Qing Kenneth Wang, Ph.D., M.B.A.

Staff and Professor

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Phone: (216) 445-0570
Fax: (216) 636-1231

Dr. Wang has made distinguished contributions to the field of genetics of cardiovascular and neurological diseases by identifying eight genes for single gene disorders and more than ten susceptibility genes for common complex diseases, and by identifying novel molecular mechanisms underlying channelopathies and other diseases. He was noted for reporting the discoveries of the first Brugada syndrome gene (SCN5A), the most common gene for long QT syndrome (LQTS) (KCNQ1), one of the first two genes reported for LQTS in the same issue of Cell (SCN5A), LQTS gene KCNE1, the first gene for autosomal recessive atrial fibrillation (NUP155), atrial fibrillation gene SCN3B, the first gene for vascular disease Klippel-Trenaunay syndrome (AGGF1), and the first gene for co-existent paroxysmal dyskinesia and generalized epilepsy (KCNMA1). Dr. Wang was the first to show that mutations in ion channels cause arrhythmias and sudden death, and also the first to link a nucleoporin defect to cardiovascular disease. He was also the first to show that autophagy is required for angiogenesis in mice in vivo. Dr. Wang’s early discoveries on cardiac arrhythmias genes have been translated into the first commercial genetic testing kit in the field of cardiovascular medicine (Familion Test), which realized the first successful case of personalized genomic medicine in cardiovascular medicine and saved many human lives. Dr. Wang’s more recent focus on translation research shows that angiogenic factor AGGF1 protein therapy can successfully restore abnormal cardiac function associated with CAD/MI, ischemia-reperfusion, and cardiac hypertrophy/heart failure. Dr. Wang has identified a protein MOG1 that promotes trafficking of cardiac sodium channels to cell membranes, and may serve as a therapy for sodium channelopathies with a trafficking defect.

In other words ...

Qing Wang is currently Staff at Department of Molecular Cardiology, Department of Cardiovascular Medicine, and Neurological Institute, and the Director of Center for Cardiovascular Genetics at the Cleveland Clinic. He is Professor of Molecular Medicine and Professor of Genetics at Case Western Reserve University.  He received B.S. from China in 1984, Ph.D. in Genetics and Developmental Biology from Cornell University in 1993, and M.B.A. from Cleveland State University in 2002.  His postdoctoral research training was with Dr. Mark Keating at the Howard Hughes Medical Institute, University of Utah Health Sciences Center.  Dr. Wang joined the faculty at Baylor College of Medicine as an Assistant Professor (tenure track) in 1996 and Cleveland Clinic as Assistant Staff in 1999.  Dr. Wang has published more than 190 scientific papers and book chapters, and edited two volumes of Methods in Molecular Medicine.  He is an elected Fellow of the American Association for the Advancement of Science.  His research mostly focuses on finding genes for cardiovascular diseases, in particular, cardiac arrhythmias, syncope, seizures, and sudden death.  He also uses a variety of technologies to identify novel molecular mechanisms and develop therapies for diseases.

Steve  Archacki
Steve Archacki
Postdoctoral Fellow
Phone:(216) 445-0571
Susmita  Chakrabarti  Ph.D.
Susmita Chakrabarti Ph.D.
Postdoctoral Fellow
Phone:(216) 445-0571
Qiuyun  Chen  Ph.D.
Qiuyun Chen Ph.D.
Project Staff
Phone:(216) 444-2122
Hyosuk  Cho
Hyosuk Cho
Graduate Student
Phone:(216) 444-2122
Yang  Guo
Yang Guo
Visting Scientist
Phone:(216) 445-0571
Yabo  Li
Yabo Li
Predoctoral Fellow
Phone:(216) 445-0571
Fan  Wang
Fan Wang
Research Associate
Phone:(216) 445-0571
Gang  Yu
Gang Yu
Predoctoral Fellow
Phone:(216) 445-0571


  1. Wang J, Fa J, Wang P, Jia X, Peng H, Chen J, Wang Y, Wang C, Chen Q, Tu X, Wang QK, Xu C. NINJ2- A novel regulator of endothelial inflammation and activation. Cell signaling. 2017; [Epub ahead of print]. PMID: 28431986
  2. Li J, Zhu X, Yu K, Jiang H, Zhang Y, Deng S, Cheng L, Liu X, Zhong J, Zhang X, He M, Chen W, Yuan J, Gao M, Bai Y, Han X, Liu B, Luo X, Mei W, He X, Sun S, Zhang L, Zeng H, Sun H, Liu C, Guo Y, Zhang B, Zhang Z, Huang J, Pan A, Yuan Y, Angileri F, Ming B, Zheng F, Zeng Q, Mao X, Peng Y, Mao Y, Ye P, Wang QK, Qi L, Hu FB, Liang L, Wu T. Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome. Circ Res. 2017; [Epub ahead of print]. PMID: 28348007
  3. Luo C, Wang F, Ren X, Ke T, Xu C, Tang B, Qin S, Yao Y, Chen Q, Wang QK. Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease. Biochim Biophys Acta. 2017; [Epub ahead of print]. PMID: 28341552
  4. Yin D, Naji DH, Xia Y, Li S, Bai Y, Jiang G, Zhao Y, Wang X, Huang Y, Chen S, Fa
    J, Tan C, Zhou M, Zhou Y, Wang L, Liu Y, Chen F, Liu J, Chen Q, Tu X, Xu C, Wang
    QK. Genomic Variant in IL-37 Confers A Significant Risk of Coronary Artery
    Disease. Scientific reports. 2017; 7:42175. PMCID: PMC5299598
  5. Zhou S, Wang H, Wang QK, Wang P, Wang F, Xu C. Loss of heterozygosity detected at
    three short tandem repeat locus commonly used for human DNA identification in a
    case of paternity testing. Legal medicine (Tokyo, Japan). 2017; 24:7-11. PMID: 28081793
  6. Zhang T, Yao Y, Wang J, Li Y, He P, Pasupuleti V, Hu Z, Jia X, Song Q, Tian XL,
    Hu C, Chen Q, Wang QK. Haploinsufficiency of Klippel-Trenaunay syndrome gene
    Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K
    and AKT and disrupts vascular integrity by activating VE-cadherin. Human
    molecular genetics. 2016; 25(23):5094-5110. PMID: 27522498
  7. Ye J, Yao Y, Song Q, Li S, Hu Z, Yu Y, Hu C, Da X, Li H, Chen Q, Wang QK.
    Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by
    targeting p21 expression. Scientific reports. 2016; 6:34034. PMCID: PMC5048429
  8. Luo C, Wang F, Qin S, Chen Q, Wang QK. Coronary artery disease susceptibility
    gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by
    global gene expression regulation. Physiological genomics. 2016; 48(8):554-64.
