Neurosciences : Seminars
The Department of Neurosciences at Cleveland Clinic's Lerner Research Institute comprises a group of internationally recognized scientists who are committed to understanding the mechanisms of brain development and function, as well as better understanding the causes of neurodegenerative diseases and developing and improving therapeutic strategies.
Title: "Mechanosensory function of Kindlin3 in microglia is crucial for retinal vascular patterning"
Tejasvi Dudiki, Ph.D., Laboratory of Dr. Tatiana Byzova
Our study demonstrates that microglia control vascular growth and patterning in retinas by altering its gene expression in response to its surrounding extra cellular matrix. Using microglia-specific genetic knockout and knock-in mouse models, we show that this process is orchestrated by Kindlin3, an intracellular integrin adaptor. Lack of Kindlin3 in microglia caused abnormal vascular patterning and excessive vascular growth, which is reminiscent of early stages of human retinal angiomatous proliferation.
Title: Cancelled-to be rescheduled
Jonathan Godbout, PhD, Professor, Department of Neuroscience, Institute for Behavioral Medicine Research, Center for Brain and Spinal Cord Repair, The Ohio State University
Hosted by: Jessica Williams
Title: Mechanisms of Blood Brain Barrier Disruption in Neuroinflammatory Disease
Nozha Borjini, Ph.D., Laboratory of Dr. Dimitrios Davalos
Title: "Thalamic MRI, histopathologic, and clinical correlations in multiple sclerosis"
Kedar R. Mahajan, MD, PhD, Associate Staff, Neurological Institute, Cleveland Clinic
Hosted by: Bruce Trapp