Publications

• Feng, W, and M Madajka, BA Kerr, GH Mahabeleshwar, SW Whiteheart, TV Byzova. “A novel role for platelet secretion in angiogenesis: Mediating bone marrow-derived cell mobilization and homing.” Blood (2011): Epub. PMID: 21224474
• McCabe, NP, and BA Kerr, M Madajka, A Vasanji, TV Byzova. “Augmented osteolysis in SPARC deficient mice with bone residing prostate cancer.” Neoplasia 13(1) (Jan. 2011): 31-9. PMID: 21245938
• Somanath PR, and EA Podrez, J Chen, Y Ma, K Marchant, M Antoch, TV Byzova.  “Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype.”  Journal of Cellular Physiology 226(1) (Jan. 2011): 132-140. PMID: 20658528
• West, XZ, and NL Malinin, AA Merkulova, M Tischenko, BA Kerr, EC Borden, EA Podrez, RG Salomon, TV Byzova. “Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands.” Nature 467(7318) (Oct. 21, 2010): 972-976. PMID: 20927103. Reviewed in Nature Reviews Immunology 10(11) (Nov. 2010): 748-749. Reviewed in Science Signaling 3(145) (Oct. 26, 2010): ec328. Reviewed by Faculty of 1000.
• Bledzka K, and K Bialkowska, H Nie, J Qin, TV Byzova, C Wu, EF Plow, YQ Ma.  “Tyrosine phosphorylation of {beta}3 integrin regulates kindlin-2 binding and integrin activation.”  Journal of Biological Chemistry 285(40) (Oct. 1, 2010): 30370-30374. PMID: 20702409
• Bialkowska, K, and YQ Ma, K Bledzka, K Sossey-Alaoui, L Izem, X Zhang, NL Malinin, J Qin, TV Byzova, EF Plow. “The integrin co-activator kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell.” Journal of Biological Chemistry 285(24) (Jun. 11, 2010): 18640-18649. PMID: 20378539
• Malinin, NL, and EF Plow, TV Byzova. “Kindlins in FERM adhesion.” Blood 115(20) (May 20, 2010): 4011-4017.  PMID: 20228270
• Kerr, BA, and R Miocinovic, AK Smith, EA Klein, TV Byzova. "Comparison of tumor and microenvironment secretomes in plasma and in platelets during prostate cancer growth in a xenograft model." Neoplasia 12(5) (May 2010): 388-396. PMID: 20454510
• Kerr, BA, and TV Byzova. “αβ-Crystallin: chaperoning VEGF at the neovascularization affair.” Blood 115(16) (Apr. 22, 2010): 3181-3183. PMID: 20413662
• Ren, B, and Y Deng, A Mukhopadhyay, AA Lanahan, ZW Zhuang, KL Moodie, MJ Mulligan-Kehoe, TV Byzova, RT Peterson, M Simons. “ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.” Journal of Clinical Investigation 120(4) (Apr. 2010): 1217-1228. PMID: 20237411
• Plow, EF, and J Qin, TV Byzova. “Kindling the flame of integrin activation and function with kindlins.”  Current Option in Hematology 16(5) (Sept. 2009): 323-328.  PMID: 19553810
• Somanath, PR, and J Vijai, JV Kichina, TV Byzova, ES Kandel.  “The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt.”  Oncogene 28(25) (June 2009): 2365-2369. PMID: 19421139
• Somanath, PR, and NL Malinin, TV Byzova. ”Cooperation between integrin aVb3 and VEGFR2 in angiogenesis.” Angiogenesis 12(2) (2009): 177-185. PMID: 19267251
• Malinin, NL, and L Zhang, J Choi, A Ciocea, OV Razorenova, Y Ma, EA Podrez, M Tosi, DP Lennon, AI Caplan, SB Shurin, EF Plow, TV Byzova. “A point mutation in KINDLIN-3 ablates activation of three integrin subfamilies in humans.”  Nature Medicine 15(3) (Mar. 2009): 313-318. PMID: 19234460
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• Somanath, PR, and A Ciocea, TV Byzova. “Integrin and Growth Factor Receptor Alliance in Angiogenesis.” Cell Biochemistry and Biophysics 53(2) (Mar. 2009): 53-64. PMID: 19048411