    PubMed [journal] PMID: 27235449, PMCID: PMC5005456
  9. Lu Q, Yao Y, Hu Z, Hu C, Song Q, Ye J, Xu C, Wang AZ, Chen Q, Wang QK. Angiogenic
    Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic
    Angiogenesis for Heart Disease. PLoS biology. 2016; 14(8):e1002529. PMCID: PMC4981375
  10. Ke T, Han M, Zhao M, Wang QK, Zhang H, Zhao Y, Ruan X, Li H, Xu C, Sun T.
    Alpha-actin-2 mutations in Chinese patients with a non-syndromatic thoracic
    aortic aneurysm. BMC medical genetics. 2016; 17(1):45. PMCID: PMC4950238
  11. Huang Y, Wang Z, Liu Y, Xiong H, Zhao Y, Wu L, Yuan C, Wang L, Hou Y, Yu G, Huang
    Z, Xu C, Chen Q, Wang QK. αB-Crystallin Interacts with Nav1.5 and Regulates
    Ubiquitination and Internalization of Cell Surface Nav1.5. The Journal of
    biological chemistry. 2016; 291(21):11030-41. PMCID: PMC4900253
  12. Fan Q, Nie S, Li S, Liao Y, Zhang H, Zha L, Wang F, Tang T, Xia N, Xu C, Wang P,
    Xie T, Xie J, Lu Q, Li Q, Qian J, Li B, Wu G, Wu Y, Yang Y, Wang QK, Tu X, Cheng
    X. Analysis of the genetic association between IL27 variants and coronary artery
    disease in a Chinese Han population. Scientific reports. 2016; 6:25782. PMCID: PMC4865940
  13. Zhang KK, Xiang M, Zhou L, Liu J, Curry N, Heine Suñer D, Garcia-Pavia P, Zhang
    X, Wang Q, Xie L. Gene network and familial analyses uncover a gene network
    involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial
    septation. Human molecular genetics. 2016; 25(6):1140-51. PMCID: PMC4764195
  14. Chen S, Wang X, Wang J, Zhao Y, Wang D, Tan C, Fa J, Zhang R, Wang F, Xu C, Huang
    Y, Li S, Yin D, Xiong X, Li X, Chen Q, Tu X, Yang Y, Xia Y, Xu C, Wang QK.
    Genomic variant in CAV1 increases susceptibility to coronary artery disease and
    myocardial infarction. Atherosclerosis. 2016; 246:148-56. NIHMSID: NIHMS752498 PMCID: PMC4764411
  15. Zhou J, Wang L, Zuo M, Wang X, Ahmed AS, Chen Q, Wang QK. Cardiac sodium channel
    regulator MOG1 regulates cardiac morphogenesis and rhythm. Scientific reports.
    2016; 6:21538. PMCID: PMC4763225
  16. Wang C, Wu M, Qian J, Li B, Tu X, Xu C, Li S, Chen S, Zhao Y, Huang Y, Shi L,
    Cheng X, Liao Y, Chen Q, Xia Y, Yao W, Wu G, Cheng M, Wang QK. Identification of
    rare variants in TNNI3 with atrial fibrillation in a Chinese GeneID population.
    Molecular genetics and genomics : MGG. 2016; 291(1):79-92. NIHMSID: NIHMS707859 PMCID: PMC4713376
  17. Zhao Y, Sun Q, Zeng Z, Li Q, Zhou S, Zhou M, Xue Y, Cheng X, Xia Y, Wang Q, Tu X.
    Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b
    transcript expression and increases sodium current in myocardial cells. BMC
    cardiovascular disorders. 2016; 16:1. PMCID:
  18. Zhao Y, Liu M, Wang X, Chen S, Zhou M, Li Q, Li S, Huang Y, Zhao L, Wang Q, Tu X.
    Elevated serum chloride is an independent risk factor for coronary heart disease:
    A retrospective study of more than 13,000 Han Chinese. International journal of
    cardiology. 2015; 198:61-2. PMID: 26151716
  19. Zhao Y, Huang Y, Li W, Wang Z, Zhan S, Zhou M, Yao Y, Zeng Z, Hou Y, Chen Q, Tu
    X, Wang QK, Huang Z. Post-transcriptional regulation of cardiac sodium channel
    gene SCN5A expression and function by miR-192-5p. Biochimica et biophysica acta.
    2015; 1852(10 Pt A):2024-34. NIHMSID: NIHMS758814 PMCID: PMC4757900
  20. Huang Y, Wang C, Yao Y, Zuo X, Chen S, Xu C, Zhang H, Lu Q, Chang L, Wang F, Wang
    P, Zhang R, Hu Z, Song Q, Yang X, Li C, Li S, Zhao Y, Yang Q, Yin D, Wang X, Si
    W, Li X, Xiong X, Wang D, Huang Y, Luo C, Li J, Wang J, Chen J, Wang L, Wang L,
    Han M, Ye J, Chen F, Liu J, Liu Y, Wu G, Yang B, Cheng X, Liao Y, Wu Y, Ke T,
    Chen Q, Tu X, Elston R, Rao S, Yang Y, Xia Y, Wang QK. Molecular Basis of
    Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS
    Gene-Gene Interaction Involved in Atrial Fibrillation. PLoS genetics. 2015;
    11(8):e1005393. PMCID: PMC4534423
  21. Liu H, Liu W, Lin Y, Liu T, Ma Z, Li M, Zhang HM, Kenneth Wang Q, Guo AY. Scoring
    the correlation of genes by their shared properties using OScal, an improved
    overlap quantification model. Scientific reports. 2015; 5:10583. PMCID: PMC4445036
  22. Chen S, Wang C, Wang X, Xu C, Wu M, Wang P, Tu X, Wang QK. Significant
    Association Between CAV1 Variant rs3807989 on 7p31 and Atrial Fibrillation in a
    Chinese Han Population. Journal of the American Heart Association. 2015; 4(5). PMCID: PMC4599427
  23. Xia N, Jiao J, Tang TT, Lv BJ, Lu YZ, Wang KJ, Zhu ZF, Mao XB, Nie SF, Wang Q, Tu
    X, Xiao H, Liao YH, Shi GP, Cheng X. Activated regulatory T-cells attenuate
    myocardial ischaemia/reperfusion injury through a CD39-dependent mechanism.
    Clinical science (London, England : 1979). 2015; 128(10):679-93. PMID: 25558978
  24. He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J,
    Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC,
    Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu
    Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M,
    Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y,
    Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang
    L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M,
    Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z,
    Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L.
    Meta-analysis of genome-wide association studies of adult height in East Asians
    identifies 17 novel loci. Human molecular genetics. 2015; 24(6):1791-800. PMCID: PMC4351379
  25. Zhang X, Bogunovic D, Payelle-Brogard B, Francois-Newton V, Speer SD, Yuan C,
    Volpi S, Li Z, Sanal O, Mansouri D, Tezcan I, Rice GI, Chen C, Mansouri N,
    Mahdaviani SA, Itan Y, Boisson B, Okada S, Zeng L, Wang X, Jiang H, Liu W, Han T,
    Liu D, Ma T, Wang B, Liu M, Liu JY, Wang QK, Yalnizoglu D, Radoshevich L, Uzé G,
    Gros P, Rozenberg F, Zhang SY, Jouanguy E, Bustamante J, García-Sastre A, Abel L,
    Lebon P, Notarangelo LD, Crow YJ, Boisson-Dupuis S, Casanova JL, Pellegrini S.
