Project Scientist candidates will have substantial experience at the postdoctoral or research associate level and have established a respectable record of publication. Project Scientists will work in collaboration with the principal investigator but work independently within the scientific framework of the principal investigator's laboratory. Project Scientists may seek grant funding from extramural sources in support of their research projects with the consent of the principal investigator and department chair. Project Scientist is a junior-level faculty position.

Please complete your application as directed and send to the investigator listed. We look forward to hearing from you!

# Date Contact Description
1 01/15/2019 Chaitali Ghosh, PhD
GHOSHC@ccf.org

Postdoctoral Fellow

Dr. Chaitali Ghosh is seeking a Postdoctoral Fellow to perform research related to the blood-brain barrier and epilepsy, specifically investigating vascular mechanisms and enzyme-regulated pathophysiological alterations to the neurovascular biology affecting drug bioavailability across the blood-brain barrier. Dr. Ghosh's lab is in the Department of Biomedical Engineering in Cleveland Clinic’s Lerner Research Institute.  Studies in this laboratory, including the current epilepsy project noted above funded by the National Institutes of Health.

Applicants should have a recent MD or PhD degree in neuroscience, biochemistry, pharmacology or a related field, with excellent verbal and written communication skills in English and a proven track record of first-author publications. Applicants should demonstrate skills in cellular and molecular biology and analytical chemistry techniques. Preference will be given to highly motivated candidates with previous experience with rodent models and surgery, human brain cells/tissue culture, and biomedical engineering. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.  For candidates outside the United States, there are English language fluency requirements. For more information about our laboratory, please visit our website: http://www.lerner.ccf.org/bme/ghosh/ 

Interested applicants should immediately send their CV, contact details for three references, and a cover letter outlining their research interests and career goals to Chaitali Ghosh, PhD, GHOSHC@ccf.org.


2 12/29/2018 Emina Huang
huange2@ccf.org

Post-doctoral Research Fellow

We are seeking a highly motivated postdoctoral fellow to join the Huang lab which focuses on cancer stem cell biology and molecular mechanisms of inflammation-association colorectal oncogenesis at the Cleveland Clinic. To this end, we utilize molecular biology, iPSCs, human colon organoids, and mouse modeling approaches. As Dr. Huang is an NIH funded surgeon-scientist, we aim to translate our research to the clinic. Applicants must have a PhD in cancer biology, cancer genetics or a related field. Prior experience with mouse modeling is preferred. A presentation will be required as an integral portion of the recruitment process. For candidates outside the United States, passing TOEFL will be required. For more information about our laboratory, please visit our website: http://www.lerner.ccf.org/cancerbio/huang/. Interested applicants should send their application with 3 references to huange2@ccf.org


3 12/11/2018 hobbsb@ccf.org
hobbsb@ccf.org

Postdoctoral Fellow-Cancer Biostatistics

Postdoctoral Fellow – Cancer Biostatistics

 

Advances in biology and immunology continue to refine our understanding of cancer pathogenesis, elucidating potential mechanisms of tumor-cell growth, survival, angiogenesis and the systematic suppression of cancer immunity progressing toward precision medicine. Implicit to the concept of precision medicine is heterogeneity of treatment benefit among patients and patient sub-populations. Yet, precision medicine presents challenges to traditional paradigms of clinical translational for which estimates of population-averaged effects are used as the basis for selecting dose-scheduling strategies as well as demonstrating comparative benefit with randomized study.

 

Aspects of the traditional clinical research paradigm may not ideally suit the development of non-cytotoxics that challenge its foundational assumptions pertaining to dose-response and inter-patient exchangeability. Tumor biology and/or host immunity may better delineate target treatment populations than histology. Several emerging molecularly targeted and immunotherapeutic agents have produced durable responses in first-in-human trials. The U.S. regulatory landscape has also changed, with a growing number of accelerated approvals on the basis of single-arm trials. Collectively, these phenomena have prompted innovations with drug development strategies devised to consolidate phases in the traditional paradigm and rapidly expand accrual with “seamless” trial designs.

