Molecular Medicine Faculty

  • Derek Abbott, M.D., Ph.D., CWRU, Pathology, signaling pathways responsible for NOD2-induced Crohn's Disease.
  • Jay Alberts, Ph.D., Biomedical Engineering, neural aspects of movement control and upper extremity function.
  • Micheala Aldred, Ph.D., Genomic Medicine Institute, chromosome deletions in development and cancer.
  • Alex Almasan, Ph.D., Cancer Biology, DNA damage responses, radiation-regulated genes, cell cycle control, and apoptosis.
  • Bela Anand-Apte, M.D., Ph.D., Ophthalmic Research, diabetic retinopathy and age-related macular degeneration.
  • Suneel Apte, M.B.B.S., D.Phil., Biomedical Engineering, extracellular matrix remodeling by metalloproteinases.
  • Mark Aronica, M.D., Medicine, synthesis and turnover of extracellular matrix in asthma.
  • William Baldwin, M.D., Ph.D., Immunology, cardiac and renal allograft rejection, vascular inflammation.
  • John Barnard, Ph.D., Quantitative Health Sciences, statistical genetics, missing data problems, Bayesian statistics, bioinformatics and statistical computing.
  • Gerald Beck, Ph.D., Quantitative Health Sciences, data coordination for clinical trials (hemodialysis and dialysis access consortium).
  • Cornelia Bergmann, Ph.D., Neurosciences, regulation of and function of CD8 T cells during viral infections of the central nervous system (CNS) associated with demyelination.
  • Kathleen Berkner, Ph.D., Molecular Cardiology, carboxylation of vitamin K- dependent proteins.
  • Henry Boom, M.D., CWRU, Medicine, heterogeneity of T-cells in M. tuberculosis infection.
  • Jonathan Mark Brown, Ph.D., Cellular and Molecular Medicine, interrelationship between lipid metabolism and the development of chronic diseases such as obesity, diabetes, and atherosclerosis.
  • Matthias Buck, Ph.D., CWRU, Physiology and Biophysics, molecular biophysics of small GTPase-protein interactions in neuronal cell signaling.
  • Tatiana Byzova, Ph.D., Molecular Cardiology, cell adhesion molecules/integrins in thrombosis, vascular biology and cancer.
  • Shu Chen, Ph.D., CWRU, Pathology, LRRK2: pathway to parkinson disease.
  • Xi Chen, Ph.D., Quantitative Health Sciences, high-throughput genomic data analysis, pharmacogenomics, genetic epidemiology and correlated data analysis.
  • Jianguo Cheng, M.D., Ph.D., Anesthesiology Research, interventional pain management and spinal cord stimulation.
  • Peter Cohen, M.D., Surgery Research, immunotherapy
  • John Crabb, Ph.D., Ophthalmic Research, biochemistry of vision in proteome changes associated with retinal degenerative diseases and the mammalian visual cycle.
  • Margot Damaser, Ph.D., Biomedical Engineering, soft-tissue biomechanics, incontinence and nerve regeneration.
  • Carol de la Motte, Ph.D., Pathobiology, role of extracellular matrix to inflammatory cell recruitment and activation involved in diseases of the intestine and lung.
  • Kathleen Derwin, Ph.D., Biomedical Engineering, tendon mechanobiology and tissue engineering.
  • Lax Devireddy, D.V.M., Ph.D., CWRU, Pathology, regulation of cell death, innate immunity, tumor microenvironment, intracellular iron transport.
  • Paul DiCorleto, Ph.D., Cell Biology, Chair of Molecular Medicine, growth factors and atherosclerosis.
  • Donna Driscoll, Ph.D., Cell Biology, posttranscriptional regulation of gene expression, RNA structure and function.
  • Raed Dweik, M.D., Pathobiology, asthma, pulmonary hypertension.
  • Thomas Egelhoff, Ph.D., Cell Biology, mechanisms regulating cytoskeletal function during cell migration and cytokinesis.
  • Paul Elson, Sc.D., Quantitative Health Sciences, group-sequential methods and clinical trials.
  • Charis Eng, M.D., Ph.D., Genomic Medicine Institute, human cancer genomics, personalized medicine.
  • Serpil Erzurum, M.D., Pathobiology, airway inflammation, reactive oxygen and nitrogen species.
