Jun Qin, Ph.D.

Staff, Professor of Molecular Medicine

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NB2-88
qinj@ccf.org
Phone: (216) 444-5392
Fax: (216) 445-1466



Every living cell in our body is composed of hundreds of thousands of proteins. These proteins are highly coordinated in their functions and are fundamental to our life. The broad theme of our research is to understand the molecular basis of some key protein-protein interactions in cell signaling and their dysfunctions in human diseases. We are currently focusing on a class of cell surface receptors, integrins, and their associated proteins. Integrins are major components of cell-extracellular matrix (ECM) adhesion, cell morphology, and cell motility. Using structural biology techniques, including NMR spectroscopy and crystallography, we are building a molecular landscape of integrin-mediated protein interaction network. Our work has significantly advanced the field by providing atomic-level visualization of some important part of this network and mechanistic insight of integrin signaling. In collaboration with a group of cell biologists and clinical scientists, we were able to link our recent atomic findings in integrin network to the pathogenesis of several human disorders such as thrombosis and cardiac failure. We will continue to resolve the molecular puzzle of this network to gain fundamental understanding of the integrin-mediated cell adhesion events. Our studies may ultimately lead to better approaches for investigating and treating the relevant human diseases.


Koichi  Fukuda Ph.D.
Koichi Fukuda Ph.D.
Research Associate

Location:NB2-25
Phone:(216) 444-8464
fukudak@ccf.org
laboratory

Sujay Subbayya Nanaiah Ithychanda Ph.D.
Sujay Subbayya Nanaiah Ithychanda Ph.D.
Research Associate

Location:NB2-25
Phone:(216) 444-8464
ithychs@ccf.org
laboratory

Jianmin  Liu Ph.D.
Jianmin Liu Ph.D.
Postdoctoral Fellow

Location:NB2-25a
Phone:(216) 445-6909
liuj5@ccf.org
laboratory

Fan  Lu
Fan Lu
Graduate Student

Location:NB5-25
Phone:(216) 444-8464
luf@ccf.org
Fax:(216) 445-8204
laboratory

Julia  Vaynberg
Julia Vaynberg
Postdoctoral Fellow

Location:NB2-25
Phone:(216) 444-8464
vaynebj@ccf.org
Fax:(216) 444-9263
laboratory

Jun  Yang Ph.D.
Jun Yang Ph.D.
Research Associate

Location:NB2-25
Phone:(216) 444-8464
yangj2@ccf.org
laboratory

Xiaolun  Zhang
Xiaolun Zhang
Research Technologist

Location:NB5-25
Phone:(216) 444-8464
zhangx@ccf.org
Fax:(216) 444-9263
laboratory

Liang  Zhu
Liang Zhu
Graduate Student

Location:NB5-25
Phone:(216) 444-8464
zhul2@ccf.org
laboratory


Vinogradova, O., et al. A structural mechanism of integrin αIIbβ3 ‘inside-out’ activation as regulated by its cytoplasmic face. Cell, 110, 587-597, 2002.

Vaynberg, J. et al. Structure of an ultra weak protein-protein complex and its crucial role in regulation of cell morphology and motility. Molecular Cell, 17:513-523,2005.

Goksoy, E., et al. Structural basis for the autoinhibition of talin in regulating integrin activation. Molecular Cell,31:124-133, 2008. 

Fukuda, K. et al. The pseudo active site of ILK is essential for its binding to a-parvin and localization to focal adhesions. Molecular Cell, 36:819-830, 2009.

Yang, J., et al. Structure of an integrin αIIbβ3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc. Natl. Acad. Sci. 106:17729-34, 2009.

Song X., et al. A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion. Cell Research 22:1533-45, 2012.