Tatiana Byzova, Ph.D. | Research | Publications | Lab

Somanath Rammohan Shenoy Ph.D.

Research Associate

Department of Molecular Cardiology
Lerner Research Institute / NB50
Cleveland Clinic
9500 Euclid Avenue
Cleveland, OH 44195
Telephone: (216) 445-8237
Fax: (216) 445-9603
E-mail: shenoys@ccf.org

Area of research interest:

  • Role of Akt kinases in vascular biology and angiogenesis

Professional education and training

  • 2007 - present: Research Associate: Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
  • 2003 - 2007: Postdoctoral fellow: Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
  • 2002 - 2003: Postdoctoral fellow: Department of Biological Sciences, Kent State University, Kent, OH - 44242.
  • 2001 - 2002: Lecturer: Department of Biochemistry, Kurukshetra University, Kurukshetra, Haryana -136119, India.
  • 2000 - 2001: Project Associate: Center for cellular and molecular biology (CCMB), Hyderabad - 500007, India.
  • 1996 - 2000: Research fellow (Ph.D.): Department of Animal Biochemistry, NDRI, Indian Council for Agricultural Research, Karnal -132001, India.
  • 1994 - 1996: M.S: Biochemistry. Annamalai University, Annamalai Nagar 608002, India.
  • 1991 - 1993: B.S: Mahatma Gandhi University, Kottayam, Kerala - 686560, India

Area of research Interest:

Role of Akt kinases in vascular biology and angiogenesis.

Awards and fellowship:

  1. Winner of the junior investigator award for best poster presentation on “Role of Akt1 on integrin activation and fibronectin assembly” at the Lerner Research Institute staff research retreat-2006.
  2. Winner of the Irvine Page award for the best publication for the year 2005-2006 at the Department of Molecular Cardiology, The Cleveland Clinic.
  3. Received Senior Research Fellowship from the Council of Scientific and Industrial research (CSIR), New Delhi (1999-2000).
  4. Received Research Fellowship from Indian Council of Agricultural Research (ICAR) (1996-1999).
  5. Won 2nd prize for the best outgoing student by The Society of Biological Chemists (India), Annamalai University Chapter (1996).

Membership in professional societies:

American Heart association and American Stroke Association

Publications:

  • Somanath, P.R., Kandel, E.S., Chen, W.S., Hay, N, Byzova, T.V. 2007. Akt1 regulates integrin activation and fibronectin matrix assembly (Under Review).
  • Mahabeleshwar, G.H., Somanath, P.R., Byzova, T.V. 2006. Methods for isolation of endothelial and smooth muscle cells and in vitro proliferation assays. In: Cardiovascular disease: Methods and protocols, Methods in Molecular Medicine. 129:197-208.
  • Somanath P.R., Razorenova, O.V., Chen, J., Byzova, T.V. 2006.  Akt1 in endothelial cell and angiogenesis. Cell Cycle. 5(5): 512-518.
  • Chen, J.*, Somanath, P.R*, Razorenova, O.V., Chen, WS, Hay, N, Bornstein, P., Byzova, T.V. 2005. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nature Med. Nov.11 (11): 1188-1196. (* Co-first authors).
  • Huang, Z., Somanath, P.R, Chakrabarti, R., Eddy, EM, Vijayaraghavan S. 2005. Changes in intracellular distribution and activity of protein phosphatase PP1g2 and its regulating proteins in spermatozoa lacking AKAP4. Biol. Reprod. 72(2): 384-392.
  • Somanath, P.R, Jack, S, Vijayaraghavan S. 2004. Changes in sperm glycogen synthase kinase-3 serine phosphorylation and activity accompany motility initiation and stimulation. J. Androl. 25(4): 605-617.
  • Somanath, P.R, and Gandhi, K.K. 2004. Isolation and partial characterization of the plasma and outer acrosomal membranes of goat spermatozoa. Small Rumin. Res. 53(1-2), 67-74.
  • Myers, K, Somanath, P.R, Berryman, M, Vijayaraghavan S. 2004. Identification of chloride intracellular channel proteins in spermatozoa. FEBS Lett. 566(1-3), 136–140.
  • Mishra, S, Somanath, P.R, Huang, Z, Vijayaraghavan S. 2003. Binding and inactivation of the germ cell specific protein phosphatase PP1g2 by Sds22 during epididymal sperm maturation. Biol. Reprod. 69(5), 1572–1579.
  • Somanath, P.R, and Gandhi, K.K. 2002. Expression of membrane associated non-genomic progesterone receptor(s) in caprine spermatozoa. Anim. Reprod. Sci. 74(3-4), 195-205.
  • Somanath, P.R, and Gandhi, K.K. 2002. Role of Ca2+ and Ca2+ channels in progesterone induced acrosome reaction in caprine spermatozoa. Asia-Aust. J. Anim. Sci. 15(7), 949-956.
  • Somanath, P.R, and Gandhi, K.K. 2001. Role of diacyl glycerol (DAG) in progesterone induced acrosome reaction in caprine spermatozoa. Asia-Aust. J. Anim.Sci. 15(8), 1092-1097.
  • Somanath, P.R, Suraj, K and Gandhi, K.K. 2000. Caprine sperm acrosome reaction: Promotion by progesterone and homologous zona pellucida. Small Rumin. Res. 37(3), 279-286.