My lab focuses on restoring motor function after injury or disease. One major research thrust focuses on using technology to bypass damaged neurons and to restore movements by thought after paralysis. Specifically, my lab is refining methods to record neural activity from the brain, decode one’s desired arm movement from that recorded neural activity, and then stimulate the muscles in a manner that will generate the desired movement in real time. We use both invasive and non-invasive brain recording methods, and our muscle stimulation algorithms are designed to be easily customizable to each person’s unique post-injury limb.
My second major research thrust is focused on understanding neural network dysfunction in Parkinson’s disease and how deep brain stimulation serves to renormalize motor processing. Our approach is to compare multichannel neural activity recorded from cortical and deep brain structures from normal and Parkinsonian brains. We also track neural activity in Parkinsonian brains when different stimulation patterns are applied to deep brain structures. The resulting data are being used to guide the development of computational models of neural network function where we can more efficiently explore what network changes can trigger abnormal activity and how to optimize deep brain stimulation to renormalize brain function.
Research Vet Tech
Hermann JK, Ravikumar M, Shoffstall AJ, Ereifej ES, Kovach KM, Chang J, Soffer A, Wong C, Srivastava V, Smith P, Protasiewicz G, Jiang J, Selkirk SM, Miller RH, Sidik S, Ziats NP, Taylor DM, Capadona JR. (2018) Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance. J Neural Eng 15(2):025002. PMID: 29219114; PMCID: PMC5818286
Bedell HW, Hermann JK, Ravikumar M, Lin S, Rein A, Li X, Molinich E, Smith PD, Selkirk SM, Miller RH, Sidik S, Taylor DM, Capadona JR. (2018) Targeting CD14 on blood derived cells improves intracortical microelectrode performance. Biomaterials 163:163-173. PMID: 29471127; PMCID: PMC5841759
Jiang J, Marathe AR, Keene JC, Taylor DM. (2017) A testbed for optimizing electrodes embedded in the skull or in artificial skull replacement pieces used after injury. J Neurosci Methods 277:21-29. PMID: 27979758; PMCID: PMC5253247
Marathe AR, Taylor DM. (2015) The impact of command signal power distribution, processing delays, and speed scaling on neurally-controlled devices. J Neural Eng 12(4):046031. PMID: 26170261; PMCID: PMC4547796
Foldes ST, Taylor DM. (2013) Speaking and cognitive distractions during EEG-based brain control of a virtual neuroprosthesis-arm. J Neuroeng Rehabil 10:116. PMID: 24359452; PMCID: PMC3878059
Vadera S, Marathe AR, Gonzalez-Martinez J, Taylor DM. (2013) Stereoelectroencephalography for continuous two-dimensional cursor control in a brain-machine interface. Neurosurg Focus 34(6):E3. PMID: 23724837
Marathe AR, Taylor DM. (2013) Decoding continuous limb movements from high-density epidural electrode arrays using custom spatial filters. J Neural Eng 10(3):036015. PMID: 23611833; PMCID: PMC3746986
Shoffstall AJ, Taylor DM, Lavik EB. (2012) Engineering therapies in the CNS: what works and what can be translated. Neurosci Lett 519(2):147-54. PMID: 22330751; PMCID: PMC3377833
Foldes ST, Taylor DM. (2011) Offline comparison of spatial filters for two-dimensional movement control with noninvasive field potentials. J Neural Eng 8(4):046022. PMID: 21712569
Muralidharan A, Chae J, Taylor DM. (2011) Early detection of hand movements from electroencephalograms for stroke therapy applications. J Neural Eng 8(4):046003. PMID: 21623009; PMCID: PMC3148608
Chadwick EK, Blana D, Simeral JD, Lambrecht J, Kim SP, Cornwell AS, Taylor DM, Hochberg LR, Donoghue JP, Kirsch RF. (2011) Continuous neuronal ensemble control of simulated arm reaching by a human with tetraplegia. J Neural Eng 8(3):034003. PMID: 21543840; PMCID: PMC3608269
Muralidharan A, Chae J, Taylor DM. (2011) Extracting Attempted Hand Movements from EEGs in People with Complete Hand Paralysis Following Stroke. Front Neurosci 5:39. PMID: 21472032; PMCID: PMC3066795
Marathe AR, Taylor DM. (2011) Decoding position, velocity, or goal: does it matter for brain-machine interfaces? J Neural Eng 8(2):025016. PMID: 21436529; PMCID: PMC3140465