 

This postdoctoral fellowship is devised to develop analytical and computational technology for optimal designs of trials and drug development strategies for non-cytotoxic oncology treatments that span multiple indications. With the mentorship of Dr. Brian Hobbs (Cleveland Clinic) the trainee will research techniques for effectively identifying sources of subpopulation heterogeneity from real-world databases as well as optimal designs of master protocols and seamless trials that enroll potentially non-exchangeable patients.

 

The fellow will interact regularly with researchers of Amgen’s Statistical Innovation Team. Additionally, it is expected that the fellow will publish their findings in peer-reviewed academic journals as well as disseminate the ideas to both clinical and data science academic communities at conferences.

 

Interested candidates should send a cover letter, CV and 2-3 reference letters to Dr Brian Hobbs at Hobbsb@ccf.org.

 

 

 

Brian P. Hobbs, PhD

Cancer Biostatistics Section Head; Associate Staff,

Taussig Cancer Institute and Lerner Research Institute,

Cleveland Clinic


4 12/07/2018 Zihua Gong
gongz@ccf.org

Postdoctoral Fellow

Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology to investigate the DNA repair pathways in cancer development and cancer treatment.

We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. 

Application Requirements: A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references.

Please send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org.

The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.


5 11/30/2018 John Pellecchia
pellecj@ccf.org

Postdoctoral Research Fellow In Cancer Immunology

Postdoctoral research fellow positions will be available in the laboratory of Dr. Li (Lily) Wang at the Cleveland Clinic Taussig Cancer Institute’s Department of Translational Hematology & Oncology Research (THOR), https://my.clevelandclinic.org/departments/cancer/depts/thor), located within the Lerner Research Institute (LRI), Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is relocating from the Medical College of Wisconsin, Milwaukee, WI to Cleveland Clinic, and will be engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI including the Department of Inflammation and Immunology (https://www.lerner.ccf.org/immuno/), and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang lab was the first group to demonstrate that a new immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer immunotherapy (1 – 5). Our studies show that VISTA regulates the effector functions of cytotoxic T cells, myeloid-derived suppressor cells (MDSC), and myeloid inflammatory DCs. Current projects are focusing on elucidating the molecular signaling mechanisms of VISTA and design innovative approaches to target this checkpoint protein for cancer therapy.

We therefore seek talented and committed candidates with a recent Ph.D. in Biochemistry, Cell Biology, Immunology, or other relevant branches of biological sciences to join our team and make significant contributions to the field of Cancer Immunotherapy. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to John Pellecchia MS, Department Administrator, at pellecj@ccf.org

References:

 

1.Wang L, RubinsteinR, Lines LJ, Wasiuk A, AhonenC, GuoYX, LuLF, Gondek D, WangY, Fava RA, Fiser A, Almo S and Noelle RJ. (2011) ­­­VISTA, a novel Ig-superfamily ligand that negatively regulates T cell responses, J Exp Med. 208(3):577-92. PMC3058578

2. Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L (2014) VISTA regulates the development of protective anti-tumor immunity. Cancer Research, 74:1933-1944. PMC4116689

3. Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ. (2014) Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. PNAS.  (41):14846-51 PMC4205642

4. Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller H, Guleria I, Barth RJ, Huang YH, Wang L (2015) Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. PNAS. 112(21):6682-7, PMC4450438

5. Xu W, Tạ MH, Malarkannan S, Wang L(2018) Review: The structure, expression, and function of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Cellular & Molecular Immunology. 2018 May 15(5):438-446PMC6068175


6 11/28/2018 Lynn Bekris
bekrisl@ccf.org

Postdoctoral Fellow

A postdoctoral fellow position is available in the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work in the Bekris lab which is supported by multiple grants and funding resources. Bekris lab research is focused on identifying and evaluating the functional impact of genetic and epigenetic factors in Alzheimer’s disease and other neurodegenerative disorders.

Recent PhDs with a degree in molecular biology or related field as well as a background in experimental genomics and epigenomics utilizing cellular models will be considered. Experience in high-throughput analysis of next-generation sequencing data and familiarity with widely-used genomic/epigenomic databases and related software is a plus.

The candidate must have excellent verbal and written communication skills as well as a publication record. In addition, the candidate must be capable of working within a team of molecular biologists, bioinformaticians, statisticians and clinicians.

Please email your CV, a brief statement of your research interests and three references to 

Dr. Lynn Bekris (bekrisl@ccf.org). 


