Hod Dana, Ph.D.

Assistant Staff
Assistant Professor, Molecular Medicine, CCLCM-CWRU

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Phone: (216) 444-9189
Fax: (216) 444-7927

“Progress in science depends on new techniques, new discoveries, and new ideas, probably in that order”

--Sydney Brenner

In the lab, we develop new technologies and platforms for enabling large-scale recording and manipulation of neurons in the living brain. These types of technologies are essential for a better understanding of how the spatially-distributed and highly-interconnected circuits in the mammalian brain integrate sensory input and transform it into motor action. This type of computation is also involved in almost any behavior or decision-making process that we do in our everyday life, and therefore we want to gain a deeper understanding of its nature. We work with state-of-the-art optical tools, such as ultrafast lasers, nonlinear microscopy, holography, as well as with novel protein sensors for detecting neuronal activity. The longer-term goal of the lab is to apply these new technologies to study how brain activity changes with the propagation of neurodegenerative diseases.

The research in the lab is interdisciplinary in its nature, and combines approaches from different fields like engineering, physics, structural biology, and systems neuroscience. We encourage interested graduate students and postdoctoral researchers to apply for a position in the lab.

Sergiy  Chornyy Ph.D.

Sergiy Chornyy Ph.D.

Research Fellow

Fax:(216) 444-7927

Aniruddha  Das Ph.D.

Aniruddha Das Ph.D.

Research Fellow

Phone:(216) 444-9189
Fax:(216) 444-7927

Shen Y, Dana H, Abdelfattah AS, Patel R, Shea J, Molina RS, Rawal B, Rancic V, Chang YF, Wu L, Chen Y, Qian Y, Wiens MD, Hambleton N, Ballanyi K, Hughes TE, Drobizhev M, Kim DS, Koyama M, Schreiter ER, Campbell RE. (2018) A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578. BMC Biol. 16(1):9. PMID: 29338710; PMCID: PMC5771076

Sun Y, Nern A, Franconville R, Dana H, Schreiter ER, Looger LL, Svoboda K, Kim DS, Hermundstad AM, Jayaraman V. Neural signatures of dynamic stimulus selection in Drosophila. Nat Neurosci. 2017 Aug;20(8):1104-1113. PMID: 28604683

Dana H, Mohar B, Sun Y, Narayan S, Gordus A, Hasseman JP, Tsegaye G, Holt GT, Hu A, Walpita D, Patel R, Macklin JJ, Bargmann CI, Ahrens MB, Schreiter ER, Jayaraman V, Looger LL, Svoboda K, Kim DS. Sensitive red protein calcium indicators for imaging neural activity. Elife 2016 Mar 24;5. pii: e12727. PMID: 27011354; PMCID: PMC4846379

Chu J, Oh Y, Sens A, Ataie N, Dana H, Macklin JJ, Laviv T, Welf ES, Dean KM, Zhang F, Kim BB, Tang CT, Hu M, Baird MA, Davidson MW, Kay MA, Fiolka R, Yasuda R, Kim DS, Ng HL, Lin MZ. A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo. Nat Biotechnol. 2016 Jul;34(7):760-7. PMID: 27240196; PMCID: PMC4942401

Paluch-Siegler S, Mayblum T, Dana H, Brosh I, Gefen I, Shoham S. All-optical bidirectional neural interfacing using hybrid multiphoton holographic optogenetic stimulation. Neurophotonics 2015 Jul;2(3):031208. PMID: 26217673; PMCID: PMC4512959

Fosque BF*, Sun Y*, Dana H*, Yang CT, Ohyama T, Tadross MR, Patel R, Zlatic M, Kim DS, Ahrens MB, Jayaraman V, Looger LL, Schreiter ER. Neural circuits. Labeling of active neural circuits in vivo with designed calcium integrators. Science 2015 Feb 13;347(6223):755-60. PMID: 25678659

Dana H, Chen TW, Hu A, Shields BC, Guo C, Looger LL, Kim DS, Svoboda K. Thy1-GCaMP6 transgenic mice for neuronal population imaging in vivo. PLoS One 2014 Sep 24;9(9):e108697. PMID: 25250714; PMCID: PMC4177405

Thestrup T, Litzlbauer J, Bartholomäus I, Mues M, Russo L, Dana H, Kovalchuk Y, Liang Y, Kalamakis G, Laukat Y, Becker S, Witte G, Geiger A, Allen T, Rome LC, Chen TW, Kim DS, Garaschuk O, Griesinger C, Griesbeck O. Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes. Nat Methods 2014 Feb;11(2):175-82. PMID: 24390440

Dana H*, Marom A*, Paluch S, Dvorkin R, Brosh I, Shoham S. Hybrid multiphoton volumetric functional imaging of large-scale bioengineered neuronal networks. Nat Commun. 2014 Jun 5;5:3997. PMID: 24898000; PMCID: PMC4113029

Dana H, Kruger N, Ellman A, Shoham S. Line temporal focusing characteristics in transparent and scattering media. Opt Express 2013 Mar 11;21(5):5677-87. PMID: 23482141

Dana H, Shoham S. Remotely scanned multiphoton temporal focusing by axial grism scanning. Opt Lett. 2012 Jul 15;37(14):2913-5. PMID: 22825176

Szameit A*, Shechtman Y*, Osherovich E*, Bullkich E, Sidorenko P, Dana H, Steiner S, Kley EB, Gazit S, Cohen-Hyams T, Shoham S, Zibulevsky M, Yavneh I, Eldar YC, Cohen O, Segev M. Sparsity-based single-shot subwavelength coherent diffractive imaging. Nat Mater. 2012 Apr 1;11(5):455-9. PMID: 22466747

Dana H, Shoham S. Numerical evaluation of temporal focusing characteristics in transparent and scattering media. Opt Express 2011 Mar 14;19(6):4937-48. PMID: 21445129

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