Neurosciences : Seminars

The Department of Neurosciences at Cleveland Clinic's Lerner Research Institute comprises a group of internationally recognized scientists who are committed to understanding the mechanisms of brain development and function, as well as better understanding the causes of neurodegenerative diseases and developing and improving therapeutic strategies.


Tuesday, 05 Mar 2019 16:00
Department of Neurosciences

Location: NC1-202
Title: "Mechanosensory function of Kindlin3 in microglia is crucial for retinal vascular patterning"

Tejasvi Dudiki, Ph.D., Laboratory of Dr. Tatiana Byzova

Our study demonstrates that microglia control vascular growth and patterning in retinas by altering its gene expression in response to its surrounding extra cellular matrix. Using microglia-specific genetic knockout and knock-in mouse models, we show that this process is orchestrated by Kindlin3, an intracellular integrin adaptor. Lack of Kindlin3 in microglia caused abnormal vascular patterning and excessive vascular growth, which is reminiscent of early stages of human retinal angiomatous proliferation.

Wednesday, 06 Mar 2019 10:00
Department of Neurosciences

Location: NE1-205
Title: Cancelled-to be rescheduled

Jonathan Godbout, PhD, Professor, Department of Neuroscience, Institute for Behavioral Medicine Research, Center for Brain and Spinal Cord Repair, The Ohio State University

Hosted by: Jessica Williams

Tuesday, 12 Mar 2019 16:00
Department of Neurosciences

Location: NC1-202
Title: Mechanisms of Blood Brain Barrier Disruption in Neuroinflammatory Disease

Nozha Borjini, Ph.D., Laboratory of Dr. Dimitrios Davalos

Wednesday, 20 Mar 2019 10:00
Department of Neurosciences

Location: NE1-205
Title: "Thalamic MRI, histopathologic, and clinical correlations in multiple sclerosis"

Kedar R. Mahajan, MD, PhD, Associate Staff, Neurological Institute, Cleveland Clinic

Hosted by: Bruce Trapp