7 11/26/2018 Ken Baker, Ph.D.
bakerk6@ccf.org

Postdoctoral Position In Neurophysiology

The Department of Neurosciences of the Cleveland Clinic’s Lerner Research Institute seeks to hire a postdoctoral fellow to support federally-funded projects exploring novel neuromodulation approaches for the treatment of stroke and Parkinson’s disease. The position forms part of our interdisciplinary program that brings together Neuroscientists, Biomedical Engineers, as well as physician-scientists from the Center for Neurological Restoration and the Department of Radiology within the number two-ranked hospital in the United States. The successful applicant will participate in work that combines behavioral assessments of therapeutic efficacy with both invasive (i.e., deep brain stimulation) and non-invasive neurostimulation techniques to carry-out a systems-based approach to understanding neurophysiological changes across the sensorimotor brain networks in both humans and preclinical models of disease.  Ph.D. (or equivalent) students with relevant education or experience in neurophysiology, biomedical engineering, or motor control are invited to apply, though preference will be given to candidates with experience in array-based multi-unit neuronal or local field potential signal processing techniques.

The neuroscience research community at Cleveland Clinic spans the research and clinical institutes and includes neuroscientists, biomedical engineers, physicists, mathematicians, geneticists, molecular biologists, and physician-scientists. Investigators within the neuroscience community are supported by one of the top and largest clinical neurological institutes in the country, comprised of more than 200 medical and surgical specialists dedicated to the treatment of neurological and psychiatric disorders. Neuroscience research is supported by state-of-the-art molecular biology labs, small and large animal neurophysiology labs, small-animal MRI, the largest single center repository of human intracranial electrophysiology data bank from patients with epilepsy (subdural grids and SEEG depth electrodes), and one of the most active and integrated neuromodulation centers in the country. Exceptional collaboration possibilities between laboratory and clinical scientists, and access to large populations of patients, provide a unique opportunity for translational investigations.

Please send your curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Kenneth Baker, Department of Neurosciences, via email at: bakerk6@ccf.org.


8 11/21/2018 Ranjan Dutta, Ph.D.
duttar@ccf.org

Postdoctoral Position In Neurosciences

A Postdoctoral Fellow position is available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute to work on an NIH-funded study to investigate the role of cell-specific proteome in altering the disease response in multiple sclerosis (MS). 
 
The successful candidate will join a multidisciplinary team to elucidate novel mechanisms that impact neuro-axonal injury and as well as remyelination during MS. Experience with large-scale data, including RNA and proteomic analyses, is required. A strong work ethic, proficiency in verbal and written English, and a PhD and/or MD are required. Experience with handling human tissue and/or a background in multiple sclerosis research will be advantageous. 
 
Please send your curriculum vitae, a brief description of your research interests, and contact information for 3 references to Ranjan Dutta, Ph.D. (
duttar@ccf.org)


9 11/16/2018 Selva Baltan, MD, PhD
baltans@ccf.org

Postdoctoral Positions: Mechanisms Of White-Matter Injury

Postdoctoral Fellow positions are available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work for Selva Baltan, MD, PhD on a comprehensive NIH R01-funded research program. Areas of interest include: 1) Investigation of the epigenetic mechanisms of white-matter injury; 2) Physiology of aging in white matter; and 3) mechanisms of mitochondrial dysfunction in white-matter stroke as a function of aging. Interested applicants should submit a curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Selva Baltan via email at: baltans@ccf.org


10 11/07/2018 mccraek@ccf.org
mccraek@ccf.org

Postdoctoral Fellow

A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute Department of Cellular and Molecular Medicine. Several project are underway including defining the effects of plasma kininogen on tumor angiogenesis and cancer stem cells, the role of extracellular vesicles in vascular complications of cancer, the structural biology of beta2-glycoprotein 1 and its role as an autoantigen and mediator of endothelial cell activation in patients with the antiphospholipid antibody syndrome, and the responses of endothelial cells differentiated from iPSC to inflammatory stimuli.  

Experience in cell culture, animal models, immunoprecipitation, analysis of signaling pathways, receptor identification, gene knockdown approaches required. Experience with bioinformatics would be a plus. A strong work ethic and ability to function in a team environment is essential.

