Publications

1. Trapp, B.D., Dwyer, B. and Bernsohn, J. Light and electron microscopic examination of isolated neurons, astrocytes and oligodendrocytes. Neurobiology 5:235-48, 1975.

2. Trapp, B.D. and Bernsohn, J. Changes in phosphoglyceride fatty acids of rat brain induced by linoleic and linolenic acids after pre- and post-natal fat deprivation. J Neurochem 28:1009-13, 1977.

3. Trapp, B.D. and Bernsohn, J. Essential fatty acid deficiency and CNS myelin. Biochemical and morphological observations. J Neurol Sci 37:249-66, 1978.

4. Matthieu, J.M., Honegger, P., Trapp, B.D., Cohen, S.R. and Webster, H.deF. Myelination in rat brain aggregating cell cultures. Neuroscience 3:565-72, 1978.

5. Quarles, R.H., Sakuragawa, N., Everly, J.L., Pansak, C.F., Webster, H.deF. and Trapp, B.D. A biochemical comparison of Xenopus Laevis and mammalian myelin from the central and peripheral nervous sys­tems. J Neurobiol 9:217-28, 1978.

6. Trapp, B.D., Honegger, P., Richelson, E. and Webster, H.deF. Morphological differentiation of mechanically dissociated fetal rat brain in aggregating cell cultures. Brain Res 160:117-30, 1979.

7. Trapp, B.D., McIntyre, L.J., Quarles, R.H., Sternberger, N.H. and Webster, H.deF. Immunocytochemical localization of PNS myelin proteins: P2 protein is not a component of all PNS myelin sheaths. Proc Natl Acad Sci USA 76:3552-56, 1979.

8. Trapp, B.D., McIntyre, L.S., Quarles, R.H., Nonaka, G., Moser, A., Moser, H. and Webster, H.deF. Biochemical characterization of myelin isolated from the central nervous system of Xenopus tadpoles. J Neurochem 34:1241-46, 1980.

9. Trapp, B.D., Marangos, P.J. and Webster, H.deF. Immunocytochemical localization and development profile of neuron specific enolase (NSE) and non-neuronal enolase (NNE) in aggregating cell cultures of fetal rat brain. Brain Res 220:121-30, 1981.

10. Trapp, B.D., Itoyama, Y., Sternberger, N.H., Quarles, R.H. and Webster, H.deF. Immunocytochemical localization of P0 protein in Golgi complex membranes and myelin of developing rat Schwann cells. J Cell Biol 90:1-6, 1981.

11. Schober, R.J., Itoyma, Y., Sternberger, N.H., Trapp, B.D., Richardson, E.P., Asbury, A.K., Quarles, R.H. and Webster, H.deF. Immunocyto­chemical study of P0 glycoprotein, P1 and P2 basic proteins and myelin-associated glycoprotein (MAG) in lesions of idiopathic polyneurites. Neuropathol Appl Neurobiol 7:421-34, 1981.

12. Trapp, B.D. and Quarles, R.H. Presence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelin. J Cell Biol 92:877-82, 1982.

13. Trapp, B.D., Webster, H.deF., Johnson, D., Quarles, R.H., Cohen, S.R. and Murray, M.R. Myelin formation in rotation-mediated ag­gregating cell cultures: Immunocytochemical, electron micro­scopic and biochemical observations. J Neurosci 2:986-93, 1982.

14. Trapp, B.D., Itoyama, Y., MacIntosh, T.D. and Quarles, R.H. P2 protein in oligodendrocytes and myelin of the rabbit central nervous system. J Neurochem 40:47-54, 1983.

15. Itoyma, Y., Webster, H.deF., Richardson, E.P. and Trapp, B.D. Schwann cell remyelination of demyelinated axons in spinal cord multiple sclerosis lesions. Ann Neurol 14:339-46, 1983.

16. Harper, J.S., Dawe, C.J., Trapp, B.D., McKeever, P.E., Collins, M., Woyciechowska, J.L., Madden, D.L. and Sever, J.L. Paralysis in nude mice caused by polyomavirus-induced vertebral tumors. Prog Clin Biol Res 105:359-67, 1983.

17. Ilyas, A.A., Quarles, R.H., MacIntosh, T.D., Dobersen, M.J., Trapp, B.D., Dalakas, M.C. and Brady, R.O. IgM in human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside. Proc Natl Acad Sci USA 81:1223-29, 1984.

18. Trapp, B.D., Quarles, R.H. and Griffin, J.W. Myelin-associated glycoprotein and myelinating Schwann cell-axon interation in ß,ß'-iminodipropionitrile neuropathy. J Cell Biol 98:1272-78, 1984.

19. Trapp, B.D. and Quarles, R.H. Immunocytochemical localization of the myelin-associated glycoprotein: Fact or artifact? J Neuroimmunol 6:231-49, 1984.

20. Trapp, B.D., Dubois-Dalcq, M. and Quarles, R.H. Ultrastructural localization of P2 protein in actively myelinating rat Schwann cells. J Neurochem 43:944-48, 1984.

21. Trapp, B.D., Quarles, R.H. and Suzuki, K. Immunocytochemical studies of quaking mice support a role for the myelin-associated glycoprotein in forming and maintaining the periaxonal space and periaxonal cytoplasmic collar of myelinating Schwann cells. J Cell Biol 99:594-606, 1984.

22. Woyciechowska, J.L., Trapp, B.D., Patrick, D.H., Shekarchi, I.C., Leinikki, P.O., Sever, J.L. and Holmes, K.V. Acute and subacute demyelination induced by MHV-A59 in CH3 mice. J Exp Pathol 1:295-306, 1984.

