Qing Kenneth Wang, Ph.D., M.B.A.

Staff and Professor

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NE4-202
wangq2@ccf.org
Phone: (216) 445-0570
Fax: (216) 636-1231



Dr. Wang has made distinguished contributions to the field of genetics of cardiovascular and neurological diseases by identifying eight genes for single gene disorders and three candidate genes for common complex disease, and by identifying novel molecular mechanismsunderlying channelopathies and other diseases. He was noted for reporting the discoveries of the first Brugada syndrome gene (SCN5A), the most common gene for long QT syndrome (LQTS) (KCNQ1), one of the first two genes reported for LQTS in the same issue of Cell (SCN5A), LQTS gene KCNE1, the first gene for autosomal recessive atrial fibrillation (NUP155), atrial fibrillation gene SCN3B, the first gene for vascular disease Klippel-Trenaunay syndrome (AGGF1), and the first gene for co-existent paroxysmal dyskinesia and generalized epilepsy (KCNMA1). Dr. Wang also identified candidate genes for familial, early-onset coronary artery disease (CAD), completed the first genome-wide association study for CAD in a non-Caucasian population and identified C6orf105 as a new CAD susceptibility gene. Dr. Wang’s early discoveries on cardiac arrhythmias genes have been translated into the first commercial genetic testing kit in the field of cardiovascular medicine (Familion Test), which realized the first successful case of personalized genomic medicine in cardiovascular medicine and saved many human lives. Dr. Wang has identified a protein MOG1 that interacts with the cardiac sodium channel and regulates trafficking of this channel to cell membranes, and established AGGF1 as a VEGF-A-like angiogenic factor for specifying veins (in contrast to arterial specification by VEGF-A).

In other words ...

Qing Wang is currently Staff at Department of Molecular Cardiology, Department of Cardiovascular Medicine, and Neurological Institute, and the Director of Center for Cardiovascular Genetics at the Cleveland Clinic. He is Professor of Molecular Medicine and Professor of Genetics at Case Western Reserve University.  He received B.S. from China in 1984, Ph.D. in Genetics and Developmental Biology from Cornell University in 1993, and M.B.A. from Cleveland State University in 2002.  His postdoctoral research training was with Dr. Mark Keating at the Howard Hughes Medical Institute, University of Utah Health Sciences Center.  Dr. Wang joined the faculty at Baylor College of Medicine as an Assistant Professor (tenure track) in 1996 and Cleveland Clinic as Assistant Staff in 1999.  Dr. Wang has published more than 190 scientific papers and book chapters, and edited two volumes of Methods in Molecular Medicine.  He is an elected Fellow of the American Association for the Advancement of Science.  His research mostly focuses on finding genes for cardiovascular diseases, in particular, cardiac arrhythmias, syncope, seizures, and sudden death.  He also uses a variety of technologies to identify novel molecular mechanisms and develop therapies for diseases.