    Human intracellular ISG15 prevents interferon-α/β over-amplification and
    auto-inflammation. Nature. 2015; 517(7532):89-93. NIHMSID: NIHMS653880 PMCID: PMC4303590
  26. Wang P, Xu C, Wang C, Wu Y, Wang D, Chen S, Zhao Y, Wang X, Li S, Yang Q, Zeng Q,
    Tu X, Liao Y, Wang QK, Cheng X. Association of SNP Rs9943582 in APLNR with Left
    Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a
    Chinese Han GeneID Population. PloS one. 2015; 10(5):e0125926. PMCID: PMC4438007
  27. Chen FF, Xia YL, Xu CQ, Li SS, Zhao YY, Wang XJ, Chen SS, Gao LJ, Zhong Y, Tu X,
    Wang Q, Yang YZ. Common variant rs7597774 in ADD2 is associated with dilated
    cardiomyopathy in Chinese Han population. International journal of clinical and
    experimental medicine. 2015; 8(1):1188-96. PMCID: PMC4358567
  28. Xu C, Yang Q, Xiong H, Wang L, Cai J, Wang F, Li S, Chen J, Wang C, Wang D, Xiong
    X, Wang P, Zhao Y, Wang X, Huang Y, Chen S, Yin D, Li X, Liu Y, Liu J, Wang J, Li
    H, Ke T, Ren X, Wu Y, Wu G, Wan J, Zhang R, Wu T, Wang J, Xia Y, Yang Y, Cheng X,
    Liao Y, Chen Q, Zhou Y, He Q, Tu X, Wang QK. Candidate pathway-based genome-wide
    association studies identify novel associations of genomic variants in the
    complement system associated with coronary artery disease. Circulation.
    Cardiovascular genetics. 2014; 7(6):887-94. NIHMSID: NIHMS633495 PMCID: PMC4270888
  29. Zhou SF, Yuan J, Liao MY, Xia N, Tang TT, Li JJ, Jiao J, Dong WY, Nie SF, Zhu ZF,
    Zhang WC, Lv BJ, Xiao H, Wang Q, Tu X, Liao YH, Shi GP, Cheng X. IL-17A promotes
    ventricular remodeling after myocardial infarction. Journal of molecular medicine
    (Berlin, Germany). 2014; 92(10):1105-16. PMID: 24965614
  30. Shen GQ, Girelli D, Li L, Rao S, Archacki S, Olivieri O, Martinelli N, Park JE,
    Chen Q, Topol EJ, Wang QK. A novel molecular diagnostic marker for familial and
    early-onset coronary artery disease and myocardial infarction in the LRP8 gene.
    Circulation. Cardiovascular genetics. 2014; 7(4):514-20. NIHMSID: NIHMS600241 PMCID: PMC4140990
  31. Xu Y, Zhou M, Wang J, Zhao Y, Li S, Zhou B, Su Z, Xu C, Xia Y, Qian H, Tu X, Xiao
    W, Chen X, Chen Q, Wang QK. Role of microRNA-27a in down-regulation of angiogenic
    factor AGGF1 under hypoxia associated with high-grade bladder urothelial
    carcinoma. Biochimica et biophysica acta. 2014; 1842(5):712-25. PMID: 24462738
  32. Xiong X, Xu C, Zhang Y, Li X, Wang B, Wang F, Yang Q, Wang D, Wang X, Li S, Chen
    S, Zhao Y, Yin D, Huang Y, Zhu X, Wang L, Wang L, Chang L, Xu C, Li H, Ke T, Ren
    X, Wu Y, Zhang R, Wu T, Xia Y, Yang Y, Ma X, Tu X, Wang QK. BRG1 variant
    rs1122608 on chromosome 19p13.2 confers protection against stroke and regulates
    expression of pre-mRNA-splicing factor SFRS3. Human genetics. 2014;
    133(5):499-508. NIHMSID: NIHMS560974 PMCID:
  33. Su Z, Si W, Li L, Zhou B, Li X, Xu Y, Xu C, Jia H, Wang QK. MiR-144 regulates
    hematopoiesis and vascular development by targeting meis1 during zebrafish
    development. The international journal of biochemistry & cell biology. 2014;
    49:53-63. PMID: 24448023
  34. Bai Y, Nie S, Jiang G, Zhou Y, Zhou M, Zhao Y, Li S, Wang F, Lv Q, Huang Y, Yang
    Q, Li Q, Li Y, Xia Y, Liu Y, Liu J, Qian J, Li B, Wu G, Wu Y, Wang B, Cheng X,
    Yang Y, Ke T, Li H, Ren X, Ma X, Liao Y, Xu C, Tu X, Wang QK. Regulation of CARD8
    expression by ANRIL and association of CARD8 single nucleotide polymorphism
    rs2043211 (p.C10X) with ischemic stroke. Stroke. 2014; 45(2):383-8. NIHMSID:
    NIHMS559913 PMCID: PMC39626865.
  35. Li L, Chen D, Li J, Wang X, Wang N, Xu C, Wang QK. Aggf1 acts at the top of the
    genetic regulatory hierarchy in specification of hemangioblasts in zebrafish.
    Blood. 2014; 123(4):501-8. PMCID: PMC3901065
  36. Gao H, Li L, Rao S, Shen G, Xi Q, Chen S, Zhang Z, Wang K, Ellis SG, Chen Q,
    Topol EJ, Wang QK. Genome-wide linkage scan identifies two novel genetic loci for
    coronary artery disease: in GeneQuest families. PloS one. 2014; 9(12):e113935. PMCID: PMC4259362
  37. Li X, Huang Y, Yin D, Wang D, Xu C, Wang F, Yang Q, Wang X, Li S, Chen S, Xiong
    X, Huang Y, Zhao Y, Wang L, Zhu X, Su Z, Zhou B, Zhang Y, Wang L, Chang L, Xu C,
    Li H, Ke T, Ren X, Cheng X, Yang Y, Liao Y, Tu X, Wang QK. Meta-analysis
    identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41
    and coronary artery disease. Atherosclerosis. 2013; 231(1):136-40. PMID: 24125424
  38. Tu X, Nie S, Liao Y, Zhang H, Fan Q, Xu C, Bai Y, Wang F, Ren X, Tang T, Xia N,
    Li S, Huang Y, Liu J, Yang Q, Zhao Y, Lv Q, Li Q, Li Y, Xia Y, Qian J, Li B, Wu
    G, Wu Y, Yang Y, Wang QK, Cheng X. The IL-33-ST2L pathway is associated with
    coronary artery disease in a Chinese Han population. American journal of human
    genetics. 2013; 93(4):652-60. PMCID: PMC3791271
  39. Zhang C, Li D, Zhang J, Chen X, Huang M, Archacki S, Tian Y, Ren W, Mei A, Zhang
    Q, Fang M, Su Z, Yin Y, Liu D, Chen Y, Cui X, Li C, Yang H, Wang Q, Wang J, Liu
    M, Deng Y. Mutations in ABCB6 cause dyschromatosis universalis hereditaria. The
    Journal of investigative dermatology. 2013; 133(9):2221-8. PMID: 23519333
  40. Zhou B, Ma R, Si W, Li S, Xu Y, Tu X, Wang Q. MicroRNA-503 targets FGF2 and VEGFA
    and inhibits tumor angiogenesis and growth. Cancer letters. 2013; 333(2):159-69. PMID: 23352645