  • Rob Fairchild, Ph.D., Immunology, skin and cardiac allograft rejection, peripheral T lymphocyte recruitment.
  • Jim Finke, Ph.D., Immunology, tumor immunity, T lymphocytes, signal transduction.
  • Claudio Fiocchi, M.D., Pathobiology, pathogenesis of inflammatory bowel disease and animal models of IBD.
  • Elizabeth Fisher, Ph.D., Biomedical Engineering, image analysis for monitoring of multiple sclerosis.
  • Aaron Fleischman, Ph.D., Biomedical Engineering, development of microelectromechanical systems (MEMS) technology for biomedical applications.
  • Paul Fox, Ph.D., Cell Biology, RNA structure and regulation of translation.
  • Kiyotaka Fukamachi, M.D., Ph.D., Biomedical Engineering, development of surgical devices for heart failure treatment.
  • Brian Gastman, M.D., Immunology, cancers actively induce suppressor cells as part of immune evasion.
  • Candece Gladson, M.D., Cancer Biology, malignant glioma and glioblastoma tumors.
  • Leonard Golding, M.D., Biomedical Engineering, devices for cardiac support and stabilization in heart failure.
  • Linda Graham, M.D., Biomedical Engineering, healing of prosthetic vascular grafts.
  • Neetu Gupta, Ph.D., Immunology, plasma membrane and actin cytoskeletal dynamics during B cell activation.
  • Stephanie Hagstrom, Ph.D., Ophthalmic Research, macular degeneration, retiniti's pigmentosa, and genetics of inherited retinal degeneration.
  • Dolores Hambardzumyan, Ph.D., Stem Cell Biology, mechanism by which the unique brain microenvironment modulates the development and progression of primary and metastatic brain tumors.
  • Thomas Hamilton, Ph.D., Immunology, inflammatory gene expression in mononuclear phagocytes.
  • Cliff Harding, M.D., Ph.D., CWRU, Pathology, antigen presentation and processing, Toll-like receptors.
  • Vincent Hascall, Ph.D., Biomedical Engineering, structure, function and metabolism of Proteoglycans and Hyaluronan in connective tissues.
  • Maria Hatzoglou, Ph.D., CWRU, Nutrition, regulation of gene expression by nutrient availability.
  • Stanley Hazen, M.D., Ph.D., Cell Biology, leukocyte peroxidases; nitric oxide, reactive oxygen species, inflammation, atherosclerosis.
  • Joe Hollyfield, Ph.D., Ophthalmic Research, study of the structure, development, and function of the eye and visual system in health and disease.
  • Jane Hoover-Plow, Ph.D., Cardiovascular Medicine, plasminogen dependent cell migration in inflammation, genetic determinants of thrombosis.
  • Arie Horowitz, D.Sc., Molecular Cardiology, endothelial cell signaling and motility in angiogenesis.
  • Janet Houghton, Ph.D., Cancer Biology, developmental therapeutics, death receptor signaling and therapeutic response.
  • Bo Hu, Ph.D., Quantitative Health Sciences, model selection, longitudinal analysis, adaptive design, Bayesian modeling and computing.
  • Peter Imrey, Ph.D., Quantitative Health Sciences, categorical data analysis, statistical methods in observational epidemiology, and sample survey methods.
  • Damir Janigro, Ph.D., Neurological Surgery, blood brain barrier, multiple drug resistance, molecular/proteomic analysis of neurological disorders.
  • Jan Jensen, Ph.D., Stem Cell Biology & Regenerative Medicine, developmental biology of the pancreas with a focus on the molecular mechanisms controlling insulin-cell development.
  • Trine Jorgensen, Ph.D., Immunology, molecular mechanisms of gender differences in lupus-like disease.
  • James Kaltenbach, Ph.D., Neurosciences, role of neural plasticity in the etiology of hearing disorders.
  • Jonathan Karn, Ph.D., CWRU, Molecular Biology and Microbiology.
  • Sadashiva Karnik, Ph.D., Molecular Cardiology, molecular and cellular mechanisms of angiotensin receptor II function and signal transduction.
  • Michael Kattan, Ph.D., Quantitative Health Sciences, development, validation, and use of prediction models. 
  • David Katz, Ph.D., CWRU, Neurosciences, define regulatory interactions in the developing nervous system and to understand how perturbations of development result in disease.