Steve  Archacki
Steve Archacki
Postdoctoral Fellow

Location:NE4-215
Phone:(216) 445-0571
archaks@ccf.org
laboratory

Susmita  Chakrabarti PhD
Susmita Chakrabarti PhD
Postdoctoral Fellow

Location:NE4-215
Phone:(216) 445-0571
chakras3@ccf.org
laboratory

Qiuyun  Chen Ph.D.
Qiuyun Chen Ph.D.
Project Staff

Location:NE4-213
Phone:(216) 444-2122
chenq3@ccf.org
laboratory

Hyosuk  Cho
Hyosuk Cho
Graduate Student

Location:NE4-215
Phone:(216) 444-2122
choh@ccf.org
Fax:(216) 636-1231
laboratory

Yang  Guo
Yang Guo
Visting Scientist

Location:NE4-215
Phone:(216) 445-0571
guoy@ccf.org
laboratory

Yabo  Li
Yabo Li
Predoctoral Fellow

Location:NE4-213
Phone:(216) 445-0571
liy3@ccf.org
laboratory

Miroslava  Tischenko B.A.
Miroslava Tischenko B.A.
Senior Research Technologist

Location:NE4-215
Phone:(216) 445-0571
tischem@ccf.org
laboratory

Fan  Wang
Fan Wang
Research Associate

Location:NE4-215
Phone:(216) 445-0571
wangf2@ccf.org
laboratory web site

Zhijie  Wang
Zhijie Wang
Predoctoral Fellow

Location:NE4-215
Phone:(215) 445-0571
wangz6@ccf.org
laboratory

Gang  Yu
Gang Yu
Predoctoral Fellow

Location:NE4-215
Phone:(216) 445-0571
yug3@ccf.org
laboratory


PUBLICATIONS

  1. Wang J, Fa J, Wang P, Jia X, Peng H, Chen J, Wang Y, Wang C, Chen Q, Tu X, Wang QK, Xu C. NINJ2- A novel regulator of endothelial inflammation and activation. Cell signaling. 2017; [Epub ahead of print]. PMID: 28431986
  2. Li J, Zhu X, Yu K, Jiang H, Zhang Y, Deng S, Cheng L, Liu X, Zhong J, Zhang X, He M, Chen W, Yuan J, Gao M, Bai Y, Han X, Liu B, Luo X, Mei W, He X, Sun S, Zhang L, Zeng H, Sun H, Liu C, Guo Y, Zhang B, Zhang Z, Huang J, Pan A, Yuan Y, Angileri F, Ming B, Zheng F, Zeng Q, Mao X, Peng Y, Mao Y, Ye P, Wang QK, Qi L, Hu FB, Liang L, Wu T. Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome. Circ Res. 2017; [Epub ahead of print]. PMID: 28348007
  3. Luo C, Wang F, Ren X, Ke T, Xu C, Tang B, Qin S, Yao Y, Chen Q, Wang QK. Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease. Biochim Biophys Acta. 2017; [Epub ahead of print]. PMID: 28341552
  4. Yin D, Naji DH, Xia Y, Li S, Bai Y, Jiang G, Zhao Y, Wang X, Huang Y, Chen S, Fa
    J, Tan C, Zhou M, Zhou Y, Wang L, Liu Y, Chen F, Liu J, Chen Q, Tu X, Xu C, Wang
    QK. Genomic Variant in IL-37 Confers A Significant Risk of Coronary Artery
    Disease. Scientific reports. 2017; 7:42175. PMCID: PMC5299598
  5. Zhou S, Wang H, Wang QK, Wang P, Wang F, Xu C. Loss of heterozygosity detected at
    three short tandem repeat locus commonly used for human DNA identification in a
    case of paternity testing. Legal medicine (Tokyo, Japan). 2017; 24:7-11. PMID: 28081793
  6. Zhang T, Yao Y, Wang J, Li Y, He P, Pasupuleti V, Hu Z, Jia X, Song Q, Tian XL,
    Hu C, Chen Q, Wang QK. Haploinsufficiency of Klippel-Trenaunay syndrome gene
    Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K
    and AKT and disrupts vascular integrity by activating VE-cadherin. Human
    molecular genetics. 2016; 25(23):5094-5110. PMID: 27522498
  7. Ye J, Yao Y, Song Q, Li S, Hu Z, Yu Y, Hu C, Da X, Li H, Chen Q, Wang QK.
    Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by
    targeting p21 expression. Scientific reports. 2016; 6:34034. PMCID: PMC5048429