Please send your curriculum vitae and contact information for 3 references to Keith McCrae, M.D., mccraek@ccf.org


11 11/04/2018 Mohamed Abazeed
abazeem@ccf.org

Postdoctoral Research Fellow

We are seeking a Postdoctoral Research Fellow to join our research team in the Department of Translational Hematology and Oncology Research at the Cleveland Clinic Lerner Research Institute.  Our NIH funded research program is focused on studying mechanisms that underliethe susceptibility of tumors to radiotherapy, clinicalresearch on newtreatments andtranslationalresearchto combinethese approachestoimprove the outcomes of cancer patients 

Our multi-faceted research program includes experts in computational, murine and cellular biology. We are seeking to augment our depth by hiring a dynamic scientist who enjoys working in a trans-disciplinary team environment with multi-faceted mentorship and career development opportunities.

Recent Ph.D. graduates or postdoctoral fellows with a background in molecular, cell and murine biology are encouraged to apply. The candidate should have a publication record demonstrating hands-on experimental expertise and experience in several labs skills including but not limited to: primary human cell culture, PCR, Western blotting, CRISPR, high-content cellular profiling and several murine tasks (breeding, genotyping, xenografting, administration of drugs [I.P. or by gavage] and radiation, et cetera).

Proficiency in spoken and written English are also required.

To apply, submit your CV, statement of research interests, and names and contact information of three references to: Mohamed E. Abazeed, MD, PhD, Department of Translational Hematology Oncology Research, Cleveland Clinic Foundation, 2111 East 96th St/NE6, 44195; E-mail: abazeem@ccf.org.


12 11/04/2018 Mohamed Abazeed
abazeem@ccf.org

Postdoctoral Research Fellow

The Abazeed laboratory at the Cleveland Clinic Foundation has an immediate opening for a highly motivated individual with expertise in genomic and machine learning informatics. These positions are supported by multi-sourced grants.

Fellows will lead the design and implementation of data analysis projects addressing fundamental biological questions about the causes and consequences of inter- and intra-tumoral genetic variation in cancer. These projects involve integrated analysis of high-volume genomic, epigenomic, and gene expression data (next-generation sequencing – WES/WGS, RNA-seq, Bisulfite-seq, etc.). Successful candidates will work independently and take a leading role in data analysis, interpretation, and visualization, and drafting of manuscripts for publication.

Recent PhDs in computer science, bioinformatics, computational biology, and related fields will be considered. A strong background in statistics, and programming experience in a UNIX/Linux environment using programming languages such as Perl are required. Experience in high-throughput analysis of next-generation sequencing data and familiarity with widely-used genomic databases and software are advantageous.

The candidate must have excellent verbal and written communication skills and be capable of working within a team of biologists and programmers. A background in biology is not required, but the ideal candidate will have some familiarity with genetics and genomics. This opportunity could present an outstanding training experience for someone with a solid computer science background who wishes to break into bioinformatics.

To apply, submit your CV, statement of research interests, and names and contact information of three references to: Mohamed E. Abazeed, MD, PhD, Department of Translational Hematology Oncology Research, Cleveland Clinic Foundation, 2111 East 96th St/NE6, 44195; E-mail: abazeem@ccf.org.


13 11/01/2018 Kali Casale
casalek@ccf.org

Postdoctoral Fellowship

Molecular Mechanisms and Translational Investigation of Advanced Prostate Cancer

A postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation are available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic. 

Our laboratory is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy.  Specific areas include:

1)      Metabolic and genetic changes required for hormone therapy resistance in prostate cancer and tumor progression

2)      Clinical validation in patients and clinical trials utilizing innovative approaches

3)      Animal models of advanced prostate cancer for translational and therapeutic studies

4)      Identifying targets for the development of new pharmacologic therapies

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084) and that we have shown in a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44; Hearn, et al. JAMA Oncol. 2018 Apr 1;4(4):558-562).  We are current evaluating this biomarker in a clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries. 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20) and genetic determination of metabolite generation (Alyamani, et al. J Clin Invest. 2018 Aug 1;128(8):3333-3340).