23. Quarles, R.H. and Trapp, B.D. Localization of myelin-associated glycoprotein. J Neurochem 43:1773-77, 1984.

24. Mendell, J.R., Sahenk, Z., Whitaker, J.N., Trapp, B.D., Yates, A.J., Griggs, R.C. and Quarles, R.H. Polyneuropathy and IgM monoclonal gammopathy: Studies on the pathogenic role of anti-MAG antibody. Ann Neurol 17:243-54, 1985.

25. Doberson, M.G., Hammer, J.K., Noronka, A.B., MacIntosch, T.D., Trapp, B.D., Brady, R.O. and Quarles, R.H. Generation and characterization of mouse monoclonal antibodies to the myelin-associated glycoprotein (MAG). Neurochem Res 10:423-37, 1985.

26. Inuzuka, T., Quarles, R.H., Heath, J. and Trapp, B.D. Myelin-associated glycoprotein and other proteins in Trembler mice. J Neurochem 44:793-97, 1985.

27. Gendelman, H.E., Pereshkpour, G.H., Pressman, N.J., Wolinsky, J.S., Quarles, R.H., Dobersen, M.J., Trapp, B.D., Kitt, C.A., Aksamit, A. and Johnson, R.T. A quantitation of myelin-associated glycoprotein and myelin basic protein in different demyelinating diseases. Ann Neurol 18:324-28, 1985.

28. Dalakas, M. and Trapp, B.D. Thymosin B-4 is a shared antigen between lymphoid cells and oligodendrocytes of normal brain. Ann Neurol 19:349-55, 1986.

29. Trapp, B.D., Moench, T., Pulley, M., Barbosa, E., Tennekoon, G. and Griffin, J. Spatial segregation of mRNA encoding myelin-specific proteins. Proc Natl Acad Sci USA 84:7773-77, 1987.

30. Duncan, I.D., Hammang, J.P. and Trapp, B.D. Abnormal compact myelin in the myelin deficient rat: absence of proteolipid protein correlates with a defect in the intraperiod line. Proc Natl Acad Sci USA 84:6287-91, 1987.

31. Willison, H.J., Ilyas, A.I., O'Shannessy, D.J., Pulley, M., Trapp, B.D. and Quarles, R.H. Myelin-associated glycoprotein and related glycoconjugates in developing cat peripheral nerve: a correlative biochemical and morphometric study. J Neurochem 49:1853-62, 1987.

32. Trapp, B.D., Small, J.A., Pulley, M., Khoury, G. and Scangos, G.A. Dysmyelination in transgenic mice containing JC virus early region. Ann Neurol 28:38-48, 1988.

33. Inuzuka, T., Quarles, R.H., Trapp, B.D. and Heath, J.W. Analysis of myelin proteins in sympathetic peripheral nerve of adult rats. Develop Brain Res 38:191-99, 1988.

34. Willison, H.J., Trapp, B.D., Bacher, J.D. and Quarles, R.H. The expression of myelin-associated glycoprotein in regenerating cat sciatic nerve. Brain Res 444:10-16, 1988.

35. Charnas, L., Trapp, B. and Griffin, J. Congenital absence of peripheral myelin: abnormal Schwann cell development causes lethal arthrogryposis multiplex congenita. Neurology 38:966-74, 1988.

36. Jackson, A.C., Moench, T.R., Trapp, B.D. and Griffin, D.E. Basis of neurovirulence in Sindbis virus encephalomyelitis of mice. Lab Invest 58:503-09, 1988.

37. Ilyas, A.A., Willison, H.J., Quarles, R.H., Jungawala, F.B., Cornblath, D.R., Trapp, B.D., Griffin, D.E., Griffin, J.W. and McKhann, G.M. Serum antibodies to gangliosides in Guillain-Barre syndrome. Ann Neurol 23:440-47, 1988.

38. Dyson, S.E., Harvey, A.R., Trapp, B.D. and Heath, J.W. Ultrastructural and immunohistochemical analysis of axonal regrowth and myelination in membranes which form over lesion sites in the rat visual system. J Neurocytol 17:797-808, 1988.

39. Trapp, B.D., Hauer, P. and Lemke, G. Axonal regulation of myelin protein mRNA levels in actively myelinating Schwann cells. J Neurosci 8:3515-21, 1988.

40. Trapp, B.D., Bernier, L., Andrews, S.B. and Colman, D.R. Cellular and subcellular distribution of 2',3'-cyclic nucleotide 3'-phosphodiesterase and its mRNA in the rat nervous system. J Neurochem 51:859-68, 1988.

41. Trapp, B.D. Distribution of the myelin-associated glycoprotein and P0 protein during myelin compaction in quaking mouse peripheral nerve. J Cell Biol 107:675-85, 1988.

42. Willison, H.J., Trapp, B.D., Bacher, J.D., Dalakas, M.C., Griffin, J.W. and Quarles, R.H. Demyelination induced by intraneural injection of human anti-myelin-associated glycoprotein antibodies. Muscle Nerve 11:1169-76, 1988.

43. Trapp, B.D., Andrews, S.B., Wong, A., O'Connell, M. and Griffin, J.W. Co-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibers. J Neurocytol 18:47-60, 1989.

44. Stoll, G., Trapp, B.D. and Griffin, J.W. Macrophage function during Wallerian degeneration of rat optic nerve: clearance of degenerating myelin and Ia expression. J Neurosci 9:2327-35, 1989.

45. Stoll, G., Mueller, H.W., Trapp, B.D. and Griffin, J.W. Oligodendrocytes but not astrocytes express apolipoprotein E after injury of rat optic nerve. Glia 2:170-76, 1989.

