Publications

  1. Yang Y, Varvel NH., Lamb BT, and K Herrup. Ectopic cell cycle events link human Alzheimer’s disease and amyloid precursor protein transgenic mouse models. J. Neurosci., 26:775-784, 2006.

  2. Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS, Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM, Nadeau JH, Matin A.The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature. ; 435(7040):360-4. 2005

  3. Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL. , Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors 289948 and BMS-299897. Biochem Pharmacol. 2005; 69(4):689-98.

  4. Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT. Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice. J Biol Chem. 2004; 279(50): 52535-42.

  5. Seyidova D, Aliyev A, Rzayev N, Obrenovich M, Lamb BT, Smith MA, de la Torre JC, Perry G, The role of nitric oxide in the pathogenesis of brain lesions during thedevelopment of Alzheimer's disease in vivo. 2004; 18(3):325-33.

  6. Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA Nixon RA. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. Int J Biochem Cell Biol. 2004; 36(12):2531-40.

  7. Aliyev A, Seyidova D, Rzayev N, Obrenovich ME, Lamb BT, Chen SG, Smith MA, Perry G, de la Torre JC, Aliev G. Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease? Neurol Res. 2004; 26(5):547-53.

  8. Mann KM, Thorngate FE, Katoh-Fukui Y, Hamanaka H, Williams DL, Fujita S, Lamb BT. Independent effects of APOE on cholesterol metabolism and brain A-beta levels in an Alzheimer disease mouse model. Hum Mol Genet. 2004; 13(17):1959-68.

  9. Desrochers PJ, LeLievre S, Johnson RJ, Lamb BT, Phelps AL, Cordes AW, Gu W, Cramer SP. A stable monomeric nickel borohydride. Inorg Chem. 2003; 42(24):7945-50.

  10. Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT. Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. Hum Mol Genet. 2003; 12(22):2949-56.

  11. Aliev G, Seyidova D, Lamb BT, Obrenovich ME, Siedlak SL, Vinters HV, Friedland RP, LaManna JC, Smith MA, Perry G. Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurol Res. 2003; 25(6):665-74.

  12. Lehman EJ, Kulnane LS, Lamb BT. Alterations in beta-amyloid production and deposition in brain regions of two transgenic models. Neurobiol Aging. 2003; 24(5):645-53.

  13. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci. 2002;977:45-64.

  14. Kulnane LS, Lehman EJ, Hock BJ, Tsuchiya KD, Lamb BT. Rapid and efficient detection of transgene homozygosity by FISH of mouse fibroblasts. Mamm Genome. 2002; 13(4):223-6.

  15. Aliev G, Smith MA, Seyidov D, Neal ML, Lamb BT, Nunomura A, Gasimov EK, Vinters HV, Perry G, LaManna JC, Friedland RP. The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease. Brain Pathol. 2002; 12(1):21-35.

  16. Kulnane LS, Lamb BT. Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice. Neurobiol Dis. 2001; 8(6):982-92.

  17. Hock BJ Jr, Lamb BT. Transgenic mouse models of Alzheimer's disease. Trends Genet. 2001; 17(10):S7-12.

  18. Jakobovits A, Lamb BT, Peterson KR. Production of transgenic mice with yeast artificial chromosomes. Methods Mol Biol. 2000;136:435-53. Review.

  19. Lamb BT, Bardel KA, Kulnane LS, Anderson JJ, Holtz G, Wagner SL, Sisodia SS, Hoeger EJ. Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. Nat Neurosci. 1999; 2(8):695-7.

  20. Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD. Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Hum Mol Genet. 1997; 6(9):1535-41.

  21. Lamb BT. Presenilins, amyloid-beta and Alzheimer's disease. Nat Med. 1997; 3(1):28-9.

  22. Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. Am J Pathol. 1996;149(3):1063-71.

  23. Rosenberg C, Voltz AK, Lawler AM, Lamb BT, Stetten G, Gearhart JD. Alterations of yeast artificial chromosome transgenic sequences in stretched embryonic stem-cell chromatin visualized by fluorescence in situ hybridization. Cytogenet Cell Genet. 1996; 75(1):67-70.

  24. Lamb BT, Gearhart JD. YAC transgenics and the study of genetics and human disease. Curr Opin Genet Dev. 1995; 5(3):342-8.

  25. Lamb BT. Making models for Alzheimer's disease. Nat Genet. 1995; 9(1):4-6.

  26. Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected] Nat Genet. 1993; 5(1):22-30. Erratum in: Nat Genet 1993; 5(3):312.

  27. Lamb BT, Satyamoorthy K, Solter D, Basu A, Xu MQ, Weinmann R, Howe CC. A DNA element that regulates expression of an endogenous retrovirus during F9 cell differentiation is E1A dependent. Mol Cell Biol. 1992; 12(11):4824-33.

  28. Lamb BT, Satyamoorthy K, Li L, Solter D, Howe CC. CpG methylation of an endogenous retroviral enhancer inhibits transcription factor binding and activity. Gene Expr. 1991; 1(3): 185-96.

  29. Tuan RS, Lamb BT, Jesinkey CB. Mouse placental 57-kDa calcium-binding protein: II. Localization of mRNA in mouse and human placentae by in situ cDNA hybridization. Differentiation. 1988; 37(3):198-204.

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