  41. Shen GQ, Girelli D, Li L, Olivieri O, Martinelli N, Chen Q, Topol EJ, Wang QK.
    Multi-allelic haplotype association identifies novel information different from
    single-SNP analysis: a new protective haplotype in the LRP8 gene is against
    familial and early-onset CAD and MI. Gene. 2013; 521(1):78-81. NIHMSID:
    NIHMS537725 PMCID: PMC3919654
  42. Chakrabarti S, Wu X, Yang Z, Wu L, Yong SL, Zhang C, Hu K, Wang QK, Chen Q. MOG1
    rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick
    sinus syndrome. Circulation. Arrhythmia and electrophysiology. 2013;
    6(2):392-401. NIHMSID: NIHMS443434 PMCID:
  43. Zhou B, Si W, Su Z, Deng W, Tu X, Wang Q. Transcriptional activation of the Prox1
    gene by HIF-1α and HIF-2α in response to hypoxia. FEBS letters. 2013;
    587(6):724-31. PMID: 23395615
  44. Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S,
    Vaccarino VL, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee
    H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, El Mokhtari NE,
    Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Whittaker
    JC, Tang WH, Johnson JA, Wang QK, Assimes TL, Nöthlings U, Farrall M, Watkins H,
    Richards AM, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen
    WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ,
    Ye S. Association between the chromosome 9p21 locus and angiographic coronary
    artery disease burden: a collaborative meta-analysis. Journal of the American
    College of Cardiology. 2013; 61(9):957-70. NIHMSID: NIHMS451694 PMCID: PMC3653306
  45. Chen D, Li L, Tu X, Yin Z, Wang Q. Functional characterization of
    Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling
    pathway for specification of vein differentiation and angiogenesis during
    embryogenesis. Human molecular genetics. 2013; 22(5):963-76. PMID: 23197652
  46. Wang Q, Liu F, Xing Y, Wei X, Li H, Zhang S, Liu J, Wang Q, Tang Z, Liu M.
    Mutation c.359_363delGTATTinsATAC in the COL4A5 causes Alport syndrome in a
    Chinese family. Gene. 2013; 512(2):482-5. PMID: 23085274
  47. Zang X, Zhang S, Xia Y, Li S, Fu F, Li X, Wang F, Zhang R, Tian X, Gao L, Zhang
    J, Yang Y, Tu X, Wang Q. SNP rs3825214 in TBX5 is associated with lone atrial
    fibrillation in Chinese Han population. PloS one. 2013; 8(5):e64966. PMCID: PMC3663751
  48. Liu Y, Wang DK, Jiang DZ, Qin X, Xie ZD, Wang QK, Liu M, Chen LM. Cloning and
    functional characterization of novel variants and tissue-specific expression of
    alternative amino and carboxyl termini of products of slc4a10. PloS one. 2013;
    8(2):e55974. PMCID: PMC3567025
  49. Timur AA, Murugesan G, Zhang L, Aung PP, Barnard J, Wang QK, Gaussem P,
    Silverstein RL, Bhatt DL, Kottke-Marchant K. P2RY1 and P2RY12 polymorphisms and
    on-aspirin platelet reactivity in patients with coronary artery disease.
    International journal of laboratory hematology. 2012; 34(5):473-83. NIHMSID:
    NIHMS365621 PMCID: PMC3419334
  50. Shen GQ, Li L, Wang QK. Genetic variant R952Q in LRP8 is associated with
    increased plasma triglyceride levels in patients with early-onset CAD and MI.
    Annals of human genetics. 2012; 76(3):193-9. PMID: 22404453
  51. Archacki SR, Angheloiu G, Moravec CS, Liu H, Topol EJ, Wang QK. Comparative gene
    expression analysis between coronary arteries and internal mammary arteries
    identifies a role for the TES gene in endothelial cell functions relevant to
    coronary artery disease. Human molecular genetics. 2012; 21(6):1364-73. PMID: 22156939
  52. Wang C, Li Y, Shi L, Ren J, Patti M, Wang T, de Oliveira JR, Sobrido MJ, Quintáns
    B, Baquero M, Cui X, Zhang XY, Wang L, Xu H, Wang J, Yao J, Dai X, Liu J, Zhang
    L, Ma H, Gao Y, Ma X, Feng S, Liu M, Wang QK, Forster IC, Zhang X, Liu JY.
    Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with
    phosphate homeostasis. Nature genetics. 2012; 44(3):254-6. PMID: 22327515
  53. Lu Q, Yao Y, Yao Y, Liu S, Huang Y, Lu S, Bai Y, Zhou B, Xu Y, Li L, Wang N, Wang
    L, Zhang J, Cheng X, Qin G, Ma W, Xu C, Tu X, Wang Q. Angiogenic factor AGGF1
    promotes therapeutic angiogenesis in a mouse limb ischemia model. PloS one. 2012;
    7(10):e46998. PMCID: PMC3479102
  54. Cui X, Zeng F, Liu Y, Zhang J, Archacki S, Zhan T, Du R, Tang Z, Liu J, Wang QK,
    Liu M. A novel SCN1A missense mutation causes generalized epilepsy with febrile
    seizures plus in a Chinese family. Neuroscience letters. 2011; 503(1):27-30. PMID: 21843600
  55. Yang Q, Li L, Chen Q, Foldvary-Schaefer N, Ondo WG, Wang QK. Association studies
    of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US
    population. Sleep medicine. 2011; 12(8):800-4. NIHMSID: NIHMS320089 PMCID: PMC3514407
  56. Wang AZ, Li L, Zhang B, Shen GQ, Wang QK. Association of SNP rs17465637 on
    chromosome 1q41 and rs599839 on 1p13.3 with myocardial infarction in an American
    caucasian population. Annals of human genetics. 2011; 75(4):475-82. NIHMSID:
    NIHMS275834 PMCID: PMC3115468
  57. Ghosh A, Murugesan G, Chen K, Zhang L, Wang Q, Febbraio M, Anselmo RM, Marchant
    K, Barnard J, Silverstein RL. Platelet CD36 surface expression levels affect
    functional responses to oxidized LDL and are associated with inheritance of
    specific genetic polymorphisms. Blood. 2011; 117(23):6355-66. PMCID: PMC3122954
  58. Ding H, Tu X, Xu Y, Xu C, Wang X, Cui G, Bao X, Hui R, Wang QK, Wang DW. No
    evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2
    gene with ischemic stroke in Chinese Han population. Atherosclerosis. 2011;
    216(2):381-2. PMID: 21376321
  59. Xu Z, Li Y, Zhang X, Zeng F, Yuan M, Liu M, Wang QK, Liu JY. Identification and
    molecular characterization of two novel mutations in COL1A2 in two Chinese
    families with osteogenesis imperfecta. Journal of genetics and genomics = Yi
    chuan xue bao. 2011; 38(4):149-56. PMID: 21530898
  60. Wang F, Xu CQ, He Q, Cai JP, Li XC, Wang D, Xiong X, Liao YH, Zeng QT, Yang YZ,
    Cheng X, Li C, Yang R, Wang CC, Wu G, Lu QL, Bai Y, Huang YF, Yin D, Yang Q, Wang
    XJ, Dai DP, Zhang RF, Wan J, Ren JH, Li SS, Zhao YY, Fu FF, Huang Y, Li QX, Shi
    SW, Lin N, Pan ZW, Li Y, Yu B, Wu YX, Ke YH, Lei J, Wang N, Luo CY, Ji LY, Gao
    LJ, Li L, Liu H, Huang EW, Cui J, Jia N, Ren X, Li H, Ke T, Zhang XQ, Liu JY, Liu
    MG, Xia H, Yang B, Shi LS, Xia YL, Tu X, Wang QK. Genome-wide association
    identifies a susceptibility locus for coronary artery disease in the Chinese Han
    population. Nature genetics. 2011; 43(4):345-9. PMID: 21378986
  61. Zhang T, Yong SL, Drinko JK, Popović ZB, Shryock JC, Belardinelli L, Wang QK.
    LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte
    apoptosis, cardiac fibrosis and contractile dysfunction in mice. International
    journal of cardiology. 2011; 147(2):239-45. NIHMSID: NIHMS144047 PMCID: PMC2891203
  62. Li C, Wang F, Yang Y, Fu F, Xu C, Shi L, Li S, Xia Y, Wu G, Cheng X, Liu H, Wang
    C, Wang P, Hao J, Ke Y, Zhao Y, Liu M, Zhang R, Gao L, Yu B, Zeng Q, Liao Y, Yang
    B, Tu X, Wang QK. Significant association of SNP rs2106261 in the ZFHX3 gene with
    atrial fibrillation in a Chinese Han GeneID population. Human genetics. 2011;
    129(3):239-46. NIHMSID: NIHMS820129 PMCID:
  63. Yang Q, Li L, Yang R, Shen GQ, Chen Q, Foldvary-Schaefer N, Ondo WG, Wang QK.
    Family-based and population-based association studies validate PTPRD as a risk
    factor for restless legs syndrome. Movement disorders : official journal of the
    Movement Disorder Society. 2011; 26(3):516-9. NIHMSID: NIHMS537722 PMCID: PMC3895410
  64. Cheng X, Shi L, Nie S, Wang F, Li X, Xu C, Wang P, Yang B, Li Q, Pan Z, Li Y, Xia
    H, Zheng C, Ke Y, Wu Y, Tang T, Yan X, Yang Y, Xia N, Yao R, Wang B, Ma X, Zeng
    Q, Tu X, Liao Y, Wang QK. The same chromosome 9p21.3 locus is associated with
    type 2 diabetes and coronary artery disease in a Chinese Han population.
    Diabetes. 2011; 60(2):680-4. PMCID: PMC3028370
  65. Ouyang P, Saarel E, Bai Y, Luo C, Lv Q, Xu Y, Wang F, Fan C, Younoszai A, Chen Q,
    Tu X, Wang QK. A de novo mutation in NKX2.5 associated with atrial septal
    defects, ventricular noncompaction, syncope and sudden death. Clinica chimica
    acta; international journal of clinical chemistry. 2011; 412(1-2):170-5. NIHMSID:
    NIHMS247841 PMCID: PMC2998397
  66. Liu H, Liu W, Liao Y, Cheng L, Liu Q, Ren X, Shi L, Tu X, Wang QK, Guo AY.
    CADgene: a comprehensive database for coronary artery disease genes. Nucleic
    acids research. 2011; 39(Database issue):D991-6. PMCID: PMC3013698
  67. Gao Y, Yang K, Xu S, Wang C, Liu J, Zhang Z, Yuan M, Luo X, Liu M, Wang QK, Liu
    JY. Identification of compound heterozygous mutations in GNPTG in three siblings
    of a Chinese family with mucolipidosis type III gamma. Molecular genetics and
    metabolism. 2011; 102(1):107-9. PMID: 20951619
  68. Zhou L, Ding H, Zhang X, He M, Huang S, Xu Y, Shi Y, Cui G, Cheng L, Wang QK, Hu
    FB, Wang D, Wu T. Genetic variants at newly identified lipid loci are associated
    with coronary heart disease in a Chinese Han population. PloS one. 2011;
    6(11):e27481. PMCID: PMC3215720
  69. Wang C, Cao D, Wang Q, Wang DZ. Synergistic activation of cardiac genes by
    myocardin and Tbx5. PloS one. 2011; 6(8):e24242. PMCID: PMC3163680
  70. Dai X, Gao Y, Xu Z, Cui X, Liu J, Li Y, Xu H, Liu M, Wang QK, Liu JY.
    Identification of a novel genetic locus on chromosome 8p21.1-q11.23 for
    idiopathic basal ganglia calcification. American journal of medical genetics.
    Part B, Neuropsychiatric genetics : the official publication of the International
    Society of Psychiatric Genetics. 2010; 153B(7):1305-10. PMID:
  71. Huang Y, Zhang J, Li C, Yang G, Liu M, Wang QK, Tang Z. Identification of a novel
    homozygous nonsense mutation in EYS in a Chinese family with autosomal recessive
    retinitis pigmentosa. BMC medical genetics. 2010; 11:121. PMCID: PMC2927534
  72. Xu C, Wang F, Wang B, Li X, Li C, Wang D, Xiong X, Wang P, Lu Q, Wang X, Yang Q,
    Yin D, Huang Y, Ji L, Wang N, Chen S, Cheng X, Liao Y, Ma X, Su D, Chen G, Xia H,
    Shi L, Tu X, Wang QK. Minor allele C of chromosome 1p32 single nucleotide
    polymorphism rs11206510 confers risk of ischemic stroke in the Chinese Han
    population. Stroke. 2010; 41(8):1587-92. PubMed [journal] PMID: 20576952
  73. Yin W, Ye X, Shi L, Wang QK, Jin H, Wang P, Bian Z. TP63 gene mutations in
    Chinese P63 syndrome patients. Journal of dental research. 2010; 89(8):813-7. PMID: 20410354
  74. Wang P, Yang Q, Wu X, Yang Y, Shi L, Wang C, Wu G, Xia Y, Yang B, Zhang R, Xu C,
    Cheng X, Li S, Zhao Y, Fu F, Liao Y, Fang F, Chen Q, Tu X, Wang QK. Functional
    dominant-negative mutation of sodium channel subunit gene SCN3B associated with
    atrial fibrillation in a Chinese GeneID population. Biochemical and biophysical
    research communications. 2010; 398(1):98-104. NIHMSID: NIHMS215253 PMCID: PMC3132081
  75. Yang R, Li L, Seidelmann SB, Shen GQ, Sharma S, Rao S, Abdullah KG, Mackinlay KG,
    Elston RC, Chen Q, Topol EJ, Wang QK. A genome-wide linkage scan identifies
    multiple quantitative trait loci for HDL-cholesterol levels in families with
    premature CAD and MI. Journal of lipid research. 2010; 51(6):1442-51. PMCID: PMC3035507
  76. Ren X, Xu C, Zhan C, Yang Y, Shi L, Wang F, Wang C, Xia Y, Yang B, Wu G, Wang P,
    Li X, Wang D, Xiong X, Liu J, Liu Y, Liu M, Liu J, Tu X, Wang QK. Identification
    of NPPA variants associated with atrial fibrillation in a Chinese GeneID
    population. Clinica chimica acta; international journal of clinical chemistry.
    2010; 411(7-8):481-5. PMID: 20064500
  77. Wang Q, Diao Y, Xu Z, Li X, Luo XP, Xu H, Ouyang P, Liu M, Hu Z, Wang QK, Liu JY.
    Identification of a novel splicing mutation in the growth hormone (GH)-releasing
    hormone receptor gene in a Chinese family with pituitary dwarfism. Molecular and
    cellular endocrinology. 2009; 313(1-2):50-6. PMID: 19733620
  78. Shi L, Li C, Wang C, Xia Y, Wu G, Wang F, Xu C, Wang P, Li X, Wang D, Xiong X,
    Bai Y, Liu M, Liu J, Ren X, Gao L, Wang B, Zeng Q, Yang B, Ma X, Yang Y, Tu X,
    Wang QK. Assessment of association of rs2200733 on chromosome 4q25 with atrial
    fibrillation and ischemic stroke in a Chinese Han population. Human genetics.
    2009; 126(6):843-9. PMID: 19707791
  79. Ke T, Gomez CR, Mateus HE, Castano JA, Wang QK. Novel CACNA1S mutation causes
    autosomal dominant hypokalemic periodic paralysis in a South American family.
    Journal of human genetics. 2009; 54(11):660-4. PMID: 19779499
  80. Li H, Zhan T, Li C, Liu M, Wang QK. Repression of MHC class I transcription by
    HPV16E7 through interaction with a putative RXRbeta motif and NF-kappaB
    cytoplasmic sequestration. Biochemical and biophysical research communications.