46. Trapp, B.D., Andrews, S.B., Cootauco, C. and Quarles, R. The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes. J Cell Biol 109:2417-26, 1989.

47. Rosenstein, J.M., Krum, J.M. and Trapp, B.D. The astroglial response to autonomic tissue grafts. Brain Res 476:110-19, 1989.

48. McArthur, J.C., Becker, P.S., Parisi, J.E., Trapp, B., Selnes, O.A., Cornblath, D.R., Balakrishnan, J., Griffin, J.W. and Price, D. Neuropathological changes in early HIV dementia. Ann Neurol 26:681-84, 1989.

49. Carbone, K.M., Trapp, B.D., Griffin, J.W., Duchala, C.S. and Narayan, O. Astrocytes and Schwann cells are virus-host cells in the nervous system of rats with Borna disease. J Neuropathol Exp Neurol 48:631-44, 1989.

50. Stoll, G., Griffin, J.W., Li, C.Y. and Trapp, B.D. Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation. J Neurocytol 18:671-83, 1989.

51. Gillespie, C.S., Trapp, B.D., Colman, D.R. and Brophy, P.J. Distribution of myelin basic protein and P2 mRNAs in rabbit spinal cord oligodendrocytes. J Neurochem 54:1556-61, 1990.

52. Kordeli, E., Davis, J., Trapp, B. and Bennett, V. An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves. J Cell Biol 110:1341-52, 1990.

53. Filbin, M.T., Walsh, F.S., Trapp, B.D., Pizzey, J.A. and Tennekoon, G.I. The role of myelin P0 protein as a homophilic adhesion molecule. Nature 344:871-72, 1990.

54. Griffin, J.W., Stocks, E.A., Fahnestock, K., van Praagh, A. and Trapp, B.D. Schwann cell proliferation following lysolecithin-induced demyelination. J Neurocytol 19:367-84, 1990.

55. Monuki, E.S., Kuhn, R., Weinmaster, G., Trapp, B.D. and Lemke, G. Expression and activity of the POU transcription factor SCIP. Science 249:1300-03, 1990.

56. Kidd, G.J., Hauer, P.E. and Trapp, B.D. Axons modulate myelin protein mRNA levels during CNS myelination in vivo. J Neurosci Res 26:409-18, 1990.

57. Quarles, R.H., Hammer, J.A. and Trapp, B.D. The immunoglobulin gene superfamily and myelination. Prog Clin Biol Res 336:49-79, 1990.

58. Wirak, D.O., Bayney, R., Kundel, C.A., Lee, A., Scangos, G.A., Trapp, B.D. and Unterbeck, A.J. Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice. EMBO J 10:289-96, 1991.

59. Heath, J.W., Inuzuka, T., Quarles, R.H. and Trapp, B.D. Distribution of P0 protein and the myelin-associated glycoprotein in peripheral nerves from Trembler mice. J Neurocytol 20:439-49, 1991.

60. Wirak, D.O., Bayney, R., Ramabhadran, T.V., Fracasso, R.P., Hart, J.T., Hauer, P.E., Hsiau, P., Pekar, S.K., Scangos, G.A., Trapp, B.D. and Unterbeck, A.J. Deposits of amyloid ß-protein in the central nervous system of transgenic mice. Science 253:323-25, 1991.

61. Heath, J.W., Kidd, G.J., Trapp, B.D. and Dunkley, P.R. Myelin maintenance by Schwann cells in the absence of axons. Neurosci Lett 128:277-80, 1991.

62. Levine, B., Hardwick, J.M., Trapp, B.D., Crawford, T.O., Bollinger, R.C. and Griffin, D.E. Antibody-mediated clearance of alphavirus infection from neurons. Science 254:856-60, 1991.

63. Wirak, D., Bayney, R., Ramabhadran, T.V., Fracasso, R.P., Hart, J.T., Hauer, P.E., Hsiau, P., Pekar, S.K., Scangos, G.A., Trapp, B.D. and Unterbeck, A.J. Age-associated inclusions in normal and transgenic mouse brain. Science 255:1445, 1992.

64. Kidd, G.J., Heath, J.W., Trapp, B.D. and Dunkley, P.R. Myelin sheath survival after guanethidine-induced axonal degeneration. J Cell Biol 116:395-403, 1992.    

65. Power, C., Kong, P.A., Crawford, T.O., Wesselingh, S., McArthur, J.C., Glass, J.D. and Trapp, B.D. Cerebral white matter changes in AIDS dementia: alterations of the blood-brain barrier. Ann Neurol 34:339-50, 1993.

66. Saito, S., Hanley, D.F., Kidd, G.J., Wilson, D.A., Trapp, B.D. and Traystman, R.J. Peri-arterial innervation within the neurohypophysis. Ann NY Acad Sci 689:544-45, 1993.

67. Stoll, G., Li, C.Y., Trapp, B.D. and Griffin, J.W. Expression of NGF-receptors during immune-mediated and lysolecithin-induced demyelination of the peripheral nervous system. J Neurocytol 22:1022-29, 1993.

68. Hsieh, S.-T, Kidd, G.J., Crawford, T.O., Xu, Z., Trapp, B.D., Cleveland, D. W. and Griffin, J.W. Regional modulation of neurofilament organization by myelination in normal axons. J Neurosci 14:6392-6401, 1994.

69. Trapp, B.D. and Hauer, P.E. Amyloid precursor protein is enriched in radial glia: implications for neuronal development. J Neurosci Res 37:538-50, 1994.