  8. Luo C, Wang F, Qin S, Chen Q, Wang QK. Coronary artery disease susceptibility
    gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by
    global gene expression regulation. Physiological genomics. 2016; 48(8):554-64.
    PubMed [journal] PMID: 27235449, PMCID: PMC5005456
  9. Lu Q, Yao Y, Hu Z, Hu C, Song Q, Ye J, Xu C, Wang AZ, Chen Q, Wang QK. Angiogenic
    Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic
    Angiogenesis for Heart Disease. PLoS biology. 2016; 14(8):e1002529. PMCID: PMC4981375
  10. Ke T, Han M, Zhao M, Wang QK, Zhang H, Zhao Y, Ruan X, Li H, Xu C, Sun T.
    Alpha-actin-2 mutations in Chinese patients with a non-syndromatic thoracic
    aortic aneurysm. BMC medical genetics. 2016; 17(1):45. PMCID: PMC4950238
  11. Huang Y, Wang Z, Liu Y, Xiong H, Zhao Y, Wu L, Yuan C, Wang L, Hou Y, Yu G, Huang
    Z, Xu C, Chen Q, Wang QK. αB-Crystallin Interacts with Nav1.5 and Regulates
    Ubiquitination and Internalization of Cell Surface Nav1.5. The Journal of
    biological chemistry. 2016; 291(21):11030-41. PMCID: PMC4900253
  12. Fan Q, Nie S, Li S, Liao Y, Zhang H, Zha L, Wang F, Tang T, Xia N, Xu C, Wang P,
    Xie T, Xie J, Lu Q, Li Q, Qian J, Li B, Wu G, Wu Y, Yang Y, Wang QK, Tu X, Cheng
    X. Analysis of the genetic association between IL27 variants and coronary artery
    disease in a Chinese Han population. Scientific reports. 2016; 6:25782. PMCID: PMC4865940
  13. Zhang KK, Xiang M, Zhou L, Liu J, Curry N, Heine Suñer D, Garcia-Pavia P, Zhang
    X, Wang Q, Xie L. Gene network and familial analyses uncover a gene network
    involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial
    septation. Human molecular genetics. 2016; 25(6):1140-51. PMCID: PMC4764195
  14. Chen S, Wang X, Wang J, Zhao Y, Wang D, Tan C, Fa J, Zhang R, Wang F, Xu C, Huang
    Y, Li S, Yin D, Xiong X, Li X, Chen Q, Tu X, Yang Y, Xia Y, Xu C, Wang QK.
    Genomic variant in CAV1 increases susceptibility to coronary artery disease and
    myocardial infarction. Atherosclerosis. 2016; 246:148-56. NIHMSID: NIHMS752498 PMCID: PMC4764411
  15. Zhou J, Wang L, Zuo M, Wang X, Ahmed AS, Chen Q, Wang QK. Cardiac sodium channel
    regulator MOG1 regulates cardiac morphogenesis and rhythm. Scientific reports.
    2016; 6:21538. PMCID: PMC4763225
  16. Wang C, Wu M, Qian J, Li B, Tu X, Xu C, Li S, Chen S, Zhao Y, Huang Y, Shi L,
    Cheng X, Liao Y, Chen Q, Xia Y, Yao W, Wu G, Cheng M, Wang QK. Identification of
    rare variants in TNNI3 with atrial fibrillation in a Chinese GeneID population.
    Molecular genetics and genomics : MGG. 2016; 291(1):79-92. NIHMSID: NIHMS707859 PMCID: PMC4713376
  17. Zhao Y, Sun Q, Zeng Z, Li Q, Zhou S, Zhou M, Xue Y, Cheng X, Xia Y, Wang Q, Tu X.
    Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b
    transcript expression and increases sodium current in myocardial cells. BMC
    cardiovascular disorders. 2016; 16:1. PMCID:
    PMC4700781
  18. Zhao Y, Liu M, Wang X, Chen S, Zhou M, Li Q, Li S, Huang Y, Zhao L, Wang Q, Tu X.
    Elevated serum chloride is an independent risk factor for coronary heart disease:
    A retrospective study of more than 13,000 Han Chinese. International journal of
    cardiology. 2015; 198:61-2. PMID: 26151716
