Richard M. Ransohoff, M.D. | Research | Publications | Laboratory

Publications

  1. Savarin-Vuaillat C, Ransohoff RM. Chemokines and chemokine receptors in neurological disease: raise, retain, or reduce? Neurotherapeutics  2007;4:590-601.Cardona AE, et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 2006;9:917-24.
  2. Ransohoff RM. EAE: pitfalls outweigh virtues of screening potential treatments for multiple sclerosis.Trends Immunol. 2006 Feb 28; (in press)
  3. Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.
  4. Rani MR, Ransohoff RM. Alternative and accessory pathways in the regulation of IFN-beta-mediated gene expression. J Interferon Cytokine Res. 2005 Dec;25(12):788-98.
  5. Ubogu EE, Cossoy MB, Ransohoff RM. The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci. 2006 Jan;27(1):48-55.
  6. Tani, M, Fuentes, ME, Peterson, JW, Trapp, BD, Durham, SK, Loy, JK, Bravo, R, Ransohoff, RM, Lira, SA. (1996). Neutrophil infiltration, glial reaction and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes. J Clin Invest. 98:529-539.
  7. Rani, M, Leaman, D, Leung, S, Foster, G, Stark, G, Ransohoff, RM. (1996). Characterization of b-R1, a gene that is selectively induced by IFN-b compared with IFN-a. J Biol Chem. 271:22878-22884.
  8. Glabinski, A, Tani, M, Strieter, R, Tuohy, V, Ransohoff, RM. (1997). Synchronous synthesis of a- and b-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of experimental autoimmune encephalomyelitis. Am J Pathol. 150:617-630.
  9. Rudick, R, Cohen, J, Weinstock-Guttman, B, Kinkel, R, Ransohoff, RM (1997). Management of multiple sclerosis. N Engl J Med. 337:1604-1612.
  10. Trapp, B., Peterson, J. Ransohoff, RM, Rudick, R. Mork, S. Bo, L. (1998). Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278-190.
  11. Zhou, ZH, Chaturvedi, P, Han, Y-L, Aras, S, Li, Y-S, Kolattukudy, PE, Ping, D, Boss, JM, Ransohoff, RM. (1998). Interferon-g induction of the human monocyte chemoattractant (hMCP)-1 gene in astrocytoma cells: functional interaction between a gamma activated site (GAS) and GC-rich element. J Immunol. 160:3908-3916.
  12. McTigue, D, Tani, M, Kravacic, K, Chernosky, A, Kelner, G, Maciejewski, D, Maki, R, Ransohoff, RM, Stokes, B. (1998) Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. J Neurosci Res. 53:368-376.
  13. Ransohoff RM, Tani M. (1998) Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation? Trends Neurol Sci (TINS) 21:154-159.
  14. Majumder, S, Zhou, LZ-H, Chaturvedi, P, Babcock, G, Aras, S, Ransohoff, RM. (1998) p48/STAT-1a-containing complexes play a predominant role in induction of IP-10 by interferon-gamma alone or in synergy with tumor necrosis factor-alpha. J Immunol. 161:4736-4744.
  15. Karpus, W, Ransohoff, RM. (1998). "Cutting edge" Chemokine regulation of experimental autoimmune encephalomyelitis. J Immunol.161:2667-2671.
  16. Robinson, S, Tani, M, Strieter, R, Ransohoff, RM, Miller, R. (1998) The chemokine GRO-a amplifies PDGF-induced proliferation of spinal cord oligodendrocyte progenitors. J Neurosci 18:10457-10463.
  17. Sørensen, TL, Tani, M, Jensen, J, Pierce, V, Lucchinetti, C, Folcik, VA, Qin, S, Rottman, J, Sellebjerg, F, Strieter, R, Frederiksen, J, Ransohoff, RM. (1999) Expression of specific chemokines and chemokine receptors in the central nervous system of mutiple sclerosis patients. J Clin Invest 103:807-815.
  18. Han, Y.-L., Z.-H.L. Zhou,, Ransohoff, RM (1999). TNF-alpha suppresses IFN-gamma-induced MHC class II expression in HT 1080 cells by destabilizing CIITA mRNA. J Immunol. 163: 1435-1440.