70. Schiffmann, R., Moller, J.R., Trapp, B.D., Shih, H.H., Farrer, R.G., Katz, D.A., Alger, J.R., Parker, C. C., Hauer, P.E., Kaneski, C.R., Heiss, J.D., Kaye, E.M., Quarles, R.H., Brady, R.O. and Barton, N.W. Childhood ataxia with diffuse central nervous system hypomyelination. Ann Neurol 35:331-40, 1994.

71. Bö, L., Mörk, S., Kong, P.A., Nyland H., Pardo, C.A. and Trapp, B.D. Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active MS lesions. J Neuroimmunol 51:135-46, 1994.

72. Saito, S., Kidd, G.J., Trapp, B.D., Dawson, T.M., Bredt, D.S., Wilson, D.A., Traystman, R.J., Snyder, S.H. and Hanley, D.F. Rat spinal cord neurons contain nitric oxide synthase. J Neurosci 59:447-56, 1994.

73. Li, C., Tropak, M.B., Gerlai, R., Clapoff, S., Abramow-Newerley, W., Trapp, B., Peterson, A. and Roder, J. Myelination in the absence of MAG. Nature 369:747-50, 1994.

74. Bö, L., Dawson, T.M., Wesselingh, S.O., Mörk, S., Choi, S., Kong, P.A., Hanley, D. and Trapp, B.D. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 36:778-86, 1994.

75. Kidd, G.J., Andrews, S.B. and Trapp, B.D. Organization of microtubules in myelinating Schwann cells. J Neurocytol 23:801-10, 1994.

76. Ulvestad, E., Williams, K., Bö, L., Trapp, B., Antel, J. and Mörk, S. HLA class II molecules (HLA-DR, -DP, -DQ) on cells in the human CNS studied in situ and in vitro. Immunology 82:535-41, 1994.

77. Bartoszewicz, Z.P., Noronha, B.A., Fujita, N., Sato, S., Bö, L., Trapp, B. D. and Quarles, R. H. Abnormal expression and glycosylation of the large and small isoforms of myelin associated glycoprotein in dysmyelinating quaking mutants. J Neurosci Res 41:27-38, 1995.

78. Trapp, B.D., Kidd, G.J., Hauer, P., Mulrenin, E., Haney, C.A. and Andrews, S.B. Polarization of myelinating Schwann cell surface membranes: role of microtubules and the trans-Golgi network. J Neurosci 15: 1797-1807,1995.

79. Bö, L., Quarles, R.H., Fujita, N., Bartoszewicz, Z., Sato, S. and Trapp, B.D. Endocytic depletion of L-MAG from CNS myelin in quaking mice. J Cell Biol 131:1811-20, 1995.

80. Kidd, G.J., Andrews, S.B. and Trapp, B.D. Axons regulate the distribution of Schwann cell microtubules. J Neurosci 16:946-54, 1996.

81. Haney, C., Snipes, G.J., Shooter, E.M., Suter, U., Garcia, C., Griffin, J.W. and Trapp, B.D. Ultrastructural distribution of PMP22 in Charcot-Marie-Tooth disease type 1A. J Neuropathol Exp Neurol 55:290-99, 1996.

82. Power, C., Kong, P.A. and Trapp, B.D. Major histocompatibility complex class I expression in oligodendrocytes induces hypomyelination in transgenic mice. J Neurosci Res 44:165-73, 1996.

83. Yu, M., Nishiyama, A., Trapp, B.D. and Tuohy, V.K. Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis. J Neuroimmunol 64:91-100, 1996.

84. Trapp, B.D., Haney, C.A. and Yin, X. Molecular pathogenesis of peripheral neuropathy. Revue Neurologique (Paris) 152:314-19, 1996.

85. Lam, H.H., Hanley, D.F., Trapp, B.D., Saito, S., Raja, S., Dawson, T.M. and Yamaguchi, H. Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw. Neurosci Lett 210:201-04, 1996.

86. Bö, L., Peterson, J.W., Mörk, S., Hoffman, P.A., Gallatin, W.M., Ransohoff, R.M., Trapp, B.D. Distribution of immunoglobulin superfamily members ICAM-1, -2, -3 and the b2 integrin LFA-1 in multiple sclerosis lesions. J Neuropathol Exp Neurol 55:1060-72, 1996.

87. Gravel, M., Peterson, J., Yong, V.W., Kottis, V., Trapp, B., and Braun, P.E. Overexpression of 2’,3’-cyclic nucleotide 3’-phosphodiesterase in transgenic mice alters oligodendrocyte development and produces aberrant myelination. Mol Cell Neurosci 7:453-66, 1996.

88. Mochizuki, A., Peterson, J.W., Mufson, E.J., and Trapp, B.D. Amyloid load and neural elements in Alzheimer’s disease and nondemented individuals with high amyloid plaque density. Exp Neurol 142:89-102, 1996.

89. Tani, M., Fuentes, M.E., Peterson, J.W., Trapp, B.D., Durham, S.K., Loy, J.K., Bravo, R., Ransohoff, R.M. and Lira, S.A. Neurotrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes. J Clin Invest 98:529-39, 1996.

90. Trapp, B.D., Nishiyama, A., Cheng, D. and Macklin, W. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. J Cell Biol 137:459-68, 1997.

91. Schiffmann, R., Tedeschi, G., Kinkel, R.P., Trapp, B.D., Frank, J.A., Kaneski, C.R., Brady, R.O., Barton, N.W., Nelson, L. and Yanovski, J.A. Leukodystrophy in patients with ovarian dysgenesis. Ann Neurol 41:654-61, 1997.

92. Ransohoff, R.M., Tani, M., Glabinski, A.R., Chernosky, A., Krivacic, K., Peterson, J.W., Chien, H.F. and Trapp, B.D. Chemokines and chemokine receptors in model neurological pathologies: molecular and immunocytochemical approaches. Methods Enzymol 287:319-48, 1997.

