Dawn M Taylor, Ph.D.

Associate Staff
Assistant Professor, Molecular Medicine, CCLCM-CWRU

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NC3-144
taylord8@ccf.org
Phone: (216) 636-0140
Fax: (216) 444-7927



My lab focuses on restoring motor function after injury or disease. One major research thrust focuses on using technology to bypass damaged neurons and to restore movements by thought after paralysis. Specifically, my lab is refining methods to record neural activity from the brain, decode one’s desired arm movement from that recorded neural activity, and then stimulate the muscles in a manner that will generate the desired movement in real time. We use both invasive and non-invasive brain recording methods, and our muscle stimulation algorithms are designed to be easily customizable to each person’s unique post-injury limb.

My second major research thrust is focused on understanding neural network dysfunction in Parkinson’s disease and how deep brain stimulation serves to renormalize motor processing. Our approach is to compare multichannel neural activity recorded from cortical and deep brain structures from normal and Parkinsonian brains. We also track neural activity in Parkinsonian brains when different stimulation patterns are applied to deep brain structures. The resulting data are being used to guide the development of computational models of neural network function where we can more efficiently explore what network changes can trigger abnormal activity and how to optimize deep brain stimulation to renormalize brain function.


Tyler  Johnson
Tyler Johnson
Research Scholar

Location:NC3-144a
Phone:(216) 445-0011
johnsot20@ccf.org
Fax:(216) 444-7927
laboratory

Sarah  Moralle
Sarah Moralle
Research Vet Tech

Location:NC3-144a
Phone:(216) 445-0011
moralls@ccf.org
Fax:(216) 444-7927
laboratory


Selected Publications:

Jiang J, Marathe AR, Keene JC, Taylor DM. (2016) A testbed for optimizing electrodes embedded in the skull or in artificial skull replacement pieces used after injury. J Neurosci Methods 277:21-29. PMID: 27979758; PMCID: PMC5253247

Marathe AR, Taylor DM. (2015) The impact of command signal power distribution, processing delays, and speed scaling on neurally-controlled devices. J Neural Eng 12(4):046031. PMID: 26170261; PMCID: PMC4547796

Foldes ST, Taylor DM. (2013) Speaking and cognitive distractions during EEG-based brain control of a virtual neuroprosthesis-arm. J Neuroeng Rehabil 10:116. PMID: 24359452; PMCID: PMC3878059

Vadera S, Marathe AR, Gonzalez-Martinez J, Taylor DM. (2013) Stereoelectroencephalography for continuous two-dimensional cursor control in a brain-machine interface. Neurosurg Focus 34(6):E3. PMID: 23724837

Marathe AR, Taylor DM. (2013) Decoding continuous limb movements from high-density epidural electrode arrays using custom spatial filters. J Neural Eng 10(3):036015. PMID: 23611833; PMCID: PMC3746986

Shoffstall AJ, Taylor DM, Lavik EB. (2012) Engineering therapies in the CNS: what works and what can be translated. Neurosci Lett 519(2):147-54. PMID: 22330751; PMCID: PMC3377833

Foldes ST, Taylor DM. (2011) Offline comparison of spatial filters for two-dimensional movement control with noninvasive field potentials. J Neural Eng 8(4):046022. PMID: 21712569

Muralidharan A, Chae J, Taylor DM. (2011) Early detection of hand movements from electroencephalograms for stroke therapy applications. J Neural Eng 8(4):046003. PMID: 21623009; PMCID: PMC3148608

Chadwick EK, Blana D, Simeral JD, Lambrecht J, Kim SP, Cornwell AS, Taylor DM, Hochberg LR, Donoghue JP, Kirsch RF. (2011) Continuous neuronal ensemble control of simulated arm reaching by a human with tetraplegia. J Neural Eng 8(3):034003. PMID: 21543840; PMCID: PMC3608269

Muralidharan A, Chae J, Taylor DM. (2011) Extracting Attempted Hand Movements from EEGs in People with Complete Hand Paralysis Following Stroke. Front Neurosci 5:39. PMID: 21472032; PMCID: PMC3066795

Marathe AR, Taylor DM. (2011) Decoding position, velocity, or goal: does it matter for brain-machine interfaces? J Neural Eng 8(2):025016. PMID: 21436529; PMCID: PMC3140465