Department of Molecular Cardiology
Christine S. Moravec, Ph.D.
Director, Research Education and Training Center, LRI
Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Phone: (216) 445-9949
Fax: (216) 445-9951
Research in my laboratory focuses on human heart failure (HF), using 2 different approaches. First, we investigate the physiological and biochemical changes during HF, and ask if these changes can be reversed by current therapies. We collaborate with clinical colleagues to obtain patient information and perform laboratory studies on tissue samples from patients. Ongoing work focuses on the Sympathetic and Parasympathetic Nervous Systems and their roles in human HF, as well as differences between males and females in HF. Secondly, we investigate the role of psychophysiologic remodeling in HF, utilizing biofeedback-assisted stress management (BFSM) and testing the hypothesis that this type of intervention can also impact the cellular and molecular phenotype in HF patients. Our goal is to demonstrate biologic remodeling of the failing heart following BFSM. The newest project in our lab tests the effects of several different stress management techniques in patients with coronary artery disease, again using biologic and clinical endpoints. Collaborative research also tests the hypothesis that BFSM will improve clinical status and quality of life in patients with diabetes and multiple sclerosis. Funding from the CCF Product Development Fund is helping us to create a handheld biofeedback device for patient use at home.
- Barrows ... Moravec, et al. Robust gene expression with amplified RNA from biopsy-sized human heart tissue. J Mol Cell Cardiol 42:260-264, 2007.
- Huang ... Moravec, et al. Co-expression of skeletal and cardiac troponin T decreases mouse cardiac function. Am J Physiol 294:C213-222, 2008.
- Moravec. Biofeedback therapy in cardiovascular disease: rationale and research overview. Cleve Clin J Med 75:S35-S38, 2008.
- Pilbrow ... Moravec, et al. Genomic selection of reference genes for real-time PCR in human myocardium. BMC Medical Genomics 2008: 1:64: doi:10.1186/1755-8794-1-64.