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates should hold a doctoral degree with a background in molecular biology, chemistry, metabolism or cancer biology.  Candidates must have proficiency in verbal and written English.  Candidates with an interest in the position should send their CV and contact information for 3 references to: 

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

casalek@ccf.org


14 10/29/2018 Angela Ting
tinga@ccf.org

Computational Biology Postdoctoral Fellow

A Computational Biology Postdoctoral Fellow position is available in the laboratory of Dr. Angela Ting (http://www.lerner.ccf.org/gmi/ting/) at the Cleveland Clinic Lerner Research Institute. Our research focuses on understanding the functional impact of abnormal DNA methylation in cancer. We employ next generation sequencing (NGS) technologies, including Illumina short reads, PacBio, and Oxford Nanopore, to identify epigenetic changes throughout the genome and carry out mechanistic studies to define the functions of these changes and their impact on the transcriptome and cancer biology. We are particularly interested in developing and testing hypotheses for novel alterations outside of the gene promoter context as well as delineating the origin of aberrant DNA methylation in oncogenesis.

Candidates must have scientific and technical expertise in computational biology, bioinformatics, or systems biology. Preference will be given to those with experience in analysis of next generation sequencing data. Additional requirements include a Ph.D. degree in biological sciences or computer science, a strong publication record, proficiency in spoken and written English, and the ability to work/troubleshoot independently as well as understanding and incorporating findings in the scientific literature into his/her research. The postdoctoral fellow will be expected to take a lead role in data analysis, interpretation, visualization, and manuscript preparation.

Please send your curriculum vitae and contact information for 3 references to Angela Ting (tinga@ccf.org).


15 10/29/2018 Angela Ting
tinga@ccf.org

Postdoctoral Fellow

A Postdoctoral Fellow position is available in the laboratory of Dr. Angela Ting (http://www.lerner.ccf.org/gmi/ting/) at the Cleveland Clinic Lerner Research Institute. Our research focuses on understanding the functional impact of abnormal DNA methylation in cancer. We employ next generation sequencing (NGS) technologies to identify epigenetic changes throughout the genome and carry out mechanistic studies to define the functions of these changes and their impact on the transcriptome and cancer biology. We are particularly interested in developing and testing hypotheses for novel alterations outside of the gene promoter context.

Candidates must have scientific and technical expertise in molecular biology, RNA biology, biochemistry, transcription mechanisms, or gene delivery by transfection and lentivirus. Additional requirements include a Ph.D. degree in biological sciences, a strong publication record, proficiency in spoken and written English, and the ability to work/troubleshoot independently as well as understanding and incorporating findings in the scientific literature into his/her research. The postdoctoral fellow will be expected to take a lead role in data generation, analysis, interpretation, visualization, and manuscript preparation.

Please send your curriculum vitae and contact information for 3 references to Angela Ting (tinga@ccf.org).


16 09/20/2018 Suneel Apte
aptes@ccf.org

Post-doctoral Fellow

A post-doctoral fellowship is available in Suneel Apte’s laboratory at the Cleveland Clinic Lerner Research Institute, Department of Biomedical Engineering. The project area will be extracellular matrix in vascular development and disease. The positions will suit PhDs, MD/PhDs or MDs with an interest in proteases, extracellular matrix, smooth muscle cell biology, mouse genetics, human vascular disease and proteomics.

 Applicants should send their curriculum vitae, a statement of research/career goals and the contact information for three references with an intimate knowledge of their work to aptes@ccf.org.


17 09/12/2018 Vijay Krishna, PhD
krishnv2@ccf.org

Postdoctoral Fellow Position

A Postdoctoral Research Fellow position is available in the Department of Biomedical Engineering at the Lerner Research Institute, Cleveland Clinic to study the interaction of nanomaterials with the immune system in animal models. The successful candidate will join a multidisciplinary team of investigators with primary focus on cancer immunology.

Candidates should have a Ph.D. in immunology, molecular biology, biochemistry, or a related field. The successful candidate should have demonstrated expertise in animal models of cancer and in immunological techniques, including immune cell isolation, flow cytometry and immunohistochemistry. Special consideration will be given to applicants with a background in the study of nanomaterial interactions with the immune system.

Preferred qualifications include an in-depth understanding of cancer immunotherapy; design of nanoparticles; and light-tissue and light-material interactions.

Prospective candidates must be creative, self-motivated, capable of working independently, proficient in both spoken and written communication in English. Candidates will be expected to design and conduct experiments, statistically analyze data and write manuscripts and reports.