  19. Trapp, B., Ransohoff, RM, Rudick, RA (1999). Axonal pathology in multiple sclerosis: relationship to disease progression. Curr Opin Neurol. 12:295-302.
  20. Rani, S. Leaman, D. Leung, S. Croze, E. Fish, E. Wolfman, A, Ransohoff, RM. (1999). Catalytically-active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon alpha/beta receptor chain (IFNAR)-1 but not for the activation of phosphoinositol 3-kinase. J Biol Chem 274:32507-32511.
  21. Wu Q, Miller R, Ransohoff RM, Robinson S, Bu J, Nishiyama A. (2000) Elevated chemokine GRO-1 correlates with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci. 20:2609-2617.
  22. Russell-Harde D, Wagner T, Rani S, Vogel D, Colamonici O, Ransohoff RM, et al. (2000) Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling: expression of IFNAR2c truncation mutants in U5A cells. J Biol Chem. 275: 23981-23985.
  23. Kivisakk P, Trebst C, Eckstein DF, Kerza-Kwiatecki AP, Ransohoff RM. (2001) Chemokine-based therapies for MS: how do we e there from here? Trends Immunol 22:591-593.
  24. Trebst C, Sorensen TL, Kivisakk P, Cathcart MK, Hesselgesser J, Horuk R, Sellebjerg F, Lassmann H, Ransohoff RM. (2001) CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis. Am J Pathol 159:1701-1710.
  25. Panenka W, Jijon H, Herx LM, Armstrong JN, Feighan D, Wei T, Yong VW, Ransohoff RM, MacVicar BA. (2001) P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J Neurosci 21:7135-7142.
  26. Zhou, Z.-H., Wei, T., Aras, S., Chaturvedi, P., Tyler, S., Rani, M., Han, Y., and Ransohoff, RM (2001) Regulation of monocyte chemoattractant protein-1 expression by interferon-gamma: post-induction refractory state of the gene, governed by its upstream elements. FASEB J 15:383-392.
  27. Schreiber R, Krivacic K, Kirby B, Vaccariello S, Wei T, Ransohoff RM, Zigmond R. (2001) Monocyte chemoattractant protein (MCP)-1 is rapidly expressed by sympathetic ganglion neurons following axonal injury. NeuroReport 12:601-606.
  28. Huang D, Wang J-T, Kivisakk P, Rollins B, Ransohoff RM. (2001) Absence of monocyte chemoattractant protein (MCP)-1 in mice leads to decreased local macrophage recruitment and antigen specific Th1 immune response in experimental autoimmune encephalomyelitis. J Exp Med 193:713-726.
  29. Ramana C, Gil M, Han Y, Ransohoff RM, Schreiber R, Stark G. (2001) Stat1-independent regulation of gene expression in response to IFN-g. Proc Nat'l Acad Sci USA 98:6674-6679.
  30. Han, Y., He, T., Huang, D., Pardo, C., Ransohoff, RM. (2001) TNF-a mediates SDF-1a-induced NK-kB activation and cytotoxic effects in primary astrocytes J Clin Invest 108:425-435.
  31. Panenka W, Jijon H, Herx L, Armstrong J, Wei T, Yong V, Ransohoff RM, MacVicar B. (2001) P2X7-like receptor activation in astrocytes increases chemokine MCP-1 expression via MAP kinase. J Neurosci 15:7135-7142.
  32. Rani M, Asthagiri A, Singh A, Sizemore N, Sathe S, Li X, DiDonato J, Stark G, Ransohoff RM. (2001) "Accelerated publication": A role for NF-kB in the induction of b-R1 by IFN-b. J Biol Chem 276:44365-44368.
  33. Wagner TC, Velichko S, Vogel D, Rani MR, Leung S, Ransohoff RM, Stark GR, Perez HD, Croze E.(2002) Interferon signaling is dependent on specific tyrosines located within the intracellular domain of INFAR2C. J Biol Chem 277:1493-1499.
  34. Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, Ransohoff RM, Miller RH. (2002) The chemokine receptor CXCR2 controls positioning of oligodendroctyoe precursors in developing spinal cord by arresting their migration. Cell 110: 373-383.