    2009; 388(2):383-8. PMID: 19665994
  81. Fan C, Chen Q, Wang QK. Functional role of transcriptional factor TBX5 in
    pre-mRNA splicing and Holt-Oram syndrome via association with SC35. The Journal
    of biological chemistry. 2009; 284(38):25653-63. PMCID: PMC2757967
  82. Chen Q, Zhang T, Roshetsky JF, Ouyang Z, Essers J, Fan C, Wang Q, Hinek A, Plow
    EF, Dicorleto PE. Fibulin-4 regulates expression of the tropoelastin gene and
    consequent elastic-fibre formation by human fibroblasts. The Biochemical journal.
    2009; 423(1):79-89. NIHMSID: NIHMS261918 PMCID:
  83. Fan C, Ouyang P, Timur AA, He P, You SA, Hu Y, Ke T, Driscoll DJ, Chen Q, Wang
    QK. Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial
    cell function. The Journal of biological chemistry. 2009; 284(35):23331-43. PMCID: PMC2749107
  84. Ye X, Shi L, Yin W, Meng L, Wang QK, Bian Z. Further evidence of genetic
    heterogeneity segregating with hereditary gingival fibromatosis. Journal of
    clinical periodontology. 2009; 36(8):627-33. PMID: 19552635
  85. Tang Z, Wang Z, Wang Z, Ke T, Wang QK, Liu M. Novel compound heterozygous
    mutations in CERKL cause autosomal recessive retinitis pigmentosa in a
    nonconsanguineous Chinese family. Archives of ophthalmology (Chicago, Ill. :
    1960). 2009; 127(8):1077-8. PMID: 19667359
  86. Martinelli N, Olivieri O, Shen GQ, Trabetti E, Pizzolo F, Busti F, Friso S, Bassi
    A, Li L, Hu Y, Pignatti PF, Corrocher R, Wang QK, Girelli D. Additive effect of
    LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in
    modulating apolipoprotein E concentration and the risk of myocardial infarction:
    a case-control study. BMC medical genetics. 2009; 10:41. PMCID: PMC2689206
  87. Xi Q, Li L, Traboulsi EI, Wang QK. Novel ABCA4 compound heterozygous mutations
    cause severe progressive autosomal recessive cone-rod dystrophy presenting as
    Stargardt disease. Molecular vision. 2009; 15:638-45. PMCID: PMC2665199
  88. Liu JZ, Yang T, Li X, Liu M, Wang QK, Liu JY. A novel mutation in the ATP2C1 gene
    is associated with Hailey-Hailey disease in a Chinese family. International
    journal of dermatology. 2009; 48(1):47-51. PMID: 19126050
  89. Zhang X, Chen S, Yoo S, Chakrabarti S, Zhang T, Ke T, Oberti C, Yong SL, Fang F,
    Li L, de la Fuente R, Wang L, Chen Q, Wang QK. Mutation in nuclear pore component
    NUP155 leads to atrial fibrillation and early sudden cardiac death. Cell. 2008;
    135(6):1017-27. PMID: 19070573
  90. Dai XH, Chen WW, Wang X, Zhu QH, Li C, Li L, Liu MG, Wang QK, Liu JY. A novel
    genetic locus for familial febrile seizures and epilepsy on chromosome
    3q26.2-q26.33. Human genetics. 2008; 124(4):423-9. PMID:
  91. Zhang X, Chen S, Zhang L, Liu M, Redfearn S, Bryant RM, Oberti C, Vincent GM,
    Wang QK. Protective effect of KCNH2 single nucleotide polymorphism K897T in LQTS
    families and identification of novel KCNQ1 and KCNH2 mutations. BMC medical
    genetics. 2008; 9:87. PMCID: PMC2570672
  92. Abdullah KG, Li L, Shen GQ, Hu Y, Yang Y, MacKinlay KG, Topol EJ, Wang QK. Four
    SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an
    American Caucasian population (GeneQuest). Annals of human genetics. 2008; 72(Pt
    5):654-7. NIHMSID: NIHMS81968 PMCID: PMC2634771
  93. Hu Y, Li L, Seidelmann SB, Timur AA, Shen PH, Driscoll DJ, Wang QK.
    Identification of association of common AGGF1 variants with susceptibility for
    Klippel-Trenaunay syndrome using the structure association program. Annals of
    human genetics. 2008; 72(Pt 5):636-43. NIHMSID: NIHMS81970 PMCID: PMC2602961
  94. Liu P, Li H, Ren X, Mao H, Zhu Q, Zhu Z, Yang R, Yuan W, Liu J, Wang Q, Liu M.
    Novel ACTG1 mutation causing autosomal dominant non-syndromic hearing impairment
    in a Chinese family. Journal of genetics and genomics = Yi chuan xue bao. 2008;
    35(9):553-8. PMID: 18804074
  95. Liu P, Zhang S, Yao Q, Liu X, Wang X, Huang C, Huang X, Wang P, Yuan M, Liu JY,
    Wang QK, Liu M. Identification of a genetic locus for autosomal dominant
    disseminated superficial actinic porokeratosis on chromosome 1p31.3-p31.1. Human
    genetics. 2008; 123(5):507-13. PMID: 18443824
  96. Zhang S, Wang L, Hao Y, Wang P, Hao P, Yin K, Wang QK, Liu M. T14484C and T14502C
    in the mitochondrial ND6 gene are associated with Leber's hereditary optic
    neuropathy in a Chinese family. Mitochondrion. 2008; 8(3):205-10. PMID: 18440284
  97. Liu P, Yang Q, Wang X, Feng A, Yang T, Yang R, Wang P, Yuang M, Liu M, Liu JY,
    Wang QK. Identification of a genetic locus for ichthyosis vulgaris on chromosome
    10q22.3-q24.2. The Journal of investigative dermatology. 2008; 128(6):1418-22. PMID: 18079749
  98. Li H, Li C, Lu Q, Su T, Ke T, Li DW, Yuan M, Liu J, Ren X, Zhang Z, Zeng S, Wang
    QK, Liu M. Cataract mutation P20S of alphaB-crystallin impairs chaperone activity
    of alphaA-crystallin and induces apoptosis of human lens epithelial cells.
    Biochimica et biophysica acta. 2008; 1782(5):303-9. PMID:
  99. Seidelmann SB, Li L, Shen GQ, Topol EJ, Wang QK. Identification of a novel locus
    for triglyceride on chromosome 1p31-32 in families with premature CAD and MI.
    Journal of lipid research. 2008; 49(5):1034-8. NIHMSID: NIHMS81971 PMCID: PMC2311437
  100. Zhang S, Yin K, Ren X, Wang P, Zhang S, Cheng L, Yang J, Liu JY, Liu M, Wang QK.
    Identification of a novel KCNQ1 mutation associated with both Jervell and
    Lange-Nielsen and Romano-Ward forms of long QT syndrome in a Chinese family. BMC
    medical genetics. 2008; 9:24. PMCID: PMC2322962
  101. Wu L, Yong SL, Fan C, Ni Y, Yoo S, Zhang T, Zhang X, Obejero-Paz CA, Rho HJ, Ke
    T, Szafranski P, Jones SW, Chen Q, Wang QK. Identification of a new co-factor,
    MOG1, required for the full function of cardiac sodium channel Nav 1.5. The
    Journal of biological chemistry. 2008; 283(11):6968-78. PMID:
  102. Liu JY, Dai X, Sheng J, Cui X, Wang X, Jiang X, Tu X, Tang Z, Bai Y, Liu M, Wang
    QK. Identification and functional characterization of a novel splicing mutation
    in RP gene PRPF31. Biochemical and biophysical research communications. 2008;
    367(2):420-6. NIHMSID: NIHMS39558 PMCID:
  103. Ren X, Liu JY, Zhai LY, Yao Q, Dai X, Cai Z, Liu P, Sun K, Huang C, Wang QK, Liu
    M. A splicing mutation in the COL7A1 gene causes autosomal dominant dystrophic
    epidermolysis bullosa pruriginosa. The British journal of dermatology. 2008;
    158(3):618-20. PMID: 18067480
  104. Shen GQ, Li L, Rao S, Abdullah KG, Ban JM, Lee BS, Park JE, Wang QK. Four SNPs on
    chromosome 9p21 in a South Korean population implicate a genetic locus that
    confers high cross-race risk for development of coronary artery disease.
