Selva Baltan, M.D., Ph.D.

Associate Staff
Associate Professor, Molecular Medicine, CCLCM-CWRU

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Phone: (216) 444-3972
Fax: (216) 444-7927

Failure to consider white matter (WM) injury is a critical gap in the development of a successful stroke therapy. As mechanisms of WM injury differ from those in gray matter and change with age, an ideal stroke therapeutic must not only be directed towards neuronal and axonal protection across age, but also must restore function when applied after injury. My research focuses on mechanisms of brain cell damage following stroke in WM in a region-specific and age-specific manner. Experimental approaches in my lab include optic nerve and corpus callosum slice models, employing electrophysiological recordings, and advanced microscopy techniques such as confocal, two-photon microscopy and 3D electron microscopy. Our current focus is on elucidating the mechanisms of post-ischemic protection conferred by Class I HDAC inhibition in young and aging WM and the gene regulatory mechanisms underlying this protective phenomenon. Our hypothesis is that Class I HDAC activation mediates WM ischemic injury by contributing to increased oxidative stress and impairing mitochondrial structure and function. Moreover, we are investigation whether oligodendrocytes and astrocyte support axon function by providing lactate as an alternative energy substrate during ischemia.

Currently we are working on the role of protein acetylation and mitochondrial dynamics in WM stroke and expanded our interest to neurodegenerative diseases such as Multiple Sclerosis and Alzheimer ’s disease that involve WM.

Chinthasagar  Bastian MBBS, Ph.D.

Chinthasagar Bastian MBBS, Ph.D.

Research Fellow

Phone:(216) 444-9885
Fax:(216) 444-7927

Jerica  Day

Jerica Day

Research Technician

Phone:(216) 444-9885
Fax:(216) 444-7927

Andrew  McCray

Andrew McCray

Research Technician

Phone:(216) 444-9885
Fax:(216) 444-7927

Selected Publications:

1. Bastian C, Quinn J, Tripathi A, Aquila D, Dutta AMR, Baltan S, Brunet S. (2018) CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways. Neurobiol Dis. Jun 23. pii: S0969-9961(18)30149-9. PMID: 29944965

2. Bastian C, Zaleski J, Stahon K, Parr B, McCray A, Day J, Brunet S, Baltan S. (2018) NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. J Neurosci. Jun 11. pii: 3017-17. PMID: 29891729

3. Parpura V, Fisher ES, Lechleiter JD, Schousboe A, Waagepetersen HS, Brunet S, Baltan S, Verkhratsky A. (2017) Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology. Neurochem Res 42(1):19-34. PMID: 26915104; PMCID: PMC5357169

4. Hu X, Hou H, Bastian C, He W, Qiu S, Ge Y, Yin X, Kidd GJ, Brunet S, Trapp BD, Baltan S, Yan R. (2017) BACE1 regulates the proliferation and cellular functions of Schwann cells. Glia 65(5):712-726. PMID: 28191691; PMCID: PMC5357169

5. Provencio JJ, Swank V, Lu H, Brunet S, Baltan S, Khapre RV, Seerapu H, Kokiko-Cochran ON, Lamb BT, Ransohoff RM. (2016) Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors. Brain Behav Immun 54:233-42. PMID: 26872422; PMCID: PMC4828315

6. Yin X, Kidd GJ, Ohno N, Perkins GA, Ellisman MH, Bastian C, Brunet S, Baltan S, Trapp BD (2016) Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling. J Cell Biol 215(4):531-542. PMID: 27872255; PMCID: PMC5119941

7. Stahon KE, Bastian C, Griffith S, Kidd GJ, Brunet S, Baltan S. (2016) Age-Related Changes in Axonal and Mitochondrial Ultrastructure and Function in White Matter. J Neurosci 36(39):9990-10001. PMID: 27683897; PMCID: PMC5039264

8. Saab AS, Tzvetavona ID, Trevisiol A, Baltan S, Dibaj P, Kusch K, Möbius W, Goetze B, Jahn HM, Huang W, Steffens H, Schomburg ED, Pérez-Samartín A, Pérez-Cerdá F, Bakhtiari D, Matute C, Löwel S, Griesinger C, Hirrlinger J, Kirchhoff F, Nave KA. (2016) Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron 91(1):119-32. PMID: 27292539

9. Baltan S. (2016) Age-specific localization of NMDA receptors on oligodendrocytes dictates axon function recovery after ischemia. Neuropharmacology pii: S0028-3908(15)30107-6. PMID: 26407763; PMCID: PMC4808487

10. Baltan S. (2015) Can lactate serve as an energy substrate for axons in good times and in bad, in sickness and in health? Metab Brain Dis 30(1):25-30. PMID: 25034458; PMCID: PMC4297510

11. Baltan S. (2014) Excitotoxicity and mitochondrial dysfunction underlie age-dependent ischemic white matter injury. Adv Neurobiol 11:151-70. PMID: 25236728

12. Murphy SP, Lee RJ, McClean ME, Pemberton HE, Uo T, Morrison RS, Bastian C, Baltan S. (2014) MS-275, a class I histone deacetylase inhibitor, protects the p53-deficient mouse against ischemic injury. J Neurochem 129(3):509-15. PMID: 24147654

13. Baltan S, Morrison RS, Murphy SP. (2013) Novel protective effects of histone deacetylase inhibition on stroke and white matter ischemic injury. Neurotherapeutics 10(4):798-807. PMID: 23881453; PMCID: PMC3805855

14. Baltan S. (2012) Histone deacetylase inhibitors preserve function in aging axons. J Neurochem 123 Suppl 2:108-15. PMID: 23050648; PMCID: PMC3481173

15. Baltan S, Bachleda A, Morrison RS, Murphy SP. (2011) Expression of histone deacetylases in cellular compartments of the mouse brain and the effects of ischemia. Transl Stroke Res 2(3):411-23. PMID: 21966324; PMCID: PMC3182145

16. Baltan S, Murphy SP, Danilov CA, Bachleda A, Morrison RS. (2011) Histone deacetylase inhibitors preserve white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity. J Neurosci 31(11):3990-9. PMID: 21411642; PMCID: PMC3061553

17. Baltan S, Inman DM, Danilov CA, Morrison RS, Calkins DJ, Horner PJ. (2010) Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration. J Neurosci 30(16):5644-52. PMID: 20410117; PMCID: PMC2884009

18. Baltan S, Besancon EF, Mbow B, Ye Z, Hamner MA, Ransom BR. (2008) White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J Neurosci 28(6):1479-89. PMID: 18256269

No news currently found.