  • James Kazura, M.D. CWRU Global Health and Diseases, mechanisms underlying susceptibility to infection andthe pathogenesis of disease due to malaria and chronic worm infections.
  • Christopher King, M.D., Ph.D., CWRU Global Health and Diseases, Schistosomiasis, filariasis, malaria, immunoparasitology, immunologic response to prenatal parasite exposure, and vaccine development.
  • John Kirwan, Ph.D., Pathobiology, systems integrated physiology.
  • Hitoshi Komuro, Ph.D., Neurosciences, neuronal cytoarchitecture and synapse function.
  • Qinzhong Kong, Ph.D., CWRU, Pathology, assessing the transmissibility of CWD to humans.
  • Diane Kunze, Ph.D., Metro, Research & Neuroscience, ion channels in the neural regulation of cardiovascular and respiratory function.
  • Vinod Labhasetwar, Ph.D., Biomedical Engineering, nuclear-targeted nano-particles for gene delivery.
  • Andrea Ladd, Ph.D., Cell Biology, regulation of RNA splicing, cardiac development.
  • Bruce Lamb, Ph.D., Neurosciences, molecular basis of Alzheimer's disease using transgenic mouse models.
  • Justin Lathia, Ph.D., Cellular and Molecular Medicine, using in vivo imaging models to interrogate the tumor microenvironment and examining communication mechanisms used by cancer stem cell to promote their maintenance
  • Michael Lederman, M.D., CWRU, Director, Center for AIDS Research (CFAR).
  • Zhenghong Lee, Ph.D., CWRU, Radiology, PET imaging of cancer.
  • Veronique Lefebvre, Ph.D., Cell Biology, transcription factor control of cell fate and differentiation.
  • Liang Li, Ph.D., Quantitative Health Sciences, longitudinal and survival analysis, measurement error models, and genetic epidemiology.
  • Xiaoxia Li, Ph.D., Immunology, signal transduction in innate and adaptive immunity.
  • Zong-Ming Li, Ph.D., Biomedical Engineering, orthopaedic biomechanics and rehabilitation research of the hand and upper extremity.
  • Daniel Lindner, M.D., Ph.D., Taussig Cancer Center, regulation of apoptosis by nitrosylcobalamin and interferon in malignancies.
  • Michelle Longworth, Ph.D., Molecular Genetics, how chromatin is organized within the nucleus of a cell and the impact that this has on cellular processes including transcription.
  • Lina Lu, M.D., Immunology, prevention of hemophilia A inhibitors by administration of tolerogenic dendritic cells.
  • Donal Luse, Ph.D., Molecular Genetics, mechanism of transcript initiation and elongation by RNA polymerase II.
  • Jaroslaw Maciejewski, M.D., Ph.D., Taussig Cancer Center, bone marrow failure syndromes.
  • Danny Manor, Ph.D., CWRU, Nutrition, signal transduction pathways that regulate cell growth.
  • Sanford Markowitz, M.D., Ph.D., Medicine/Cancer Genetics, genetic mutations in human gastrointestinal cancers.
  • Edward Mascha, Ph.D., Quantitative Health Sciences, clinical trials, causal effects, reliability studies, longitudinal data analyses, and correlated data problems.
  • Edward Maytin, M.D., Ph.D., Dermatology/Biomedical Engineering, dermatology research.
  • Keith McCrae, M.D., Cellular and Molecular Medicine, several projects relevant to vascular fuinction¬†in health and disease.
  • Christine McDonald, Pathobiology, Nod2 signaling in inflammatory bowel disease.
  • Jocelyn McDonald, Ph.D. , Molecular Genetics, mechanisms regulating cellular movement within the three-dimensional environment of tissues during development and disease.
  • Thomas McIntyre, Ph.D., Cell Biology, inflammation, signaling and lipid mediators.
  • Ronald Midura, Ph.D., Biomedical Engineering, regulation of primary bone formation, connective tissue biology.
  • Booki Min, Ph.D., Immunology, T cell homeostasis, memory T cells.
  • Saurav Misra, Ph.D., Molecular Cardiology, structural biology of ubiquitin signaling and intracellular trafficking.
  • Rocio Moran, M.D., Genomic Medicine Institute, inborn errors of metabolism and cardiovascular genetics.
  • Richard Morton, Ph.D., Cell Biology, lipid and lipoprotein metabolism.
  • Laura Nagy, Ph.D., Pathobiology, regulation of G-protein mediated signal transduction ethanol.