    Arteriosclerosis, thrombosis, and vascular biology. 2008; 28(2):360-5. PMID: 18048766
  105. Gupta S, Young D, Maitra RK, Gupta A, Popovic ZB, Yong SL, Mahajan A, Wang Q, Sen
    S. Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB.
    Journal of molecular biology. 2008; 375(3):637-49. NIHMSID: NIHMS38808 PMCID: PMC2277468
  106. Shen GQ, Rao S, Martinelli N, Li L, Olivieri O, Corrocher R, Abdullah KG, Hazen
    SL, Smith J, Barnard J, Plow EF, Girelli D, Wang QK. Association between four
    SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian
    population. Journal of human genetics. 2008; 53(2):144-50. PMID: 18066490
  107. Zhang S, Liu M, Dong JM, Yin K, Wang P, Bu J, Li J, Hao YS, Hao P, Wang QK, Wang
    L. Identification of a genetic locus for autosomal dominant infantile cataract on
    chromosome 20p12.1-p11.23 in a Chinese family. Molecular vision. 2008; 14:1893-7. PMCID: PMC2573730
  108. Shen GQ, Li L, Girelli D, Seidelmann SB, Rao S, Fan C, Park JE, Xi Q, Li J, Hu Y,
    Olivieri O, Marchant K, Barnard J, Corrocher R, Elston R, Cassano J, Henderson S,
    Hazen SL, Plow EF, Topol EJ, Wang QK. An LRP8 variant is associated with familial
    and premature coronary artery disease and myocardial infarction. American journal
    of human genetics. 2007; 81(4):780-91. PMCID:
  109. Chang W, Ding Q, Tang Z, Liu P, Jiang F, Ke T, Ren X, Wang Z, Liu J, Wang QK, Liu
    M. A novel de novo frameshift mutation of RPGR ORF15 is associated with X-linked
    retinitis pigmentosa in a Chinese family. Molecular vision. 2007; 13:1548-54. PMID: 17893654
  110. Zhang X, Chen L, Liu J, Zhao Z, Qu E, Wang X, Chang W, Xu C, Wang QK, Liu M. A
    novel DSPP mutation is associated with type II dentinogenesis imperfecta in a
    Chinese family. BMC medical genetics. 2007; 8:52. PMCID: PMC1995191
  111. Jane-wit D, Altuntas CZ, Johnson JM, Yong S, Wickley PJ, Clark P, Wang Q, Popović
    ZB, Penn MS, Damron DS, Perez DM, Tuohy VK. Beta 1-adrenergic receptor
    autoantibodies mediate dilated cardiomyopathy by agonistically inducing
    cardiomyocyte apoptosis. Circulation. 2007; 116(4):399-410. PMID: 17620508
  112. Wu L, Archacki SR, Zhang T, Wang QK. Induction of high STAT1 expression in
    transgenic mice with LQTS and heart failure. Biochemical and biophysical research
    communications. 2007; 358(2):449-54. NIHMSID: NIHMS24268 PMCID: PMC3505674
  113. Zhang T, Yong SL, Tian XL, Wang QK. Cardiac-specific overexpression of SCN5A gene
    leads to shorter P wave duration and PR interval in transgenic mice. Biochemical
    and biophysical research communications. 2007; 355(2):444-50. NIHMSID: NIHMS19385 PMCID: PMC1885482
  114. Tian XL, Cheng Y, Zhang T, Liao ML, Yong SL, Wang QK. Optical mapping of
    ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S. Biochemical and
    biophysical research communications. 2007; 352(4):879-83. NIHMSID: NIHMS29776 PMCID: PMC2699586
  115. Yong SL, Ni Y, Zhang T, Tester DJ, Ackerman MJ, Wang QK. Characterization of the
    cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular
    myocytes. Biochemical and biophysical research communications. 2007;
    352(2):378-83. NIHMSID: NIHMS15448 PMCID:
  116. Liu JY, Ren X, Yang X, Guo T, Yao Q, Li L, Dai X, Zhang M, Wang L, Liu M, Wang
    QK. Identification of a novel GPR143 mutation in a large Chinese family with
    congenital nystagmus as the most prominent and consistent manifestation. Journal
    of human genetics. 2007; 52(6):565-70. PMID: 17516023
  117. Topol EJ, Smith J, Plow EF, Wang QK. Genetic susceptibility to myocardial
    infarction and coronary artery disease. Human molecular genetics. 2006; 15 Spec
    No 2:R117-23. PMID: 16987874
  118. Wang X, Xiao F, Yang Q, Liang B, Tang Z, Jiang L, Zhu Q, Chang W, Jiang J, Jiang
    C, Ren X, Liu JY, Wang QK, Liu M. A novel mutation in GDF5 causes autosomal
    dominant symphalangism in two Chinese families. American journal of medical
    genetics. Part A. 2006; 140A(17):1846-53. PMID: 16892395
  119. Liu M, Ke T, Wang Z, Yang Q, Chang W, Jiang F, Tang Z, Li H, Ren X, Wang X, Wang
    T, Li Q, Yang J, Liu J, Wang QK. Identification of a CRYAB mutation associated
    with autosomal dominant posterior polar cataract in a Chinese family.
    Investigative ophthalmology & visual science. 2006; 47(8):3461-6. PMID: 16877416
  120. Ke T, Wang QK, Ji B, Wang X, Liu P, Zhang X, Tang Z, Ren X, Liu M. Novel HSF4
    mutation causes congenital total white cataract in a Chinese family. American
    journal of ophthalmology. 2006; 142(2):298-303. PMID: 16876512
  121. Melamud A, Shen GQ, Chung D, Xi Q, Simpson E, Li L, Peachey NS, Zegarra H,
    Hagstrom SA, Wang QK, Traboulsi EI. Mapping a new genetic locus for X linked
    retinitis pigmentosa to Xq28. Journal of medical genetics. 2006; 43(6):e27. PMCID: PMC2593026
  122. Luo L, Shen GQ, Stiffler KA, Wang QK, Pretlow TG, Pretlow TP. Loss of
    heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon
    cancer. Carcinogenesis. 2006; 27(6):1153-9. PMID: 16474178
  123. Li X, Rao S, Jiang W, Li C, Xiao Y, Guo Z, Zhang Q, Wang L, Du L, Li J, Li L,
    Zhang T, Wang QK. Discovery of Time-Delayed Gene Regulatory Networks based on
    temporal gene expression profiling. BMC bioinformatics. 2006; 7:26. PMCID: PMC1386718
  124. Liu JY, Ji MF, Wang XR, Luo RL, Ren X, Liu M, Wang QK. Detection of human
    chromosomal abnormalities using a new technique combining
    4',6-diamidino-2-phenyl-indole staining and image analysis. Clinical genetics.