• Somanath, PR, and TV Byzova. "14-3-3ß-Rac1-p21 activated kinase signaling regulates Akt1 mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly." Journal of Cellular Physiology 218(2) (Feb. 2009): 394-404. PMID: 18853424
• Feng, W, and NP McCabe, GH Mahabeleshwar, PR Somanath, DR Phillips, TV Byzova. "The Angiogenic Response is dictated by β3 Integrin on Bone Marrow-derived Cells." Journal of Cell Biology 183(6) (Dec. 15, 2008): 1145-1157. PMID: 19075116
• Malinin, NL, and TV Byzova. "CD40/TRAF6 switch in neointimal hyperplasia." Blood 111(9) (May 1, 2008): 4424.  Comment in Blood 111(9) (May 1, 2008): 4596-4604. PMID: 18441239
• Mahabaleshwar, GH, and TV Byzova. "Vascular integrin signaling." Methods of Enzymology 443 (2008): 199-226. PMID: 18772018
• Valiyaveettil, M, and N Kar, MZ Ashraf, TV Byzova, M Febbraio, EA Podrez. “Oxidized high-density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI.” Blood 111(4) (Feb. 15, 2008):1962-1971. PMID: 17993610
• Mahabeleshwar, GH, and J Chen, PR Somanath, OV Razorenova, TV Byzova. "Integrin affinity modulation in angiogenesis." Cell Cycle 7(3) (Feb. 1, 2008): 335-347. PMID: 18287811
• Somanath, PR, and J Chen, TV Byzova. "Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing." Angiogenesis 11(3) (2008): 277-288. PMID: 18415691
• McCabe, NP, and M Madajka, A Vasanij, TV Byzova. "Intraosseous injection of RM1 murine prostate cancer cells promotes rapid osteolysis and periosteal bone deposition." Clinical & Experimental Metastasis 25(5) (2008): 581-590. PMID: 18506587
• McCabe, NP, and M Madajka, A Vasanij, TV Byzova. "Intraosseous injection of RM1 murine prostate cancer cells promotes rapid osteolysis and periosteal bone deposition." Clinical & Experimental Metastasis 25(5) (2008): 581-590. PMID: 18506587
• Mahabaleshwar, GH, and TV Byzova. "Angiogenesis in melanoma." Seminars in Oncology 34(6) (Dec. 2007): 555-565. PMID: 18083379
• Mahabeleshwar, GH, and W Feng, K Reddy, EF Plow, TV Byzova. "Mechanisms of integrin-VEGF receptor cross-activation in angiogenesis." Circulation Research 101(6) (Sept. 14, 2007): 570-580. Comment in Circulation Research 101(6) (Sep. 14, 2007):  536-538. PMID: 17641225
• McCabe, NP, and S De, A Vasanji, J Brainard, TV Byzova. "Prostate cancer specific integrin αvβ3 modulates bone metastatic growth and tissue remodeling.” Oncogene 26(42) (Sep. 13, 2007): 6238-6243. PMID: 17369840
• Podrez, EA, and TV Byzova, M Febbraio, RG Salomon, Y Ma, M Valiyaveettil et al.  "Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype." Nature Medicine 13 (9) (Sep. 2007): 1086-1095.  Comment in Nature Medicine 13(9) (Sep. 2007): 1015-1016. PMID: 17721545
• Somanath, PR, and ES Kandel, WS Chen, N Hay, TV Byzova.  "Akt1 signaling regulates integrin activation, matrix recognition and fibronectin assembly." Journal of Biological Chemistry 282(31) (Aug. 3, 2007): 22964-22976. PMID: 17562714
• Mahabeleshwar, GH, and W Feng, DR Phillips, TV Byzova. "Integrin signaling is critical for pathological angiogenesis." Journal of Experimental Medicine 203(11) (Oct. 30, 2006): 2495-2507. PMID: 17030947
• Byzova, TV. “Matrix rules: Key role for microfibrillar protein in vascular development.” Blood 107(11) (Jun. 2006): 4202-4203.