  19. Zhao Y, Huang Y, Li W, Wang Z, Zhan S, Zhou M, Yao Y, Zeng Z, Hou Y, Chen Q, Tu
    X, Wang QK, Huang Z. Post-transcriptional regulation of cardiac sodium channel
    gene SCN5A expression and function by miR-192-5p. Biochimica et biophysica acta.
    2015; 1852(10 Pt A):2024-34. NIHMSID: NIHMS758814 PMCID: PMC4757900
  20. Huang Y, Wang C, Yao Y, Zuo X, Chen S, Xu C, Zhang H, Lu Q, Chang L, Wang F, Wang
    P, Zhang R, Hu Z, Song Q, Yang X, Li C, Li S, Zhao Y, Yang Q, Yin D, Wang X, Si
    W, Li X, Xiong X, Wang D, Huang Y, Luo C, Li J, Wang J, Chen J, Wang L, Wang L,
    Han M, Ye J, Chen F, Liu J, Liu Y, Wu G, Yang B, Cheng X, Liao Y, Wu Y, Ke T,
    Chen Q, Tu X, Elston R, Rao S, Yang Y, Xia Y, Wang QK. Molecular Basis of
    Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS
    Gene-Gene Interaction Involved in Atrial Fibrillation. PLoS genetics. 2015;
    11(8):e1005393. PMCID: PMC4534423
  21. Liu H, Liu W, Lin Y, Liu T, Ma Z, Li M, Zhang HM, Kenneth Wang Q, Guo AY. Scoring
    the correlation of genes by their shared properties using OScal, an improved
    overlap quantification model. Scientific reports. 2015; 5:10583. PMCID: PMC4445036
  22. Chen S, Wang C, Wang X, Xu C, Wu M, Wang P, Tu X, Wang QK. Significant
    Association Between CAV1 Variant rs3807989 on 7p31 and Atrial Fibrillation in a
    Chinese Han Population. Journal of the American Heart Association. 2015; 4(5). PMCID: PMC4599427
  23. Xia N, Jiao J, Tang TT, Lv BJ, Lu YZ, Wang KJ, Zhu ZF, Mao XB, Nie SF, Wang Q, Tu
    X, Xiao H, Liao YH, Shi GP, Cheng X. Activated regulatory T-cells attenuate
    myocardial ischaemia/reperfusion injury through a CD39-dependent mechanism.
    Clinical science (London, England : 1979). 2015; 128(10):679-93. PMID: 25558978
  24. He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J,
    Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC,
    Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu
    Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M,
    Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y,
    Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang
    L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M,
    Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z,
    Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L.
    Meta-analysis of genome-wide association studies of adult height in East Asians
    identifies 17 novel loci. Human molecular genetics. 2015; 24(6):1791-800. PMCID: PMC4351379
  25. Zhang X, Bogunovic D, Payelle-Brogard B, Francois-Newton V, Speer SD, Yuan C,
    Volpi S, Li Z, Sanal O, Mansouri D, Tezcan I, Rice GI, Chen C, Mansouri N,
    Mahdaviani SA, Itan Y, Boisson B, Okada S, Zeng L, Wang X, Jiang H, Liu W, Han T,
    Liu D, Ma T, Wang B, Liu M, Liu JY, Wang QK, Yalnizoglu D, Radoshevich L, Uzé G,
    Gros P, Rozenberg F, Zhang SY, Jouanguy E, Bustamante J, García-Sastre A, Abel L,
    Lebon P, Notarangelo LD, Crow YJ, Boisson-Dupuis S, Casanova JL, Pellegrini S.
    Human intracellular ISG15 prevents interferon-α/β over-amplification and
    auto-inflammation. Nature. 2015; 517(7532):89-93. NIHMSID: NIHMS653880 PMCID: PMC4303590
  26. Wang P, Xu C, Wang C, Wu Y, Wang D, Chen S, Zhao Y, Wang X, Li S, Yang Q, Zeng Q,
