Edward Plow, Ph.D.

Department Chair

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NB5-59
plowe@ccf.org
Phone: (216) 445-8200
Fax: (216) 445-8204



Integrins are a large and broadly distributed family of adhesion receptors. Each member is a noncovalent heterodimer composed of an alpha and a beta subunit. The key to the many functions of integrins is their capacity to rapidly modulate their affinity for ligands, to recognize multiple and structurally unrelated ligands, to engage these ligands in a divalention-dependent manner, and mediate intracellular signaling events. Development of a molecular understanding of these central properties of integrins is a major goal of the laboratory. Mutagenesis, expression, biophysical, immunochemical and functional analyses are employed in our studies. Integrins of particular interest are alphaMbeta2, which plays a pivotal role in leukocyte responses during inflammation, and alphaIIbbeta3, which mediates platelet aggregation. Plasminogen is the precursor of the proteolytic enzyme plasmin. In addition to its central role in fibrinolysis, plasmin(ogen) is also involved in cell migration, a function that depends on plasminogen receptors on the surfaces of cells. Ex vivo and in vivo analyses are being performed to determine the roles of plasminogen and its receptors in inflammatory responses.


Kasia  Bialkowska Ph.D.
Kasia Bialkowska Ph.D.
Project Staff

Location:NB5-48
Phone:(216) 445-5139
bialkok@ccf.org
Fax:(216) 444-9263
laboratory

Kamila  Bledzka Ph.D.
Kamila Bledzka Ph.D.
Research Associate

Location:NB5-37
Phone:(216) 445-3721
bledzkk@ccf.org
Fax:(216) 445-8204
laboratory

Qiuyun  Chen Ph.D.
Qiuyun Chen Ph.D.
Project Staff

Location:NE4-217
Phone:(216) 444-2122
chenq3@ccf.org
laboratory

Riku  Das Ph.D.
Riku Das Ph.D.
Project Staff

Location:NB5-48
Phone:(216) 445-8213
dasr@ccf.org
laboratory

Mitali  Das PhD
Mitali Das PhD
Research Associate

Location:ND5-18A
Phone:(216) 445-8211
dasm@ccf.org
laboratory

Swetha  Ganapathy
Swetha Ganapathy
Research Technologist

Location:NB5-40
Phone:(216) 445-8211
ganapas2@ccf.org
laboratory

Huiqin  Nie
Huiqin Nie
Research Technologist

Location:NB5-40
Phone:(216) 445-5139
nieh@ccf.org
Fax:(216) 445-2051
laboratory

Elzbieta  Pluskota Ph.D.
Elzbieta Pluskota Ph.D.
Project Staff

Location:NB5-40
Phone:(216) 445-8211
pluskote@ccf.org
Fax:(216) 444-9263
laboratory

Khalid  Sossey-Alaoui Ph.D.
Khalid Sossey-Alaoui Ph.D.
Project Staff

Location:ND5-32
Phone:(216) 444-7393
sosseyk@ccf.org
Fax:(216) 445-8204
laboratory

Dorota  Szpak
Dorota Szpak
Research Technologist

Location:NB5-40
Phone:(216) 445-8211
szpakd@ccf.org
laboratory

Rajani  Tendulkar BS, MHA
Rajani Tendulkar BS, MHA
Department Administrator I

Location:NB5-56
Phone:(216) 444-0251
tendulr2@ccf.org
Fax:(216) 445-8204
laboratory


HIGHLIGHTED PUBLICATIONS

  1. Das R, Ganapathy S, Settle M, Plow EF. Plasminogen promotes macrophage phagocytosis in mice. Blood. 2014 Jul 31;124(5):679-88. PMCID: PMC4118484
  2. Sossey-Alaoui K, Pluskota E, Davuluri G, Bialkowska K, Das M, Szpak D, Lindner DJ, Downs-Kelly E, Thompson CL, Plow EF. Kindlin-3 enhances breast cancer progression and metastasis by activating Twist-mediated angiogenesis. FASEB J. 2014 May;28(5):2260-71. PMCID: PMC3986835
  3. Pluskota E, Ma Y, Bledzka KM, Bialkowska K, Soloviev DA, Szpak D, Podrez EA, Fox PL, Hazen SL, Dowling JJ, Ma YQ, Plow EF. Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism. Blood. 2013 Oct 3;122(14):2491-9. PMCID: PMC3790514
  4. Bledzka K, Smyth SS, Plow EF. Integrin αIIbβ3: from discovery to efficacious therapeutic target. Circ Res. 2013 Apr 12;112(8):1189-200. PMCID: PMC3711133
  5. Das R, Ganapathy S, Mahabeleshwar GH, Drumm C, Febbraio M, Jain MK, Plow EF. Macrophage gene expression and foam cell formation are regulated by plasminogen. Circulation. 2013 Mar 19;127(11):1209-18, e1-16. PMCID: PMC3638243