• Mahabaleshwar, GH, and PR Somanath, TV Byzova. "Methods for isolation of endothelial and smooth muscle cells and in vitro proliferation assays." Methods in Molecular Medicine 129 (2006): 197-208. PMID: 17085813
• Chen, J, and PR Somanath, O Razorenova, P Bornstein, WS Chen, N Hay, TV Byzova. “Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.” Nature Medicine 11(11) (Nov. 2005): 1188-1196. PMID: 16227992
• Narizhneva, NV, and OV Razorenova, EA Podrez, J Chen, UM Chandraesekharan, PE DiCorleto, EF Plow, EJ Topol, TV Byzova. “Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium.” FASEB Journal 19(9) (Jul. 2005): 1158-1160. PMID: 15833768
• De, S, and OV Razorenova, NP McCabe, T O’Toole, J Qin, TV Byzova. “VEGF–Integrin Interplay Controls Tumor Growth and Vascularization.” Proc. Natl. Acad. Sci. 102(21) (May 24, 2005): 7589-7594. PMID: 15897451
• Dreicer, R, and Pl Elson, D Peereboom, TV Byzova, EF Plow, EA Klein. “Phase II trial of GM-CSF + Thalidomide in patients with androgen-independent metastatic prostate cancer.” Urologic Oncology 23(2) (Mar. - Apr. 2005): 82-86. PMID: 15869991
• Chen, J, and S De, D Damron, WS Chen, N Hay, TV Byzova. “Impaired platelet response to thrombin and collagen in AKT-1 deficient mice.” Blood 104(6) (Sep. 15, 2004):1703-1710. PMID: 15105289
• Stenina, OI, and TV Byzova, JC Adams, EJ Topol, EF Plow. “Cardiovascular Disease and the Thrombospondin Single Nucleotide Polymorphisms.” International Journal of Biochemistry and Cell Biology 36(6) (Jun. 2004): 1013-1030. PMID: 15094117
• Narizhneva, NV, and VJ Byers-Ward, MJ Quinn, FJ Zidar, EF Plow, EJ Topol, TV Byzova. “Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction.” Journal of Biological Chemistry 279(20) (May 14, 2004): 21651-21657. PMID: 15007078
• Chen, J, and S De, N Narijneva and TV Byzova. “Metastatic properties of prostate cancer cells are controlled by VEGF.” Cell Communication and Adhesion 11(1) (2004): 1-12 (cover page). PMID: 15500293
• De, S, and J Chen, NV Narijneva, J Brainard, W Heston, EH Sage, TV Byzova. “Molecular pathway for prostate cancer metastasis to bone.” Journal of Biological Chemistry 278(4) (Oct. 3, 2003): 39044-39050. PMID: 12885781
• Quinn, MJ, and TV Byzova, J Qin, EJ Topol, EF Plow. “Integrin {α}IIb{β}3 and Its Antagonism.“ Arteriosclerosis, Thrombosis, and Vascular Biology 23(6) (Jun. 1, 2003): 945-952. PMID: 12637342
• Mazurov, AV, and DV Pevzner, OA Antonova, TV Byzova, SG Khaspekova, AV Semenov, TN Vlasik, AN Samko, II Staroverov, MY Ruda. “Safety, inhibition of platelet aggregation and pharmacokinetics of F(ab')2 fragments of the anti-glycoprotein IIb-IIIa monoclonal antibody in high-risk coronary angioplasty.” Platelets 13(8) (Dec. 2002): 465-477. PMID: 12487780
• Byzova, TV, and CK Goldman, J Chen, G Cabrera, MG Achen, M Seminaow, SR Deitcher, PE DiCorleto. “Adenovirus encoding VEGF-D induces tissue-specific vascular patterns in vivo.” Blood 99(12) (Jun. 15, 2002): 4434-4442. PMID: 12036873
• Plow, EF, and TA Haas, TV Byzova.  “Platelet receptors: fibrinogen.” Platelets in Thrombotic and Non-Thrombotic Disorders. Cambridge, UK, Cambridge University Press, 2002. Ch. 13, 188-195.
• Plow, EF, and CS Cierniewski, Z Xiao, TA Haas, TV Byzova. “α-IIb-β-3 and Its Antagonism at the New Millennium.” Thrombosis and Haemostasis 86(1) (Jul. 2001): 34-40. PMID: 11487023
• Mazurov, AV, and DV Pevzner, SG Khaspekova, OA Dudnik, TV Byzova, TN Vlasik, VN Bakharev, M Pistsov, II Staroverov, MI Ruda. “Inhibition of thrombocyte aggregation by F(ab')2-fragments of monoclonal antibodies FraMon (CRC64) to glycoproteins IIb-IIIa.” Ter Arkh 73(9) (2001): 66-73. Russian. PMID: 11642086
• Byzova, TV, and CK Goldman, N Pampori, KA Thomas, A Bett, SJ Shattil, EF Plow. “A Mechanism for Modulation of Cellular Responses to VEGF: Activation of the Integrins.” Molecular Cell 6(4) (Oct. 2000): 1-10. PMID: 11090623
• Byzova, TV, and EF Plow. “The PlA2 Allele and Cardiovascular Disease: The Pro33 and Con.” Journal of Clinical Investigation 105(6) (Mar. 2000): 697-698. PMID: 10727434
• Byzova, TV, and W Kim, RJ Midura, EF Plow. “Activation of integrin αvβ3 regulates cell adhesion and migration to bone sialoprotein.” Experimental Cell Research 254(2) (Feb. 1, 2000): 299-308. PMID: 10640428
• Plow, EF, and TV Byzova. “The biology of glycoprotein IIb-IIIa.” Journal of Coronary Artery Disease 10(8) (Dec. 1999): 547-553. PMID: 10599532
• Topol, EJ, and TV Byzova, EF Plow. “Of platelets, integrin α-IIb-β-3 and GPIIb-IIIa blockers: past, present and future perspectives.” Lancet 353(9148) (Jan. 16, 1999): 227-231. PMID: 9923894
• Cierniewski, CS, and TV Byzova, M Papierak, T Haas, J Niewiarovska, L Zhang, M Cieslak, EF Plow. “Peptide ligands can bind to distinct sites in integrin α-IIb-β-3 and elicit different functional responses.”  Journal of Biological Chemistry 274(24) (Jun. 11, 1999): 16923-16932. PMID: 10358039
• Plow, EF, and TV Byzova. “Prothrombin as a ligand for aIIbb3 and aVb3 defines new paradigms in the recognition specificity of b3 integrins.” New Frontier in Vascular Biology: Thrombosis and Hemostasis (1999): 65-75.