93. Yin, X., Peterson, J., Gravel, M., Braun, P.E., and Trapp, B.D. CNP overexpression induces aberrant oligodendrocyte membranes and inhibits MBP accumulation and myelin compaction. J Neurosci Res 50:238-47, 1997.

94. Zhou, A., Paranjape, J., Brown, T.L., Nie, H., Naik, S., Dong, B., Chang, A., Trapp, B., Fairchild, R., Colmenares, C. and Silverman, R.H. Interferon action and apoptosis are defective in mice devoid of 2’,5’-oligoadenylate-dependent RNase L. EMBO J 16:6355-63, 1997.

95. Trapp, B.D., Peterson, J., Ransohoff, R.M., Rudick, R., Mörk, S. and Bö, L. Axonal transection in multiple sclerosis lesions. N Engl J Med 338:278-85, 1998.

96. Yin, X., Crawford, T.O., Griffin, J.W., Tu, P., Lee, V.M., Li, C., Roder, J. and Trapp, B.D. Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J Neurosci 18:1953-62, 1998.

97. Ikezu, T., Trapp, B.D., Song, K.S., Schlegel, A., Lisanti, M.P. and Okamoto, T. Caveolae, plasma membrane micro-domains for alpha-secretase-mediated processing of the amyloid precursor protein. J Biol Chem 273:10485-95, 1998.

98. Zhou, L., Trapp, B.D. and Miller, R.H. Demyelination in the central nervous system mediated by an anti-oligodendrocyte antibody. J Neurosci Res 54:158-68, 1998.

99. Bokesch, P.M., Seirafi, P.A., Warner, K.G., Marchand, J.E., Kream, R.M. and Trapp, B. Differential immediate-early gene expression in ovine brain after cardiopulmonary bypass and hypothermic circulatory arrest. Anesthesiology 89:961-68, 1998.

100. Pioro, E.R., Wang, Y., Moore, J.K., Ng, T.C., Trapp, B.D., Klinkosz, B. and Mitsumoto, H. Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry. Clin Neurosci 9:3041-46, 1998.

101. Ikezu, T., Ueda, H., Trapp, B.D., Nishiyama, K., Sha, J.F., Volonte, D., Galbiati, F., Byrd, A.L., Bassell, G., Serizawa, H., Lane, W.S., Lisanti, M.P. and Okamoto, T. Affinity-purification and characterization of caveolins from the brain. Differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types. Brain Res 804:177-92, 1998.

102. Li, C., Trapp, B., Ludwin, S., Peterson, A., and Roder, J. Myelin associated glycoprotein modulates glia-axon contact in vivo. J Neurosci Res 51:210-17, 1998.

103. Trapp, B.D., Ransohoff, R.M., Fisher, E. and Rudick, R.A. Neurodegeneration in multiple sclerosis: relationship to neurological disability. The Neuroscientist 5:48-57, 1999.

104. Trapp, B.D., Bö, L., Mörk, S. and Chang, A. Pathogenesis of tissue injury in MS lesions. J Neuroimmunol 98:49-56, 1999.

105. Madison, D.L., Krueger, W.H., Cheng, D., Trapp, B.D. and Pfeiffer, S.E. SNARE complex proteins, including the cognate pair VAMP-2 and Syntaxin-4, are expressed in cultured oligodendrocytes. J Neurochem 72:988-98, 1999.

106. Ueda, H., Levine, J.M., Miller, R.H. and Trapp, B.D. Rat optic nerve oligodendrocytes develop in the absence of viable retinal ganglion cell axons. J Cell Biol 146:1365-74, 1999.

107. Haney, C.A., Sahenk, Z., Li, C., Lemmon, V.P., Roder, J. and Trapp, B.D. Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival. J Cell Biol 146:1173-84, 1999.

108. Trapp, B.D., Ransohoff, R. and Rudick, R. Axonal pathology in multiple sclerosis: relationship to neurologic disability. Curr Opin Neurol 12:295-302, 1999.

109. Shoshan, Y., Nishiyama, A., Chang, A., Mörk, S., Barnett, G.H., Cowell, J.K., Trapp, B.D. and Staugaitis, S.M. Expression of oligodendrocyte progenitor cell antigens by gliomas: implication for the histogenesis of brain tumors. Proc Natl Acad Sci USA 96:10361-66, 1999.

110. Nishiyama, A., Chang, A. and Trapp, B.D. NG2+ glial cells: a novel glial cell population in the adult brain. J Neuropathol Exp Neurol 58:1113-24, 1999.

111. Nishiyama, K., Trapp, B.D., Ikezu, T., Ransohoff, R.M., Tomita, T., Iwatsubo, T., Kanazawa, I., Hsiao, K.K., Lisanti, M.P. and Okamoto T. Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer’s disease. J Neurosci 19: 6538-48, 1999.

112. Bjartmar, C., Yin, X. and Trapp, B.D. Axonal pathology in myelin disorders. J Neurocytol 28:383-95, 2000.

113. Yin, X., Kidd, G.J., Wrabetz, L., Feltri, M.L., Messing, A. and Trapp, B.D. Schwann cell myelination requires timely and precise targeting of P0 protein. J Cell Biol 148:1009-20, 2000.

114. Wrabetz, L., Feltri, M.L., Quattrini, A., Imperiale, D., Previtali, S., D'Antonio, M., Martini, R., Yin, X., Trapp, B.D., Zhou, L., Chiu, S.Y. and Messing, A. P0 glycoprotein overexpression causes congenital hypomyelination of peripheral nerves. J Cell Biol 148:1021-34, 2000.