Interested candidates should submit a brief summary of research expertise, curriculum vitae and contact information for 3 references to Dr. Vijay Krishna (krishnv2@ccf.org).


18 09/07/2018 Zihua Gong
gongz@ccf.org

Postdoctoral Fellow

Postdoctoral Fellow positions are available in the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology to investigate the DNA repair pathways in cancer development and cancer treatment.

We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. 

Application Requirements: A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references.

Please send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org.

The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.


19 08/17/2018 Bruce Trapp
trappb@ccf.org

Postdoctoral Positions: Neurodegeneration And Altered Cognition In MS

Postdoctoral Positions: Cellular/Molecular Mechanisms of Neurodegeneration and Altered Cognition in Multiple Sclerosis

Postdoctoral Fellow positions are available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work for Professor and Department Chairman Bruce Trapp on a comprehensive NIH R35-funded research program. Areas of interest include: 1) Investigation of the molecular events responsible for primary neuronal degeneration in a new subtype of multiple sclerosis. 2) Molecular and physiological consequences of learning impairment caused by hippocampal demyelination. Candidates should have a Ph.D. and/or M.D. in a relevant discipline and a background in neuroscience. Interested applicants should submit a curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Bruce D. Trapp, Chairman, Department of Neurosciences, via email at: trappb@ccf.org.


20 08/16/2018 Yu-Shang Lee
leey2@ccf.org

Post-doc Position

A Postdoctoral Researcher position is available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute to investigate the potential therapeutic intervention to promote the nerve regeneration and/or the motor, sensory and autonomic functional recovery after spinal cord injury or traumatic brain injury. The mechanisms (neuroprotection, macrophage polarization and/or demyelination) underlying these effects are also the topics of our studies. These studies are supported by fund from NIH R01, DOD and Foundation. This position offers an excellent work environment with competitive salary and benefits.

 We are seeking a highly motivated, independent, creative, and interactive scientist to work with.  Applicants with a strong background in neuroanatomy, neurophysiology, and molecular biology are encouraged to apply. Extensive experience in western blotting, real-time rtPCR, animal surgery, animal behavior, histological techniques, confocal microscopy, and related field is desirable. Applications with limited experience but highly motivated with strong work ethic may also be considered. Good English communication skills and a Ph.D. and / or M.D. in a relevant discipline are required.  Interested applicants please submit a curriculum vitae, brief description of research interests and career goals, and contact information for three references to Dr. Yu-Shang Lee via email at: leey2@ccf.org


21 08/15/2018 Florian Rieder, M.D.
riederf@ccf.org

Postdoctoral Fellow

We have an opening for a Postdoctoral Fellow position in the Dr. Florian Rieder Laboratory in the Department of Inflammation & Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interest in studying intestinal inflammation and fibrosis and cell to extracellular matrix interactions are encouraged to apply.

A highly motivated candidate will join a productive research team to participate in NIH and industry funded projects focusing on the roles of the extracellular matrix and cell to matrix interactions during tissue inflammation and fibrosis of the intestine. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise.

The candidate should furthermore be familiar with primary human cell culture, Western blotting, and RNA based methods including quantitative PCR and reporter assays, immunohistochemistry and mouse models of gut inflammation. Excellent communication skills in English are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Dr. Florian Rieder; Department of Pathobiology; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445 7156; E-mail: riederf@ccf.org.


22 08/06/2018 Philip Ahern
ahernp@ccf.org

Postdoctoral Researcher

The Ahern Group (http://www.lerner.ccf.org/cmm/ahern/), in the Department of Cellular and Molecular Medicine at the Cleveland Clinic Lerner Research Institute, seeks a postdoctoral researcher to study the interplay between the intestinal immune system and gut microbiota in the development of inflammatory bowel disease (IBD).

The gut microbiota has long been appreciated to be a major driver of the development and pathogenesis of IBD. Despite this, the specific members of the gut microbiota that are responsible for disease initiation and progression, and the molecular details of immune-microbiota interactions that promote IBD, have remained enigmatic. We have developed a strategy to systematically identify effector microbes that reside within complex microbial communities that are capable of modulating phenotypes of interest. We will leverage this approach, allied to cutting-edge microbiological and immunological techniques in gnotobiotic mouse models of IBD, to identify and characterize the microbes that contribute to the development and pathogenesis of IBD, and the mechanisms underlying these interactions. This position is ideally suited to candidates who are interested in working at the interface of immunology and microbiology in the context of inflammatory disease.