• Byzova, TV, and EF Plow. “Activation of αvβ3 on vascular cells controls recognition of prothrombin.”  Journal of Cell Biology 143(7) (Dec. 28, 1998): 2081-2092. PMID: 9864377
• Byzova, TV, and R Rabbani, SD Souza, EF Plow. “Role of integrin αvβ3 in vascular biology.” Thrombosis and Haemostasis 80(5) (Nov. 1998): 726-734. PMID: 9843163
• Byzova, TV, and EF Plow. “Networking in the hemostatic system: integrin Alpha-IIb-beta-3 binds prothrombin and influence its activation.” Journal of Biological Chemistry 272(43) (Oct. 24, 1997): 27183-27188. PMID: 9341161
• Mazurov, AV, and SG Khaspekova, TV Byzova, OY Tikhomirov, MC Berndt, B Steiner, WC Kouns. “Stimulation of platelet glycoprotein IIb-IIIa (α IIb β 3-integrin) functional activity by a monoclonal antibody to the N-terminal region of glycoprotein IIIa.” FEBS Letters 391(1-2) (Aug. 5, 1996): 84-88. PMID: 8706936
• Khaspekova, SG, and TV Byzova, OY Tikhomirov, MC Berndt, WC Kouns and AV Mazurov.  “Conformational changes in platelet glycoprotein IIb-IIIa (α IIb β 3-integrin) stimulated by a monoclonal antibody to the N-terminal region of glycoprotein IIIa.” Biochemistry (Moscow) 61(3) (Mar. 1996): 305-317. Russian. PMID: 8724599
• Bochkov, VN, and EV Sorokin, TV Byzova, AV Mazurov, P Little, A Bobik, VA Tkachuk. “Do glycoproteins IIb/IIIa participate in activation of human platelets by low density lipoproteins?” Biochemistry (Moscow) 60(8) (Aug. 1995): 1187-1194. Russian. PMID: 7578573
• Byzova, TV, and YA Romanov, TN Vlasik, AV Mazurov. “Interaction of monoclonal antibody against P-selectin with activated platelets and endothelial cells. Heterogeneity of P-selectin expression in endothelial cells from human aorta.”  Biochemistry (Moscow) 60(8) (Aug. 1995): 218-235. Russian. PMID: 7578581
• Romanov, YA, and IV Balyasnikova, VB Bystrevskaya, TV Byzova, OP Ilyinskaya, AV Krushinsky, RV Latsis, EL Soboleva, EM Tararak, VN Smirnov. “Endothelial heterogeneity and intimal blood born cells: relation to human atherosclerosis.” Ann. New York Academy of Science 748 (Jan. 1995): 12-37. No abstract available. PMID: 7535024
• Byzova, TV, and TN Vlasik, AV Mazurov. “Inhibition of platelet aggregation by monoclonal antibody against glycoprotein IIb-IIIa complex.” Bull. Exp. Biol. Med. 118(10) (Oct. 1994): 402-405. Russian. No abstract available. PMID: 7865820
• Khaspekova, SG, and TN Vlasik, TV Byzova, DV Vinogradov, MC Berndt, AV Mazurov. “Detection of an epitope specific for the dissociated form of glycoprotein IIIa of platelet membrane glycoprotein IIb-IIIa complex and its expression on the surface of adherent platelets.” British Journal of Haematology 85(2) (Oct. 1993): 332-340. PMID: 7506568