115. Chang, A., Nishiyama, A., Peterson, J., Prineas, J. and Trapp, B.D. NG2-postitive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci 20:6404-12, 2000.

116. Trapp, B.D. and Kidd, G.J. Axo-glial septate junctions: the maestro of nodal formation and myelination? J Cell Biol 150:F97-99, 2000.

117. Bjartmar, C., Kidd, G., Mörk, S., Rudick, R. and Trapp, B.D. Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl-aspartate in chronic multiple sclerosis patients. Ann Neurol 48:893-901, 2000.

118. Bokesch, P.M., Kapural, M., Drummond-Webb, J., Baird, K., Kapural, L., Mee, R.B., Trapp, B. and Starr, N.J. Neuroprotective, anesthetic, and cardiovascular effects of the NMDA antagonist, CNS 5161A, in isoflurane-anesthetized lambs. Anesthesiology 93:202-08, 2000.

119. Nave, K.A. and Trapp, B. Forward: Special issue: Myelinating glial cells. Glia 29:103, 2000.

120. O'Hanlon, G.M., Plomp, J.J., Chakrabarti, M., Morrison, I., Wagner, E.R., Goodyear, C.S., Yin, X., Trapp, B.D., Conner, J., Molenaar, P.C., Stewart, S., Rowan, E.G. and Willison, H.J. Anti-GQ1b ganglioside antibodies mediate complement-dependent destruction of the motor nerve terminal. Brain 124:893-906, 2001.

121. Bjartmar, C., Kinkel, R.P., Kidd, G., Rudick, R.A. and Trapp, B.D. Axonal loss in normal-appearing white matter in a patient with acute MS. Neurology 57:1248-52, 2001.

122. Peterson, J.W., Bö, L., Mörk, S., Chang, A. and Trapp, B.D. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 50:389-400, 2001.

123. Bjartmar, C. and Trapp, B.D. Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Curr Opin Neurol 14:271-78, 2001.

124. Arnold, D.L., de Stefano, N., Matthews, P.M. and Trapp, B.D. N-Acetylaspartate: usefulness as an indicator of viable neuronal tissue. Ann Neurol 50:823-25, 2001.

125. Battistuta, J., Bjartmar, C. and Trapp, B.D. Postmortem degradation of N-acetyl aspartate and N-acetyl aspartylglutamate: an HPLC analysis of different rat CNS regions. Neurochem Res 26:695-702, 2001.

126. Bjartmar, C., Battistuta, J., Terada, N., Dupree, E. and Trapp, B.D. N-acetylaspartate is an axon-specific marker of mature myelinated axons in vivo: A biochemical and immunohistochemical study on the rat optic nerve. Ann Neurol 51:51-58, 2002.

127. Wujek, J.R., Bjartmar, C., Richer, E., Yu, M., Tuohy, V.K. and Trapp, B.D. Axon loss in the spinal cord determines permanent neurological disability in a chronic-relapsing animal model of multiple sclerosis. J Neuropathol Exp Neurol 61:23-32, 2002.

128. Chang, A., Tourtellotte, W.W., Rudick, R., and Trapp, B.D. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 346:165-73, 2002.

129. Kumar, S., Yin, X., Trapp, B.D., Hoh, J.H. and Paulaitis, M.E. Relating interactions between neurofilaments to the structure of axonal neurofilament distributions through polymer brush models. Biophys J 82:2360-72, 2002.

130. Kumar, S., Yin, X., Trapp, B.D., Paulaitis, M.E. and Hoh, J.H. Role of long-range repulsive forces in organizing axonal neurofilament distributions: evidence from mice deficient in myelin-associated glycoprotein. J Neurosci Res 68:681-90, 2002.

131. Matsui, M., Weaver, J., Proudfoot, A.E., Wujek, J.R., Wei, T., Richer, E., Trapp, B.D., Rao, A. and Ransohoff, R.M. Treatment of experimental autoimmune encephalomyelitis with the chemokine receptor antagonist Met-RANTES. J Neuroimmunol 128:16-22, 2002.

132. Peterson, J.W., Bö, L., Mörk, S., Chang, A., Ransohoff, R. and Trapp, B.D. VCAM-1-positive microglia target oligodendrocytes at the border of multiple sclerosis lesions. J Neuropathol Exp Neurol 61:539-46, 2002.

133. Terada, N., Baracskay, K., Kinter, M., Melrose, S., Brophy, P.J., Boucheix, C., Bjartmar, C., Kidd, G. and Trapp, B.D. The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to beta1 integrin, CD81, and Tspan-2. Glia 40:350-59, 2002.

134. Baracskay, K.L., Duchala, C.S., Miller, R.H., Macklin, W.B. and Trapp, B.D. Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice. J Neurosci Res 70:645-54, 2002.

135. Bjartmar, C. and Trapp, B.D. Axonal degeneration and progressive neurological disability in multiple sclerosis. Neurotox Res 5:157-64, 2003.

136. Bjartmar, C., Wujek, J.R. and Trapp, B.D. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J Neurol Sci 206:165-71, 2003.

137. Forsberg-Nilsson, K., Erlandsson, A., Zhang, X.Q., Ueda, H., Svensson, K., Nister, M., Trapp, B.D., Peterson, A.C. and Westermark, B. Oligodendrocyte precursor hypercellularity and abnormal retina development in mice overexpressing PDGF-B in myelinating tracts. Glia 41:276-89, 2003.

138. Bö, L., Vedeler, C.A., Nyland, H.I., Trapp, B.D. and Mörk, S.J. Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J Neuropath Exp Neurol 62:723-32, 2003.