The candidate will have completed, or be close to completing, a Ph.D. degree (or M.D. with at least 3 years research experience), and have experience in cellular immunology and rodent models of inflammation OR intestinal microbiology, including genetic modification of intestinal microbes.

The candidate will join a dynamic research department (http://www.lerner.ccf.org/), whose areas of interest encompass a breadth of topics related to the cellular and molecular pathways that mediate disease. The Department is also home to a number of groups whose work focuses on the contributions of the microbiota to host health and pathology, as well as numerous state-of-the-art core facilities that facilitate these studies. Our group, and the Department as a whole, seeks to provide a stimulating and collaborative research environment, committed to the training and development of its trainees and enabling their growth as independent researchers. A competitive benefits and salary package is available.

Interested candidates should submit a cover letter (2 pages maximum) outlining their research interests, as well as a CV and the contact information for 3 references to Dr. Philip Ahern at ahernp@ccf.org   


23 08/03/2018 Ela Plow
plowe2@ccf.org

Post-doctoral Fellow

A postdoctoral fellow position is available at Cleveland Clinic’s Lerner Research Institute in the Department of Biomedical Engineering in the field of clinical neuroscience and neuro-rehabilitation. This is an exciting opportunity to join a laboratory that identifies mechanisms of plasticity and capitalizes on restorative mechanisms using rehabilitation and brain stimulation techniques to promote neurologic recovery.  

The successful candidate will have the opportunity to participate in one or more ongoing clinical trials and neuroscientific studies involving brain stimulation, rehabilitation/training and structural and functional neuroimaging.  The position requires a highly creative, motivated and independent individual with a Ph.D. in kinesiology, rehabilitation science, exercise science/physiology, biomechanics and movement science, neuroscience, or biomedical engineering or a related field. Candidates must demonstrate this experience through a record of relevant publications. Strong laboratory and clinical research skills, ability to lead as well as work well in a team, an understanding of human neuro-motor control in health and disease, and basic knowledge of human neuro-imaging would be desirable. Past experience in medical research is not required, but candidates must be willing to perform experiments in clinical settings. The successful candidate will be expected to interface with clinical staff, clinical coordinators, graduate students and fellows as well as participate in independent laboratory research. It would be desirable if candidates can begin in fall 2018.

Please send your curriculum vitae and contact information for 3 references to Ela Plow PhD PT at plowe2@ccf.org


24 07/31/2018 Olga Cherepanova, Ph.D.
cherepol@ccf.org

Postdoctoral Research Fellow

A Postdoctoral Fellow position is available at Cleveland Clinic's Lerner Research Institute Department of Molecular Cardiology in the Cherepanova Lab to study the role of the pluripotency/iPS factor OCT4 and its downstream signaling in vascular smooth muscle cells and endothelial cells during atherosclerosis and after vascular injury. 

Our lab is interested in molecular and cellular mechanisms responsible for smooth muscle cells and endothelial cells phenotypic transitions. We use a combination of animal and cell culture models to better understand these transitions, with the goal to develop novel therapeutic interventions for stabilizing atherosclerotic plaques in order to reduce the risk of plaque rupture with possible myocardial infarction or stroke.

Although outstanding candidates in all areas of biomedical science will be considered, special consideration will be given to individuals with strong experience/expertise in: 1) working with transgenic and knockout animals; 2) studies of atherosclerosis and/or mouse vascular injury models; 3) studies of molecular mechanisms responsible for smooth muscle cell phonotypic transitions and/or endothelial cell dysfunction.   

Applicants must have (or have nearly completed) a PhD degree or MD degree with relevant laboratory experience, as well as proficient written and oral communication skills.  The successful applicant is expected to apply for external fellowships, present results at scientific conferences, and prepare manuscripts for publication.

Review of applicants will begin immediately and continue until the position is filled. The contract will be renewed annually and extended for a period of 4 years or possibly longer, dependent upon satisfactory progress and the lab’s funding situation.