  • Imad Najm, M.D., Epilepsy Center, xploring the topic of mechanisms of epilepsy and malformations of cortical dysplasia.
  • Marvin Natowicz, M.D., Ph.D., Genomic Medicine Institute, clinical chemistry of inherited metabolic disorders.
  • Noa Noy, Ph.D. Pharmacology CWRU, Various lipid-soluble nutrients and hormones, such as vitamin A, vitamin D, and long chain fatty acids regulate cellular behavior by modulating gene transcription.
  • Nancy Obuchowski, Ph.D., Quantitative Health Sciences, design and analysis of studies of screening and diagnostic tests.
  • Richard Padgett, Ph.D., Molecular Genetics, mechanisms of RNA splicing in vivo and in vitro.
  • Paul Park, Ph.D., CWRU, Ophthalmology, mechanism of action of rhodopsin and other G protein-coupled receptors.
  • Neal Peachey, Ph.D., Ophthalmic Research, hereditary retinal disease.
  • Dianne Perez, Ph.D., Molecular Cardiology, structure-function and physiological studies of adrenergic receptors.
  • Brian Perkins, Ph.D., Ophthalmic Research, determine how the basal body localizes and is maintained at the correct position on the apical surface of photoreceptors
  • Sanjay Pimplikar, Ph.D., Neurosciences, cell biology of alzheimer’s disease.
  • Gregory Plautz, M.D., Pediatric Hematology & Oncology, dendritic cell-brain tumor stem cell fusion vaccines.
  • Ed Plow, Ph.D., Molecular Cardiology, cell adhesion and migration, integrins, platelets, plasminogen.
  • Eugene Podrez, Ph.D., Molecular Cardiology, cholesterol and lipid uptake and signaling in atherosclerosis.
  • Sathyamangla Prasad, Ph.D., Molecular Cardiology, regulation of G-protein coupled receptor (GPCR) signaling.
  • Shiguang Qian, Ph.D., Immunology, mechanistic insights into liver transplant tolerance, effect of antagonism of chemokines on allograft rejection.
  • Jun Qin, Ph.D., Molecular Cardiology, structural biology and biochemistry of integrin signal transduction.
  • Parameswaran Ramakrishnan M.S., Ph.D., signal transduction in immunity, metabolism and cancer using cellular and molecular approaches and animal models with the aim of identifying fundamental mechanisms leading to development and evaluation of therapeutic targets.
  • Richard Ransohoff, M.D., Neurosciences, multiple sclerosis and chemokine expression in central nervous system inflammation.
  • Ofer Reizes, Ph.D., Cell Biology, obesity, adipose tissue development and maintenance.
  • Jeremy Rich, M.D., Stem Cell Biology, brain tumors, malignant gliomas and medulloblastomas.
  • Steven Rosenfeld, M.D., Ph.D., Cancer Biology, the role of molecular motors in driving the malignant phenotype of glioblastoma.
  • Brian Rubin, M.D., Ph.D., Molecular Genetics, bone and soft tissue pathology, cancer genetics, targeted cancer therapies.
  • Kurt Runge, Ph.D., Molecular Genetics, yeast telomeres: length regulation and roles in chromosome stability.
  • Takuya Sakaguchi, Ph.D., Stem Cell Biology, paracrine signaling betweeen endothelial cells and target tissue cells in the embryo and in adult organs.
  • Yogen Saunthararajah, M.D., Hematology and Oncology, myelodysplastic syndrome, acute myeloid leukemia, sickle cell disease, thalassemia.
  • Peter Scacheri, Ph.D., CWRU, Genetics and Genome Sciences, the role of epigenetics and the histone code in human health and disease.
  • William Schiemann, Ph.D., CWRU, Oncology, the process of mammary tumorigenesis and its assortment of associated genetic and epigenetic events.
  • Ganes Sen, Ph.D., Molecular Genetics, host responses to virus infection.
  • David Serre, Ph.D., Genomic Medicine Institute, genetic basis of Type 2 Diabetes and obesity and their origins.
  • Robert Silverman, Ph.D., Cancer Biology, innate defense against viruses and cancer.
  • Neena Singh, M.D., Ph.D., CWRU, Pathology, the pathophysiology underlying human Prion disorders.
  • Jonathan Smith, Ph.D., Cell Biology, lipoprotein metabolism, cholesterol trafficking, genetics of atherosclerosis.