    Tu X, Liao Y, Wang QK, Cheng X. Association of SNP Rs9943582 in APLNR with Left
    Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a
    Chinese Han GeneID Population. PloS one. 2015; 10(5):e0125926. PMCID: PMC4438007
  27. Chen FF, Xia YL, Xu CQ, Li SS, Zhao YY, Wang XJ, Chen SS, Gao LJ, Zhong Y, Tu X,
    Wang Q, Yang YZ. Common variant rs7597774 in ADD2 is associated with dilated
    cardiomyopathy in Chinese Han population. International journal of clinical and
    experimental medicine. 2015; 8(1):1188-96. PMCID: PMC4358567
  28. Xu C, Yang Q, Xiong H, Wang L, Cai J, Wang F, Li S, Chen J, Wang C, Wang D, Xiong
    X, Wang P, Zhao Y, Wang X, Huang Y, Chen S, Yin D, Li X, Liu Y, Liu J, Wang J, Li
    H, Ke T, Ren X, Wu Y, Wu G, Wan J, Zhang R, Wu T, Wang J, Xia Y, Yang Y, Cheng X,
    Liao Y, Chen Q, Zhou Y, He Q, Tu X, Wang QK. Candidate pathway-based genome-wide
    association studies identify novel associations of genomic variants in the
    complement system associated with coronary artery disease. Circulation.
    Cardiovascular genetics. 2014; 7(6):887-94. NIHMSID: NIHMS633495 PMCID: PMC4270888
  29. Zhou SF, Yuan J, Liao MY, Xia N, Tang TT, Li JJ, Jiao J, Dong WY, Nie SF, Zhu ZF,
    Zhang WC, Lv BJ, Xiao H, Wang Q, Tu X, Liao YH, Shi GP, Cheng X. IL-17A promotes
    ventricular remodeling after myocardial infarction. Journal of molecular medicine
    (Berlin, Germany). 2014; 92(10):1105-16. PMID: 24965614
  30. Shen GQ, Girelli D, Li L, Rao S, Archacki S, Olivieri O, Martinelli N, Park JE,
    Chen Q, Topol EJ, Wang QK. A novel molecular diagnostic marker for familial and
    early-onset coronary artery disease and myocardial infarction in the LRP8 gene.
    Circulation. Cardiovascular genetics. 2014; 7(4):514-20. NIHMSID: NIHMS600241 PMCID: PMC4140990
  31. Xu Y, Zhou M, Wang J, Zhao Y, Li S, Zhou B, Su Z, Xu C, Xia Y, Qian H, Tu X, Xiao
    W, Chen X, Chen Q, Wang QK. Role of microRNA-27a in down-regulation of angiogenic
    factor AGGF1 under hypoxia associated with high-grade bladder urothelial
    carcinoma. Biochimica et biophysica acta. 2014; 1842(5):712-25. PMID: 24462738
  32. Xiong X, Xu C, Zhang Y, Li X, Wang B, Wang F, Yang Q, Wang D, Wang X, Li S, Chen
    S, Zhao Y, Yin D, Huang Y, Zhu X, Wang L, Wang L, Chang L, Xu C, Li H, Ke T, Ren
    X, Wu Y, Zhang R, Wu T, Xia Y, Yang Y, Ma X, Tu X, Wang QK. BRG1 variant
    rs1122608 on chromosome 19p13.2 confers protection against stroke and regulates
    expression of pre-mRNA-splicing factor SFRS3. Human genetics. 2014;
    133(5):499-508. NIHMSID: NIHMS560974 PMCID:
    PMC3988217
  33. Su Z, Si W, Li L, Zhou B, Li X, Xu Y, Xu C, Jia H, Wang QK. MiR-144 regulates
    hematopoiesis and vascular development by targeting meis1 during zebrafish
    development. The international journal of biochemistry & cell biology. 2014;
    49:53-63. PMID: 24448023
  34. Bai Y, Nie S, Jiang G, Zhou Y, Zhou M, Zhao Y, Li S, Wang F, Lv Q, Huang Y, Yang
    Q, Li Q, Li Y, Xia Y, Liu Y, Liu J, Qian J, Li B, Wu G, Wu Y, Wang B, Cheng X,
    Yang Y, Ke T, Li H, Ren X, Ma X, Liao Y, Xu C, Tu X, Wang QK. Regulation of CARD8
    expression by ANRIL and association of CARD8 single nucleotide polymorphism