    2006; 69(1):65-71. PMID: 16451138
  125. Liu M, Wang X, Cai Z, Tang Z, Cao K, Liang B, Ren X, Liu JY, Wang QK. A novel
    heterozygous mutation in the Indian hedgehog gene (IHH) is associated with
    brachydactyly type A1 in a Chinese family. Journal of human genetics. 2006;
    51(8):727-31. PMID: 16871364
  126. Huang C, Yang Q, Ke T, Wang H, Wang X, Shen J, Tu X, Tian J, Liu JY, Wang QK, Liu
    M. A novel de novo frame-shift mutation of the EDA gene in a Chinese Han family
    with hypohidrotic ectodermal dysplasia. Journal of human genetics. 2006;
    51(12):1133-7. PMID: 17066260
  127. Song YL, Zhang WF, Peng B, Wang CN, Wang Q, Bian Z. Germline mutations of the
    PTCH gene in families with odontogenic keratocysts and nevoid basal cell
    carcinoma syndrome. Tumour biology : the journal of the International Society for
    Oncodevelopmental Biology and Medicine. 2006; 27(4):175-80. PMID: 16675912
  128. Glatter KA, Chiamvimonvat N, Viitasalo M, Wang Q, Tuteja D. Risk stratification
    in Brugada syndrome. Lancet (London, England). 2005; 366(9485):530-1. NIHMSID:
    NIHMS12104 PMCID: PMC1579825
  129. Timur AA, Driscoll DJ, Wang Q. Biomedicine and diseases: the Klippel-Trenaunay
    syndrome, vascular anomalies and vascular morphogenesis. Cellular and molecular
    life sciences : CMLS. 2005; 62(13):1434-47. NIHMSID: NIHMS12098 PMCID: PMC1579804
  130. Du W, Bautista JF, Yang H, Diez-Sampedro A, You SA, Wang L, Kotagal P, Lüders HO,
    Shi J, Cui J, Richerson GB, Wang QK. Calcium-sensitive potassium channelopathy in
    human epilepsy and paroxysmal movement disorder. Nature genetics. 2005;
    37(7):733-8. PMID: 15937479
  131. You SA, Wang Q. Ferritin in atherosclerosis. Clinica chimica acta; international
    journal of clinical chemistry. 2005; 357(1):1-16. PMID: 15963791
  132. Wang Q. Advances in the genetic basis of coronary artery disease. Current
    atherosclerosis reports. 2005; 7(3):235-41. NIHMSID: NIHMS12100 PMCID: PMC1783687
  133. Wang Q. Molecular genetics of coronary artery disease. Current opinion in
    cardiology. 2005; 20(3):182-8. NIHMSID: NIHMS12101 PMCID: PMC1579824
  134. Guo Z, Zhang T, Li X, Wang Q, Xu J, Yu H, Zhu J, Wang H, Wang C, Topol EJ, Wang
    Q, Rao S. Towards precise classification of cancers based on robust gene
    functional expression profiles. BMC bioinformatics. 2005; 6:58. PMCID: PMC1274255
  135. Wang Q, Liu M, Xu C, Tang Z, Liao Y, Du R, Li W, Wu X, Wang X, Liu P, Zhang X,
    Zhu J, Ren X, Ke T, Wang Q, Yang J. Novel CACNA1S mutation causes autosomal
    dominant hypokalemic periodic paralysis in a Chinese family. Journal of molecular
    medicine (Berlin, Germany). 2005; 83(3):203-8. NIHMSID: NIHMS12097 PMCID: PMC1579762
  136. Wang QK. Update on the molecular genetics of vascular anomalies. Lymphatic
    research and biology. 2005; 3(4):226-33. NIHMSID: NIHMS12107 PMCID: PMC1579841
  137. Li L, Jiang W, Li X, Moser KL, Guo Z, Du L, Wang Q, Topol EJ, Wang Q, Rao S. A
    robust hybrid between genetic algorithm and support vector machine for extracting
    an optimal feature gene subset. Genomics. 2005; 85(1):16-23. PMID: 15607418
  138. Oberti C, Wang L, Li L, Dong J, Rao S, Du W, Wang Q. Genome-wide linkage scan
    identifies a novel genetic locus on chromosome 5p13 for neonatal atrial
    fibrillation associated with sudden death and variable cardiomyopathy.
    Circulation. 2004; 110(25):3753-9. NIHMSID: NIHMS12092  PMCID: PMC1618875
  139. Bhagavatula MR, Fan C, Shen GQ, Cassano J, Plow EF, Topol EJ, Wang Q.
    Transcription factor MEF2A mutations in patients with coronary artery disease.
    Human molecular genetics. 2004; 13(24):3181-8. NIHMSID: NIHMS12094 PMCID: PMC1579761
  140. Archacki S, Wang Q. Expression profiling of cardiovascular disease. Human
    genomics. 2004; 1(5):355-70. PMCID: PMC3525101
  141. Timur AA, Sadgephour A, Graf M, Schwartz S, Libby ED, Driscoll DJ, Wang Q.
    Identification and molecular characterization of a de novo supernumerary ring
    chromosome 18 in a patient with Klippel-Trenaunay syndrome. Annals of human
    genetics. 2004; 68(Pt 4):353-61. PMID: 15225160
  142. Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rüb U, Shattuck D, Salamon G, Kudo
    LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB,
    Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q,
    Wang L, Andrews C, Yamada K, Demer JL, Karim S, Alger JR, Geschwind DH, Deller T,
    Sicotte NL, Nelson SF, Baloh RW, Engle EC. Mutations in a human ROBO gene disrupt
    hindbrain axon pathway crossing and morphogenesis. Science (New York, N.Y.).
    2004; 304(5676):1509-13. NIHMSID: NIHMS12091 PMCID: PMC1618874
  143. Glatter KA, Wang Q, Keating M, Chen S, Chiamvimonvat N, Scheinman MM.
    Effectiveness of sotalol treatment in symptomatic Brugada syndrome. The American
    journal of cardiology. 2004; 93(10):1320-2. PMID: 15135718
  144. Chen S, Ondo WG, Rao S, Li L, Chen Q, Wang Q. Genomewide linkage scan identifies
    a novel susceptibility locus for restless legs syndrome on chromosome 9p.
    American journal of human genetics. 2004; 74(5):876-85. PMCID: PMC1181982
  145. McCarthy JJ, Parker A, Salem R, Moliterno DJ, Wang Q, Plow EF, Rao S, Shen G,
    Rogers WJ, Newby LK, Cannata R, Glatt K, Topol EJ. Large scale association
    analysis for identification of genes underlying premature coronary heart disease:
    cumulative perspective from analysis of 111 candidate genes. Journal of medical
    genetics. 2004; 41(5):334-41. NIHMSID: NIHMS12086 PMCID: PMC1579684
  146. Wang Q, Chen S, Chen Q, Wan X, Shen J, Hoeltge GA, Timur AA, Keating MT, Kirsch
    GE. The common SCN5A mutation R1193Q causes LQTS-type electrophysiological
    alterations of the cardiac sodium channel. Journal of medical genetics. 2004;
    41(5):e66. NIHMSID: NIHMS12082 PMCID: PMC1618878
  147. Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q, Szafranski P, Rao S,
    Wu L, Housman DE, DiCorleto PE, Driscoll DJ, Borrow J, Wang Q. Identification of
    an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay
    syndrome. Nature. 2004; 427(6975):640-5. NIHMSID: NIHMS12088 PMCID: PMC1618873

No news currently found.