  • William Smith, D.Eng., Biomedical Engineering, engineering pumps and devices for cardiac assist treatment, engineering of artificial hearts.
  • George Stark, Ph.D., Molecular Genetics, signal transduction pathways involving interferons, STATs, NFKB, p53 and TGF ß, methods for forward genetics in mammalian cells.
  • Susan Staugaitis, M.D., Ph.D., Neurosciences, properties of glial cells and glial brain tumors.
  • Olga Stenina, Ph.D., Molecular Cardiology, regulation of vascular gene expression by glucose, functions of thrombospondin-4.
  • Stephen Stohlman, Ph.D., Neurosciences, interactions of the immune system and CNS in models of MS.
  • Dennis Stuehr, Ph.D., Pathobiology, structure and biochemistry of nitric oxide synthases.
  • Hisashi Tanaka, M.D., Ph.D., Molecular Genetics, genetic and genomic factors regulating the evolution of cancer genomes.
  • Wai Hong Wilson Tang, M.D., Cellular and Molecular Medicine, myeloperoxidase, ceruloplasmin, and dysregulated arginine metabolites, and cardiotonic steroids as mediators of nitrative stress in human heart failure, correlating physiologic alterations with metabolites and proteins measured by mass spectroscopy techniques or immunoassays in blood samples or enzyme expression in explanted human hearts
  • Yuankai Tao, Ph.D., Ophthalmic Research, focused on the development of novel optical imaging systems by leveraging technologies in engineering and biomedical sciences to create multimodal imaging tools for the clinical diagnosis and treatment monitoring of pathologies in ophthalmology, gastroenterology, and oncology.
  • Paul Tesar, Ph.D., CWRU, Genetics, molecular mechanisms and therapeutic potential of stem cells.
  • Angela Ting, Ph.D., Genomic Medicine Institute, epigenetic gene regulation involves DNA methylation and histone modifications.
  • Bruce Trapp, Ph.D., Neurosciences, cellular and molecular biology of myelination, demyelination, and dysmyelination.
  • Pierre Triozzi, M.D., Taussig Cancer Center, medical oncology, melanoma, hematology, experimental therapeutics, and cancer vaccines.
  • Vince Tuohy, Ph.D., Immunology, immunoregulation of autoimmunity, T-cell biology and gene therapy for autoimmunity.
  • Anna Valujskikh, Ph.D., Immunology, CD4 memory T cells and allograft rejection.
  • David Van Wagoner, Ph.D., Molecular Cardiology, myocyte biology, electrophysiology, and arrhythmias.
  • Michael Vogelbaum, Ph.D., M.D., Brain Tumor and Neuro-Oncology Center, treatment of benign and malignant tumors of the brain and spinal cord.
  • Bingcheng Wang, Ph.D., CWRU Pharmacology, the roles of Eph receptor tyrosine kinases in invasive growth and distal metastasis of cancer cells.
  • Qing Wang, Ph.D., Molecular Cardiology, human genetics of heart attacks and arrhythmias.
  • Xiaofeng Wang, Ph.D., Quantitative Health Sciences, neuroinformatics, biomedical signal analysis, and statistical image analysis.
  • Scott Welford, Ph.D., Radiation Oncology, the impact of hypoxia (low oxygen) on tumor initiation and resistance to therapy.
  • Oliver Wessely, Ph.D., Cell Biology, kidney development and its perturbation during polycystic kidney disease formation.
  • Steven Wilson, M.D., Ophthalmic Research, refractive surgery -- LASIK and PRK.
  • Qingyu Wu, M.D., Ph.D., Molecular Cardiology, serine proteases of the trypsin superfamily.
  • Riqiang Yan, Ph.D., Neurosciences, molecular and functional study of Alzheimer's beta-secretase and its modulators in Alzheimer's disease.
  • Alex Yuan, M.D., Ph.D., Ophthalmology, compare the microglial cell response to laser induced injury.
  • Maceij Zborowski, Ph.D., Biomedical Engineering, development of separation technologies for medical applications.
  • Bin Zhang, Ph.D., Genomic Medicine Institute, mechanisms of protein transport from the endoplasmic reticulum (ER) to the Golgi body.
  • Lan Zhou, M.D., Ph.D., Neurology, role of TGF-B1 in duchenne muscular dystrophy.