Hisashi Tanaka M.D., Ph.D. Assistant Staff Department of Molecular Genetics Lerner Research Institute / NE20 9500 Euclid Avenue Cleveland, Ohio 44195 Tel.: (216) 444-9107 Fax: (216) 444-0512 E-mail: tanakah@ccf.org

Areas of general interest:

Genetic and genomic factors regulating the evolution of cancer genomes

Current programs:

• Molecular mechanisms initiating palindrome formation and gene amplification in mammalian cells
• Genomic-wide analysis of somatic DNA palindromes in cancer genomes
• Genome-wide alterations of CpG island methylation during differentiation and carcinogenesis

Investigators:

• Marotta, Michael, (Technologist)
• Zhao, Yongzhong, Ph.D. (Postdoctoral Fellow)

Collaborators:

• Andrei V. Gudkov, Ph.D., Roswell Park Cancer Institute
• Stephen J. Tapscott MD Ph.D., Fred Hutchinson Cancer Research Center