    rs2043211 (p.C10X) with ischemic stroke. Stroke. 2014; 45(2):383-8. NIHMSID:
    NIHMS559913 PMCID: PMC39626865.
  35. Li L, Chen D, Li J, Wang X, Wang N, Xu C, Wang QK. Aggf1 acts at the top of the
    genetic regulatory hierarchy in specification of hemangioblasts in zebrafish.
    Blood. 2014; 123(4):501-8. PMCID: PMC3901065
  36. Gao H, Li L, Rao S, Shen G, Xi Q, Chen S, Zhang Z, Wang K, Ellis SG, Chen Q,
    Topol EJ, Wang QK. Genome-wide linkage scan identifies two novel genetic loci for
    coronary artery disease: in GeneQuest families. PloS one. 2014; 9(12):e113935. PMCID: PMC4259362
  37. Li X, Huang Y, Yin D, Wang D, Xu C, Wang F, Yang Q, Wang X, Li S, Chen S, Xiong
    X, Huang Y, Zhao Y, Wang L, Zhu X, Su Z, Zhou B, Zhang Y, Wang L, Chang L, Xu C,
    Li H, Ke T, Ren X, Cheng X, Yang Y, Liao Y, Tu X, Wang QK. Meta-analysis
    identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41
    and coronary artery disease. Atherosclerosis. 2013; 231(1):136-40. PMID: 24125424
  38. Tu X, Nie S, Liao Y, Zhang H, Fan Q, Xu C, Bai Y, Wang F, Ren X, Tang T, Xia N,
    Li S, Huang Y, Liu J, Yang Q, Zhao Y, Lv Q, Li Q, Li Y, Xia Y, Qian J, Li B, Wu
    G, Wu Y, Yang Y, Wang QK, Cheng X. The IL-33-ST2L pathway is associated with
    coronary artery disease in a Chinese Han population. American journal of human
    genetics. 2013; 93(4):652-60. PMCID: PMC3791271
  39. Zhang C, Li D, Zhang J, Chen X, Huang M, Archacki S, Tian Y, Ren W, Mei A, Zhang
    Q, Fang M, Su Z, Yin Y, Liu D, Chen Y, Cui X, Li C, Yang H, Wang Q, Wang J, Liu
    M, Deng Y. Mutations in ABCB6 cause dyschromatosis universalis hereditaria. The
    Journal of investigative dermatology. 2013; 133(9):2221-8. PMID: 23519333
  40. Zhou B, Ma R, Si W, Li S, Xu Y, Tu X, Wang Q. MicroRNA-503 targets FGF2 and VEGFA
    and inhibits tumor angiogenesis and growth. Cancer letters. 2013; 333(2):159-69. PMID: 23352645
  41. Shen GQ, Girelli D, Li L, Olivieri O, Martinelli N, Chen Q, Topol EJ, Wang QK.
    Multi-allelic haplotype association identifies novel information different from
    single-SNP analysis: a new protective haplotype in the LRP8 gene is against
    familial and early-onset CAD and MI. Gene. 2013; 521(1):78-81. NIHMSID:
    NIHMS537725 PMCID: PMC3919654
  42. Chakrabarti S, Wu X, Yang Z, Wu L, Yong SL, Zhang C, Hu K, Wang QK, Chen Q. MOG1
    rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick
    sinus syndrome. Circulation. Arrhythmia and electrophysiology. 2013;
    6(2):392-401. NIHMSID: NIHMS443434 PMCID:
    PMC3633223
  43. Zhou B, Si W, Su Z, Deng W, Tu X, Wang Q. Transcriptional activation of the Prox1
    gene by HIF-1α and HIF-2α in response to hypoxia. FEBS letters. 2013;
    587(6):724-31. PMID: 23395615
  44. Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S,
    Vaccarino VL, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee
    H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, El Mokhtari NE,
    Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Whittaker
    JC, Tang WH, Johnson JA, Wang QK, Assimes TL, Nöthlings U, Farrall M, Watkins H,
    Richards AM, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen
    WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ,