Applicants should send their CV, a statement of research interests and long term scientific goals, and the names and contact information for 3 references as a single PDF file to Dr. Olga A. Cherepanova at cherepol@ccf.org.


25 07/25/2018 Brian Gastman, M.D.
gastmanb@ccf.org

Postdoctoral Fellow Or Research Associate

Postdoctoral Fellow or Research Associate– Tumor immunology and immunotherapeutics.

Immediate opening for a Postdoctoral Fellow position in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in immunology, molecular biology and biochemistry, and with expertise in cell, animal, or human models of cancer, and specifically cancer immunity are encouraged to apply. 

Must be familiar with immunologic assays (FACS, cytotoxicity, mouse tumor models, etc..), cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting,  expression of exogenous proteins, and the Casp9/Crispr system.    Experience with in vivo murine models is also important.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the role of suppressor cells in the tumor microenvironment.  The applicant will have significant exposure to human specimens from a multitude of research protocols and clinical trials.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Our laboratory is highly collaborative and works closely with industry.  The prospective applicant would be expected to not only be involved in high level research, but also to act as an ambassador between our lab and our industry partners.  Thus, proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE4-303; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-6950; gastmab@ccf.org


26 07/19/2018 Feixiong Cheng
chengf@ccf.org

Postdoctoral Research Fellow

Postdoctoral Fellow – Network Medicine and Pharmacogenomics

We are seeking 1-2 Postdoctoral Research Fellow to join my Network Medicine and Pharmacogenomics research group in the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute and Department of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University. Although often described as a disease of the genome, it is perhaps more appropriate to describe cancer as a “disease of the human macromolecular interactome”. My group hypothesize that cellular networks gradually rewire throughout cancer initiation, progression and maintenance, leading to progressive shifts of local and global network properties and systems states, all of which in turn underlie tumorigenesis and disease progression. It follows that most steps of cancer initiation, progression, maintenance and metastasis should be understood by considering network models in which every perturbed interaction, biophysical, biochemical or functional, is taken into account. The primary goal of my group is to combine tools from genetics and genomics, chemical biology, network medicine, bioinformatics, computational biology, and experimental pharmacology and systems biology assays (e.g., single cell sequencing and iPS-derived cardiomyocytes), to address the challenging questions toward understanding of complex diseases (including cancer, cardiovascular disease, and Cardio-Oncology), which could have a major impact in identifying novel real-world data-driven diagnostic biomarkers and therapeutic targets for precision medicine. A highly motivated candidate will join my NIH-funded research project focusing on analyzing, visualizing, and mining data from real world (e.g., electronic health records, and health care claims) and experiments that profile the molecular state of human cells and tissues by interactomics, transcriptomics, genomics, proteomics, and metabolomics for drug discovery and precision patient care. The postdoctoral fellow will have great opportunities to collaborate with diverse groups of physicians and computational biologists, and get access the large-scale patient data at the Genomic Medicine Institute, Miller Family Heart & Vascular Institute, Taussig Cancer Institute at Cleveland Clinic, and CASE Comprehensive Cancer Center at Case Western Reserve University.

Requirements: Highly motivated candidates with a PhD/MD/PharmD degree in computational biology, bioinformatics, mathematical biology, network science, data science, genome science, pharmacogenomics, or a related field are encouraged to apply. A strong computational background, proficiency in at least one programming language (e.g., R, Python, Perl, C++, Java) and knowledge of statistics and mathematics are required. Training experience in artificial intelligence (such as machine learning and deep learning), experience working in high computing cluster environment, experience working with TCGA, ICGC, GTEx, 1000 Genomes, ENCODE, or ExAC, PDB, or other large-scale DNA-seq or RNA-seq data analysis is highly preferred. A good understanding of biology, genetics and genomics, pharmacokinetics/pharmacodynamics (PK/PD), cell signaling networks, and human protein-protein interactome is also preferred. Proficiency in spoken and written English is required.

How to Apply: Interested applicants should send a cover letter describing your research experience/skills and future research interests/plans, a curriculum vitae and the contact information of two or three references to Dr. Feixiong Cheng (chengf@ccf.org) with the subject line ‘Postdoc-Application - Your Name’.

Application Deadline: Open Until Filled