  35. Lucchinetti CF, Mandler RN, McGavern D, Bruck W, Gleich G, Ransohoff RM, Trebst C, Weinshenker B, Wingerchuk D, Parisi JE, Lassmann H. (2002) A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. Brain 125:1450-1461.
  36. Kieseier BC, Tani M, Mahad D, Oka N, Ho T, Woodroofe N, Griffin JW, Toyka KV, Ransohoff RM, Hartung HP. (2002) Chemokines and chemokine receptors in inflammatory demyelinaitng neuropathies: a central role for IP-10. Brain 125:823-834.
  37. Ransohoff RM, Wei T, Pavelko KD, Lee JC, Murray PD, Rodriguez M. (2002)Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: roles of CD4+ and CD8+ T cells and viral persistence. J Virol 76:2217-2224.
  38. Wujek J, Bjartmar C, Richer E, Ransohoff RM, Yu M, Tuohy V, Trapp B. (2002) Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. J Neuropathol Exp Neurol. 61:23-32.
  39. Ma M, Wei T, Boring L, Charo IF, Ransohoff RM, Jakeman LB. (2002) Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion. J Neurosci Res. 68:691-702.
  40. Lucchinetti C, Mandler R, McGavern D, Bruck W, Gleich J, Ransohoff RM, Trebst C, Weinshenker B, Wingerchuck D, Parisi JP, Lassmann H. (2002) A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. Brain 125:1450-1461.
  41. Kivisakk,P., Trebst,C., Liu,Z., Tucky,B.H., Sorensen,T.L., Rudick,R.A., Mack,M., Ransohoff,R.M. (2002). T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking. Clin.Exp.Immunol. 129:510-518.
  42. Rani, MRS, Hibbert, L, Sizemore, N, Stark, GR, Ransohoff, RM. (2002) Requirement of phosphoinositide 3-kinase and Akt for interferon-beta -mediated induction of beta -R1 (SCYB11) gene. J Biol Chem. 277:38456-38461.
  43. Huang,D, Tani,M, Wang,J, Han,Y, He,TT, Weaver,J, Charo,IF, Tuohy,VK, Rollins,BJ, Ransohoff,RM.. (2002) Pertussis toxin induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice. J Neurosci 22: 10633-42.
  44. Pavelko K, Howe CL, Drescher KM, Gamez JD, Johnson A.J., Wei T, Ransohoff RM, Rodriguez M. (2003) Interleukin-6 protects anterior horn neurons from lethal virus-induced injury. J. Neurosci. 23:481-492.
  45. Trebst,C, Staugaitis,SM, Kivisäkk,P, Mahad,D, Cathcart,MK, Tucky,B, Wei,T, Rani,MRS, Horuk,R, Aldape,KR, Pardo,CR, Lucchinetti,CF, Lassmann,H, Ransohoff,RM. (2003) CC chemokine receptor 8 (CCR8) in the central nervous system is associated with phagocytic macrophages. Am J Pathol 163:427-438.
  46. Kivisäkk, P, Mahad, DJ, Callahan, MK, Trebst, C, Tucky, B, Wei, T, Wu, L, Baekkevold, ES, Lassmann, H, Staugaitis, SM, Campbell, JJ, Ransohoff, RM. (2003) Human cerebrospinal fluid central memory CD4+ T-cells: Evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Nat'l Acad Sci USA 100:8389-8394.
  47. Kawakami N, Lassmann S, Li Z, Odoardi F, Ritter T, Ziemssen T, Klinkert WEF, Ellwart JW, Bradl M, Lassmann H, Ransohoff Rm, Volk H-D, Wekerle H, Linington C, Flugel A. (2004) The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of experimental autoimmune encephalomyelitis J Exp Med 199: 185-197.
  48. Kivisakk P, Callahan MK, Mahad D, Sikora K, Trebst C, Tucky B, Wu L, Wujek JR, Ravid R, Staugaitis SM, Lassmann H, Ransohoff RM. (2004) Intrathecal Expression of CCR7 in Multiple Sclerosis: Implications for Central Nervous System Immunity. Ann Neurol 55:627-638.
  49. Mahad D, Trebst C, Kivisakk P, Staugaitis SM, Tucky B, WeiT, Lucchinetti C, Lassmann H, Ransohoff RM. (2004) J Neuropathol Exp Neurol (in press).

back to top