139. Ouardouz, M., Nikolaeva, M.A., Coderre, E., Zamponi, G.W., McRory, J.E., Trapp, B.D., Yin, X., Wang, W., Woulfe, J., and Stys, P.K. Depolarization-induced Ca2+ release in ischemic spinal cord white matter involves L-type Ca2+ channel activation of ryanodine receptors. Neuron 40:53-63, 2003.

140. Bö, L., Vedeler, C.A., Nyland, H., Trapp, B.D. and Mörk, S.J. Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Mult Scler 9:323-31, 2003.

141. Yin, X., Kidd, G.J., Pioro, E.P., McDonough, J., Dutta, R., Feltri, M.L., Wrabetz, L., Messing, A., Wyatt, R.M., Balice-Gordon, R.J., and Trapp, B.D. Dysmyelinated lower motor neurons retract and regenerate dysfunctional synaptic terminals. J Neurosci 24:3890-98, 2004.

142. Morris, J.K., Willard, B.B., Yin, X., Jeserich, G., Kinter, M. and Trapp, B.D. The 36K protein of zebrafish CNS myelin is a short-chain dehydrogenase. Glia 45:378-91, 2004.

143. Vande Velde, C., Garcia, M.L., Yin, X., Trapp, B.D. and Cleveland, D.W. The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease. Neuromolecular Med 5:193-203, 2004.

144. Trapp, B.D. Pathogenesis of multiple sclerosis: the eyes only see what the mind is prepared to comprehend. Ann Neurol 55:455-57, 2004.

145. Terada, N., Kidd, G.J., Kinter, M., Bjartmar, C., Moran-Jones, K. and Trapp, B.D. Beta IV tubulin is selectively expressed by oligodendrocytes in the central nervous system. Glia 50:212-22, 2005.

146. Mi, S., Miller, R.H., Lee, X., Scott, M.L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M., Hession, C., Sah, D., Trapp, B., He, Z., Jung, V., McCoy, J.M., and Pepinsky, R.B. LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci 6:745-51, 2005.

147. Back, S.A., Tuohy, T.M., Chen, H., Wallingford, N., Craig, A., Struve, J., Luo, N.L., Banine, F., Liu, Y., Chang, A., Trapp, B.D., Bebo, B.F., Rao, M.S., and Sherman, L.S. Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nat Med 11:966-72, 2005.

148. Ransohoff, R.M. and Trapp, B.D. Taking two TRAILS. Neuron 46:355-56, 2005.

149. Avila, R.L., Inouye, H., Baek, R.C., Yin, X., Trapp, B.D., Feltri, M.L., Wrabetz, L., and Kirschner, D.A. Structure and stability of internodal myelin in mouse models of hereditary neuropathy. J Neuropathol Exp Neurol 64:976-90, 2005.

150. Peterson, J.W. and Trapp, B.D. Neuropathobiology of multiple sclerosis. Neurol Clin 23: 107-29, 2005.

151. Micu, I., Jiang, Q., Coderre, E., Ridsdale, A., Zhang, L., Woulfe, J., Yin, X., Trapp, B.D., McRory, J.E., Rehak, R., Zamponi, G.W., Wang, W. and Stys, P.K. NMDA receptors mediate calcium accumulation in myelin during chemical ischemia. Nature 439:988-92, 2006.

152. Greco, C.M., Berman, R.F., Martin, R.M., Tassone, F., Schwartz, P.H., Chang, A., Trapp, B.D., Iwahashi, C., Brunberg, J., Grigsby, J., Hessl, D., Becker, E.J., Papazian, J., Leehey, M.A., Hagerman, R.J., and Hagerman, P.J. Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain 129:243-55, 2006.

153. Dutta, R., McDonough, J., Yin, X., Peterson, J., Chang, A., Torres, T., Gudz, T., Macklin, W.B., Lewis, D.A., Fox, R.J., Rudick, R., Mirnics, K., and Trapp, B.D. Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol 59:478-89, 2006.

154. Yin, X., Baek, R.C., Kirschner, D.A., Peterson, A., Fujii, Y., Nave, K.-A., Macklin, W.B. and Trapp, B.D. Evolution of a neuroprotective function of central nervous system myelin. J Cell Biol 172:469-78, 2006.

155. Dhib-Jalbut, S., Arnold, D.L., Cleveland, D.W., Fisher, M., Friedlander, R.M., Mouradian, M.M., Przedborski, S., Trapp, B.D., Wyss-Coray, T. and Yong, V.W. Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. J Neuroimmunol 176:198-215, 2006.

156. Dutta, R. and Trapp, B.D. Anatomopathologie et definition de la sclerose en plaques. Le Revue du Praticien 56:1293-98, 2006.

157. Hu, X., Hicks, C.W., He, W., Wong, P., Macklin, W.B., Trapp, B.D. and Yan, R. BACE1 modulates myelination in the central and peripheral nervous system. Nat Neurosci 9:1520-25, 2006.

158. Criste, G.A. and Trapp, B.D. N-acetyl-L-aspartate in multiple sclerosis. Adv Exp Med Biol 576: 199-214, 2006.

159. Kidd, G.J., Yadav, V.K., Huang, P., Brand, S.L., Low, S.H., Weimbs, T. and Trapp, B.D. A dual tyrosine-leucine motif mediates myelin protein P0 targeting in MDCK cells. Glia 54:135-45, 2006.

160. Ohno, N., Terada, N., Yamakawa, H., Komada, M., Ohara, O., Trapp, B.D. and Ohno, S. Expression of protein 4.1G in Schwann cells of the peripheral nervous system. J Neurosci Res 84:568-77, 2006.

161. Trapp, B.D., Wujek, J.R., Criste, G.A., Jalabi, W., Yin, X., Kidd, G.J., Stohlman, S., and Ransohoff, R.M. Evidence for synaptic stripping by cortical microglia. Glia 55:360-68 2007.