    Ye S. Association between the chromosome 9p21 locus and angiographic coronary
    artery disease burden: a collaborative meta-analysis. Journal of the American
    College of Cardiology. 2013; 61(9):957-70. NIHMSID: NIHMS451694 PMCID: PMC3653306
  45. Chen D, Li L, Tu X, Yin Z, Wang Q. Functional characterization of
    Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling
    pathway for specification of vein differentiation and angiogenesis during
    embryogenesis. Human molecular genetics. 2013; 22(5):963-76. PMID: 23197652
  46. Wang Q, Liu F, Xing Y, Wei X, Li H, Zhang S, Liu J, Wang Q, Tang Z, Liu M.
    Mutation c.359_363delGTATTinsATAC in the COL4A5 causes Alport syndrome in a
    Chinese family. Gene. 2013; 512(2):482-5. PMID: 23085274
  47. Zang X, Zhang S, Xia Y, Li S, Fu F, Li X, Wang F, Zhang R, Tian X, Gao L, Zhang
    J, Yang Y, Tu X, Wang Q. SNP rs3825214 in TBX5 is associated with lone atrial
    fibrillation in Chinese Han population. PloS one. 2013; 8(5):e64966. PMCID: PMC3663751
  48. Liu Y, Wang DK, Jiang DZ, Qin X, Xie ZD, Wang QK, Liu M, Chen LM. Cloning and
    functional characterization of novel variants and tissue-specific expression of
    alternative amino and carboxyl termini of products of slc4a10. PloS one. 2013;
    8(2):e55974. PMCID: PMC3567025
  49. Timur AA, Murugesan G, Zhang L, Aung PP, Barnard J, Wang QK, Gaussem P,
    Silverstein RL, Bhatt DL, Kottke-Marchant K. P2RY1 and P2RY12 polymorphisms and
    on-aspirin platelet reactivity in patients with coronary artery disease.
    International journal of laboratory hematology. 2012; 34(5):473-83. NIHMSID:
    NIHMS365621 PMCID: PMC3419334
  50. Shen GQ, Li L, Wang QK. Genetic variant R952Q in LRP8 is associated with
    increased plasma triglyceride levels in patients with early-onset CAD and MI.
    Annals of human genetics. 2012; 76(3):193-9. PMID: 22404453
  51. Archacki SR, Angheloiu G, Moravec CS, Liu H, Topol EJ, Wang QK. Comparative gene
    expression analysis between coronary arteries and internal mammary arteries
    identifies a role for the TES gene in endothelial cell functions relevant to
    coronary artery disease. Human molecular genetics. 2012; 21(6):1364-73. PMID: 22156939
  52. Wang C, Li Y, Shi L, Ren J, Patti M, Wang T, de Oliveira JR, Sobrido MJ, Quintáns
    B, Baquero M, Cui X, Zhang XY, Wang L, Xu H, Wang J, Yao J, Dai X, Liu J, Zhang
    L, Ma H, Gao Y, Ma X, Feng S, Liu M, Wang QK, Forster IC, Zhang X, Liu JY.
    Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with
    phosphate homeostasis. Nature genetics. 2012; 44(3):254-6. PMID: 22327515
  53. Lu Q, Yao Y, Yao Y, Liu S, Huang Y, Lu S, Bai Y, Zhou B, Xu Y, Li L, Wang N, Wang
    L, Zhang J, Cheng X, Qin G, Ma W, Xu C, Tu X, Wang Q. Angiogenic factor AGGF1
    promotes therapeutic angiogenesis in a mouse limb ischemia model. PloS one. 2012;
    7(10):e46998. PMCID: PMC3479102
  54. Cui X, Zeng F, Liu Y, Zhang J, Archacki S, Zhan T, Du R, Tang Z, Liu J, Wang QK,
    Liu M. A novel SCN1A missense mutation causes generalized epilepsy with febrile
    seizures plus in a Chinese family. Neuroscience letters. 2011; 503(1):27-30. PMID: 21843600
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