162. Fisher, E., Chang, A., Fox, R.J., Tkach, J.A., Svarovsky, T., Nakamura, K., Rudick, R.A. and Trapp, B.D. Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Ann Neurol 62:219-28, 2007.

163. Zipp, F. and Trapp, B.D. Introduction: Special Issue: Inflammation, neurodegeneration and neuroprotection in the central nervous system. J Neuroimmunol 184:1-3, 2007.

164. Baracskay, K.L., Kidd, G.J., Miller, R.H. and Trapp, B.D. NG2-positive cells generate A2B5-positive oligodendrocyte precursor cells. Glia 55:1001-10, 2007.

165. Dutta, R., McDonough, J., Chang, A., Swamy, L., Siu, A., Kidd, G.J., Rudick, R., Mirnics, K. and Trapp, B.D. Activation of the ciliary neurotrophic factor (CTNF) signaling pathway in cortical neurons of multiple sclerosis patients. Brain 130: 2566-76, 2007.

166. Black, J.A., Newcombe, J., Trapp, B.D. and Waxman, S.G. Sodium channel expression within multiple sclerosis plaques. J Neuropathol Exp Neurol 66: 828-37, 2007.

167. Dutta, R. and Trapp, B.D. Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology 68 (Suppl 3):S22-31; S43-54, 2007.

168. Shpargel, K., Jalabi, W., Jin, Y., Dadabayev, A., Penn, M.S. and Trapp, B.D. Preconditioning paradigms and pathways in the brain. Cleve Clin J Med 75:S77-82, 2008.

169. Young, E.B., Fowler, C.D., Kidd, G.J., Chang, A., Rudick, R.A., Fisher, E. and Trapp, B.D. Imaging correlates of decreased axonal Na+/K+ ATPase in chronic MS lesions. Ann Neurol 63:428-35, 2008.

170. Moll, N.M., Rietsch, A.M., Ransohoff, A.J., Cossoy, M.B., Huang, D., Eichler, F.S., Trapp, B.D. and Ransohoff, R.M. Cortical demyelination in PML and MS: similarities and differences. Neurology 70:336-43, 2008.

171. Nave, K.A. and Trapp, B.D. Axon-glial signaling and the glial support of axon function. Annu Rev Neurosci 31:535-61, 2008.

172. Trapp, B.D. and Nave, K.A. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 31:247-69, 2008.

173. Hu, X., He, W., Diaconu, C., Tang, X., Kidd, G.J., Macklin, W.B., Trapp, B.D. and Yan, R. Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J 22:2970-80, 2008.

174. Trapp, B.D. Rescue of congenital hypomyelination by progenitor cell transplantation. Cell Stem Cell 2:519-20, 2008.

175. Yin, X., Kidd, G.J., Nave, K.A. and Trapp, B.D. P0 protein is required for and can induce formation of Schmidt-Lantermann incisures in myelin internodes. J Neurosci 28:7068-73, 2008.

176. Chang, A., Smith, M.C., Yin, X., Fox, R.J., Staugaitis, S.M. and Trapp, B.D. Neurogenesis in the chronic lesions of multiple sclerosis. Brain 131:2366-75, 2008.

177. Moll, N.M., Cossoy, M.B., Fisher, E., Staugaitis, S.M., Tucky, B.H., Rietsch, A.M., Chang, A., Fox, R.J., Trapp, B.D. and Ransohoff, R.M. Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in multiple sclerosis. Arch Neurol 66: 44-53, 2009.

178. Ouardouz, M., Coderre, E., Basak, A., Chen, A., Zamponi, G.W., Hameed, S., Rehak, R., Yin, X., Trapp, B.D. and Stys, P.K. Glutamate receptors on myelinated spinal cord axons: I. Glutamate receptor 6 kainate receptors. Ann Neurol 65:151-59, 2009.

179. Ouardouz, M., Coderre, E., Zamponi, G.W., Hameed, S., Yin, X., Trapp, B.D. and Stys, P.K. Glutamate receptors on myelinated spinal cord axons: II. AMPA and glutamate receptor 5 receptors. Ann Neurol 65:160-66, 2009.

180. Trapp, B.D. and Stys, P.K. Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. Lancet Neurol 8:280-91, 2009.

181. Wu, S., Chang, A., Smith, M.C., Won, R., Yin, X., Staugaitis, S.M., Agamanolis, D., Kidd, G.J., Miller, R.H. and Trapp, B.D. Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain. J Neurosci 29:7649-57, 2009.

182. Trapp, B.D. Neurodegeneration: The pathologic evidence. Johns Hopkins Advanced Studies in Medicine 9:37-41, 2009.

183. Ishii, A., Duttam R., Wark, G.M., Hwang, S.I., Han, D.K., Trapp, B.D., Pfeiffer, S.E. and Bansal, R. Human myelin pretome and comparative analysis with mouse myelin. Proc Natl Acad Sci USA 106:14605-10, 2009.

184. Staugaitis, S.M. and Trapp, B.D. NG2-positive glia in the human central nervous system. Neuron Glia Biol XX:1-10, 2010, in press.

185. Rudick, R.A. and Trapp, B.D. Gray-matter injury in multiple sclerosis. N Engl J Med 361:1505-06, 2009.

186. Chen, Y., Wu, H., Wang, S., Koito, H., Li, J., Ye, F., Hoang, J., Escobar, S.S., Gow, A., Arnett, H.A., Trapp, B.D., Karandikar, N.J., Hsieh, J., and Lu, Q.R. The ologodendrocye-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci 12:1398-406, 2009.

 

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